702,673 results match your criteria events

Community-Onset Venous Thromboembolism in Children: Pediatric Emergency Medicine Perspectives.

Semin Thromb Hemost 2021 May 10. Epub 2021 May 10.

Division of Hematology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Pediatric venous thromboembolism (VTE) is a condition increasingly encountered by emergency medicine physicians. Unfortunately, despite increased incidence, the diagnosis of pediatric VTE relies on a high index of suspicion from clinicians. Delays in diagnosis and initiation of treatment can lead to poor outcomes in children, including an increased risk of mortality from pulmonary embolism, increased risk of VTE recurrence, and the development of the post-thrombotic syndrome. Read More

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Efficacy and Safety of Non-Vitamin K Antagonist Oral Anticoagulants in Pediatric Venous Thromboembolism Treatment and Thromboprophylaxis: A Systematic Review of the Literature.

Semin Thromb Hemost 2021 May 10. Epub 2021 May 10.

Johns Hopkins All Children's Institute for Clinical and Translational Research, St. Petersburg, Florida.

Venous thromboembolism (VTE) in children can lead to significant morbidity and mortality. Traditionally, treatment for thrombotic events in pediatric patients has been limited mainly to unfractionated heparin, low-molecular-weight heparin (LMWH), or vitamin K antagonists. Since the first non-vitamin K antagonist oral anticoagulant (NOAC) was approved for adult use, these agents have gained popularity for a variety of indications. Read More

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Arterial Thrombosis in Patients with Antiphospholipid Syndrome: A Review and Meta-Analysis.

Semin Thromb Hemost 2021 May 10. Epub 2021 May 10.

Department of Medicine, Thrombosis and Atherosclerosis Research Institute, McMaster University, Hamilton, Ontario, Canada.

There is a scarcity of high-quality randomized controlled trials (RCTs) comparing antithrombotic regimens for secondary prevention of arterial thrombosis (AT) in antiphospholipid syndrome (APS). We reviewed different antithrombotic regimens used for this purpose. We searched for studies on management of AT in APS on PubMed and Web of Science. Read More

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Sepsis and Mortality Prediction in Very Low Birth Weight Infants: Analysis of HeRO and nSOFA.

Am J Perinatol 2021 May 10. Epub 2021 May 10.

Division of Neonatology, Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, Virginia.

Objective:  Scores to predict sepsis or define sepsis severity could improve care for very low birth weight (VLBW) infants. The heart rate characteristics (HRC) index (HeRO score) was developed as an early warning system for late-onset sepsis (LOS), and also rises before necrotizing enterocolitis (NEC). The neonatal sequential organ failure assessment (nSOFA) was developed to predict sepsis-associated mortality using respiratory, hemodynamic, and hematologic data. Read More

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Targeting Poison Exons to Treat Developmental and Epileptic Encephalopathy.

Dev Neurosci 2021 May 10:1-6. Epub 2021 May 10.

Ken and Ruth Davee Department of Neurology, Northwestern University School of Medicine, Chicago, Illinois, USA.

Developmental and epileptic encephalopathies (DEEs) describe a subset of neurodevelopmental disorders categorized by refractory epilepsy that is often associated with intellectual disability and autism spectrum disorder. The majority of DEEs are now known to have a genetic basis with de novo coding variants accounting for the majority of cases. More recently, a small number of individuals have been identified with intronic SCN1A variants that result in alternative splicing events that lead to ectopic inclusion of poison exons (PEs). Read More

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Comparisons of Efficacy and Safety between Triple (Inhaled Corticosteroid/Long-Acting Muscarinic Antagonist/Long-Acting Beta-Agonist) Therapies in Chronic Obstructive Pulmonary Disease: Systematic Review and Bayesian Network Meta-Analysis.

Respiration 2021 May 10:1-13. Epub 2021 May 10.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital, Jongno-Gu, Seoul, Republic of Korea.

Background: Various combinations of inhaled corticosteroid (ICS), long-acting muscarinic antagonist (LAMA), and long-acting beta-agonist (LABA) have been used as triple therapy for stable chronic obstructive pulmonary disease (COPD).

Objective: Our study was conducted to answer whether there were significant differences among various combinations in efficacy, for reducing exacerbation or mortality, and in safety, for increasing cardiovascular events or pneumonia.

Method: We searched parallel-group randomized controlled trials (RCTs) comparing ICS/LAMA/LABA with other inhaled drugs in patients with stable COPD for at least 12 weeks in PubMed, EMBASE, the Cochrane Library, and clinical trial registries from inception to December 31, 2019. Read More

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Detection of anticancer drugs in wastewater effluents: Grab versus passive sampling.

