147,659 results match your criteria event-related potentials

Test anxiety impairs filtering ability in visual working memory: Evidence from event-related potentials.

J Affect Disord 2021 Jun 19;292:700-707. Epub 2021 Jun 19.

Department of Psychology, Nanjing University, Nanjing 210023, China. Electronic address:

Attentional control theory regards individuals with high anxiety as having deficits of inhibitory control when faced with distractors, especially under high-load conditions and with threatening distractors. Research on test anxiety has a long history, but the working memory (WM) characteristics of individuals with high test anxiety (HTA) remain unclear. We used two experiments to test the WM filtering ability of individuals with HTA, and the salient results were those of the contralateral delay activity amplitude rather than K score. Read More

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Applying Spike-density component analysis for high-accuracy auditory event-related potentials in children.

Clin Neurophysiol 2021 May 29;132(8):1887-1896. Epub 2021 May 29.

Center for Music in the Brain, Department of Clinical Medicine, Aarhus University and Royal Academy of Music, Aarhus/Aalborg, Universitetsbyen 3, 8000 Aarhus C, Denmark; Department of Education, Psychology, Communication, University of Bari Aldo Moro, Italy.

Objective: Overlapping neurophysiological signals are the main obstacle preventing from using cortical auditory event-related potentials (AEPs) in clinical settings. Children AEPs are particularly affected by this problem, as their cerebral cortex is still maturing. To overcome this problem, we applied a new version of Spike-density Component Analysis (SCA), an analysis method recently developed, to isolate with high accuracy the neural components of auditory responses of 8-year-old children. Read More

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Therapeutic efficacy of connectivity-directed transcranial magnetic stimulation on anticipatory anhedonia.

Depress Anxiety 2021 Jun 22. Epub 2021 Jun 22.

School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, China.

Background: There are currently no effective treatments specifically targeting anticipatory anhedonia, a major symptom of severe depression which is associated with poor outcomes. The present study investigated the efficacy of individualized repetitive transcranial magnetic stimulation (rTMS) targeting the left dorsolateral prefrontal cortex (lDLPFC)-nucleus accumbens (NAcc) network on anticipatory anhedonia in depression.

Methods: This randomized, double-blind, sham-controlled clinical trial (NCT03991572) enrolled 56 depression patients with anhedonia symptoms. Read More

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Effects of Translumbosacral Neuromodulation Therapy on Gut and Brain Interactions and Anorectal Neuropathy in Fecal Incontinence: A Randomized Study.

Neuromodulation 2021 Jun 22. Epub 2021 Jun 22.

GI Sciences, School of Medical Sciences, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, UK.

Objectives: Translumbosacral neuromodulation therapy (TNT) improves symptoms of fecal incontinence (FI), but its mechanism of action is unknown. We tested the hypothesis that TNT at one or more frequency will significantly improve underlying pathophysiology of FI through modulation of ascending and/or descending signaling pathways in the gut and brain axis and anorectal sensorimotor function.

Materials And Methods: We assessed afferent anorectal-cortical evoked potentials (CEP) following electrical stimulation of anorectum, efferent cortico-anorectal and lumbo-anorectal and sacro-anorectal motor evoked potentials (MEP) after transcranial and lumbosacral magnetic stimulations, and anorectal manometry before and after six weekly TNT sessions in FI subjects, randomized to 1, 5, or 15 Hz repetitive magnetic stimulations. Read More

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Spontaneous activity competes with externally evoked responses in sensory cortex.

Proc Natl Acad Sci U S A 2021 Jun;118(25)

Optophysiology Lab, Institute of Biology III, University of Freiburg, 79104 Freiburg, Germany;

The interaction between spontaneous and externally evoked neuronal activity is fundamental for a functional brain. Increasing evidence suggests that bursts of high-power oscillations in the 15- to 30-Hz beta-band represent activation of internally generated events and mask perception of external cues. Yet demonstration of the effect of beta-power modulation on perception in real time is missing, and little is known about the underlying mechanism. Read More

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Relationship between advanced glycated end products and maternal cognition in gestational diabetes: a case control study.

J Matern Fetal Neonatal Med 2021 Jun 21:1-6. Epub 2021 Jun 21.

Department of Physiology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India.

Objective: Gestational diabetes (GDM) is a form of glucose intolerance which manifests during pregnancy. There is lack of literature regarding the study of cognitive functions in GDM. Recent evidences suggests an increase in accumulation of serum Advanced glycated end products (AGE'S) during GDM. Read More

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A noise-robust sparse approach to the time-frequency representation of visual evoked potentials.

