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[Age-related differences in the management and outcome of acute coronary syndrome under the chest pain center model: a multicenter retrospective study].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 Mar;33(3):318-323

Department of Cardiology, Third People's Hospital of Chengdu Affiliated to Southwest Jiaotong University, Chengdu 610031, Sichuan, China. Corresponding author: Cai Lin, Email:

Objective: To assess the age-related differences in the management strategies and outcomes of patients with acute coronary syndrome (ACS) under the chest pain center model.

Methods: Clinical data of 2 833 patients with ACS were enrolled in the retrospective observational registry between January 2017 and June 2019 at 11 hospitals with chest pain centers in Chengdu. The patients were divided into four groups according to their ages: < 55 years old group (n = 569), 55-64 years old group (n = 556), 65-74 years old group (n = 804), ≥ 75 years old group (n = 904). Read More

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Effects of Smoking on Long-Term Clinical Outcomes and Lung Cancer in Patients with Acute Myocardial Infarction.

Korean Circ J 2021 Apr;51(4):336-348

Division of Cardiology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Background And Objectives: Smoking is well-established as a risk factor for coronary artery disease. However, recent studies demonstrated favorable results, including reduced mortality, among smokers, which are referred to as the "smoker's paradox". This study examined the impact of smoking on clinical outcomes in patients with acute myocardial infarction (AMI) undergoing percutaneous coronary intervention (PCI). Read More

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Clinical Features and Multiplatform Molecular Analysis Assist in Understanding Patient Response to Anti-PD-1/PD-L1 in Renal Cell Carcinoma.

Cancers (Basel) 2021 Mar 23;13(6). Epub 2021 Mar 23.

Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Predicting response to ICI therapy among patients with renal cell carcinoma (RCC) has been uniquely challenging. We analyzed patient characteristics and clinical correlates from a retrospective single-site cohort of advanced RCC patients receiving anti-PD-1/PD-L1 monotherapy (N = 97), as well as molecular parameters in a subset of patients, including multiplexed immunofluorescence (mIF), whole exome sequencing (WES), T cell receptor (TCR) sequencing, and RNA sequencing (RNA-seq). Clinical factors such as the development of immune-related adverse events (odds ratio (OR) = 2. Read More

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CarDiac magnEtic Resonance for prophylactic Implantable-cardioVerter defibrillAtor ThErapy in Non-Ischaemic dilated CardioMyopathy: an international Registry.

Europace 2021 Apr 1. Epub 2021 Apr 1.

Department of Cardiology, ASST Monza, P.O. Desio, Italy.

Aims: The aim of this registry was to evaluate the additional prognostic value of a composite cardiac magnetic resonance (CMR)-based risk score over standard-of-care (SOC) evaluation in a large cohort of consecutive unselected non-ischaemic cardiomyopathy (NICM) patients.

Methods And Results: In the DERIVATE registry (www.clinicaltrials. Read More

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Primary stability of a proximally coated and tapered stem.

Bone Joint J 2021 04;103-B(4):644-649

Nuffield Orthopaedic Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.

Aims: The aim of this prospective cohort study was to evaluate the early migration of the TriFit cementless proximally coated tapered femoral stem using radiostereometric analysis (RSA).

Methods: A total of 21 patients (eight men and 13 women) undergoing primary total hip arthroplasty (THA) for osteoarthritis of the hip were recruited in this study and followed up for two years. Two patients were lost to follow-up. Read More

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Lasmiditan efficacy in migraine attacks with mild vs. moderate or severe pain.

Curr Med Res Opin 2021 Apr 7:1-8. Epub 2021 Apr 7.

Neurology and Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Objective: To evaluate the efficacy of lasmiditan (LTN) in treating migraine attacks of mild vs. moderate or severe pain intensity.

Methods: Pooled data from two single-attack, placebo-controlled studies (SAMURAI [NCT02439320] and SPARTAN [NCT02605174]), and a prospective, randomized, open-label study (GLADIATOR [NCT02565186]) were assessed. Read More

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An analysis of prehospital critical care events and management patterns from 97 539 emergency helicopter medical service missions: A retrospective registry-based study.

