153,977 results match your criteria event-related potential

A noise-robust sparse approach to the time-frequency representation of visual evoked potentials.

Comput Biol Med 2021 Jun 10;135:104561. Epub 2021 Jun 10.

Department of Electrical Engineering, National Institute of Technology, Calicut, 673601, Kerala, India. Electronic address:

Background: Visual evoked potential (VEP) offers a promising research strategy in the effort to characterise brain disorders. Pertinent signal processing techniques enable the development of potential applications of VEP. A joint time-frequency (TF) representation provides more comprehensive information about the underlying complex structures of these signals than individual time or frequency analysis. Read More

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Impact of COVID-19 on healthcare organisation and cancer outcomes.

Eur J Cancer 2021 May 28;153:123-132. Epub 2021 May 28.

Department of Biostatistics and Epidemiology, Gustave Roussy, Paris-Saclay University, Villejuif, France; Oncostat U1018, Inserm, Paris-Saclay University, Labeled Ligue Contre le Cancer, Villejuif, France.

Background: Changes in the management of patients with cancer and delays in treatment delivery during the COVID-19 pandemic may impact the use of hospital resources and cancer mortality.

Patients And Methods: Patient flows, patient pathways and use of hospital resources during the pandemic were simulated using a discrete event simulation model and patient-level data from a large French comprehensive cancer centre's discharge database, considering two scenarios of delays: massive return of patients from November 2020 (early-return) or March 2021 (late-return). Expected additional cancer deaths at 5 years and mortality rate were estimated using individual hazard ratios based on literature. Read More

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Transdermal nicotine in non-smokers: A systematic review to design COVID-19 clinical trials.

Respir Med Res 2021 Jun 7;80:100844. Epub 2021 Jun 7.

Department of Psychiatry, Service Hospitalo-Universitaire, GHU Paris Psychiatrie & Neurosciences, 75014 Paris, France; Université de Paris, 75006 Paris, France; Unité de Neuropathologie expérimentale, Département Santé Globale, Institut Pasteur, 75015 Paris, France.

Recent data show an interaction between COVID-19 and nicotine and indicate the need for an assessment of transdermal nicotine use in non-smokers. Assessments have been conducted into the short-term cognitive effects of nicotine and into diseases such as Parkinson's, Tourette syndrome, ADHD or ulcerative colitis.

Methods: Analyses of nicotine administration protocols and safety were conducted after reviewing Medline and Science Direct databases performing a search using the words [transdermal nicotine] AND [non-smoker] AND selected diseases. Read More

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A real-world evaluation of radium-223 in combination with abiraterone or enzalutamide for the treatment of metastatic castration-resistant prostate cancer.

PLoS One 2021 21;16(6):e0253021. Epub 2021 Jun 21.

Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.

Introduction: Radium-223, abiraterone, and enzalutamide have each been shown to significantly improve survival as monotherapy in patients with metastatic castration-resistant prostate cancer. However, effects of combination radium-223 plus abiraterone or enzalutamide on survival and safety remain unclear.

Patients And Methods: This single-center retrospective cohort study used electronic health record data of patients with metastatic castration-resistant prostate cancer and bone metastases who were treated with radium-223 between April 1, 2014 and February 19, 2019. Read More

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Monitoring Cortical Response and Electrode-Retina Impedance under Epiretinal Stimulation in Rats.

IEEE Trans Neural Syst Rehabil Eng 2021 Jun 21;PP. Epub 2021 Jun 21.

Retinal prosthesis can restore partial vision in patients with retinal degenerative diseases such as retinitis pigmentosa and age-related macular degeneration. Epiretinal prosthesis is one of three therapeutic approaches, which received regulatory approval several years ago. The thresholds of an epiretinal stimulation is partly determined by the size of the physical gap between the electrode and the retina after implantation. Read More

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Factors Influencing Infusion-Related Reactions Following Dosing of Reference Rituximab and PF-05280586, a Rituximab Biosimilar.

BioDrugs 2021 Jun 21. Epub 2021 Jun 21.

Pfizer Inc, 219 East 42nd Street, New York, NY, 10017, USA.

Background: Infusion-related reactions (IRRs) are the most common adverse event (AE) associated with infusion of rituximab, an anti-CD20 monoclonal antibody.

