2,398 results match your criteria evidences early

A Systematic Review and Meta-Analysis of the SuperPATH Approach in Hip Arthroplasty.

Biomed Res Int 2021 21;2021:5056291. Epub 2021 Jul 21.

The First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, 310053 Zhejiang, China.

Objective: To compare the clinical and radiographic results of the supercapsular percutaneously assisted total hip (SuperPATH) approach and the conventional approach in hip arthroplasty.

Design: Based on a prepublished protocol (PROSPERO: CRD42020177717), we searched PubMed, Embase, and Cochrane for relevant literatures up to January 30, 2021. The methodological qualities were assessed using the guidelines provided by the Cochrane Collaboration for Systematic Reviews. Read More

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Linear growth and puberty in childhood obesity: what is new?

Minerva Pediatr (Torino) 2021 Jul 26. Epub 2021 Jul 26.

Department of Movement Sciences and Wellbeing, University of Naples Parthenope, Naples, Italy -

Pediatric obesity is a growing and alarming global health problem and represents an important determinant of morbidity. Since nutrition plays an important role in regulating growth and development, the excess weight gain related to overnutrition can affect growth patterns, bone maturation and pubertal development. The purpose of this review is to summarize the current knowledge about the effect of primary obesity on linear growth and pubertal development in children and adolescents. Read More

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A New Multidimensional Questionnaire of Empathy for Early and Middle Adolescents in Spanish.

Int J Psychol Res (Medellin) 2021 Jan-Jun;14(1):91-105

Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) Buenos Aires Argentina.

The aim of this study was to develop a Multidimensional Questionnaire of Empathy for Adolescents, since a model of cognitive social neuroscience, operationalizing the dimensions of emotional contagion, self-awareness, perspective-taking, emotional regulation, and empathic attitude. For the psychometric study of the instrument, 320 young adolescents in school participated, from both genders (125 male, 195 female), aged 13 to 16 (M = 14.23; SD = . Read More

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September 2020

Nuclear factor OsNF-YB4 promotes flowering by negatively regulating the floral repressor gene Ghd7 in rice.

Biochem Biophys Res Commun 2021 Jul 21;571:32-37. Epub 2021 Jul 21.

Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, 610065, PR China. Electronic address:

Flowering time or heading date is a critical agronomic trait of rice and is regulated by numerous genes, including several genes encoding nuclear factor YB (NF-YB) in rice, NF-YB11 is one of the genes well known to be involved in the process, delaying flowering under long-day (LD) conditions but promoting flowering under short-day (SD) conditions. In this study, we identified another NF-YB gene, OsNF-YB4. Overexpression of OsNF-YB4 promoted rice flowering under both natural long-day (NLD) and natural short-day (NSD) conditions, whereas suppression or loss-of-function of this gene delayed flowering. Read More

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Women's knowledge and attitude towards cervical cancer preventive measures and associated factors In South Gondar Zone, Amhara Region, North Central Ethiopia: a cross-sectional study.

Arch Public Health 2021 Jul 23;79(1):136. Epub 2021 Jul 23.

Department of Biomedical Sciences, College of Health Sciences, Debre Tabor University , Debre Tabor, Ethiopia.

Background: Cervical cancer is a leading cause of morbidity and mortality among women in Ethiopia, often due to late disease diagnosis. Early prevention of cancer has been shown to be the most effective measure against the disease. Scientific evidences indicate that lack of awareness towards cervical cancer is a barrier to prevention strategies. Read More

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[Oncology Society of Chinese Medical Association guideline for clinical diagnosis and treatment of lung cancer (2021 edition)].


Zhonghua Zhong Liu Za Zhi 2021 Jun;43(6):591-621

In China, the incidence and mortality of lung cancer are ranked the first among malignant tumors. In order to further standardize the prevention and treatment measures of lung cancer, improve the prognosis of patients, and provide professional evidence-based medical recommendations to clinical medical staffs, Oncology Society of Chinese Medical Association organized experts from departments of pulmonary medicine, oncology, thoracic surgery, radiotherapy, imaging and pathology, based on the international guidelines and clinical practices in China, integrated the latest evidence-based medical evidences in lung cancer pathology, genetic testing, immune molecular marker detection and treatment methods in recent years. After consensus meetings, the Oncology Society of Chinese Medical Association guideline for clinical diagnosis and treatment of lung cancer in China was conducted, which provided recommendations of lung cancer screening, diagnosis, pathology, treatment and follow-up to clinicians, imaging, laboratory, and rehabilitation professionals. Read More

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Complications, clinical manifestations of congenital syphilis, and aspects related to its prevention: an integrative review.

