235 results match your criteria evidence ppr

OsMORF9 is necessary for chloroplast development and seedling survival in rice.

Plant Sci 2021 Jun 7;307:110907. Epub 2021 Apr 7.

State Key Lab of Rice Biology, China National Rice Research Institute, Hangzhou, 310006, China. Electronic address:

Chloroplasts are closely associated with the growth and development of higher plants. Accumulating evidence has revealed that the multiple organellar RNA editing factors (MORF) family of proteins influences plastidic and mitochondrial development through post-transcriptional regulation. However, the role of MORFs in regulating the development of chloroplasts in rice is still unclear. Read More

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The general fault in our fault lines.

Nat Hum Behav 2021 Apr 22. Epub 2021 Apr 22.

Department of Psychology, Columbia College, Columbia University, New York, NY, USA.

Pervading global narratives suggest that political polarization is increasing, yet the accuracy of such group meta-perceptions has been drawn into question. A recent US study suggests that these beliefs are inaccurate and drive polarized beliefs about out-groups. However, it also found that informing people of inaccuracies reduces those negative beliefs. Read More

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Serological Evidence of Exposure to Peste des Petits Ruminants in Small Ruminants in Rwanda.

Front Vet Sci 2021 4;8:651978. Epub 2021 Mar 4.

Department of Clinical Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden.

The status of Peste des Petits Ruminants (PPR) in Rwanda is unknown, despite its prevalence in neighboring countries. A cross-sectional sampling of goats and sheep was carried out in five districts of Rwanda located closer to neighboring countries endemic to PPR. Serum samples were analyzed using a commercial ELISA, to detect antibodies to PPR virus (PPRV). Read More

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Combining viral genetic and animal mobility network data to unravel peste des petits ruminants transmission dynamics in West Africa.

PLoS Pathog 2021 Mar 18;17(3):e1009397. Epub 2021 Mar 18.

ASTRE, Univ Montpellier, CIRAD, INRAE, Montpellier, France.

Peste des petits ruminants (PPR) is a deadly viral disease that mainly affects small domestic ruminants. This disease threaten global food security and rural economy but its control is complicated notably because of extensive, poorly monitored animal movements in infected regions. Here we combined the largest PPR virus genetic and animal mobility network data ever collected in a single region to improve our understanding of PPR endemic transmission dynamics in West African countries. Read More

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Functioning of PPR Proteins in Organelle RNA Metabolism and Chloroplast Biogenesis.

Front Plant Sci 2021 9;12:627501. Epub 2021 Feb 9.

Beijing Advanced Innovation Center for Tree Breeding by Molecular Design, Beijing Forestry University, Beijing, China.

The pentatricopeptide repeat (PPR) proteins constitute one of the largest nuclear-encoded protein families in higher plants, with over 400 members in most sequenced plant species. The molecular functions of these proteins and their physiological roles during plant growth and development have been widely studied. Generally, there is mounting evidence that PPR proteins are involved in the post-transcriptional regulation of chloroplast and/or mitochondrial genes, including RNA maturation, editing, intron splicing, transcripts' stabilization, and translation initiation. Read More

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February 2021

Mechanisms and impact of public reporting on physicians and hospitals' performance: A systematic review (2000-2020).

PLoS One 2021 24;16(2):e0247297. Epub 2021 Feb 24.

Centre for Health Policy, Melbourne School of Population and Global Health, The University of Melbourne, Carlton, Australia.

Background: Public performance reporting (PPR) of physician and hospital data aims to improve health outcomes by promoting quality improvement and informing consumer choice. However, previous studies have demonstrated inconsistent effects of PPR, potentially due to the various PPR characteristics examined. The aim of this study was to undertake a systematic review of the impact and mechanisms (selection and change), by which PPR exerts its influence. Read More

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February 2021

The impact of public performance reporting on cancer elective surgery waiting times: a data linkage study.