Objective: Our objective was to evaluate the impact of dosing/infusion patterns and certain baseline characteristics on IRR occurrence during the first rituximab infusion administered as the biosimilar PF-05280586 (RTX-PF) or reference rituximab sourced from the EU (RTX-EU, MabThera) in patients with CD20+ low-tumor-burden follicular lymphoma.

Patients And Methods: Rituximab (RTX-PF, n=196; RTX-EU, n=198) was administered (375 mg/m) on days 1, 8, 15, and 22 (one cycle), with a follow-up period through 52 weeks. Read More

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Complications associated with deep brain stimulation for Parkinson's disease: a MAUDE study.

Br J Neurosurg 2021 Jun 20:1-4. Epub 2021 Jun 20.

Department of Neurological Surgery, Rutgers New Jersey Medical School, Newark, NJ, USA.

Introduction: Deep brain stimulation (DBS) is a common surgical option for the treatment of medically refractory Parkinson's disease (PD). Manufacturer and User Facility Device Experience (MAUDE), a United States Food and Drug Administration (FDA)-compiled database of adverse event reports related to medical devices, is a public resource that can provide insight into the relative frequency of complications and patient complaints.

Materials And Methods: We accessed the MAUDE database and queried for adverse reports for deep brain stimulators implanted for PD from January 1, 2009 to December 31, 2018. Read More

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Cortical Responses to Vagus Nerve Stimulation Are Modulated by Brain State in Nonhuman Primates.

Cereb Cortex 2021 Jun 21. Epub 2021 Jun 21.

Institute of Bioelectronic Medicine, Feinstein Institutes for Medical Research, Manhasset NY 11030, USA.

Vagus nerve stimulation (VNS) has been tested as therapy for several brain disorders and as a means to modulate cortical excitability and brain plasticity. Cortical effects of VNS, manifesting as vagal-evoked potentials (VEPs), are thought to arise from activation of ascending cholinergic and noradrenergic systems. However, it is unknown whether those effects are modulated by brain state at the time of stimulation. Read More

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Clinical Benefits and Safety of FMS-Like Tyrosine Kinase 3 Inhibitors in Various Treatment Stages of Acute Myeloid Leukemia: A Systematic Review, Meta-Analysis, and Network Meta-Analysis.

Front Oncol 2021 3;11:686013. Epub 2021 Jun 3.

Department of Hematology and Oncology, International Cancer Center, Shenzhen Key Laboratory, Shenzhen University General Hospital, Shenzhen University Clinical Medical Academy, Shenzhen University Health Science Center, Shenzhen, China.

Background: Given the controversial roles of FMS-like tyrosine kinase 3 inhibitors (FLT3i) in various treatment stages of acute myeloid leukemia (AML), this study was designed to assess this problem and further explored which FLT3i worked more effectively.

Methods: A systematic review, meta-analysis and network meta-analysis (NMA) were conducted by filtering PubMed, Embase, Cochrane library, and Chinese databases. We included studies comparing therapeutic effects between FLT3i and non-FLT3i group in AML, particularly (+) patients, or demonstrating the efficiency of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in (+) AML. Read More

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Severe Air Pollution and Psychological Distress in China: The Interactive Effects of Coping and Perceived Controllability.

Front Psychol 2021 2;12:601964. Epub 2021 Jun 2.

Department of Psychology, Wake Forest University, Winston-Salem, NC, United States.

The coping styles of focusing on a stressor (i.e., trauma focus), and moving beyond the emotional impact of a stressor (i. Read More

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The Effects of Angry Expressions and Fearful Expressions on Duration Perception: An ERP Study.

Front Psychol 2021 3;12:570497. Epub 2021 Jun 3.

Hunan Provincial Key Laboratory of Intelligent Computing and Language Information Processing, Hunan Normal University, Changsha, China.

Little is known about the electrophysiological basis of the effect of threat-related emotional stimuli with different motivational direction on duration perception. Thus, event-related potentials were employed to examine the effects of angry expressions and fearful expressions on perception of different duration (490-910 ms). Behavioral results showed there was a greater underestimation of the duration of angry expressions (approach-motivated negative stimuli) than fearful expressions (withdrawal-motivated negative stimuli), compared with neutral expressions. Read More

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Inhibitory Top-Down Control Deficits in Schizophrenia With Auditory Verbal Hallucinations: A Go/NoGo Task.

Front Psychiatry 2021 4;12:544746. Epub 2021 Jun 4.