Rev Bras Enferm 2021 14;74(4):e20190318. Epub 2021 Jul 14.

Universidade de Fortaleza. Fortaleza, Ceará, Brazil.

Objectives: to identify the scientific evidence about the clinical complications and manifestations of congenital syphilis and aspects related to its prevention.

Methods: integrative review after a search in the databases LILACS and MEDLINE, carried out in March 2018, using the descriptors "syphilis, congenital", "complications", and "signs and symptoms", leading to the selection of 27 researches.

Results: the publications found were published from 1966 to 2017, and most of them were from Latin America and Africa. Read More

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Substantial shifts in flowering phenology of Sternbergia vernalis in the Himalaya: Supplementing decadal field records with historical and experimental evidences.

Sci Total Environ 2021 Jul 1;795:148811. Epub 2021 Jul 1.

Centre for Biodiversity & Taxonomy, Department of Botany, University of Kashmir, Srinagar 190 006, J&K, India. Electronic address:

In an age of anthropocene, shifting plant phenology is one of the most striking biological indicators of global environmental change. Majority of the studies reporting shifts in plant phenology are available from the North America and Europe and largely scarce from the developing world, including the Himalaya; and studies integrating multiple methodological approaches to investigate the climate-driven phenological shifts are too rare. Here, we report the shifts in spring flowering phenology of model plant species, Sternbergia vernalis in response to the changing climate in Kashmir Himalaya, by integrating decadal field observational records with long-term herbarium and dated-photograph data, and supported with experimental evidences. Read More

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Direct Quantification and Visualization of Homocysteine, Cysteine, and Glutathione in Alzheimer's and Parkinson's Disease Model Tissues.

Anal Chem 2021 Jul 6;93(28):9878-9886. Epub 2021 Jul 6.

Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education), College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081, China.

Alzheimer's disease (AD) and Parkinson's disease (PD) are chronic neurodegenerative diseases with high morbidity and mortality. Homocysteine (Hcy), cysteine (Cys), and glutathione (GSH) are closely related to AD and PD. However, the dynamics of Hcy, Cys, and GSH in the brain tissues and the potential pathogenesis between Cys/Hcy/GSH with AD and PD remain unclear. Read More

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Difficulties encountered by public health workers in COVID-19 outbreak: a cross-sectional study based on five provinces.

BMC Health Serv Res 2021 Jul 5;21(1):656. Epub 2021 Jul 5.

School of Public Health, Global Health Institute, Key Laboratory of Tropical Disease Control, Sun Yat-sen University, 510080, Guangzhou, China.

Objectives: The aim of this study is to address the difficulties encountered by public health workers in the early and middle stages of their efforts to combat COVID-19, compare the gaps among different types of institutions, and identify shortcomings in epidemic control.

Methods: Using multi-stage sampling, a survey of public health workers involved in the prevention and control of COVID-19 was conducted from 18 February to 1 March 2020 through a self-administered questionnaire. These public health workers were from the primary health care center (defined as "primary-urban" and "primary-rural" for those in urban and rural areas, respectively) and the center for disease control and prevention (defined as "non-primary") in five provinces including Hubei, Guangdong, Sichuan, Jiangsu and Gansu, China. Read More

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Inflammatory biomarkers as a part of diagnosis in diabetic peripheral neuropathy.

J Diabetes Metab Disord 2021 Jun 15;20(1):869-882. Epub 2021 Jan 15.

Department of Pharmacology, GITAM Institute of Pharmacy, GITAM Deemed to be University, Visakhapatnam, Andhra Pradesh India.

Diabetic peripheral neuropathy (DPN), a chronic neurological complication of diabetes mellitus, remains scantily addressed area of research. Many lacunae in the temporal sequence between cause and effect of DPN still remain unfilled and therefore treatment of DPN remains unsatisfactory. This is largely due to the conventional glucocentric focus to resolve the problem. Read More

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Evolution of β-catenin-independent Wnt-GSK3-mTOR signalling in regulation of energy metabolism in isoproterenol-induced cardiotoxicity model.

