57 results match your criteria evolution bone-implant


Fixation of Transparent Bone Pins with Photocuring Biocomposites.

ACS Biomater Sci Eng 2021 09 13;7(9):4463-4473. Epub 2021 Aug 13.

School of Materials Science and Engineering (MSE), Nanyang Technological University (NTU), 639798 Singapore.

Bone fractures are in need of rapid fixation methods, but the current strategies are limited to metal pins and screws, which necessitate secondary surgeries upon removal. New techniques are sought to avoid surgical revisions, while maintaining or improving the fixation speed. Herein, a method of bone fixation is proposed with transparent biopolymers anchored in place via light-activated biocomposites based on expanding CaproGlu bioadhesives. Read More

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September 2021

Evolution of anodised titanium for implant applications.

Heliyon 2021 Jul 26;7(7):e07408. Epub 2021 Jun 26.

Department of Manufacturing Engineering, Faculty of Mechanical and Manufacturing Engineering, UTHM Parit Raja 86400, Batu Pahat, Johor, Malaysia.

Anodised titanium has a long history as a coating structure for implants due to its bioactive and ossified surface, which promotes rapid bone integration. In response to the growing literature on anodised titanium, this article is the first to revisit the evolution of anodised titanium as an implant coating. The review reports the process and mechanisms for the engineering of distinctive anodised titanium structures, the significant factors influencing the mechanisms of its formation, bioactivity, as well as recent pre- and post-surface treatments proposed to improve the performance of anodised titanium. Read More

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A simple and effective 1D-element discrete-based method for computational bone remodeling.

Comput Methods Biomech Biomed Engin 2021 Jun 30:1-17. Epub 2021 Jun 30.

Universidad Nacional de Colombia, Bogotá, Colombia.

In-silico models applied to bone remodeling are widely used to investigate bone mechanics, bone diseases, bone-implant interactions, and also the effect of treatments of bone pathologies. This article proposes a new methodology to solve the bone remodeling problem using one-dimensional (1D) elements to discretize trabecular structures more efficiently for 2D and 3D domains. An Euler integration scheme is coupled with the momentum equations to obtain the evolution of material density at each step. Read More

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A stochastic micro to macro mechanical model for the evolution of bone-implant interface stiffness.

Acta Biomater 2021 09 12;131:415-423. Epub 2021 Jun 12.

Department of Biomaterials, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden.

Upon placement of an implant into living bone, an interface is formed through which various biochemical, biological, physical, and mechanical interactions take place. This interface evolves over time as the mechanical properties of peri-implant bone increase. Owing to the multifactorial nature of interfacial processes, it is challenging to devise a comprehensive model for predicting the mechanical behavior of the bone-implant interface. Read More

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September 2021

A mechanobiological approach to find the optimal thickness for the locking compression plate: Finite element investigations.

Proc Inst Mech Eng H 2021 Apr 9;235(4):408-418. Epub 2021 Jan 9.

Bone and Joint Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

This study aimed at finding the acceptable range, and the optimal value for the locking compression plate (LCP) thickness (THK), through simulating the osteogenic pathway of bone healing, and by checking bone-plate construct's strength and stability. To attain the goals of this research, a multi-objective approach was adopted, which should trade-off between some conflicting objectives. A finite element model of the long bone-plate construct was made first, and validated against an experimental study. Read More

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Quantitative ultrasound assessment of the influence of roughness and healing time on osseointegration phenomena.

Sci Rep 2020 12 15;10(1):21962. Epub 2020 Dec 15.

MSME, CNRS UMR 8208, Univ Paris Est Creteil, Univ Gustave Eiffel, CNRS, 61, Avenue du Général de Gaulle, 94010, Créteil Cedex, France.

The evolution of bone tissue quantity and quality in contact with the surface of orthopedic and dental implants is a strong determinant of the surgical outcome but remains difficult to be assessed quantitatively. The aim of this study was to investigate the performance of a quantitative ultrasound (QUS) method to measure bone-implant interface (BII) properties. A dedicated animal model considering coin-shaped titanium implants with two levels of surface roughness (smooth, S = 0. Read More

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December 2020

Microstructure evolution and texture tailoring of reduced graphene oxide reinforced Zn scaffold.

Bioact Mater 2021 May 7;6(5):1230-1241. Epub 2020 Nov 7.