Department of Psychiatry, Mental Health Institute of the Second Xiangya Hospital, Central South University, Changsha, China.

Auditory verbal hallucinations (AVH), with unclear mechanisms, cause extreme distresses to schizophrenia patients. Deficits of inhibitory top-down control may be linked to AVH. Therefore, in this study, we focused on inhibitory top-down control in schizophrenia patients with AVH. Read More

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The Electrophysiological Correlates of Phoneme Perception in Primary Progressive Aphasia: A Preliminary Case Series.

Front Hum Neurosci 2021 2;15:618549. Epub 2021 Jun 2.

Department of Rehabilitation Sciences, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.

: This study aimed to investigate phoneme perception in patients with primary progressive aphasia (PPA) by using the event-related potential (ERP) technique. These ERP components might contribute to the diagnostic process of PPA and its clinical variants (NFV: nonfluent variant, SV: semantic variant, LV: logopenic variant) and reveal insights about phoneme perception processes in these patients. : Phoneme discrimination and categorization processes were investigated by the mismatch negativity (MMN) and P300 in eight persons with early- and late-stage PPA (3 NFV, 2 LV, 2 SV, and 1 PPA-NOS; not otherwise specified) and 30 age-matched healthy adults. Read More

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Neurophysiological Correlates of Asymmetries in Vowel Perception: An English-French Cross-Linguistic Event-Related Potential Study.

Front Hum Neurosci 2021 3;15:607148. Epub 2021 Jun 3.

Department of Speech, Language, and Hearing Sciences, University of Florida, Gainesville, FL, United States.

Behavioral studies examining vowel perception in infancy indicate that, for many vowel contrasts, the ease of discrimination changes depending on the order of stimulus presentation, regardless of the language from which the contrast is drawn and the ambient language that infants have experienced. By adulthood, linguistic experience has altered vowel perception; analogous asymmetries are observed for non-native contrasts but are mitigated for native contrasts. Although these directional effects are well documented behaviorally, the brain mechanisms underlying them are poorly understood. Read More

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Temporal Fluctuation of Mood in Gaming Task Modulates Feedback Negativity: EEG Study With Virtual Reality.

Front Hum Neurosci 2021 3;15:536288. Epub 2021 Jun 3.

Center for Information and Neural Networks (CiNet), National Institute of Information and Communications Technology and Osaka University, Kobe, Japan.

Feedback outcomes are generally classified into positive and negative feedback. People often predict a feedback outcome with information that is based on both objective facts and uncertain subjective information, such as a mood. For example, if an action leads to good results consecutively, people performing the action overestimate the behavioral result of the next action. Read More

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Classification of Schizophrenia by Combination of Brain Effective and Functional Connectivity.

Front Neurosci 2021 3;15:651439. Epub 2021 Jun 3.

School of Medical Engineering, Xinxiang Medical University, Xinxiang, China.

At present, lots of studies have tried to apply machine learning to different electroencephalography (EEG) measures for diagnosing schizophrenia (SZ) patients. However, most EEG measures previously used are either a univariate measure or a single type of brain connectivity, which may not fully capture the abnormal brain changes of SZ patients. In this paper, event-related potentials were collected from 45 SZ patients and 30 healthy controls (HCs) during a learning task, and then a combination of partial directed coherence (PDC) effective and phase lag index (PLI) functional connectivity were used as features to train a support vector machine classifier with leave-one-out cross-validation for classification of SZ from HCs. Read More

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Mass drug administration for the acceleration of malaria elimination in a region of Myanmar with artemisinin-resistant falciparum malaria: a cluster-randomised trial.

Lancet Infect Dis 2021 Jun 17. Epub 2021 Jun 17.

Medical Action Myanmar, Yangon, Myanmar; Myanmar Oxford Clinical Research Unit, Yangon, Myanmar; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK. Electronic address:

Background: To contain multidrug-resistant Plasmodium falciparum, malaria elimination in the Greater Mekong subregion needs to be accelerated while current antimalarials remain effective. We evaluated the safety, effectiveness, and potential resistance selection of dihydroartemisinin-piperaquine mass drug administration (MDA) in a region with artemisinin resistance in Myanmar.

Methods: We did a cluster-randomised controlled trial in rural community clusters in Kayin (Karen) state in southeast Myanmar. Read More

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Screening the genome for HCC-specific CpG methylation signatures as biomarkers for diagnosis and prognosis evaluation.