Sci Total Environ 2021 Apr 30;786:147477. Epub 2021 Apr 30.

iBET - Instituto de Biologia Experimental e Tecnológica, Oeiras, Portugal; Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Oeiras, Portugal. Electronic address:

The occurrence of six anticancer drugs was evaluated in wastewater effluents. Several grab samples from wastewater effluent were collected throughout a year. Capecitabine, cyclophosphamide and ifosfamide were detected at concentrations ranging from 8 to 46 ng·L. Read More

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The use of first-generation long-acting injectable antipsychotics in children and adolescents-A retrospective audit from India.

Asian J Psychiatr 2021 May 4;61:102663. Epub 2021 May 4.

Dept of Child & Adolescent Psychiatry, NIMHANS, Bangalore, India.

Objectives: There is a dearth of knowledge regarding the usage of first-generation long-acting injectable (LAI) antipsychotics in children and adolescents, despite their off-label use, in low and middle-income countries (LAMIC).

Methods: Case records of subjects less than 18 years of age who received any first-generation LAI antipsychotics in the last 10 years(between 2010-19) were reviewed. Details documented for the study from the records included ICD-10 diagnoses, clinical profile, indication for use, medication details, severity of illness, improvement, and global functioning. Read More

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Cultivar replacement increases water use efficiency in foxtail millet in Shaanxi Province, China.

Plant Physiol Biochem 2021 May 5;164:73-81. Epub 2021 May 5.

Shaanxi Key Laboratory of Ecological Restoration in Shanbei Mining Area, College of Life Science, Yulin University, Yulin, China.

Cultivar replacement-induced genetic improvement is considered an important factor in enhancing crop grain yield. However, the effect of cultivar replacement of foxtail millet, an important crop in arid and semi-arid regions, on grain yield and drought resistance has rarely been considered. In the present study, we grew five millet cultivars, representative of widely cultivated varieties released from the 1950s to the 2010s in Shaanxi Province, China, in an open rainout shelter (closed during rain events) under two contrasting water treatments (35 ± 5% field water capacity (FWC), and 75 ± 5% FWC) with an aim to detect yield-related parameters, biomass accumulation, water use efficiency (WUE), and plant water-related indices. Read More

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Does the environmental condition affect the tolerance of the bivalve Anomalocardia flexuosa to different intensities and durations of marine heatwaves?

Mar Pollut Bull 2021 May 7;168:112410. Epub 2021 May 7.

Universidade Federal de Santa Catarina, Coordenadoria Especial de Oceanografia, Laboratório de Biodiversidade Costeira, Florianópolis, SC, Brazil.

Populations of the clam Anomalocardia flexuosa, subjected to different pollution conditions, were experimentally exposed to marine heatwaves of actual and future intensities and varying durations. We measured physiological and biochemical biomarkers and survival rates of the species under simulated heatwave events of 7 and 11 days. We observed that both the response of A. Read More

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Detecting pollutant sources and pathways: High-frequency automated online monitoring in a small rural French/German transborder catchment.

J Environ Manage 2021 May 7;290:112619. Epub 2021 May 7.

Institute of Inorganic and Analytical Chemistry, Saarland University, Dudweiler Zeile 4, 66125, Saarbruecken, Germany.

Great temporal and spatial variability of inputs make comprehensive monitoring in small and middle sized rivers difficult. In this study, relevant inputs in a small river were recorded with suitable online monitoring equipment coupled in mobile water quality monitoring stations, the study area being a transborder catchment with French and German (Saarland federal state) subcatchments. In addition to a pronounced spatial variability necessitating a denser net of measuring points this catchment has also to be assessed in the light of different national regulations. Read More

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Non-parameningeal head and neck rhabdomyosarcoma in children, adolescents, and young adults: Experience of the European paediatric Soft tissue sarcoma Study Group (EpSSG) - RMS2005 study.

Eur J Cancer 2021 May 7;151:84-93. Epub 2021 May 7.

SIREDO Oncology Center, Institute Curie, PSL University, Paris, France.

Background/objectives: The primary aim of this study was to analyse and evaluate the impact of different local treatments on the pattern of relapse in children with primary head and neck non-parameningeal (HNnPM) rhabdomyosarcoma (RMS), treated in the European paediatric Soft tissue sarcoma Study Group (EpSSG) RMS2005 study. The secondary aim was to assess whether current risk stratification is valid for this specific site.