Eur J Anaesthesiol 2021 Jun;38(6):644-651

From the Research and Development Unit, FinnHEMS, Vantaa (AS, PL-N, JON), University of Eastern Finland, Kuopio (AS), Centre for Prehospital Emergency Care, Oulu University Hospital, Oulu (LR), Research group of anaesthesiology, MRC Oulu, (LR), Kuopio University Hospital, Center for Prehospital Emergency Care, Kuopio (HJ) and Emergency Medicine and Services, Helsinki University Hospital and Emergency Medicine, University of Helsinki, Helsinki, Finland (JON).

Background: It is largely unknown how often physicians in emergency helicopter medical services (HEMS) encounter various critical care events and if HEMS exposure is associated with particular practice patterns or outcomes.

Objectives: This study aimed: to describe the frequency and distribution of critical care events; to investigate whether HEMS exposure is associated with differences in practice patterns and determine if HEMS exposure factors are associated with mortality.

Design: A retrospective registry-based study. Read More

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Association of Clinical, Biological, and Brain Magnetic Resonance Imaging Findings With Electroencephalographic Findings for Patients With COVID-19.

JAMA Netw Open 2021 03 1;4(3):e211489. Epub 2021 Mar 1.

Sorbonne Université, Paris Brain Institute, Institut du Cerveau, Institut National de la Santé et de la Recherche Médicale U 1127, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7225, Paris, France.

Importance: There is evidence of central nervous system impairments associated with coronavirus disease 2019 (COVID-19) infection, including encephalopathy. Multimodal monitoring of patients with COVID-19 may delineate the specific features of COVID-19-related encephalopathy and guide clinical management.

Objectives: To investigate clinical, biological, and brain magnetic resonance imaging (MRI) findings in association with electroencephalographic (EEG) features for patients with COVID-19, and to better refine the features of COVID-19-related encephalopathy. Read More

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Future bradyarrhythmia in patients with hypertrophic cardiomyopathy.

Int J Cardiol Heart Vasc 2021 Apr 26;33:100735. Epub 2021 Feb 26.

Department of Cardiology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.

Background: A few studies to evaluate an incidence of bradyarrhythmia in patients with hypertrophic cardiomyopathy (HCM) have been reported.

Methods: We enrolled 161 patients with HCM to evaluate their bradyarrhythmia risk, especially the risk of patients who were at risk for sudden cardiac death (SCD) and eligible for implantation of an implantable cardiac defibrillator (ICD). We defined symptomatic bradyarrhythmia requiring a pacing therapy as a bradyarrhythmia event and collected the data on an occurrence of the event after the time of diagnosis of HCM. Read More

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Retrospective European Multicentric Evaluation of Selective Transarterial Chemoembolisation with and without Balloon-Occlusion in Patients with Hepatocellular Carcinoma: A Propensity Score Matched Analysis.

Cardiovasc Intervent Radiol 2021 Mar 11. Epub 2021 Mar 11.

Department of Interventional Radiology, Gustave Roussy Cancer Center, Villejuif, France.

Purpose: The aim of this retrospective multicentric study was to compare the tumour response rates of Balloon-occluded Transarterial Chemoembolisation (B-TACE) to non-B-TACE using propensity score matching (PSM) in patients with hepatocellular carcinoma and to investigate the clinical benefit, such as lower rates of TACE re-intervention achieved using B-TACE.

Material And Methods: The B-TACE procedures (n = 96 patients) were compared with a control group of non-B-TACE treatments (n = 434 pts), performed with conventional (cTACE) or drug-eluting microspheres TACE (DEM-TACE). Data were collected from six European centres from 2015 to 2019. Read More

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Impact of left ventricular ejection fraction and preoperative hemoglobin level on perioperative adverse cardiovascular events in noncardiac surgery.

Heart Vessels 2021 Mar 9. Epub 2021 Mar 9.

Department of Cardiovascular Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama, 641-8509, Japan.

The prediction of a perioperative adverse cardiovascular event (PACE) is an important clinical issue in the medical management of patients undergoing noncardiac surgery. Although several predictors have been reported, simpler and more practical predictors of PACE have been needed. The aim of this study was to investigate the predictors of PACE in noncardiac surgery. Read More

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Transient global amnesia does not increase the risk of subsequent ischemic stroke: a propensity score-matched analysis.

J Neurol 2021 Mar 2. Epub 2021 Mar 2.

Department of Neurology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA, 52242, USA.