Comput Biol Med 2021 Jun 10;135:104561. Epub 2021 Jun 10.

Department of Electrical Engineering, National Institute of Technology, Calicut, 673601, Kerala, India. Electronic address:

Background: Visual evoked potential (VEP) offers a promising research strategy in the effort to characterise brain disorders. Pertinent signal processing techniques enable the development of potential applications of VEP. A joint time-frequency (TF) representation provides more comprehensive information about the underlying complex structures of these signals than individual time or frequency analysis. Read More

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Electrophysiological correlates of improved executive function following EEG neurofeedback in adult attention deficit hyperactivity disorder.

Clin Neurophysiol 2021 Jun 11;132(8):1937-1946. Epub 2021 Jun 11.

Department of Psychiatry, University of Geneva, Geneva, Switzerland; Centre for Biomedical Imaging (CIBM) Lausanne-Geneva, Geneva, Switzerland; Functional Brain Mapping Laboratory, Department of Basic Neurosciences, University of Geneva, Geneva, Switzerland.

Objective: Event-related potentials (ERPs) are reported to be altered in relation to cognitive processing deficits in attention deficit hyperactivity disorder (ADHD). However, this evidence is mostly limited to cross-sectional data. The current study utilized neurofeedback (NFB) as a neuromodulatory tool to examine the ERP correlates of attentional and inhibitory processes in adult ADHD using a single-session, within-subject design. Read More

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The effect of acute exercise for reducing cognitive alterations associated with individuals high in anxiety.

Int J Psychophysiol 2021 Jun 18. Epub 2021 Jun 18.

Department of Psychology, Michigan State University, United States of America.

Single bouts of exercise have been observed to exhibit therapeutic benefits for reducing affective responses associated with anxiety. However, anxiety has also been found to relate to less efficient cognitive processing as well as a greater reliance on action monitoring processes. Given the extant body of evidence demonstrating that single bouts of exercise result in cognitive enhancements; the present investigation sought to determine the extent to which exercise might be effective at reducing these anxiety-related impairments in cognition. Read More

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Motivated attention to stimuli related to social networking sites: A cue-reactivity study.

J Behav Addict 2021 Jun 21. Epub 2021 Jun 21.

Department of General Psychology, University of Padova, Padova, Italy.

Background And Aims: It has been argued that similar to addictive behaviors, problematic Social Network sites use (PSNSU) is characterized by sensitized reward processing and cue-reactivity. However, no study to our knowledge has yet investigated cue-reactivity in PSNSU. The present study aims at investigating cue-reactivity to Social Network sites (i. Read More

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Monitoring Cortical Response and Electrode-Retina Impedance under Epiretinal Stimulation in Rats.

IEEE Trans Neural Syst Rehabil Eng 2021 Jun 21;PP. Epub 2021 Jun 21.

Retinal prosthesis can restore partial vision in patients with retinal degenerative diseases such as retinitis pigmentosa and age-related macular degeneration. Epiretinal prosthesis is one of three therapeutic approaches, which received regulatory approval several years ago. The thresholds of an epiretinal stimulation is partly determined by the size of the physical gap between the electrode and the retina after implantation. Read More

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Cortical Responses to Vagus Nerve Stimulation Are Modulated by Brain State in Nonhuman Primates.

Cereb Cortex 2021 Jun 21. Epub 2021 Jun 21.

Institute of Bioelectronic Medicine, Feinstein Institutes for Medical Research, Manhasset NY 11030, USA.

Vagus nerve stimulation (VNS) has been tested as therapy for several brain disorders and as a means to modulate cortical excitability and brain plasticity. Cortical effects of VNS, manifesting as vagal-evoked potentials (VEPs), are thought to arise from activation of ascending cholinergic and noradrenergic systems. However, it is unknown whether those effects are modulated by brain state at the time of stimulation. Read More

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The Effects of Angry Expressions and Fearful Expressions on Duration Perception: An ERP Study.

Front Psychol 2021 3;12:570497. Epub 2021 Jun 3.

Hunan Provincial Key Laboratory of Intelligent Computing and Language Information Processing, Hunan Normal University, Changsha, China.