Design/methods: This study includes all patients with localised HNnPM RMS enrolled in the RMS2005 study between 2005 and 2016. Read More

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Tetrafluoroterephthalonitrile-crosslinked β-cyclodextrin polymer as a binding agent of diffusive gradients in thin-films for sampling endocrine disrupting chemicals in water.

Chemosphere 2021 May 3;280:130774. Epub 2021 May 3.

State Key Laboratory of Biogeology and Environmental Geology, China University of Geosciences, Wuhan, 430074, China.

β-Cyclodextrin (β-CD) is an inexpensive and reproducible material derived from corn starch. It is possible that tetrafluoroterephthalonitrile-crosslinked β-cyclodextrin polymer (TFN-CD), a cheap but efficient adsorbent, could be a suitable binding agent for use in the passive sampling technique, diffusive gradients in thin-films (DGT). Herein, the TFN-CD binding gel was prepared and then evaluated as the binding phase of DGT to sample six endocrine disrupting chemicals (EDCs) in water. Read More

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The role of PKA/PP2B-mediated Drp1 phosphorylation and the subsequent EGFR inhibition in Cr(VI)-induced premature senescence.

Ecotoxicol Environ Saf 2021 May 7;218:112300. Epub 2021 May 7.

Xiangya School of Public Health, Central South University, Changsha 410078, PR China. Electronic address:

In recent years, frequent hexavalent chromium [Cr(VI)] pollution incidents have severely damaged the ecology and endangered the public health. It is well known that cell senescence could promote the carcinogenesis, thus the related research on the occurrence of premature senescence is of great significance to the elucidation of the carcinogenic mechanism of Cr(VI). We previously confirmed that long-term low-dose Cr(VI) exposure induced premature senescence, but the key molecular events that determine the occurrence of premature senescence are still unclear. Read More

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Neratinib as extended adjuvant therapy in patients with copositive early breast cancer: German health technology assessment-driven analyses from the ExteNET study.

Eur J Cancer 2021 May 7;150:268-277. Epub 2021 May 7.

LMU University Hospital, Breast Center, Dept. OB&GYN, Marchioninistr. 15, Munich, 81377, Germany. Electronic address:

Background: Neratinib is approved in the European Union for extended adjuvant treatment of human epidermal growth factor receptor 2-positive/hormone receptor-positive (copositive) early breast cancer ≤1 year of completion of prior trastuzumab-based therapy. Here, we report analyses of the hormone receptor-positive subgroup (N = 1631) from the ExteNET trial performed for the German health technology assessment (HTA).

Results: With 2 years of median follow-up, HTA analyses revealed a significant advantage in disease-free survival (DFS) for neratinib vs. Read More

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Dengue in pregnancy: Review article.

Eur J Obstet Gynecol Reprod Biol 2021 Apr 30;261:205-210. Epub 2021 Apr 30.

Sidra Medicine, Education City, Al Luqta Street, Doha, Qatar.

Dengue is the most common viral mosquito- borne disease. It is a major public health problem, especially in tropical and sub-tropical areas worldwide. According to the World Health Organization (WHO), approximately 40% of the world's population (over 2. Read More

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Treatment methods for vulvovaginal candidiasis in pregnancy.

J Mycol Med 2021 May 7;31(3):101138. Epub 2021 May 7.

Department of Obstetrics and Gynecology, Okan University School of Medicine, Istanbul, Turkey.

Introduction: Vulvovaginal candidiasis (VVC) is one of the three most common vaginal infections of women. Our goal is to check which treatment method (vaginal or vaginal combined with oral) is more effective for each trimester to treat VVC.

Materials And Method: A retrospective analysis was performed and vaginal culture results after treatment of 61 pregnant women who were treated with vaginal or vaginal plus oral antifungals, were collected. Read More

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Clinical Characteristics and Outcomes of Eyes with Intraocular Inflammation after Brolucizumab: Post Hoc Analysis of HAWK and HARRIER.

Ophthalmol Retina 2021 May 7. Epub 2021 May 7.

Ophthalmology, Sorbonne University, APHP, Paris, France.

Purpose: This analysis of the pivotal phase III HAWK and HARRIER trials aimed to provide insights on the timing of presentation, management, and outcomes of intraocular inflammation (IOI)-related adverse events (AEs), as reported by investigators in these trials.

Design: Post hoc analysis of investigator-reported IOI-related AEs in HAWK and HARRIER.