BMC Med Genomics 2021 Jun 19;14(1):163. Epub 2021 Jun 19.

Department of Hepatobiliary and Pancreatic Surgery, Shenzhen Traditional Chinese Medicine Hospital, No.1 Fuhua Road, Shenzhen, 518000, Guangdong, China.

Background: Hepatocellular carcinoma (HCC) is one of the most common and invasive malignant tumors in the world. The change in DNA methylation is a key event in HCC.

Methods: Methylation datasets for HCC and 17 other types of cancer were downloaded from The Cancer Genome Atlas (TCGA). Read More

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Sensory attenuation in the absence of movement: Differentiating motor action from sense of agency.

Cortex 2021 May 11;141:436-448. Epub 2021 May 11.

School of Psychology, The University of New South Wales (UNSW Sydney), Sydney, Australia.

Sensory attenuation is the phenomenon that stimuli generated by willed motor actions elicit a smaller neurophysiological response than those generated by external sources. It has mostly been investigated in the auditory domain, by comparing ERPs evoked by self-initiated (active condition) and externally-generated (passive condition) sounds. The mechanistic basis of sensory attenuation has been argued to involve a duplicate of the motor command being used to predict sensory consequences of self-generated movements. Read More

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Event-related potential (ERP) measures of error processing as biomarkers of externalizing disorders: A narrative review.

Int J Psychophysiol 2021 Jun 16. Epub 2021 Jun 16.

Department of Psychology, Education and Child Studies, Erasmus University Rotterdam, P.O. 1738, 3000 DR Rotterdam, the Netherlands. Electronic address:

Previous studies have shown that electrophysiological measures of error processing are affected in patients at risk or diagnosed with internalizing disorders, hence, suggesting that error processing could be a suitable biomarker for internalizing disorders. In this narrative review, we will evaluate studies that address the role of event-related potential (ERP) measures of error-processing in externalizing disorders and discuss to what extend these can be considered a biomarker for externalizing disorders. Currently, there is evidence for the notion that electrophysiological indices of error processing such as the error-related negativity (ERN) and error positivity (Pe) are reduced in individuals with substance use disorders, attention-deficit/hyperactivity disorder, and in forensic populations. Read More

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Integrated multi-omics profiling of high-grade estrogen receptor-positive, HER2-negative breast cancer.

Mol Oncol 2021 Jun 19. Epub 2021 Jun 19.

Department of Endocrine and Breast Surgery, The First Affiliated hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, 400016, China.

Estrogen-receptor-positive, and human epidermal growth factor receptor 2-negative (ER+HER2-) breast cancer accounts for ~60-70% of all cases of invasive breast carcinoma. High-grade ER+HER2- tumors respond poorly to endocrine therapy. In this study, we systematically analyzed clinical and multi-omics data to find potential strategies for personalized therapy of patients with high-grade ER+HER2- disease. Read More

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Mammalian target of rapamycin signaling pathway is involved in synaptic plasticity of the spinal dorsal horn and neuropathic pain in rats by regulating autophagy.

Neuroreport 2021 Jun 17. Epub 2021 Jun 17.

Department of Anesthesiology, Hubei Tongcheng People's Hospital, Tongcheng Department of Anesthesiology, Wuhan Children Hospital, Wuhan, China.

Unveiling the etiology and the underlying mechanism of neuropathic pain, a poorly treated disease, is essential for the development of effective therapies. This study aimed to explore the role of mammalian target of rapamycin (mTOR) signaling in autophagy-mediated neuropathic pain. We established a spared nerve injury (SNI) model in adult male SD rats by ligating the common peroneal nerve and tibial, with the distal end cutoff. Read More

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Impact of Prior Brain Injury on Concussion Recovery in Military Personnel: Evaluation of Timing Between Concussions.

J Head Trauma Rehabil 2021 Jun 15. Epub 2021 Jun 15.

Traumatic Brain Injury Center of Excellence, Silver Spring, Maryland (Drs Remigio-Baker, Babakhanyan, Gregory, Ettenhofer, Mullins, and Bailie); Naval Hospital Camp Pendleton, Camp Pendleton, California (Drs Remigio-Baker, Babakhanyan, and Bailie); Henry M. Jackson Foundation, Bethesda, Maryland (Dr Remigio-Baker); General Dynamics Information Technology, Fairfax, Virginia (Drs Babakhanyan and Bailie); Intrepid Spirit Center, Womack Army Medical Center, Fort Bragg, North Carolina (Dr Cole); Naval Medical Center San Diego, San Diego, California (Drs Ettenhofer and Mullins); University of California, San Diego (Dr Ettenhofer); US Army Medical Research and Materiel Command, Fort Detrick, Maryland (Dr West); and National Institutes of Health, Bethesda, Maryland (Dr Qashu).

