19,015 results match your criteria evolution prevention

Prevalence of GII.4 Sydney Norovirus Strains and Associated Factors of Acute Gastroenteritis in Children: 2019/2020 Season in Guangzhou, China.

Food Environ Virol 2021 Jun 21. Epub 2021 Jun 21.

Medical Genetic Centre, Guangdong Women and Children's Hospital, Guangzhou Medical University, Guangzhou, 511442, People's Republic of China.

Norovirus, the leading cause of non-bacterial acute gastroenteritis (AGE) worldwide, is constantly mutating. Continuous monitoring of the evolution of epidemic genotypes and emergence of novel genotypes is, therefore, necessary. This study determined the prevalence and clinical characteristics of norovirus strains in AGE in Guangzhou, China in 2019/2020 season. Read More

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Analysing different exposures identifies that wearing masks and establishing COVID-19 areas reduce secondary-attack risk in aged-care facilities.

Int J Epidemiol 2021 Jun 21. Epub 2021 Jun 21.

Maladies Infectieuses et Vecteurs: Écologie Génétique Évolution Contrôle (MIVEGEC), Centre National de la Recherche Scientifique (CNRS), Institut de Recherche pour le Développement (IRD), Université de Montpellier, France.

Background: The COVID-19 epidemic has spread rapidly within aged-care facilities (ACFs), where the infection-fatality ratio is high. It is therefore urgent to evaluate the efficiency of infection prevention and control (IPC) measures in reducing SARS-CoV-2 transmission.

Methods: We analysed the COVID-19 outbreaks that took place between March and May 2020 in 12 ACFs using reverse transcription-polymerase chain reaction (RT-PCR) and serological tests for SARS-CoV-2 infection. Read More

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Thermal Properties and Key Groups Evolution of Low-Temperature Oxidation for Bituminous Coal under Lean-Oxygen Environment.

ACS Omega 2021 Jun 2;6(23):15115-15125. Epub 2021 Jun 2.

School of Safety Science and Engineering, Henan Polytechnic University (HPU), 2001, Century Avenue, Jiaozuo, Henan 454000, China.

To deeply explore the spontaneous combustion disaster of coal caused by air leakage and oxygen supply, low-temperature coal oxidation experiments under different oxygen concentrations (DOC) were carried out. Within the coal spontaneous combustion characteristic measurement system, a synchronous thermal analyzer (STA) and a Fourier transform infrared spectrometer (FTIR), the macro laws of gas and heat generation under DOC are analyzed, and the mechanism of the development of coal spontaneous combustion restricted by the lean-oxygen environment is also revealed. The results show that the change of oxygen concentration (OC) does not affect the critical temperature value and gas index change trend, but the lean-oxygen environment reduces the gas concentration and heat production rate very obviously. Read More

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A Systems-Based Key Innovation-Driven Approach Infers Co-option of Jaw Developmental Programs During Cancer Progression.

Front Cell Dev Biol 2021 2;9:682619. Epub 2021 Jun 2.

Institute of Experimental Gene Therapy and Cancer Research, Rostock University Medical Center, Rostock, Germany.

Cancer acquires metastatic potential and evolves via co-opting gene regulatory networks (GRN) of embryonic development and tissue homeostasis. Such GRNs are encoded in the genome and frequently conserved among species. Considering that all metazoa have evolved from a common ancestor via major macroevolutionary events which shaped those GRNs and increased morphogenetic complexity, we sought to examine whether there are any key innovations that may be consistently and deterministically linked with metastatic potential across the metazoa clades. Read More

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Xeroderma pigmentosum A homolog from partially complements DNA repair defect in human XPA-deficient cells.

J Biosci 2021 ;46

Developmental Biology Group, MACS-Agharkar Research Institute, Pune 411 004, India.

Nucleotide excision repair (NER) pathway is a DNA repair mechanism that rectifies a wide spectrum of DNA lesions. Xeroderma pigmentosum group of proteins (XPA through XPG) orchestrate the NER pathway in humans. We have earlier studied XPA homolog from (HyXPA) and found it to be similar to human XPA. Read More

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January 2021

Health threats from increased antigenicity changes in H5N6-dominant subtypes, 2020 China.

J Infect 2021 Jun 17. Epub 2021 Jun 17.

National Avian Influenza Para-Reference Laboratory, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China; Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, China; Key Laboratory of Zoonoses Prevention and Control of Guangdong Province, Guangzhou 510642, China. Electronic address:

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Complications of laser-assisted keratomileusis.

