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Fibrinolysis in Venous Thromboembolism.

Anetta Undas

Semin Thromb Hemost 2021 Apr 20. Epub 2021 Apr 20.

Institute of Cardiology, Jagiellonian University Medical College, Krakow, Poland.

Fibrinolysis is of paramount importance in maintaining or regaining the patency of veins and pulmonary arteries obstructed by thrombi. Growing experimental and clinical evidence indicates that impaired fibrinolysis mediated by multiple complex mechanisms is involved in venous thromboembolism (VTE). Global plasma fibrin clot lysis markers, especially clot lysis time, have been reported to predict recurrent deep-vein thrombosis and pulmonary embolism. Read More

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Tranexamic Acid Treatment for Trauma Victims.

Semin Thromb Hemost 2021 Apr 20. Epub 2021 Apr 20.

Department of Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom.

Worldwide, traumatic injury is responsible for over 5 million deaths per year, the majority due to exsanguination and head injury. The antifibrinolytic drug tranexamic acid is the only drug proven to reduce deaths after traumatic injury. Several large randomized controlled trials have provided high-quality evidence of its effectiveness and safety in trauma patients. Read More

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Fibrinolysis in Acute and Chronic Cardiovascular Disease.

Semin Thromb Hemost 2021 Apr 20. Epub 2021 Apr 20.

Department of Metabolic Medicine, Leeds Institute of Cardiovascular and Metabolic Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, United Kingdom.

The formation of an obstructive thrombus within an artery remains a major cause of mortality and morbidity worldwide. Despite effective inhibition of platelet function by modern antiplatelet therapies, these agents fail to fully eliminate atherothrombotic risk. This may well be related to extensive vascular disease, beyond the protective abilities of the treatment agents used. Read More

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Fibrinolysis in Traumatic Brain Injury: Diagnosis, Management, and Clinical Considerations.

Semin Thromb Hemost 2021 Apr 20. Epub 2021 Apr 20.

Department of Surgery, Duke University Medical Center, Durham, North Carolina.

Posttraumatic coagulopathy involves disruption of both the coagulation and fibrinolytic pathways secondary to tissue damage, hypotension, and inflammatory upregulation. This phenomenon contributes to delayed complications after traumatic brain injury (TBI), including intracranial hemorrhage progression and systemic disseminated intravascular coagulopathy. Development of an early hyperfibrinolytic state may result in uncontrolled bleeding and is associated with increased mortality in patients with TBI. Read More

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[Therapy of Language Disorders in Childhood: A Guideline is long overdue].

Laryngorhinootologie 2021 Apr 20. Epub 2021 Apr 20.

Phoniatrisch/Pädaudiologische Psychologie, Georg-August-Universität Göttingen, UMG, Germany.

In speech and language therapy of developmental language disorders, it is still largely unclear how evidence from individual therapeutic expertise integrates into clinical-practical procedure. Therefore, development of a therapy guideline addressing language disorders in childhood, especially for kindergarten- and preschool children, is long overdue for two reasons and poses a particular challenge: (1) Language disorders that are not associated with a comorbidity are given varying terms; (2) all language disorders are an interface between medical, psychological, educational, linguistic and language therapeutic disciplines. The German Society for Phoniatrics and Pedaudiology has registered now an evidence-based (S3) national "Interdisciplinary Guideline for the Therapy of Language Disorders in Childhood" (in the Association of the Scientific Medical Societies AWMF; register no. Read More

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Investigation of the magnetic ground state of GaVSusing powder neutron diffraction.

J Phys Condens Matter 2021 Apr 20. Epub 2021 Apr 20.

Department of Physics, University of Warwick, Gibbet Hill Road, Coventry, Coventry, CV4 7AL, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.

The magnetic ground state of polycrystalline Néel skyrmion hosting material GaVShas been investigated usingsusceptibility and powder neutron diffraction. In the absence of an applied magnetic field GaVSundergoes a transition from a paramagnetic to a cycloidal state below 13 K and then to a ferromagnetic-like state below 6 K. With evidence fromsusceptibility and powder neutron diffraction, we have identified the commensurate magnetic structure at 1. Read More

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TORS elective lingual tonsillectomy has less acute morbidity than therapeutic base of tongue TORS.

Oral Oncol 2021 Apr 16;117:105294. Epub 2021 Apr 16.

Department of Radiation Oncology, Emory University School of Medicine, Atlanta, GA, United States.

Objective: To determine the impact of diagnostic TORS lingual tonsillectomy (DTLT) on objective swallowing measures for carcinoma of unknown primary (CUP).

Methods: Between 10/2016-1/2020, 27 patients with p16+ squamous cell carcinoma (SCC) level 2a nodal disease underwent DTLT and ipsilateral neck dissection for CUP. No patient had a history of cutaneous SCC. Read More

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Superior sternoclavicular joint dislocation presented with shoulder motion limitation: A case report and literature review.

Int J Surg Case Rep 2021 Apr 15;82:105887. Epub 2021 Apr 15.