Participants: Of 1088 brolucizumab-treated eyes (3 mg or 6 mg), 49 eyes experienced at least 1 IOI-related AE and were included in this analysis. Read More

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Longer Operative Time Associated with Prolonged Length of Stay, Non-Home Discharge and Transfusion Requirement after Anterior Cervical Discectomy and Fusion: an Analysis of 24,593 Cases.

Spine J 2021 May 7. Epub 2021 May 7.

Department of Orthopaedic Surgery, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH, USA; Center for Spine Health, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH, USA.

Background: Prolonged operative time of single-level ACDF has been associated with adverse postoperative outcomes. The current literature does not contain a comprehensive quantitative description of these associations PURPOSE: This study characterized the associations between single-level anterior cervical discectomy and fusion(ACDF) operative time and 1)30-day postoperative healthcare utilization, and 2)the incidence of local wound complications, need for transfusion and mechanical ventilation.

Design/setting: Retrospective database analysis PATIENT SAMPLE: The American College of Surgeons National Surgical Quality Improvement Program(ACS-NSQIP) database was queried for single-level ACDF cases(2012-2018) using current procedural terminology codes. Read More

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Re-operative aortic arch surgery in a contemporary series.

Semin Thorac Cardiovasc Surg 2021 May 7. Epub 2021 May 7.

Division of Cardiothoracic Surgery, Emory University School of Medicine, Atlanta, GA. Electronic address:

Re-operative aortic arch operations (REDO) following previous cardiac surgery are challenging procedures associated with significant morbidity and mortality. We investigated post-operative outcomes for patients undergoing REDO and identified risk-factors for mortality in a contemporary series. From 1/2005-6/2018, 365 consecutive patients at an academic center underwent REDO: 257 HEMIARCH and 108 COMPLETE arch (45 stage I elephant trunk, 63 total arch) replacements. Read More

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Development of duplex TaqMan-based real-time PCR assay for the simultaneous detection of Perkinsus olseni and P. chesapeaki in host Manila clam tissue samples.

J Invertebr Pathol 2021 May 7:107603. Epub 2021 May 7.

Univ Brest, CNRS, IRD, Ifremer, LEMAR, F-29280, Plouzané, France. Electronic address:

The aetiological agent Perkinsus olseni is globally recognised as a major threat for shellfish production considering its wide geographical distribution across Asia, Europe, Australia and South America. Another species, Perkinsus chesapeaki, which has never been known to be associated with significant mortality events, was recently detected along French coasts infecting clam populations sporadically in association with P. olseni. Read More

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Post-surgical complications after bladder outlet reducing surgery: an analysis of the FDA Manufacturer and User Facility Device Experience (MAUDE) database.

Urology 2021 May 7. Epub 2021 May 7.

Department of Urology, Oregon Health & Science University. Electronic address:

Objective: To examine voluntary reports in the Food & Drug Administration (FDA) Manufacturer and User Facility Device Experience (MAUDE) database, categorize complications and assign device-related causality with transurethral resection of the prostate (TURP), prostatic urethral lift (PUL), and transurethral water vapor therapy (TWVT).

Methods: A review was performed using the terms "Urolift," "Rezum," and "transurethral resection of the prostate" between 01/01/2015 and 12/31/2019. Duplicate and incomplete reports were excluded. Read More

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Sex Differences in Ascending Aortic and Arch Surgery: A Propensity-matched Comparison of 1153 Pairs.

Ann Thorac Surg 2021 May 7. Epub 2021 May 7.

Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine; Section of Adult Cardiac Surgery, Department of Cardiovascular Surgery, Texas Heart Institute; Department of Cardiovascular Surgery, CHI St Luke's Health-Baylor St Luke's Medical Center; Cardiovascular Research Institute, Baylor College of Medicine, Houston, Texas.

Background: We investigated the relationship of sex with clinical outcomes after proximal aortic (ascending and arch) operations, and whether sex-specific preoperative factors are associated with mortality.

Methods: Of 3745 patients who underwent elective, urgent, and emergency proximal aortic operations over a 20-year period, 1153 pairs of men and women were propensity-matched, and their early and long-term outcomes were compared. Kaplan-Meier survival analysis was used to estimate late survival. Read More

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The inflammatory profile of exacerbations in patients with severe refractory eosinophilic asthma receiving mepolizumab (the MEX study): a prospective observational study.

Lancet Respir Med 2021 May 7. Epub 2021 May 7.