Institute of Bioadditive Manufacturing, Jiangxi University of Science and Technology, Nanchang, 330013, China.

Zinc (Zn) possesses desirable degradability and favorable biocompatibility, thus being recognized as a promising bone implant material. Nevertheless, the insufficient mechanical performance limits its further clinical application. In this study, reduced graphene oxide (RGO) was used as reinforcement in Zn scaffold fabricated via laser additive manufacturing. Read More

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Oral microbial profile variation during canine ligature-induced peri-implantitis development.

BMC Microbiol 2020 09 29;20(1):293. Epub 2020 Sep 29.

Department of Implant Dentistry, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai, 200011, PR China.

Background: Dental implants have become well-established in oral rehabilitation for fully or partially edentulous patients. However, peri-implantitis often leads to the failure of dental implants. The aim of this study was to understand the core microbiome associated with peri-implantitis and evaluate potential peri-implantitis pathogens based on canine peri-implantitis model. Read More

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September 2020

Spatio-temporal evolution of hydroxyapatite crystal thickness at the bone-implant interface.

Acta Biomater 2020 10 13;116:391-399. Epub 2020 Sep 13.

MSME, CNRS UMR 8208, Univ Paris Est Creteil, Univ Gustave Eiffel, F-94010 Creteil, France.

A better understanding of bone nanostructure around the bone-implant interface is essential to improve longevity of clinical implants and decrease failure risks. This study investigates the spatio-temporal evolution of mineral crystal thickness and plate orientation in newly formed bone around the surface of a metallic implant. Standardized coin-shaped titanium implants designed with a bone chamber were inserted into rabbit tibiae for 7 and 13 weeks. Read More

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October 2020

Bone Damage Evolution Around Integrated Metal Screws Using X-Ray Tomography - Pullout and Digital Volume Correlation.

Front Bioeng Biotechnol 2020 5;8:934. Epub 2020 Aug 5.

Department of Biomedical Engineering, Lund University, Lund, Sweden.

Better understanding of the local deformation of the bone network around metallic implants subjected to loading is of importance to assess the mechanical resistance of the bone-implant interface and limit implant failure. In this study, four titanium screws were osseointegrated into rat tibiae for 4 weeks and screw pullout was conducted under x-ray microtomography, recording macroscopic mechanical behavior and full tomographies at multiple load steps before failure. Images were analyzed using Digital Volume Correlation (DVC) to access internal displacement and deformation fields during loading. Read More

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Analytical modeling of the interaction of an ultrasonic wave with a rough bone-implant interface.

Ultrasonics 2020 Dec 25;108:106223. Epub 2020 Jul 25.

CNRS, Laboratoire Modélisation et Simulation Multi Echelle, MSME UMR 8208 CNRS, 94010 Créteil Cedex, France. Electronic address:

Quantitative ultrasound can be used to characterize the evolution of the bone-implant interface (BII), which is a complex system due to the implant surface roughness and to partial contact between bone and the implant. The determination of the constitutive law of the BII would be of interest in the context of implant acoustical modeling in order to take into account the imperfect characteristics of the BII. The aim of the present study is to propose an analytical effective model describing the interaction between an ultrasonic wave and a rough BII. Read More

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December 2020

Influence of Smoking on Dental Implant Osseointegration: A Radiofrequency Analysis of 194 Implants.

J Oral Implantol 2021 Apr;47(2):110-117

Universidad Católica de Valencia San Vicente Mártir, Valencia, Spain.

Although many studies have related smoking to peri-implantitis and marginal bone loss, little is known of its potential impact on dental implant osseointegration. The present clinical study explores the influence of smoking on secondary stabilization based in radiofrequency analysis. A total of 194 implants in 114 patients were included. Read More

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Rational design, bio-functionalization and biological performance of hybrid additive manufactured titanium implants for orthopaedic applications: A review.

J Mech Behav Biomed Mater 2020 05 6;105:103671. Epub 2020 Feb 6.