Joint Reconstruction Research Center, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran; Joint Reconstruction Research Center, Orthopedic Surgery Department, Imam Khomeini Hospital, End of Keshavarz Blvd, Tehran, 1419733141, Iran. Electronic address:

Introduction And Importance: Sternoclavicular joint dislocation accounts for 1 percent of the human joint dislocations. Sternoclavicular joint dislocation most commonly occurs in anterior or posterior dislocation. To the best of the authors knowledge, only six cases of superior sternoclavicular joint dislocation are reported in the literature. Read More

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Drivers of successful implementation of integrated care for multi-morbidity: Mechanisms identified in 17 case studies from 8 European countries.

Soc Sci Med 2021 Feb 3;277:113728. Epub 2021 Feb 3.

Erasmus School of Health Policy & Management, Erasmus University Rotterdam, The Netherlands, P.O. Box 1738, 3000 DR, Rotterdam, the Netherlands; Institute for Medical Technology Assessment, Erasmus University Rotterdam, Rotterdam, The Netherlands, P.O. Box 1738, 3000 DR, Rotterdam, the Netherlands. Electronic address:

This paper provides a deeper understanding of the mechanisms underlying implementation strategies for integrated care. As part of the SELFIE project, 17 integrated care programmes addressing multi-morbidity from eight European countries were selected and studied. Data was extracted from 'thick descriptions' of the 17 programmes and analysed both inductively and deductively using implementation theory. Read More

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February 2021

Social factors and worry associated with COVID-19: Evidence from a large survey in China.

Min Zhou Wei Guo

Soc Sci Med 2021 Apr 14;277:113934. Epub 2021 Apr 14.

Department of Social Work and Social Policy, School of Social and Behavioral Sciences, Nanjing University, Jiangsu Province, 210023, P. R. China; The Centre for Asia-Pacific Development Studies, Nanjing University, Jiangsu Province, 210023, PR China. Electronic address:

Objective: Worry about COVID-19 is an important cognitive component and manifestation of COVID-19-related anxiety. It has a social dimension and is shaped by various social factors.

Data: We employ original data from a large survey (N = 20,632) conducted in China from April 21 to 23, 2020, which provide us with a rare opportunity to investigate COVID-19-induced worry among ordinary Chinese citizens. Read More

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Politicisation, depoliticisation, and repoliticisation of health care controversies: Vaccination and mental health care reform in the Czech Republic.

Soc Sci Med 2021 Apr 17;277:113916. Epub 2021 Apr 17.

Department of Sociology, Faculty of Social Sciences, Charles University Prague, Czech Republic. Electronic address:

This article analyses the politicisation of public health debates by focusing on vaccination and mental health care in the Czech Republic. The mainstream understanding of politicisation commonly refers to politics-as-sphere, linked with the political instrumentalisation of health care controversies as part of electoral campaigning and power struggles. In our analysis, we conceive politicisation more broadly, as politics-as-activity, which encompasses the role of civic engagement and the involvement of patients in these processes. Read More

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Opioid prescribing practices in academic otolaryngology: A single institutional survey.

Am J Otolaryngol 2021 Apr 15;42(5):103038. Epub 2021 Apr 15.

Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear, Boston, MA, USA; Department of Otolaryngology, Harvard Medical School, Boston, MA, USA.

Objectives: Opioids are highly addictive medications and otolaryngologists have a responsibility to practice opioid stewardship. We investigated postoperative opioid prescribing patterns among resident and attending physicians as an educational platform to underscore the importance of conscientious opioid prescribing.

Methods: This quality improvement study was designed as a cross-sectional electronic survey. Read More

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A classification of primary care streaming pathways in UK emergency departments: Findings from a multi-methods study comprising cross-sectional survey; site visits with observations, semi-structured and informal interviews.

Int Emerg Nurs 2021 Apr 17;56:101000. Epub 2021 Apr 17.

Division of Population Medicine, Cardiff University, Heath Park, Cardiff, UK.

Background: Variation in initial assessment methods at emergency departments in with primary care service models and a conflated terminology causes difficulties in assessing relative performance, improving quality or gathering evidence about safety and clinical effectiveness. We aim to describe and classify streaming pathways in emergency departments in different models of emergency department primary care services in England and Wales.

Methods: We used a multi-stage method, including an online survey completed by 77 emergency departments across England & Wales, interviews with 21 clinical leads, and in-depth case studies of 13 emergency departments. Read More

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Responses to Navon tasks differ across development and between tasks with differing attentional demands.

Vision Res 2021 Apr 17;185:17-28. Epub 2021 Apr 17.

School of Psychology, University of Surrey, Guildford, Surrey GU2 7HX, UK.

Navon hierarchical stimuli are designed to measure responses to the global level (grouped local elements, e.g. a forest) and the local level (individuated local elements, e. Read More

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The intergenerational interplay of adversity on salivary inflammation in young children and caregivers.

Psychoneuroendocrinology 2021 Apr 17;128:105222. Epub 2021 Apr 17.