Indian J Ophthalmol 2021 Jul;69(7):1658-1669

Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Laser-assisted in situ keratomileusis (LASIK) is one of the most commonly performed kerato-refractive surgery globally. Since its introduction in 1990, there has been a constant evolution in its technology to improve the visual outcome. The safety, efficacy, and predictability of LASIK are well known, but complications with this procedure, although rare, are not unknown. Read More

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influences quorum sensing-controlled phenotypes of acute hepatopancreatic necrosis disease-causing .

PeerJ 2021 1;9:e11567. Epub 2021 Jun 1.

Division of Biological Science, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla, Thailand.

Background: Acute hepatopancreatic necrosis syndrome (AHPND) caused by strain (VP) impacts the shrimp industry worldwide. With the increasing problem of antibiotic abuse, studies on quorum sensing (QS) system and anti-QS compounds bring potential breakthroughs for disease prevention and treatment.

Methods: In this study, the cell-free culture supernatant (CFCS) and its extract of BC25 were investigated for anti-QS activity against a reporter bacteria, DMST46846. Read More

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Genomic evolution, transmission dynamics, and pathogenicity of avian influenza A (H5N8) viruses emerging in China, 2020.

Virus Evol 2021 Jan 6;7(1):veab046. Epub 2021 May 6.

National Avian Influenza Para-Reference Laboratory, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.

Multiple recent outbreaks of highly pathogenic H5N8 viruses originating in aquatic birds frequently occurred in most European countries, Russia, South Korea, and Japan during the winter of 2020-21, and one zoonotic event of poultry workers infected with novel H5N8 viruses were reported in Russia. Strikingly, these novel H5N8 viruses had emerged and been co-circulating in wild birds and poultry in multiple provinces of China during 2020-21. In China, the population of aquatic birds has risen significantly in the past twenty years, and China is regarded as the largest reservoir for influenza viruses carried in aquatic birds across the globe. Read More

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January 2021

Systematic Coronary Risk Evaluation (SCORE): JACC Focus Seminar 4/8.

J Am Coll Cardiol 2021 Jun;77(24):3046-3057

University College Dublin, Dublin, Ireland.

Clinical estimation of the combined effect of several risk factors is unreliable and this resulted in the development of a number of risk estimation systems to guide clinical practice. Here, after defining general principles of risk estimation, the authors describe the evolution of the European Society of Cardiology's (ESC) Systematic COronary Risk Evaluation (SCORE) risk estimation system and some learnings from the data. They move on to describe the establishment of the ESC's Cardiovascular Risk Collaboration and outline its proposed research directions. Read More

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[Genomic characterization of food-borne Listeria monocytogenes isolates from Nanshan district of Shenzhen during 2009-2019].

Zhonghua Yu Fang Yi Xue Za Zhi 2021 Jun;55(6):774-779

Shenzhen Nanshan Center for Disease Control and Prevention, The Department of Microbiological Laboratory, Shenzhen 518054, China.

The study aims to investigate the characteristic baseline information about genetic lineages, drug-resistance genes, virulence genes and evolutionary relationships of food-borne Listeria monocytogenes (Lm) isolates from Nanshan district of Shenzhen. The whole genomes of 46 Lm isolates during 2009-2019 were extracted and sequenced (Illumina PE-150, 100×). The CLC Genomics Workbench 12. Read More

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Assembly and annotation of whole-genome sequence of Fusarium equiseti.

Genomics 2021 Jun 14. Epub 2021 Jun 14.

Institute of Plant Protection, Gansu Academy of Agricultural Sciences, Lanzhou 730070, China.

Fusarium equiseti is a plant pathogen with a wide range of hosts and diverse effects, including probiotic effects. However, the molecular mechanisms underlying these effects remain unclear, hindering its effective utilization. The final assembly included 16 scaffolds of contiguous sequence without gaps. Read More

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Pan-Genome Analysis of and Strains Isolated From Migratory Birds at Dali Nouer Lake in Chifeng, China.

Front Vet Sci 2021 31;8:638820. Epub 2021 May 31.

The Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun, China.