Little is known about the electrophysiological basis of the effect of threat-related emotional stimuli with different motivational direction on duration perception. Thus, event-related potentials were employed to examine the effects of angry expressions and fearful expressions on perception of different duration (490-910 ms). Behavioral results showed there was a greater underestimation of the duration of angry expressions (approach-motivated negative stimuli) than fearful expressions (withdrawal-motivated negative stimuli), compared with neutral expressions. Read More

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Inhibitory Top-Down Control Deficits in Schizophrenia With Auditory Verbal Hallucinations: A Go/NoGo Task.

Front Psychiatry 2021 4;12:544746. Epub 2021 Jun 4.

Department of Psychiatry, Mental Health Institute of the Second Xiangya Hospital, Central South University, Changsha, China.

Auditory verbal hallucinations (AVH), with unclear mechanisms, cause extreme distresses to schizophrenia patients. Deficits of inhibitory top-down control may be linked to AVH. Therefore, in this study, we focused on inhibitory top-down control in schizophrenia patients with AVH. Read More

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The Electrophysiological Correlates of Phoneme Perception in Primary Progressive Aphasia: A Preliminary Case Series.

Front Hum Neurosci 2021 2;15:618549. Epub 2021 Jun 2.

Department of Rehabilitation Sciences, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.

: This study aimed to investigate phoneme perception in patients with primary progressive aphasia (PPA) by using the event-related potential (ERP) technique. These ERP components might contribute to the diagnostic process of PPA and its clinical variants (NFV: nonfluent variant, SV: semantic variant, LV: logopenic variant) and reveal insights about phoneme perception processes in these patients. : Phoneme discrimination and categorization processes were investigated by the mismatch negativity (MMN) and P300 in eight persons with early- and late-stage PPA (3 NFV, 2 LV, 2 SV, and 1 PPA-NOS; not otherwise specified) and 30 age-matched healthy adults. Read More

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Neurophysiological Correlates of Asymmetries in Vowel Perception: An English-French Cross-Linguistic Event-Related Potential Study.

Front Hum Neurosci 2021 3;15:607148. Epub 2021 Jun 3.

Department of Speech, Language, and Hearing Sciences, University of Florida, Gainesville, FL, United States.

Behavioral studies examining vowel perception in infancy indicate that, for many vowel contrasts, the ease of discrimination changes depending on the order of stimulus presentation, regardless of the language from which the contrast is drawn and the ambient language that infants have experienced. By adulthood, linguistic experience has altered vowel perception; analogous asymmetries are observed for non-native contrasts but are mitigated for native contrasts. Although these directional effects are well documented behaviorally, the brain mechanisms underlying them are poorly understood. Read More

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Temporal Fluctuation of Mood in Gaming Task Modulates Feedback Negativity: EEG Study With Virtual Reality.

Front Hum Neurosci 2021 3;15:536288. Epub 2021 Jun 3.

Center for Information and Neural Networks (CiNet), National Institute of Information and Communications Technology and Osaka University, Kobe, Japan.

Feedback outcomes are generally classified into positive and negative feedback. People often predict a feedback outcome with information that is based on both objective facts and uncertain subjective information, such as a mood. For example, if an action leads to good results consecutively, people performing the action overestimate the behavioral result of the next action. Read More

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Classification of Schizophrenia by Combination of Brain Effective and Functional Connectivity.

Front Neurosci 2021 3;15:651439. Epub 2021 Jun 3.

School of Medical Engineering, Xinxiang Medical University, Xinxiang, China.

At present, lots of studies have tried to apply machine learning to different electroencephalography (EEG) measures for diagnosing schizophrenia (SZ) patients. However, most EEG measures previously used are either a univariate measure or a single type of brain connectivity, which may not fully capture the abnormal brain changes of SZ patients. In this paper, event-related potentials were collected from 45 SZ patients and 30 healthy controls (HCs) during a learning task, and then a combination of partial directed coherence (PDC) effective and phase lag index (PLI) functional connectivity were used as features to train a support vector machine classifier with leave-one-out cross-validation for classification of SZ from HCs. Read More

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Detection without further processing or processing without automatic detection? Differential ERP responses to lexical-semantic processing in toddlers at high clinical risk for autism and language disorder.

Cortex 2021 May 27;141:465-481. Epub 2021 May 27.

Child Psychopathology Unit, Scientific Institute, IRCCS Eugenio Medea, Bosisio Parini, Lecco, Italy.