BMC Health Serv Res 2021 Feb 8;21(1):129. Epub 2021 Feb 8.

Centre for Health Policy, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.

Background: Excessive waiting times for cancer elective surgery are a concern in publicly funded healthcare systems. Several countries including Australia have introduced healthcare reforms involving time-based targets and public performance reporting (PPR) of hospital data. However, there is mixed evidence of their benefits. Read More

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February 2021

Road towards promoting patient safety practices among hospital pharmacists: Hospital-based baseline patient safety culture assessment cross-sectional survey.

Medicine (Baltimore) 2021 Jan;100(2):e23670

King Saud bin Abdulaziz University for Health Sciences.

Abstract: Patient safety is a fundamental aspect of a healthcare system. The aim of this study was to assess the perception and determinants of the patient safety culture of pharmacists in hospitals, in Riyadh, Saudi Arabia.A survey was conducted with pharmacists in the pharmacies of governmental, /military and private hospitals in Riyadh, Saudi Arabia. Read More

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January 2021

The novel E-subgroup pentatricopeptide repeat protein DEK55 is responsible for RNA editing at multiple sites and for the splicing of nad1 and nad4 in maize.

BMC Plant Biol 2020 Dec 9;20(1):553. Epub 2020 Dec 9.

State Key Laboratory of Crop Biology, College of Life Sciences, Shandong Agricultural University, Taian, Shandong, 271018, PR China.

Background: Pentatricopeptide repeat (PPR) proteins compose a large protein family whose members are involved in both RNA processing in organelles and plant growth. Previous reports have shown that E-subgroup PPR proteins are involved in RNA editing. However, the additional functions and roles of the E-subgroup PPR proteins are unknown. Read More

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December 2020

Sex-dependent alterations in the physiology of entorhinal cortex neurons in old heterozygous 3xTg-AD mice.

Biol Sex Differ 2020 11 16;11(1):63. Epub 2020 Nov 16.

Faculty of Pharmacy, Université Laval, Quebec City, QC, Canada.

While the higher prevalence of Alzheimer's disease (AD) in women is clear, studies suggest that biological sex may also influence AD pathogenesis. However, mechanisms behind these differences are not clear. To investigate physiological differences between sexes at the cellular level in the brain, we investigated the intrinsic and synaptic properties of entorhinal cortex neurons in heterozygous 3xTg-AD mice of both sexes at the age of 20 months. Read More

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November 2020

Statement on the translocation potential by MA342 in plants after seed treatment of cereals and peas and assessment of the risk to humans.

EFSA J 2020 Oct 24;18(10):e06276. Epub 2020 Oct 24.

The European Commission requested EFSA to provide scientific advice on the translocation potential by MA342 in plants after seed treatment of cereals and peas and, if applicable, for a revision of the assessment of the risk to humans by its metabolite 2,3-deepoxy-2,3-didehydro-rhizoxin (DDR) and this based on the evidence available in the dossier for renewal of the approval. The information from other strains than MA342 was taken into account with care, because the studies available in the dossier did not confirm the identity of the strain MA342 as belonging to the species . It has been concluded that there is a potential for translocation of MA342 to edible plant parts following seed treatment till an estimated concentration up to about 10 cfu/g and some exposure can be assumed by consumption of fresh commodities. Read More

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October 2020

Inclusion of Older People Reflective of Real-World Clinical Practice in Cardiovascular Drug Trials.

J Am Heart Assoc 2020 11 26;9(21):e016936. Epub 2020 Oct 26.

Discipline of Pharmacology Adelaide Medical School The University of Adelaide Australia.

Background Underrepresentation of older people in clinical trials remains. This study aimed to examine the inclusion of older people and associated safety and efficacy reports from clinical trials of new molecular entities for cardiovascular disease indications since commencement of the US Food and Drug Administration Drug Trial Snapshot (DTS) Program. The DTS provides concise information on participants included in clinical trials supporting US Food and Drug Administration approval of new drugs. Read More

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November 2020

Automated Grading of Lumbar Disc Degeneration Using a Push-Pull Regularization Network Based on MRI.