Inflamm Res 2021 Jul 29;70(7):743-747. Epub 2021 Jun 29.

Department of Pharmacology, ISF College of Pharmacy, Moga, Punjab, India.

Objective: Isoproterenol (ISO) is widely used agent to study the effects of interventions which could prevent or attenuate the development of myocardial infarction. The sequence of pathological event's revealed that increased myocardial tissue oxygen demand and energy dysregulation exist early during Iso-induced cardiac toxicity. Later, tissue hypoxia results in increased oxidative stress, inflammation and fibrosis along with cardiac dysfunction in this model. Read More

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[Sociology of contraception in France].

Alexandra Roux

Med Sci (Paris) 2021 Jun-Jul;37(6-7):647-653. Epub 2021 Jun 28.

École des hautes études en sciences sociales (EHESS)/Institut de recherche interdisciplinaire sur les enjeux sociaux (IRIS), Campus Condorcet, Bâtiment Recherche Sud, 5 cours des Humanités, 93322 Aubervilliers, France - Centre de recherche médecine, sciences, santé, santé mentale, société (Cermes3), Chercheure associée.

In France, research on contraception is a dynamic field that has been expanding since the publication of early socio-demographic work in the 1980s. This article offers a synthesis of these publications, by classifying them in four main sociological approaches: a sociology of contraceptive demand (1); a sociology of contraceptive offer, with an attention drawn to the prescription, production, and promotion of contraceptives (2); an institutional approach, focusing on how contraceptive systems are shaped at a national level (3); finally, research on social inequalities in the access to contraceptives (4). The article highlights that the centrality of the pill in the French contraceptive system has been stable for the past 40 years, though oral contraceptives have been the object of growing criticism, particularly in the aftermath of the 2012-13 French pill scare. Read More

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Dysregulation of nitric oxide synthases during early and late pathophysiological conditions of diabetes mellitus leads to amassing of microvascular impedement.

J Diabetes Metab Disord 2021 Jun 21;20(1):989-1002. Epub 2021 Apr 21.

Animal Cell Culture Laboratory, Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kancheepuram District-603203, Kattankulathur, Tamil Nadu India.

Diabetes is a major killer worldwide and its unprecedented rise poses a serious threat to mankind. According to recent estimation, 387 million people worldwide are affected from the disease with a prevalence rate of 8.3 and 46. Read More

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Endovascular Versus Open Surgical Repair for Ruptured Descending Aortic Pathologies: A Systematic Review and Meta-Analysis of Observational Studies.

Cardiovasc Intervent Radiol 2021 Jun 25. Epub 2021 Jun 25.

Division of Cardiac Surgery, Ospedale Policlinico San Martino, Genoa, Italy.

Purpose: Ruptured descending thoracic aorta (rDTA) is an harmful condition requiring emergent treatment. Thoracic endovascular aortic repair (TEVAR) is replacing the traditional open repair in the majority of descending thoracic aortic disease. An unanimous agreement regarding the optimal approach to treat rDTA has not been reached yet due to the lack of evidences supporting the improvement of long-term survival. Read More

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A multi-OMIC characterisation of biodegradation and microbial community succession within the PET plastisphere.

Microbiome 2021 06 21;9(1):141. Epub 2021 Jun 21.

School of Life Sciences, University of Warwick, Coventry, UK.

Background: Plastics now pollute marine environments across the globe. On entering these environments, plastics are rapidly colonised by a diverse community of microorganisms termed the plastisphere. Members of the plastisphere have a myriad of diverse functions typically found in any biofilm but, additionally, a number of marine plastisphere studies have claimed the presence of plastic-biodegrading organisms, although with little mechanistic verification. Read More

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A novel homozygous missense variant in the NAXE gene in an Iranian family with progressive encephalopathy with brain edema and leukoencephalopathy.

Acta Neurol Belg 2021 Jun 13. Epub 2021 Jun 13.

Department of Medical Genetics, Faculty of Medical Sciences, Tarbiat Modares University, Jalah-Al Ahmad Hwy, 14117-1316, Tehran, Iran.