Christchurch Regenerative Medicine and Tissue Engineering (CReaTE) Group, Department of Orthopedic Surgery & Musculoskeletal Medicine, Centre for Bioengineering & Nanomedicine, University of Otago, Christchurch, New Zealand; Medical Technologies Centre of Research Excellence (MedTech CoRE), New Zealand. Electronic address:

Evolution of metallurgy and biomaterials has progressively shifted the focus of metallic bone-interfacing implant design from adequate mechanical strength and biocompatibility to rapid osseointegration and infection inhibition. The now relatively well-established technology - powder bed additive manufacturing (AM), offers the ability to fabricate porous implants with precise mechanical properties, topological pore architectures and patient-specific design functions, has revolutionized the production of customized multifunctional metallic implants for the individual patient with anatomic-specific requirement. Even though AM titanium and its alloy Ti-6Al-4V have been investigated and adopted for clinical application for decades, the development of porous AM titanium implants is far from complete and further research is required to achieve excellent long-term clinical performance. Read More

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Micromechanical modeling of the contact stiffness of an osseointegrated bone-implant interface.

Biomed Eng Online 2019 Dec 3;18(1):114. Epub 2019 Dec 3.

CNRS, Laboratoire Modélisation et Simulation Multi Echelle, MSME, UMR CNRS 8208, 61 Avenue du Général de Gaulle, 94010, Créteil, France.

Background: The surgical success of cementless implants is determined by the evolution of the biomechanical properties of the bone-implant interface (BII). One difficulty to model the biomechanical behavior of the BII comes from the implant surface roughness and from the partial contact between bone tissue and the implant. The determination of the constitutive law of the BII would be of interest in the context of implant finite element (FE) modeling to take into account the imperfect characteristics of the BII. Read More

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December 2019

Modeling ultrasonic wave propagation in a dental implant - Bone system.

J Mech Behav Biomed Mater 2020 03 20;103:103547. Epub 2019 Nov 20.

Faculty of Mechanical Engineering, Technion, 32000, Haifa, Israel. Electronic address:

The evolution of the bone-implant interface reflects the implant osseointegration and bond strength, thereby determining the overall implant stability in the jawbone. Quantitative ultrasound represents a promising alternative technique to characterize the interfacial integrity, precisely due to the fact that those waves propagate essentially along the bone-implant interface, and are therefore influenced by its state. This study reports a numerical investigation of ultrasonic wave propagation for a commercial implant-jawbone system in which the thickness and mechanical properties of the interfacial layer (corresponding to the interphase) are systematically varied through the application of a rule of mixtures, in order to mimic the evolution from a dominantly soft tissue - like medium up to a fully healed bone. Read More

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Biomechanical behaviours of the bone-implant interface: a review.

J R Soc Interface 2019 07 31;16(156):20190259. Epub 2019 Jul 31.

CNRS, Laboratoire Modélisation et Simulation Multi Echelle, UMR CNRS 8208, 61 avenue du Général de Gaulle, 94010 Créteil cedex, France.

In recent decades, cementless implants have been widely used in clinical practice to replace missing organs, to replace damaged or missing bone tissue or to restore joint functionality. However, there remain risks of failure which may have dramatic consequences. The success of an implant depends on its stability, which is determined by the biomechanical properties of the bone-implant interface (BII). Read More

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Reflection of an ultrasonic wave on the bone-implant interface: Effect of the roughness parameters.

J Acoust Soc Am 2019 06;145(6):3370

CNRS, Laboratoire Modélisation et Simulation Multi-Échelle, MSME UMR 8208 CNRS, 61 avenue du Général de Gaulle, 94010 Créteil Cedex, France.

Quantitative ultrasound can be used to characterize the evolution of the bone-implant interface (BII), which is a complex system due to the implant surface roughness and to partial contact between bone and the implant. The aim of this study is to derive the main determinants of the ultrasonic response of the BII during osseointegration phenomena. The influence of (i) the surface roughness parameters and (ii) the thickness W of a soft tissue layer on the reflection coefficient r of the BII was investigated using a two-dimensional finite element model. Read More

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Influence of a Novel Surface of Bioactive Implants on Osseointegration: A Comparative and Histomorfometric Correlation and Implant Stability Study in Minipigs.

Int J Mol Sci 2019 May 9;20(9). Epub 2019 May 9.

Porto Dental Institute, 4150-518 Oporto, Portugal.

Purpose: The objective of this study was to assess the influence of a novel surface of dental implants (ContacTi) on the osseointegration process in a minipig model. The surface was compared with other existing surfaces on the market (SLA and SLActive) by employing bone implant contact analysis (BIC) and implant stability.