Introduction: Data regarding the risk of cerebrovascular events following transient global amnesia (TGA) remain controversial. While some neuroradiological studies suggest an underlying cerebrovascular etiology, results from the clinical studies have been largely conflicting. We, therefore, aimed to evaluate the risk of ischemic stroke in a large, nationally representative sample of patients with TGA. Read More

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Prediction of Lipoprotein-Associated Phospholipase A2 and Inflammatory Markers in Subclinical Atherosclerosis in Premature Ovarian Failure Patients.

Acta Cardiol Sin 2021 Jan;37(1):30-37

Department of Internal Medicine, Ege University Faculty of Medicine, İzmir, Turkey.

Background: Lipoprotein-associated phospholipase A2 (Lp-PLA2) activity has been associated with the risk of clinical cardiovascular events.

Objectives: In this study, we aimed to investigate whether the activity of Lp-PLA2 presents a risk for subclinical atherosclerosis in young patients with premature ovarian failure (POF).

Methods: Consecutive patients with clinical and biochemical evidence of naïve POF (n = 66) in January and February 2018 and age-matched healthy controls (n = 73) were enrolled. Read More

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January 2021

Electroencephalography, Hospital Complications, and Longitudinal Outcomes After Subarachnoid Hemorrhage.

Neurocrit Care 2021 Jan 22. Epub 2021 Jan 22.

Department of Neurology, Massachusetts General Hospital, 55 Fruit Street, Lunder 644, Boston, MA, 02114, USA.

Background: Following non-traumatic subarachnoid hemorrhage (SAH), in-hospital delayed cerebral ischemia is predicted by two chief events on continuous EEG (cEEG): new or worsening epileptiform abnormalities (EAs) and deterioration of cEEG background frequencies. We evaluated the association between longitudinal outcomes and these cEEG biomarkers. We additionally evaluated the association between longitudinal outcomes and other in-hospital complications. Read More

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January 2021

Efficacy and Safety of Inotuzumab Ozogamicin (CMC-544) for the Treatment of Relapsed/Refractory Acute Lymphoblastic Leukemia and Non-Hodgkin Lymphoma: A Systematic Review and Meta-Analysis.

Clin Lymphoma Myeloma Leuk 2021 Mar 17;21(3):e227-e247. Epub 2020 Dec 17.

National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China; Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China; Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou, China; State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou, China. Electronic address:

Introduction: The purpose of this systematic review and meta-analysis was to evaluate the efficacy and safety of inotuzumab ozogamicin (INO) in patients with relapsed/refractory acute lymphocytic leukemia (ALL) and non-Hodgkin lymphoma (NHL).

Materials And Methods: Databases (PubMed, EMBASE, and Cochrane databases) were searched through April 4, 2020. Outcome measures of efficacy covered complete remission (CR) rates and minimal residual disease response rates. Read More

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Mental health of Italian adults during COVID-19 pandemic.

Br J Health Psychol 2021 05 7;26(2):644-656. Epub 2021 Jan 7.

Department of Dynamic and Clinical Psychology, Sapienza University of Rome, Italy.

Objectives: On 31 January 2020, a new type of coronavirus was first confirmed in Italy and spread rapidly across the country leading to a national lockdown. The aim of this pilot study was to explore the impact of the public health emergency due to COVID-19 on individual's mental health among 299 Italian adults after a month of home isolation due to COVID-19.

Design: Cross-sectional study design. Read More

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Development and psychometric testing of a questionnaire to assess Nurse's perception of risks during enteral nutrition.

BMC Nurs 2021 Jan 5;20(1). Epub 2021 Jan 5.

Department of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.

Background: Enteral nutrition (EN) therapy is widely used in clinical practice to provide artificial nutrition to patients, while the incidence of adverse events are relatively highly. In the clinical setting, the occurrence of adverse events is associated with the nurse's risk perception. Thus, using tool to evaluate nurse's risk perception of enteral nutrition is necessary. Read More

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January 2021

Effects of an Integrative Mind-Body-Medicine Group Program on Breast Cancer Patients During Chemotherapy: An Observational Study.

Curr Pharm Des 2021 ;27(8):1112-1120

Department of Internal and Integrative Medicine, Evang. Kliniken Essen-Mitte, Faculty of Medicine, University of Duisburg-Essen, Essen, Germany.

Background: Breast cancer is one of the leading cancers in women in the Western world. Cancer treatment, especially chemotherapy, is often associated with physical and psychosocial side effects.