Delays in early expressive vocabulary can reflect a specific delay in language acquisition or more general impairments in social communication. The neural mechanisms underlying the (dis)ability to establish the first lexical-semantic representations remain relatively unknown. Here, we investigate the electrophysiological underpinnings of these mechanisms during the critical phase of lexical acquisition in two groups of 19-month-old toddlers at risk for neurodevelopmental disorders, i. Read More

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Do categorical representations modulate early automatic visual processing? A visual mismatch-negativity study.

Biol Psychol 2021 Jun 17;163:108139. Epub 2021 Jun 17.

Cognitive and Developmental Psychology Unit, Center for Cognitive Science, University of Kaiserslautern, Kaiserslautern, Germany; Facultad de Lenguas y Educación, Universidad Nebrija, Madrid, Spain; University of Leuven, Leuven, Belgium. Electronic address:

Perceptual categorization is an important cognitive function. In the auditory domain, categorization already occurs within the first 200 ms of information processing, as indexed by the mismatch negativity. Here, we assessed the characteristics of the visual mismatch negativity (vMMN) elicited during the categorization of previously unknown visual stimuli. Read More

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Problematic smartphone use: The role of reward processing, depressive symptoms and self-control.

Addict Behav 2021 Jun 11;122:107015. Epub 2021 Jun 11.

DePauw University, Department of Psychology and Neuroscience, United States.

The widespread adoption of smartphones has been associated with the emergence of problematic smartphone use. Problematic smartphone use is consistently associated with increased levels of depression and lower self-control, and pathological technology use more generally may be associated with reduced activity in the reward system, an effect that is also observed in depression and with poor self-control. The current study sought to examine the association between problematic smartphone use and event-related potentials (ERPs) related to reward processing, and to determine whether reward processing, depressive symptoms and self-control have shared or unique influences on problematic smartphone use. Read More

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Sensory attenuation in the absence of movement: Differentiating motor action from sense of agency.

Cortex 2021 May 11;141:436-448. Epub 2021 May 11.

School of Psychology, The University of New South Wales (UNSW Sydney), Sydney, Australia.

Sensory attenuation is the phenomenon that stimuli generated by willed motor actions elicit a smaller neurophysiological response than those generated by external sources. It has mostly been investigated in the auditory domain, by comparing ERPs evoked by self-initiated (active condition) and externally-generated (passive condition) sounds. The mechanistic basis of sensory attenuation has been argued to involve a duplicate of the motor command being used to predict sensory consequences of self-generated movements. Read More

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Altered sub-processes of working memory in fibromyalgia patients: An ERP study using N-back task.

Pain Med 2021 Jun 18. Epub 2021 Jun 18.

Psychobiology Unit, School of Health Sciences, Rey Juan Carlos University, Madrid, Spain.

Objective: Cognitive dysfunction in fibromyalgia has become a key symptom considered by patients as more disabling than pain itself. Experimental evidence from neuropsychological and neuroimaging studies indicates that such cognitive impairments are especially robust when patients need to set in motion working memory processes, suggesting the existence of an altered functioning underlying the cerebral cortices of the frontoparietal memory network. However, the temporal dynamics of working memory sub-processes have not yet been explored in fibromyalgia. Read More

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Mammalian target of rapamycin signaling pathway is involved in synaptic plasticity of the spinal dorsal horn and neuropathic pain in rats by regulating autophagy.

Neuroreport 2021 Jun 17. Epub 2021 Jun 17.

Department of Anesthesiology, Hubei Tongcheng People's Hospital, Tongcheng Department of Anesthesiology, Wuhan Children Hospital, Wuhan, China.

Unveiling the etiology and the underlying mechanism of neuropathic pain, a poorly treated disease, is essential for the development of effective therapies. This study aimed to explore the role of mammalian target of rapamycin (mTOR) signaling in autophagy-mediated neuropathic pain. We established a spared nerve injury (SNI) model in adult male SD rats by ligating the common peroneal nerve and tibial, with the distal end cutoff. Read More

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Effects of Bihemispheric Transcranial Direct Current Stimulation Combined With Repetitive Peripheral Nerve Stimulation in Acute Stroke Patients.

J Clin Neurophysiol 2021 May 31. Epub 2021 May 31.