Homozygous or compound heterozygous mutations in the NAD(P)HX epimerase (NAXE) gene, cause early-onset progressive encephalopathy with brain edema and/or leukoencephalopathy 1. This disorder is characterized by psychomotor regression, hypotonia, ataxia, respiratory insufficiency, tetraparesis, and seizures, leading to coma and death in early childhood. In this study, whole-exome sequencing was used to identify the pathogenic variant, followed by confirmation of identified variant in the proband and segregation analysis in the family by Sanger sequencing. Read More

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Early pregnancy essential and non-essential metal mixtures and gestational glucose concentrations in the 2nd trimester: Results from project viva.

Environ Int 2021 Oct 10;155:106690. Epub 2021 Jun 10.

Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA, USA; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA. Electronic address:

Metals are involved in glucose metabolism, and some may alter glycemic regulation. However, joint effects of essential and non-essential metals on glucose concentrations during pregnancy are unclear. This study explored the joint associations of pregnancy exposures to essential (copper, magnesium, manganese, selenium, zinc) and non-essential (arsenic, barium, cadmium, cesium, lead, mercury) metals with gestational glucose concentrations using 1,311 women enrolled 1999-2002 in Project Viva, a Boston, MA-area pregnancy cohort. Read More

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October 2021

Bi-allelic variants in MTMR5/SBF1 cause Charcot-Marie-Tooth type 4B3 featuring mitochondrial dysfunction.

BMC Med Genomics 2021 Jun 12;14(1):157. Epub 2021 Jun 12.

Department of Medical Basic Sciences, Neurosciences and Sense Organs, University of Bari Aldo Moro, Piazza G. Cesare, 11, 70124, Bari, Italy.

Background: Charcot-Marie-Tooth disease (CMT) type 4B3 (CMT4B3) is a rare form of genetic neuropathy associated with variants in the MTMR5/SBF1 gene. MTMR5/SBF1 is a pseudophosphatase predicted to regulate endo-lysosomal trafficking in tandem with other MTMRs. Although almost ubiquitously expressed, pathogenic variants primarily impact on the peripheral nervous system, corroborating the involvement of MTMR5/SBF1 and its molecular partners in Schwann cells-mediated myelinization. Read More

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Pseudolaric acid B ameliorates synovial inflammation and vessel formation by stabilizing PPARγ to inhibit NF-κB signalling pathway.

J Cell Mol Med 2021 Jul 11;25(14):6664-6678. Epub 2021 Jun 11.

Department of Immunology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.

Synovial macrophage polarization and inflammation are essential for osteoarthritis (OA) development, yet the molecular mechanisms and regulation responsible for the pathogenesis are still poorly understood. Here, we report that pseudolaric acid B (PAB) attenuated articular cartilage degeneration and synovitis during OA. PAB, a diterpene acid, specifically inhibited NF-κB signalling and reduced the production of pro-inflammatory cytokines, which further decreased M1 polarization and vessel formation. Read More

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Diagnostic value of ultrasound combined with MRI in cholecystolithiasis: A protocol for systematic review and meta analysis.

Medicine (Baltimore) 2021 May;100(19):e25896

Beibei Traditional Chinese Medical Hospital, Chongqing, China.

Background: Early diagnosis of cholecystolithiasis is significant for prevention of further development of situation. Ultrasound is the best choice for the diagnosis of cholecystolithiasis with a sensitivity of >95% and specificity of practically 100%. However, ultrasound is not perfect for it is not so clear sometimes. Read More

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Assessment of the Autism Spectrum Disorder Based on Machine Learning and Social Visual Attention: A Systematic Review.

J Autism Dev Disord 2021 Jun 8. Epub 2021 Jun 8.

Institute for Research and Innovation in Bioengineering (i3B), Universitat Politécnica de Valencia, Ciudad de la Innovación, Building 8B, s/n Camino de Vera, 46022, Valencia, Spain.

The assessment of autism spectrum disorder (ASD) is based on semi-structured procedures addressed to children and caregivers. Such methods rely on the evaluation of behavioural symptoms rather than on the objective evaluation of psychophysiological underpinnings. Advances in research provided evidence of modern procedures for the early assessment of ASD, involving both machine learning (ML) techniques and biomarkers, as eye movements (EM) towards social stimuli. Read More

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Behavioural tagging: Effect of novelty exploration on plasticity related molecular signatures.