Objective: To improve the quality of life and manage side effects, a new integrative mind-body-medicine group concept for breast cancer patients receiving chemotherapy was developed and pilot tested. Read More

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January 2021

Efficacy and Safety of Ixekizumab in Patients with Psoriatic Arthritis and Inadequate Response to TNF Inhibitors: 3-Year Follow-Up (SPIRIT-P2).

Rheumatol Ther 2021 Mar 5;8(1):199-217. Epub 2020 Dec 5.

Hospital Pierre-Paul Riquet and Université Toulouse III, Toulouse, France.

Purpose: Ixekizumab is a high-affinity monoclonal antibody that selectively targets interleukin-17A. The objective of this study was to assess the long-term efficacy and safety (to week 156) of ixekizumab in patients with active psoriatic arthritis and inadequate response or intolerance to one or two tumor necrosis factor inhibitors.

Methods: In the SPIRIT-P2 study (ClinicalTrials. Read More

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Association of long-term inhalation of caffeine-sodium benzoate with coronary heart disease in men.

Int J Clin Pharmacol Ther 2021 Mar;59(3):247-253

Objective: A possible correlation between caffeine and coronary heart disease (CHD) is controversial. The objective of this study was to explore the effect of long-term inhalation of caffeine-sodium benzoate (CSB) on the development of CHD in men, the severity of coronary artery lesions and the possible contributing effects of smoking.

Materials: A retrospective analysis was performed on 2,001 consecutive men who underwent selective coronary angiography. Read More

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Nature-Based Interventions and Mind-Body Interventions: Saving Public Health Costs Whilst Increasing Life Satisfaction and Happiness.

Int J Environ Res Public Health 2020 10 23;17(21). Epub 2020 Oct 23.

School of Sport, Rehabilitation and Exercise Sciences, University of Essex, Colchester CO4 3SQ, UK.

A number of countries have begun to adopt prevention pays policies and practices to reduce pressure on health and social care systems. Most affluent countries have seen substantial increases in the incidence and costs of non-communicable diseases. The interest in social models for health has led to the growth in use of social prescribing and psychological therapies. Read More

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October 2020

Elucidation of the Chemical Role of the Pyroclastic Materials on the State of Conservation of Mural Paintings from Pompeii.

Angew Chem Int Ed Engl 2021 Feb 3;60(6):3028-3036. Epub 2020 Dec 3.

Department of Analytical Chemistry, Faculty of Pharmacy, University of the Basque Country (UPV/EHU), P.O. Box 450, 01080, Vitoria-Gasteiz, Basque Country, Spain.

Pyroclastic strata have always been thought to protect the archaeological remains of the Vesuvian area (Italy), hence allowing their conservation throughout the centuries. In this work, we demonstrate that they constitute a potential threat for the conservation state of the mural paintings of Pompeii. The ions that could be leached from them and the ion-rich groundwater coming from the volcanic soil/rocks may contribute to salt crystallisation. Read More

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February 2021

Removal of Drugs in Polluted Waters with Char Obtained by Pyrolysis of Hair Waste from the Tannery Process.

ACS Omega 2020 Sep 17;5(38):24389-24402. Epub 2020 Sep 17.

Department of Civil and Environmental Engineering, Universidad de los Andes, Carrera 1Este #19A-40, Bogotá 111711, Colombia.

The presence and final destination of pharmaceutical compounds in waters constitute one of the emerging events in current environmental chemistry. Two widely consumed compounds have been evaluated in this study, amoxicillin (AMOX) and diclofenac (DFC), at a concentration of 200 mg L. The presence of both in wastewater has been verified, generating problems in ecosystems and human health. Read More

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September 2020

Do prolonged fasting periods influence the postprandial metabolic responses in turtles? What can Trachemys scripta elegans teach us about this?

J Exp Zool A Ecol Integr Physiol 2020 11 30;333(9):644-651. Epub 2020 Sep 30.

Programa de Pós-Graduação em Ecologia e Evolução, Laboratório de Ecologia, Zoologia e Fisiologia Comparada, Instituto de Ciências Ambientais, Químicas e Farmacêuticas, Universidade Federal de São Paulo, campus Diadema, Diadema, São Paulo, Brazil.