Neurophysiology Unit, Neurology Department, Hospital Universitari de Bellvitge, Barcelona, Spain; Department of Clinical Neurophysiology, Hospital Universitari Dexeus, Barcelona, Spain; Neurology Department, Hospital Universitari de Bellvitge, Barcelona, Spain; Neurology Department, Hospital de Neurorehabilitación, Institut Guttmann, Barcelona, Spain; and EMG Unit, Neurology Department, Hospital Clínic, Department of Medicine, University of Barcelona, August Pi Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain.

Purpose: Transcranial direct current stimulation (tDCS) can change the excitability of the central nervous system and contribute to motor recovery of stroke patients. The aim of our study was to examine the short- and long-term effects of real versus sham bihemispheric tDCS combined with repetitive peripheral nerve stimulation in patients with acute stroke and a severe motor impairment.

Methods: The study was prospective, randomized, double blind, and placebo controlled. Read More

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The impact of artifact removal approaches on TMS-EEG signal.

Neuroimage 2021 Jun 16;239:118272. Epub 2021 Jun 16.

Neurophysiology lab, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Via Pilastroni 4, 25125 Brescia, Italy. Electronic address:

Transcranial magnetic stimulation (TMS)-evoked potentials (TEPs) allow one to assess cortical excitability and effective connectivity in clinical and basic research. However, obtaining clean TEPs is challenging due to the various TMS-related artifacts that contaminate the electroencephalographic (EEG) signal when the TMS pulse is delivered. Different preprocessing approaches have been employed to remove the artifacts, but the degree of artifact reduction or signal distortion introduced in this phase of analysis is still unknown. Read More

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Phonemic Training Modulates Early Speech Processing in Pre-reading Children.

Front Psychol 2021 1;12:643147. Epub 2021 Jun 1.

Developmental Psychology, Department of Psychology, University of Tuebingen, Tuebingen, Germany.

Phonemic awareness and rudimentary grapheme knowledge concurrently develop in pre-school age. In a training study, we tried to disentangle the role of both precursor functions of reading for spoken word recognition. Two groups of children exercised with phonemic materials, but only one of both groups learnt corresponding letters to trained phonemes. Read More

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IMI2-PainCare-BioPain-RCT3: a randomized, double-blind, placebo-controlled, crossover, multi-center trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by electroencephalography (EEG).

Trials 2021 Jun 17;22(1):404. Epub 2021 Jun 17.

Department of Neurophysiology, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.

Background: IMI2-PainCare-BioPain-RCT3 is one of four similarly designed clinical studies aiming at profiling a set of functional biomarkers of drug effects on the nociceptive system that could serve to accelerate the future development of analgesics, by providing a quantitative understanding between drug exposure and effects of the drug on nociceptive signal processing in human volunteers. IMI2-PainCare-BioPain-RCT3 will focus on biomarkers derived from non-invasive electroencephalographic (EEG) measures of brain activity.

Methods: This is a multisite single-dose, double-blind, randomized, placebo-controlled, 4-period, 4-way crossover, pharmacodynamic (PD) and pharmacokinetic (PK) study in healthy subjects. Read More

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Gradual development of non-adjacent dependency learning during early childhood.

Dev Cogn Neurosci 2021 Jun 11;50:100975. Epub 2021 Jun 11.

Department of Neuropsychology, Max Planck Institute for Human Cognitive and Brain Sciences, Germany; Berlin School of Mind and Brain, Humboldt Universität zu Berlin, Germany.

In order to become proficient native speakers, children have to learn the morpho-syntactic relations between distant elements in a sentence, so-called non-adjacent dependencies (NADs). Previous research suggests that NAD learning in children comprises different developmental stages, where until 2 years of age children are able to learn NADs associatively under passive listening conditions, while starting around the age of 3-4 years children fail to learn NADs during passive listening. To test whether the transition between these developmental stages occurs gradually, we tested children's NAD learning in a foreign language using event-related potentials (ERPs). Read More

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Disease modifying treatment of spinal cord injury with directly reprogrammed neural precursor cells in non-human primates.

World J Stem Cells 2021 May;13(5):452-469

New World Laboratories, Laval H7V 4A7, Quebec, Canada.

Background: The development of regenerative therapy for human spinal cord injury (SCI) is dramatically restricted by two main challenges: the need for a safe source of functionally active and reproducible neural stem cells and the need of adequate animal models for preclinical testing. Direct reprogramming of somatic cells into neuronal and glial precursors might be a promising solution to the first challenge. The use of non-human primates for preclinical studies exploring new treatment paradigms in SCI results in data with more translational relevance to human SCI. Read More

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