Migratory birds are recently recognized as disease vectors, but may be widespread transporters of strains. We isolated and strains from migratory bird epidemic samples from 2017 to 2018 and isolated from migratory bird feces in 2019 from bird samples taken from the Inner Mongolia autonomous region of China. To investigate the evolution of these two species, we sequenced the genomes of 40 strains and 34 strains isolated from the bird samples and compared these genomes with reference strain genomes. Read More

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Review of the measles epidemic in children from Central Eastern Europe in the third millennium.

Exp Ther Med 2021 Aug 2;22(2):816. Epub 2021 Jun 2.

Department of Paediatrics, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.

Measles is an extremely contagious viral disease. Even though a safe vaccine exists for this disease, it remains one of the leading causes of mortality and morbidity in infants and young children. We aimed to create a retrospective descriptive study in which to analyze the evolution of the measles epidemic at the European level. Read More

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Genetic variation analysis of Type 2 porcine reproductive and respiratory syndrome virus in Guangdong Province from 2016 to 2018.

Acta Virol 2021 ;65(2):221-231

Porcine reproductive and respiratory syndrome virus (PRRSV) is a notable threat to the pig industry. Long-term epidemiological investigations and genetic variation analyses of PRRSV isolates benefit PRRSV prevention and control. In our study, 43 PRRSV strains were  successfully isolated from the lungs of sick pigs, and the genetic variations of these isolates were analyzed. Read More

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Detection and molecular characterization of a highly oncogenic Marek's disease virus from vaccinated hens in Turkey.

Acta Virol 2021 ;65(2):212-220

Marek's disease (MD) is a highly contagious neoplastic disease of chickens associated with economic losses, often due to visceral lymphomas. The etiological agent is MD virus serotype 1 (MDV-1), also called Gallid alphaherpesvirus 2 (GaHV-2). Despite intensive vaccination, MDV is constantly evolving and maintaining its presence in the world. Read More

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[Genotype and genetic characteristics of human respiratory syncytial virus circulating in Quanzhou, 2018-2019].

Zhonghua Yi Xue Za Zhi 2021 Jun;101(22):1695-1699

WHO WPRO Regional Reference Measles/Rubella Laboratory National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China.

To study the prevalence and genetic characteristics of human respiratory syncytial virus (HRSV) in Quanzhou city, from 2018 to 2019. A total of 141 throat swabs were collected from children patients of lower respiratory tract infection in Quanzhou children Hospital, Fujian Province from November 2018 to May 2019. RT-PCR was used to amplify the 3 'end of G gene HRSV. Read More

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Genomic evolution and virulence association of sequence type 37 (ribotype 017) in China.

Emerg Microbes Infect 2021 Jun 14:1-0. Epub 2021 Jun 14.

School of Laboratory Medicine, Hangzhou Medical College, Hangzhou, Zhejiang, 310053, China.

sequence type (ST) 37 (ribotype 017) is one of the most prevalent genotypes circulating in China. However, its genomic evolution and virulence determinants were rarely explored. Whole-genome sequencing, phylogeographic and phylogenetic analyses were conducted for ST37 isolates. Read More

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Long-term evolution of cartilage abnormalities and osteophytes in the fingers of elite sport climbers: a cross-sectional 10-year follow-up study.

Eur J Sport Sci 2021 Jun 13:1-15. Epub 2021 Jun 13.

University Centre for Prevention and Sports Medicine, Department of Orthopaedics, Balgrist University Hospital, University of Zurich, Switzerland.

The sequelae of high mechanical stress to the proximal interphalangeal (PIP) and distal interphalangeal (DIP) joints of the fingers in elite sport climbers and its contribution to the development of osteoarthritis are still relatively unknown. The purpose of this study was to investigate the evolution of cartilage abnormalities of the PIP and DIP joints, as well as the progress of osteophytes, in the fingers of elite sport climbers with a minimum of 25 years of climbing history over the time period of the last 10 years. Moreover, their actual cartilage abnormalities and osteophyte occurrence were compared to non-climbing age-matched controls. Read More

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Co-mutation modules capture the evolution and transmission patterns of SARS-CoV-2.

Brief Bioinform 2021 Jun 14. Epub 2021 Jun 14.

Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005; Suzhou Institute of Systems Medicine, Suzhou, Jiangsu 215123, China.

The rapid spread and huge impact of the COVID-19 pandemic caused by the emerging SARS-CoV-2 have driven large efforts for sequencing and analyzing the viral genomes. Mutation analyses have revealed that the virus keeps mutating and shows a certain degree of genetic diversity, which could result in the alteration of its infectivity and pathogenicity. Therefore, appropriate delineation of SARS-CoV-2 genetic variants enables us to understand its evolution and transmission patterns. Read More

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Genetic and pathogenic characterization of a novel recombinant avian infectious bronchitis virus derived from GI-1, GI-13, GI-28, and GI-19 strains in Southwestern China.