Department of Biobehavioral Health, The Pennsylvania State University, 219 Biobehavioral Health Building, University Park, PA 16802, USA. Electronic address:

Systemic inflammation links exposure to early childhood adversity to later disease. The associations among adversity and disease risk might in part operate through poor oral hygiene and subsequent periodontal inflammation, which can be measured in saliva. Few studies, however, have examined the association between adversity and salivary inflammation in young children. Read More

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Assessing the contribution of mangrove carbon and of other basal sources to intertidal flats adjacent to one of the largest West African mangrove forests.

Mar Environ Res 2021 Apr 9;169:105331. Epub 2021 Apr 9.

Centro de Estudos do Ambiente e do Mar (CESAM), Departamento de Biologia Animal, Faculdade de Ciências da Universidade de Lisboa, Lisboa, Portugal.

Mangrove forests are productive habitats and major potential exporters of organic matter and nutrients to adjacent habitats. Here we examine the extent to which mangrove carbon is transferred to adjacent intertidal food webs in the second largest mangrove-covered area in Africa, in Guinea-Bissau. Applying stable isotope analysis and mixing models, we made comparisons at two spatial scales: (1) a large scale, comparing intertidal flats with (mangrove sites) and without (control sites) adjacent mangrove forests regarding the carbon isotopic signature of macrozoobenthos and sediment organic matter (SOM), and the relative importance of potential primary food sources in sustaining macrozoobenthos, and (2) a fine scale, performing stable carbon isotope measurements along 200 m transects from the coastline out to open intertidal flats, to trace mangrove carbon in macrozoobenthos and in the SOM. Read More

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Tricky diagnosis and robot-laparoscopic surgical approach of disseminated peritoneal leiomyomatosis.

J Minim Invasive Gynecol 2021 Apr 17. Epub 2021 Apr 17.

Hospital Israelita Albert Einstein, São Paulo, Brazil.

Objective: To show the challenging diagnosis and safe robotic surgical approach of a rare case of disseminated peritoneal leiomyomatosis (DPL).

Design: A clinical case shown by a sequential demonstration of investigation, diagnosis and surgical approach, with narrated video footage.

Setting: DPL is a rare disease, with just over 150 cases reported in literature. Read More

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Disease modifying therapies in relapsing-remitting multiple sclerosis: A systematic review and network meta-analysis.

Autoimmun Rev 2021 Apr 17:102826. Epub 2021 Apr 17.

Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China. Electronic address:

Objective: To compare the efficacy and compliance of up-to-date disease modifying therapies (DMTs) in patients with remitting-relapsing MS (RRMS).

Methods: We searched PubMed, EMBASE and Cochrane Library for eligible studies. Annualized relapse rate, discontinuation due to adverse events (AEs) were assessed as primary outcomes. Read More

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Human mesenchymal stem cells for the management of systemic sclerosis. Systematic review.

Autoimmun Rev 2021 Apr 17:102831. Epub 2021 Apr 17.

Research Institute, Fundación Universitaria De Ciencias De La Salud, University of Health Sciences, Bogota, Colombia.

Introduction: Sistemic Sclerosis (SSc) is a heterogeneous autoimmune disease with a high rate of progression and therapeutic failure, and treatment is a challenge, new therapeutic proposals being needed, being mesenchymal stem cells (MSCs) considered as alternative therapy for SSc for its immunomodulatory capacity. We evaluated the efficacy and safety of human MSC (hMSC) in patients with SSc through a systematic literature review (SLR).

Methods: SLR (PRISMA guideline) on MEDLINE/OVID, LILACS, EMBASE, and Cochrane/OVID bases (until July 2020, without limits). Read More

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Long-term follow-up of the three-ligament tenodesis for scapholunate ligament lesions: 9-year results.

Hand Surg Rehabil 2021 Apr 17. Epub 2021 Apr 17.

UZ Leuven, Department of Orthopedic Surgery, Herestraat 49, 3000 Leuven, Belgium. Electronic address:

We report on a retrospective cohort of 50 cases of three-ligament tenodesis for scapholunate instability. Fifteen cases (30% of our cohort) needed salvage surgery (11 proximal row carpectomies, 2 partial and 2 total wrist fusions) at an average of 33 months and are considered "failures". Of the 35 remaining cases ("success"), 16 (32% of our cohort) were reviewed at average 111 months and had good functional outcomes (QuickDASH 18/100, PRWE 11/100, pain 1/10, satisfaction 9/10). Read More

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Association of Adenoma Detection Rate and Adenoma Characteristics with Colorectal Cancer Mortality after screening colonoscopy.

Clin Gastroenterol Hepatol 2021 Apr 17. Epub 2021 Apr 17.

Dept. of Internal Medicine, Div. of Gastroenterology and Hepatology, Medical University of Vienna, Austria; Quality Assurance Working Group, Austrian Society for Gastroenterology and Hepatology, Austria. Electronic address:

Background & Aims: The adenoma detection rate (ADR) and characteristics of previously resected adenomas are associated with colorectal cancer (CRC) incidence and mortality. However, the combined effect of both factors on CRC mortality is unknown.

Patients And Methods: Using data of the Austrian quality assurance program for screening colonoscopy, we evaluated the combined effect of ADR and lesion characteristics on subsequent risk for CRC mortality. Read More

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