Centre for Experimental Medicine, School of Medicine, Dentistry, and Biological Sciences, Queen's University, Belfast, UK. Electronic address:

Background: Clinical trials with mepolizumab, a humanised monoclonal antibody against interleukin-5, show a 50% reduction in severe asthma exacerbations in people with severe eosinophilic asthma. Exacerbations in patients treated with mepolizumab seem to be different to exacerbations in those given placebo, as patients treated with mepolizumab report fewer symptoms, have a lower sputum eosinophil count, and smaller fall in peak expiratory flow. We aimed to investigate the inflammatory phenotype and physiological characteristics of exacerbation events in patients with severe eosinophilic asthma who were treated with mepolizumab. Read More

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Association of sex with outcome in elderly patients with acute coronary syndrome undergoing percutaneous coronary intervention.

Am J Med 2021 May 7. Epub 2021 May 7.

Manzoni Hospital, Lecco, Italy. Electronic address:

Background: Worse outcomes have been reported for women, compared to men, after an acute coronary syndrome (ACS). Whether this difference persists in elderly patients undergoing similar invasive treatment has not been studied. We investigated sex-related differences in one-year outcome of elderly acute coronary syndrome patients treated by percutaneous coronary intervention (PCI). Read More

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Peroxide stimulated transition between the ferryl intermediates of bovine cytochrome c oxidase.

Biochim Biophys Acta Bioenerg 2021 May 7:148447. Epub 2021 May 7.

Center for Interdisciplinary Biosciences, Technology and Innovation Park, University of P. J. Safarik, Jesenna 5, 041 54 Kosice, Slovak Republic. Electronic address:

During catalysis of cytochrome c oxidases (CcO) several ferryl intermediates of the catalytic heme a-Cu center are observed. In the P ferryl state, produced by the reaction of two-electron reduced CcO with O, the ferryl iron of heme a and a free radical are present at the catalytic center. The radical reduction stimulates the transition of the P into another ferryl F state. Read More

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Efficacy and safety of voclosporin versus placebo for lupus nephritis (AURORA 1): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial.

Lancet 2021 May 7. Epub 2021 May 7.

Research, Aurinia Pharmaceuticals, Victoria, BC, Canada. Electronic address:

Background: Voclosporin, a novel calcineurin inhibitor approved for the treatment of adults with lupus nephritis, improved complete renal response rates in patients with lupus nephritis in a phase 2 trial. This study aimed to evaluate the efficacy and safety of voclosporin for the treatment of lupus nephritis.

Methods: This multicentre, double-blind, randomised phase 3 trial was done in 142 hospitals and clinics across 27 countries. Read More

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F-fluciclovine-PET/CT imaging versus conventional imaging alone to guide postprostatectomy salvage radiotherapy for prostate cancer (EMPIRE-1): a single centre, open-label, phase 2/3 randomised controlled trial.

Lancet 2021 May 7. Epub 2021 May 7.

Department of Radiology and Imaging Sciences, Emory University, Atlanta GA, USA.

Background: Molecular imaging is increasingly used to guide treatment decisions and planning in prostate cancer. We aimed to evaluate the role of F-fluciclovine-PET/CT in improving cancer control compared with conventional imaging (bone scan and either CT or MRI) alone for salvage postprostatectomy radiotherapy.

Methods: In EMPIRE-1, a single-centre, open-label, phase 2/3 randomised controlled trial, patients with prostate cancer with detectable PSA after prostatectomy and negative conventional imaging (no extrapelvic or bone findings) were randomly assigned in a 1:1 ratio to radiotherapy directed by conventional imaging alone or to conventional imaging plus F-fluciclovine-PET/CT. Read More

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Apatinib as second-line or later therapy in patients with advanced hepatocellular carcinoma (AHELP): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial.

Lancet Gastroenterol Hepatol 2021 May 7. Epub 2021 May 7.

Department of Intervention, Fujian Cancer Hospital, Fuzhou, China.

Background: Inhibition of vascular endothelial growth factor receptor (VEGFR) has shown antitumour activity in advanced hepatocellular carcinoma, but few studies of VEGFR inhibitors have been done in populations with a high prevalence of hepatitis B virus infection. The aim of this study was to evaluate the efficacy and safety of apatinib in patients with pretreated advanced hepatocellular carcinoma.

Methods: AHELP was a randomised, double-blind, placebo-controlled, phase 3 trial done at 31 hospitals in China, in patients (aged ≥18 years) with advanced hepatocellular carcinoma who had previously been refractory or intolerant to at least one line of systemic chemotherapy or targeted therapy. Read More

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