Method: Twelve minipigs were used with prior authorisation from an ethics committee. Read More

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Correlation Between Conditional Approval and Customized Bone Implant Devices.

Orthop Surg 2019 Feb;11(1):10-14

Centre for Medical Device Evolution, Beijing, China.

This report aims to summarize key concerns regarding customized devices and conditional approval during the premarket evaluation of bone implants, and to explore the correlation between them. Based on the experience of approval of the first domestic custom-designed bone implant, we consider the process of gaining conditional approval for urgently-needed medical devices and medical devices for rare diseases, as well as the guidance available for clinical investigation. We also streamlined the scientifically administrative concept of this unique device, from the design and development of premarket technical evaluation to continuous post-market study. Read More

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February 2019

The functional loading of implants increases their stability: A retrospective clinical study.

Clin Implant Dent Relat Res 2019 Feb 13;21(1):122-129. Epub 2018 Dec 13.

Department of Stomatology I, Faculty of Medicine and Dentistry, University of the Basque Country, Leioa, Spain.

Purpose: To assess the difference in the evolution of implant stability values, determined by resonance frequency analysis (RFA), between two groups of implants subjected to two different loading protocols: immediate and delayed.

Materials And Methods: A retrospective clinical study was conducted, including a total of 93 implants placed in 38 patients. All implants corresponded to one of two models of the Klockner Implant System (Essential Cone and Vega) and were divided into two groups according to the loading protocol adopted: delayed loading in group A (>10 weeks) and immediate loading in group B (<48 hours). Read More

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February 2019

Osteoimmunomodulation, osseointegration, and in vivo mechanical integrity of pure Mg coated with HA nanorod/pore-sealed MgO bilayer.

Biomater Sci 2018 Nov;6(12):3202-3218

State Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, Xi'an 710049, China.

Fast degradation of Mg-based implants results in the loss of mechanical integrity and poor osseointegration. Herein, a bilayer-structured coating (termed as HAT), comprising an outer layer of hydroxyapatite (HA) nanorods and an inner layer of pores-sealed MgO with HA/Mg(OH)2, was formed on Mg using plasma electrolytic oxidation and hydrothermal treatment. Osteoimmunomodulation, osseointegration, mechanical integrity, and bone-implant interfacial structure evolution of the HAT-coated Mg were investigated by implantation in rabbit femora, together with Mg coated with plasma electrolytic oxidized porous MgO (termed as PEO0) and bare Mg. Read More

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November 2018

Modeling the effect of osseointegration on dental implant pullout and torque removal tests.

Clin Implant Dent Relat Res 2018 Oct 27;20(5):683-691. Epub 2018 Jul 27.

Technion, Faculty of Mechanical Engineering, 32000, Haifa, Israel.

Background: Osseointegration of dental implants is a key factor for their success. It can be assessed either by destructive (eg, pullout or torque extraction), or nondestructive methods (eg, resonant frequency analysis). However, as of today there is a scarcity of models that can relate the outcome of destructive tests to the level of osseointegration. Read More

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October 2018

Evolution of fracture treatment with bone plates.

Injury 2018 Jun;49 Suppl 1:S2-S7

Institute of Biomechanics, BG Trauma Center Murnau, Germany; Institute of Biomechanics, Paracelsus Medical University, Salzburg, Austria; Department of Trauma Surgery, BG Trauma Center Murnau, Germany.

Internal fixation of bone fractures by plate osteosynthesis has continuously evolved for more than 100 years. The aim of internal fracture fixation has always been to restore the functional capacity of the broken bone. The principal requirements of operative fracture management, those being anatomical fracture reduction, durable fixation, preservation of biology, promotion of fracture healing and early patient mobilization, have always been crucial but were accomplished to different extents depending on the focus of the specific fracture fixation principle employed. Read More

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Periprosthetic Bone Mineral Density Around Uncemented Titanium Stems in the Second and Third Decade After Total Hip Arthroplasty: A DXA Study After 12, 17 and 21 Years.

Calcif Tissue Int 2018 10 1;103(4):372-379. Epub 2018 Jun 1.

Clinic of Orthopaedic and Trauma Surgery, Center for Orthopaedics, Trauma Surgery and Spinal Cord Injury, University of Heidelberg, Schlierbacher Landstrasse 200a, 69118, Heidelberg, Germany.