J Magn Reson Imaging 2021 03 23;53(3):799-806. Epub 2020 Oct 23.

College of Engineering, Peking University, Beijing, China.

Background: Lower back pain is one of the most widely experienced health problems and is strongly associated with intervertebral disc (IVD) degeneration. The quantification of the degeneration is valuable for estimation of the material properties of the IVDs and then to perform biomechanical simulation of the spinal conditions and treatments. The MR image characteristics of relatively high intraclass variability and small interclass differences pose challenges for the classification algorithm to perform automatic grading of degenerated IVD. Read More

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Partial prostate re-irradiation for the treatment of isolated local recurrence of prostate cancer in patients previously treated with primary external beam radiotherapy: short-term results of a monocentric study.

Neoplasma 2021 Jan 7;68(1):216-226. Epub 2020 Oct 7.

Department of Radiation Oncology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy.

Many different therapeutic options are available for locally recurrent prostate cancer (PCa). However, standard treatment has not yet been established. We conducted a partial prostate re-irradiation (PPR) program for the treatment of isolated and limited-size intraprostatic recurrences, in patients who previously underwent external beam radiation therapy (EBRT) as primary treatment for prostatic cancer (PCa). Read More

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January 2021

Evaluation of the efficacy of subantimicrobial dose doxycycline in rosacea: a systematic review of clinical trials and meta-analysis.

J Dtsch Dermatol Ges 2021 01 28;19(1):7-17. Epub 2020 Sep 28.

Translational Research Institute, Hamad Medical Corporation, Doha, Qatar.

Background: Low-dose doxycycline (SDD) is an antimicrobial agent that appears to improve common inflammatory skin diseases. Few data are available regarding the overall effectiveness, appropriate length of treatment and optimal patient selection for rosacea. We therefore reviewed the efficacy of sub-antimicrobial doses of SDD in papulopustular rosacea (PPR) and aimed to determine the most suitable patients for this approach. Read More

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January 2021

Frailty Intervention through Nutrition Education and Exercise (FINE). A Health Promotion Intervention to Prevent Frailty and Improve Frailty Status among Pre-Frail Elderly-A Study Protocol of a Cluster Randomized Controlled Trial.

Nutrients 2020 Sep 10;12(9). Epub 2020 Sep 10.

Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor 43400, Malaysia.

The ageing process has been associated with various geriatric issues including frailty. Without early prevention, frailty may cause multiple adverse outcomes. However, it potentially may be reversed with appropriate interventions. Read More

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September 2020

Primary prophylaxis was associated with lower arthropathy in Colombian men with haemophilia B: A longitudinal analysis (2015-2019).

Haemophilia 2020 Nov 6;26(6):e282-e290. Epub 2020 Sep 6.

Cuenta de Alto Costo, Fondo Colombiano de Enfermedades de Alto Costo, Bogotá, Colombia.

Introduction: The risk of chronic haemophilic arthropathy (CHA) is related to severity. Evidence suggests that primary prophylaxis (PPr) could reduce CHA incidence and its impact on quality of life.

Aim: To evaluate the association between PPr and CHA in Colombian males with haemophilia B (HB) during 2015 to 2019. Read More

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November 2020

Taking Advantage of Plant Defense Mechanisms to Promote Human Health. The Plant Immune System. First of Two Parts.

Endocr Metab Immune Disord Drug Targets 2020 Aug 31. Epub 2020 Aug 31.

Department of Basic Medical Sciences, Neuroscience and Sensory Organs, School of Medicine, University of Bari, Bari. Italy.