The postprandial period is characterized by a modification of the gastrointestinal activity after food intake, accompanied by an increase in metabolic rate, secretion of acids, and absorption of nutrients. For ectothermic vertebrates, those changes are particularly prominent given the relatively low metabolic cost and the low frequency of food uptake. However, prolonged fasting periods decrease energy reserves and may compromise the upregulation of costly processes, such as the increase in metabolic rate after resuming the meal intake. Read More

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November 2020

Genomic and Functional Regulation of TRIB1 Contributes to Prostate Cancer Pathogenesis.

Cancers (Basel) 2020 Sep 11;12(9). Epub 2020 Sep 11.

Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Building 801A, 48160 Derio, Spain.

Prostate cancer is the most frequent malignancy in European men and the second worldwide. One of the major oncogenic events in this disease includes amplification of the transcription factor cMYC. Amplification of this oncogene in chromosome 8q24 occurs concomitantly with the copy number increase in a subset of neighboring genes and regulatory elements, but their contribution to disease pathogenesis is poorly understood. Read More

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September 2020

N metabolism performance in Chenopodium quinoa subjected to drought or salt stress conditions.

Plant Physiol Biochem 2020 Oct 13;155:725-734. Epub 2020 Aug 13.

Department of Plant Biology and Ecology, Faculty of Science and Technology, University of the Basque Country (UPV/EHU), Apdo. 644, E-48080, Bilbao, Spain. Electronic address:

Currently it is estimated that the 20% of total cultivated land is affected by salt. Besides, drought events will increase worldwide. These factors are affecting plant growth and crop production compromising food security. Read More

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October 2020

Clinical implication of neointimal burden in in-stent restenosis treated with drug-coated balloon.

Catheter Cardiovasc Interv 2020 Aug 27. Epub 2020 Aug 27.

Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, South Korea.

Background: Although drug-coated balloon (DCB) angioplasty is a well-established drug-eluting stent (DES) in-stent restenosis (ISR) strategy, there are minimal data regarding the association of neointimal burden on optical coherence tomography (OCT) before and after DCB and adverse clinical events. This study aimed to investigate the clinical impact of neointimal burden measured with OCT in patients with DES ISR after DCB angioplasty.

Methods: From 2010 through 2013, a total of 122 patients with 122 ISR lesions were treated with DCB, which was preceded and followed by OCT examination. Read More

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Impact of Early Revascularization on Major Adverse Cardiovascular Events in Relation to Automatically Quantified Ischemia.

JACC Cardiovasc Imaging 2021 Mar 19;14(3):644-653. Epub 2020 Aug 19.

Department of Imaging, Medicine, and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA. Electronic address:

Objectives: Using a contemporary, multicenter international single-photon emission computed tomography myocardial perfusion imaging (SPECT-MPI) registry, this study characterized the potential major adverse cardiovascular event(s) (MACE) benefit of early revascularization based on automatic quantification of ischemia.

Background: Prior single-center data reported an association between moderate to severe ischemia SPECT-MPI and reduced cardiac death with early revascularization.

Methods: Consecutive patients from a multicenter, international registry who underwent Tc SPECT-MPI between 2009 and 2014 with solid-state scanners were included. Read More

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Association Between Prolonged Grief and Attitudes Toward Reconciliation in Bereaved Survivors of the Khmer Rouge Regime in Cambodia.

Front Psychiatry 2020 10;11:644. Epub 2020 Jul 10.

Department of Clinical Psychological Intervention, Freie Universität Berlin, Berlin, Germany.

Background: During the Khmer Rouge regime in Cambodia, about a quarter of the population died, resulting in many individuals losing close relatives. Still today, many individuals are suffering from the psychological consequences of these losses, which might also affect the process of reconciliation within the Cambodian society. The aim of this paper is therefore to investigate the association between symptoms of prolonged grief and attitudes toward reconciliation. Read More

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Feasibility of a cluster randomized controlled trial on the effectiveness of peer-led health education interventions to increase uptake of retinal examination for diabetic retinopathy in Kirinyaga, Kenya: a pilot trial.

Pilot Feasibility Stud 2020 16;6:102. Epub 2020 Jul 16.

London School of Hygiene and Tropical Medicine, London, UK.

Background: People living with diabetes can reduce their risk of vision loss from diabetic retinopathy by attending screening, which enables early detection and timely treatment. The aim of this pilot trial was to assess the feasibility of a full-scale cluster randomized controlled trial of an intervention to increase uptake of retinal examination in this population, as delivered within existing community-based diabetes support groups (DSGs).

Methods: All 16 DSGs in Kirinyaga county were invited to participate in the study. Read More

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