Poult Sci 2021 Apr 29;100(7):101210. Epub 2021 Apr 29.

Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province; Key Laboratory of Bio-Resources and Eco-Environment, Ministry of Education, College of Life Science Sichuan University, Chengdu 610064, China. Electronic address:

Avian infectious bronchitis (IB), caused by avian infectious bronchitis virus (IBV), is an acute and highly contagious disease that is extremely harmful to the poultry industry throughout the world. The cross-using of different attenuated live vaccine strains has led to the occurrence of diverse IBV serotypes. In this study, we isolated an IBV strain from a chicken farm in southwest China and designated it CK/CH/SCMY/160315. Read More

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IgG Subclass Analysis in Patients with Chagas Disease 4 Years After Benznidazole Treatment.

Acta Parasitol 2021 Jun 11. Epub 2021 Jun 11.

Department of Microbiology, Immunology and Parasitology, Institute of Biological and Natural Sciences, Federal University of Triângulo Mineiro. Uberaba, Minas Gerais, Brazil.

Background: In humans, Trypanosoma cruzi infection is controlled by a complex immune response. Immunoglobulin G (IgG) is important for opsonizing blood trypomastigotes, activating the classic complement pathway, and reducing parasitemia. The trypanocidal activity of benznidazole is recognized, but its effects on the prevention and progression of Chagas disease is not well understood OBJECTIVE: We aimed to evaluate the levels of total IgG and cross-specific IgG subclasses in patients with chronic Chagas disease of different clinical forms before and after 4 years of benznidazole treatment. Read More

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COVID-19-Associated Pneumonia: Radiobiological Insights.

Front Pharmacol 2021 25;12:640040. Epub 2021 May 25.

Department of Radiation Biological Effects, French Armed Forces Biomedical Research Institute, Brétigny-sur-Orge, France.

The evolution of SARS-CoV-2 pneumonia to acute respiratory distress syndrome is linked to a virus-induced "cytokine storm", associated with systemic inflammation, coagulopathies, endothelial damage, thrombo-inflammation, immune system deregulation and disruption of angiotensin converting enzyme signaling pathways. To date, the most promising therapeutic approaches in COVID-19 pandemic are linked to the development of vaccines. However, the fight against COVID-19 pandemic in the short and mid-term cannot only rely on vaccines strategies, in particular given the growing proportion of more contagious and more lethal variants among exposed population (the English, South African and Brazilian variants). Read More

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The predictive ability of the 313 variant-based polygenic risk score for contralateral breast cancer risk prediction in women of European ancestry with a heterozygous BRCA1 or BRCA2 pathogenic variant.

Genet Med 2021 Jun 10. Epub 2021 Jun 10.

Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic.

Purpose: To evaluate the association between a previously published 313 variant-based breast cancer (BC) polygenic risk score (PRS) and contralateral breast cancer (CBC) risk, in BRCA1 and BRCA2 pathogenic variant heterozygotes.

Methods: We included women of European ancestry with a prevalent first primary invasive BC (BRCA1 = 6,591 with 1,402 prevalent CBC cases; BRCA2 = 4,208 with 647 prevalent CBC cases) from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA), a large international retrospective series. Cox regression analysis was performed to assess the association between overall and ER-specific PRS and CBC risk. Read More

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Topical estrogen, testosterone, and vaginal dilator in the prevention of vaginal stenosis after radiotherapy in women with cervical cancer: a randomized clinical trial.

BMC Cancer 2021 Jun 10;21(1):682. Epub 2021 Jun 10.

Department of Gynecology, Faculty of Medical Sciences, State University of Campinas - UNICAMP, Rua Alexander Fleming, 101, Cidade Universitária Zeferino Vaz, Campinas, SP, 13083-881, Brazil.

Background: We aimed to evaluate the effects of different therapeutic options to prevent the evolution of vaginal stenosis after pelvic radiotherapy in women with cervical cancer.