Background: Despite the evidence that plants do not possess sessile cells, they are able to mount a vigorous immune response against invaders or under stressful conditions. Mechanisms of action: Plants are endowed with pattern recognition receptors (PPRs) which perceive damage-associated molecular patterns and microbe-associated molecular patterns or pathogen-associated molecular patterns (PAMPs), respectively. PPR activation leads to either the initiation of PAMP-triggered immunity (PTI) (early response) or the effectortriggered immunity (ETI). Read More

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Scientific Opinion of the Scientific Panel on Plant Protection Products and their Residues (PPR Panel) on the genotoxic potential of triazine amine (metabolite common to several sulfonylurea active substances).

EFSA J 2020 Mar 9;18(3):e06053. Epub 2020 Mar 9.

The Panel received a mandate from the European Commission to assess the genotoxic potential of triazine amine based on available information submitted by the applicants. Available information includes experimental genotoxicity data on triazine amine, Quantitative Structure-Activity Relationship (QSAR) analysis and read across with structurally similar compounds. Based on the overall weight of evidence, the Panel, in agreement with the cross-cutting Working Group Genotoxicity, concluded that there is no concern for the potential of triazine amine to induce gene mutations and clastogenicity; however, the potential to induce aneugenicity was not adequately investigated. Read More

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Deletion of NRXN1α impairs long-range and local connectivity in amygdala fear circuit.

Transl Psychiatry 2020 07 19;10(1):242. Epub 2020 Jul 19.

Disorders of Neural Circuit Function, Max Planck Florida Institute for Neuroscience Jupiter, Jupiter, FL, USA.

Neurexins are a family of presynaptic cell adhesion proteins that regulate synaptic structure and maintain normal synaptic transmission. Mutations in the α-isoform of neurexin1-gene (NRXN1α) are linked with cognitive and emotional dysregulation, which are heavily dependent on the amygdala and medial prefrontal cortex (mPFC). It is however not known whether deletion of NRXN1α gene affect specific synaptic elements within the amygdala microcircuit and connectivity with mPFC. Read More

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Scientific statement on the coverage of bats by the current pesticide risk assessment for birds and mammals.

EFSA J 2019 Jul 29;17(7):e05758. Epub 2019 Jul 29.

Bats are an important group of mammals, frequently foraging in farmland and potentially exposed to pesticides. This statement considers whether the current risk assessment performed for birds and ground dwelling mammals exposed to pesticides is also protective of bats. Three main issues were addressed. Read More

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Scientific Opinion on the setting of health-based reference values for metabolites of the active substance terbuthylazine.

EFSA J 2019 Jun 4;17(6):e05712. Epub 2019 Jun 4.

The EFSA Panel on Plant Protection Products and their Residues was requested to establish health-based reference values for groundwater metabolites (LM2, LM3, LM4, LM5 and LM6) of the active substance terbuthylazine based on the available evidence, unless the evidence was considered insufficient to do so. The request was accepted under the explicit circumstance that the reassessment would be made according to a different methodology than the routine methodology currently applied for the assessment of metabolites in groundwater. While for metabolites LM2, LM4 and LM5, it was concluded that the reference values for terbuthylazine are applicable, substance-specific reference values could not be derived for metabolites LM3 and LM6. Read More

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Poly(A) binding KPAF4/5 complex stabilizes kinetoplast mRNAs in Trypanosoma brucei.

Nucleic Acids Res 2020 09;48(15):8645-8662

Department of Molecular and Cell Biology, Boston University Medical Campus, Boston, MA 02118, USA.

In Trypanosoma brucei, mitochondrial pre-mRNAs undergo 3'-5' exonucleolytic processing, 3' adenylation and uridylation, 5' pyrophosphate removal, and, often, U-insertion/deletion editing. The 3' modifications are modulated by pentatricopeptide repeat (PPR) Kinetoplast Polyadenylation Factors (KPAFs). We have shown that KPAF3 binding to the 3' region stabilizes properly trimmed transcripts and stimulates their A-tailing by KPAP1 poly(A) polymerase. Read More

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September 2020

Prediction modelling studies for medical usage rates in mass gatherings: A systematic review.