Exp Brain Res 2021 Jun 7. Epub 2021 Jun 7.

Department of Toxicology, School of Chemical and Life Sciences, Jamia Hamdard, New Delhi, 110062, India.

Learning and memory are one of those frontier areas of neurobiology which attract us to investigate the intricacy of this process. Here, we aimed to investigate the general mechanism of "Behavioural Tagging and Capture" in long term memory (LTM) formation and to find the key factors playing role in consolidation of LTM. In this study, we've shown that not only plasticity related proteins (PRPs) but neurotransmitters and immediate early genes (IEGs) also play an important role in memory formation process. Read More

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Walking metals: catalytic difunctionalization of alkenes at nonclassical sites.

Chem Sci 2020 Sep 7;11(36):9757-9774. Epub 2020 Sep 7.

Department of Chemistry, The Pennsylvania State University University Park Pennsylvania 16802 USA

Migration of metals along a carbon chain is triggered by two of the most common organometallic elementary steps - β-hydride (β-H) elimination and alkene hydrometallation. This process heralds a new future for creating bonds at carbon sites that fall outside the tenets of the conventional wisdom for reactivity and bond formation, and provides an opportunity to leverage β-H elimination to advance the very reaction of alkene difunctionalization it is intrinsically predestined to disrupt. Almost four decades since its genesis, the early adventure for alkene difunctionalization by metal migration was sporadic, and its later development went on a hiatus primarily due to original impetus on arresting β-H elimination for vicinal alkene difunctionalization. Read More

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September 2020

Investing preventive care and economic development in ageing societies: empirical evidences from OECD countries.

Health Econ Rev 2021 Jun 4;11(1):18. Epub 2021 Jun 4.

Department of Public Health, National Cheng Kung University College of Medicine, Tainan, Taiwan.

Background: The proportion of the elderly aged 65 years old or above will reach 16% in 2050 worldwide. Early investment in effective prevention would generally reduce the morbidity, complication, functional disability, and mortality of most chronic illnesses and save resources in both healthcare and social services. This research aims to investigate how the optimal allocation of medical resources between prevention and treatment adds value to the population's health as well as examine the interaction between ageing, health, and economic performance. Read More

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Metabolomic Analysis Evidences That Uterine Epithelial Cells Enhance Blastocyst Development in a Microfluidic Device.

Cells 2021 May 13;10(5). Epub 2021 May 13.

School of Electronic and Electrical Engineering, University of Leeds, Leeds LS2 9JT, UK.

Here we report the use of a microfluidic system to assess the differential metabolomics of murine embryos cultured with endometrial cells-conditioned media (CM). Groups of 10, 1-cell murine B6C3F1 × B6D2F1 embryos were cultured in the microfluidic device. To produce CM, mouse uterine epithelial cells were cultured in potassium simplex optimized medium (KSOM) for 24 h. Read More

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Astrocytes and Adenosine A Receptors: Active Players in Alzheimer's Disease.

Front Neurosci 2021 13;15:666710. Epub 2021 May 13.

Center for Neuroscience and Cell Biology, Coimbra, Portugal.

Astrocytes, through their numerous processes, establish a bidirectional communication with neurons that is crucial to regulate synaptic plasticity, the purported neurophysiological basis of memory. This evidence contributed to change the classic "neurocentric" view of Alzheimer's disease (AD), being astrocytes increasingly considered a key player in this neurodegenerative disease. AD, the most common form of dementia in the elderly, is characterized by a deterioration of memory and of other cognitive functions. Read More

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The role of CaMKII autophosphorylation for NMDA receptor-dependent synaptic potentiation.

Karl Peter Giese

Neuropharmacology 2021 08 26;193:108616. Epub 2021 May 26.

Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, Maurice Wohl Building, King's College London, 5 Cutcombe Road, London, SE5 9NU, UK. Electronic address:

Potentiation of glutamatergic synaptic transmission is thought to underlie memory. The induction of this synaptic potentiation relies on activation of NMDA receptors which allows for calcium influx into the post-synapse. A key mechanistic question for the understanding of synaptic potentiation is what signaling is activated by the calcium influx. Read More

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