Methods: open-label randomized clinical trial of 195 women, stage I-IIIB, aged 18-75 years, using topical estrogen (66), topical testosterone (34), water-based intimate lubricant gel (66), and vaginal dilators (29) to assess the incidence and severity of vaginal stenosis after radiotherapy at UNICAMP-Brazil, from January/2013 to May/2018. The main outcome measure was vaginal stenosis assessed using the Common Terminology Criteria for Adverse Events (CTCAE) scale and percental changes in vaginal volume. Read More

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The identification of a B-cell epitope in bovine viral diarrhea virus (BVDV) core protein based on a mimotope obtained from a phage-displayed peptide library.

Int J Biol Macromol 2021 Jun 7;183:2376-2386. Epub 2021 Jun 7.

College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou, Henan 450002, China; Henan Provincial Key Laboratory of Animal Immunology, Henan Academy of Agricultural Sciences, Zhengzhou 450002, China.

Bovine pestivirus A and B, previously known as bovine viral diarrhea virus (BVDV)-1 and 2, respectively, are important pathogens of cattle worldwide, which causes significant economic losses. B-cell epitopes in BVDV glycoprotein E2 and nonstructural protein NS2/3 have been extensively identified. In this study, we screened a 12-mer phage display peptide library using commercial goat anti-BVDV serum, and identified a mimotope "LTPHKHHKHLHA" referred to as P3. Read More

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Sex-related effects in major depressive disorder: Results of the European Group for the Study of Resistant Depression.

Depress Anxiety 2021 Jun 10. Epub 2021 Jun 10.

Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.

Background: Sex-related effects on the evolution and phenotype of major depressive disorder (MDD) were reported previously.

Methods: This European multicenter cross-sectional study compared sociodemographic, clinical, and treatment patterns between males and females in a real-world sample of 1410 in- and outpatients with current MDD.

Results: Male MDD patients (33. Read More

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Trace elements and the carotid plaque: the GOOD (Mg, Zn, Se), the UGLY (Fe, Cu), and the BAD (P, Ca)?

Eur Rev Med Pharmacol Sci 2021 05;25(10):3772-3790

Department of Medical Sciences and Public Health, Division of Pathology, Azienda Ospedaliero Universitaria (A.O.U.), di Cagliari - University Hospital San Giovanni di Dio, University of Cagliari, Cagliari, Italy.

Multiple epidemiological studies have suggested that industrialization and progressive urbanization should be considered one of the main factors responsible for the rising of atherosclerosis in the developing world. In this scenario, the role of trace metals in the insurgence and progression of atherosclerosis has not been clarified yet. In this paper, the specific role of selected trace elements (magnesium, zinc, selenium, iron, copper, phosphorus, and calcium) is described by focusing on the atherosclerotic prevention and pathogenesis plaque. Read More

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Characterization and Recombinant genotypes of HIV-1 in Gansu Province, China.

AIDS Res Hum Retroviruses 2021 Jun 9. Epub 2021 Jun 9.

Gansu Provincial Center for Disease Control and Prevention, Lanzhou, China;

Objectives: It is important to monitor the diversity and evolution of HIV-1 genotypes especially in some remote and undeveloped regions in China where the diversity and distribution of HIV-1 genotypes are not fully clear.

Methods: To investigate the genotypes and distribution of HIV-1 in far Northwestern Gansu Province of China, we selected 220 HIV-1 positive plasma samples from the center of disease prevention and control (CDC) in Gansu from January 2016 to December 2018. The viral load of inclusion samples were over 1000 copies per milliliter. Read More

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Evolution of DNA aptamers against esophageal squamous cell carcinoma using cell-SELEX.

Analyst 2021 Jun 9. Epub 2021 Jun 9.

Department of Pathophysiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China. and Henan Provincial Cooperative Innovation Center for Cancer Chemoprevention, Zhengzhou, Henan, China and State Key Laboratory of Esophageal Cancer Prevention and Treatment, Zhengzhou University, Zhengzhou, Henan, China and China-US Hormel (Henan) Cancer Institute, Zhengzhou, Henan, China and Cancer Chemoprevention International Collaboration Laboratory, Zhengzhou, Henan, China.

Esophageal cancer is the ninth most common cancer and the sixth most common cause of cancer-related death worldwide, and the esophageal squamous cell carcinoma (ESCC) subtype accounts for about 90% of all cases of esophageal cancer globally. Currently, ESCC is usually diagnosed in late stages, and targeted therapy is lacking. Therefore, the development of ESCC-specific recognition molecules for an early detection and targeted treatment of ESCC is urgently needed. Read More

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