PLoS One 2020 23;15(6):e0234977. Epub 2020 Jun 23.

Department of Public Health and Primary Care, Faculty of Medicine, KU Leuven, Leuven, Belgium.

Background: Mass gathering manifestations attended by large crowds are an increasingly common feature of society. In parallel, an increased number of studies have been conducted that developed and/or validated a model to predict medical usage rates at these manifestations.

Aims: To conduct a systematic review to screen, analyse and critically appraise those studies that developed or validated a multivariable statistical model to predict medical usage rates at mass gatherings. Read More

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September 2020

Participation of Women and Older Participants in Randomized Clinical Trials of Lipid-Lowering Therapies: A Systematic Review.

JAMA Netw Open 2020 05 1;3(5):e205202. Epub 2020 May 1.

Johns Hopkins School of Medicine, Ciccarone Center for the Prevention of Cardiovascular Disease, Baltimore, Maryland.

Importance: Randomized clinical trials (RCTs) of lipid-lowering therapies form the evidence base for national and international guidelines. However, concerns exist that women and older patients are underrepresented in RCTs.

Objective: To determine the trends of representation of women and older patients (≥65 years) in RCTs of lipid-lowering therapies from 1990 to 2018. Read More

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Replicating patterns of prospect theory for decision under risk.

Nat Hum Behav 2020 06 18;4(6):622-633. Epub 2020 May 18.

JDM Lab, Department of Developmental Psychology and Socialization, University of Padova, Padova, Italy.

Prospect theory is among the most influential frameworks in behavioural science, specifically in research on decision-making under risk. Kahneman and Tversky's 1979 study tested financial choices under risk, concluding that such judgements deviate significantly from the assumptions of expected utility theory, which had remarkable impacts on science, policy and industry. Though substantial evidence supports prospect theory, many presumed canonical theories have drawn scrutiny for recent replication failures. Read More

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Rate of diagnostic errors and serious misdiagnosis-related harms for major vascular events, infections, and cancers: toward a national incidence estimate using the "Big Three".

Diagnosis (Berl) 2021 02 14;8(1):67-84. Epub 2020 May 14.

Director of Patient Safety, CRICO Strategies, Boston, MA, USA.

Background: Missed vascular events, infections, and cancers account for ~75% of serious harms from diagnostic errors. Just 15 diseases from these "Big Three" categories account for nearly half of all serious misdiagnosis-related harms in malpractice claims. As part of a larger project estimating total US burden of serious misdiagnosis-related harms, we performed a focused literature review to measure diagnostic error and harm rates for these 15 conditions. Read More

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February 2021

The association between use of opiates, cocaine, and amphetamines during pregnancy and maternal postpartum readmission in the United States: A retrospective analysis of the Nationwide Readmissions Database.

Drug Alcohol Depend 2020 05 20;210:107963. Epub 2020 Mar 20.

Department of Family and Community Medicine, Baylor College of Medicine, Houston, TX, United States.

Background: Substance use during pregnancy has increased in the United States, with adverse consequences for mother and baby. Similarly, postpartum readmission (PPR) imposes physical, emotional, and financial stressors causing disruption to family functioning and childcare. We used national data to estimate the extent to which women who used opiates, cocaine, and amphetamines during pregnancy are at increased risk of PPR. Read More

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The Need for an Evidence-Based Encyclopaedia in Health Services Research in Pharmacy.

Int J Environ Res Public Health 2020 04 8;17(7). Epub 2020 Apr 8.

Centre for Pharmaceutical Policy and Practice Research, Department of Pharmacy, University of Huddersfield, West Yorkshire HD1 3DH, UK.

Pharmacy practice research (PPR) is a specialty field within the wider area of health services research and it focuses on studies of how and why people access pharmacy services. This stream of research is also referred to as more universally recognized term such as health services research in pharmacy. The health services research in pharmacy has increased manifold; however, the impact of this research is not visible at the global level. Read More

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