Implant failure and periprosthetic fractures because of periprosthetic bone loss are a major concern in total hip arthroplasty (THA). Hardly any clinical data exist on the long-term evolution of bone mineral density (BMD) around uncemented femoral implants. The question to address is whether relevant bone loss continues into third decade around well-fixed uncemented femoral implants. Read More

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October 2018

Effect of calcium pyrophosphate on microstructural evolution and in vitro biocompatibility of Ti-35Nb-7Zr composite by spark plasma sintering.

Mater Sci Eng C Mater Biol Appl 2018 Sep 17;90:8-15. Epub 2018 Apr 17.

School of Materials Science and Engineering, Kunming University of Science and Technology, Kunming 650093, China.

β-type Ti-35Nb-7Zr alloy has attracted considerable attentions as a bone implant material. The alloy, however, has poor bioactivity, which difficult to form a strong osseointegration between the bone tissues. Combining Ti alloy with a bioactive and biodegradable ceramic has been of interest to researchers. Read More

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September 2018

In vitro and in vivo assessment of biomedical Mg-Ca alloys for bone implant applications.

J Appl Biomater Funct Mater 2018 Jul 2;16(3):126-136. Epub 2018 Apr 2.

1 Institute of Tissue Regeneration, College of Medicine, Soonchunhyang University, Cheonan, South Korea.

Background: Magnesium (Mg)-based alloys are considered to be promising materials for implant application due to their excellent biocompatibility, biodegradability, and mechanical properties close to bone. However, low corrosion resistance and fast degradation are limiting their application. Mg-Ca alloys have huge potential owing to a similar density to bone, good corrosion resistance, and as Mg is essential for Ca incorporation into bone. Read More

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Long-term in vivo evolution of high-purity Mg screw degradation - Local and systemic effects of Mg degradation products.

Acta Biomater 2018 04 17;71:215-224. Epub 2018 Mar 17.

Shanghai Biomaterials Research & Testing Center, Shanghai, Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200023, China. Electronic address:

Magnesium (Mg) based materials are the focus of research for use as degradable materials in orthopedics and cranio-maxillofacial surgery. However, corrosion rate control and biosecurity are still the key issues that need to be solved prior to their clinical applications. In the present study, as-rolled high-purity magnesium (HP Mg, 99. Read More

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Recent developments on intramedullary nailing: a biomechanical perspective.

Ann N Y Acad Sci 2017 11 1;1408(1):20-31. Epub 2017 Nov 1.

DEMec, Faculty of Engineering, University of Porto, Porto, Portugal.

Combining contributions from engineering and medicine, we highlight the biomechanical turning points in the historical evolution of the intramedullary nailing stabilization technique and discuss the recent innovations concerning increase in bone-implant system stability. Following the earliest attempts, where stabilization of long bone fractures was purely based on intuition, intramedullary nailing evolved from allowing alignment and translational control through press-fit fixation to current clinical widespread acceptance marked by the mechanical linkage between nail and bone with interlocking screws that allow alignment, translation, rotation, and length control. In an attempt to achieve an optimum interfragmentary mechanical environment, recent improvements considered the impact of different biomaterials on bone-implant stiffness. Read More

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November 2017

Complications of intramedullary nailing-Evolution of treatment.

Injury 2017 Jun 24;48 Suppl 1:S59-S63. Epub 2017 Apr 24.

Department of Trauma, Hand and Reconstructive Surgery, University Hospital Münster, Münster, Germany.

Intramedullary nailing of diaphyseal long bone fractures is a standard procedure in today's trauma and orthopedic surgery due to the numerous advantages (e.g. minimal invasive, limited soft tissue damage, load stability). Read More

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Modelling dental implant extraction by pullout and torque procedures.

J Mech Behav Biomed Mater 2017 07 11;71:416-427. Epub 2017 Apr 11.

Faculty of Mechanical Engineering Technion, 32000 Haifa, Israel.

Dental implants extraction, achieved either by applying torque or pullout force, is used to estimate the bone-implant interfacial strength. A detailed description of the mechanical and physical aspects of the extraction process in the literature is still missing. This paper presents 3D nonlinear dynamic finite element simulations of a commercial implant extraction process from the mandible bone. Read More

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