Objective: To evaluate the potential impact of timing between the current and the most recent previous concussions on symptom severity among acutely concussed active duty military Service members (SMs).

Setting: Three military installations.

Participants: Eighty-four SMs aged 18 to 44 years who sustained a concussion within 72 hours of enrollment. Read More

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Pericardial disease in patients treated with immune checkpoint inhibitors.

J Immunother Cancer 2021 Jun;9(6)

Cardiovascular Imaging Research Center (CIRC), Department of Radiology and Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.

Background: There are limited data on the occurrence, associations and outcomes of pericardial effusions and pericarditis on or after treatment with immune checkpoint inhibitors (ICIs).

Methods: This was a retrospective study at a single academic center that compared 2842 consecutive patients who received ICIs with 2699 age- and cancer-type matched patients with metastatic disease who did not receive ICI. A pericardial event was defined as a composite outcome of pericarditis and new or worsening moderate or large pericardial effusion. Read More

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Effects of Bihemispheric Transcranial Direct Current Stimulation Combined With Repetitive Peripheral Nerve Stimulation in Acute Stroke Patients.

J Clin Neurophysiol 2021 May 31. Epub 2021 May 31.

Neurophysiology Unit, Neurology Department, Hospital Universitari de Bellvitge, Barcelona, Spain; Department of Clinical Neurophysiology, Hospital Universitari Dexeus, Barcelona, Spain; Neurology Department, Hospital Universitari de Bellvitge, Barcelona, Spain; Neurology Department, Hospital de Neurorehabilitación, Institut Guttmann, Barcelona, Spain; and EMG Unit, Neurology Department, Hospital Clínic, Department of Medicine, University of Barcelona, August Pi Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain.

Purpose: Transcranial direct current stimulation (tDCS) can change the excitability of the central nervous system and contribute to motor recovery of stroke patients. The aim of our study was to examine the short- and long-term effects of real versus sham bihemispheric tDCS combined with repetitive peripheral nerve stimulation in patients with acute stroke and a severe motor impairment.

Methods: The study was prospective, randomized, double blind, and placebo controlled. Read More

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COVID-19 blues: Lockdowns and mental health-related google searches in Latin America.

Soc Sci Med 2021 May 25;281:114040. Epub 2021 May 25.

Universidad Anahuac Mexico, Business and Economics School, Av. Universidad Anáhuac 46, Huixquilucan, 52786, Mexico. Electronic address:

Rationale: Stress process theory considers that actual and perceived isolation, caused by mobility restrictions from attempted containment of the COVID-19 pandemic, deteriorates mental health.

Objective: We examine the relationship between the COVID-19 lockdowns and mental health-related Google searches in 11 Latin American countries. We include the following countries: Argentina, Bolivia, Chile, Colombia, Ecuador, Guatemala, Honduras, Mexico, Paraguay, Peru, and Uruguay. Read More

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The impact of artifact removal approaches on TMS-EEG signal.

Neuroimage 2021 Jun 15:118272. Epub 2021 Jun 15.

Neurophysiology lab, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy. Electronic address:

Transcranial magnetic stimulation (TMS)-evoked potentials (TEPs) allow one to assess cortical excitability and effective connectivity in clinical and basic research. However, obtaining clean TEPs is challenging due to the various TMS-related artifacts that contaminate the electroencephalographic (EEG) signal when the TMS pulse is delivered. Different preprocessing approaches have been employed to remove the artifacts, but the degree of artifact reduction or signal distortion introduced in this phase of analysis is still unknown. Read More

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Facial Expressions of Anger Improve Neural Correlates of Memory Retrieval but not Encoding of Only Same-Race Faces.

Neuropsychologia 2021 Jun 15:107915. Epub 2021 Jun 15.

Department of Psychology, Neuroscience Program, The College of Wooster, 1189 Beall Ave, Wooster, OH 44691, U.S.A.. Electronic address:

The other-race effect is the phenomenon that people are better able to recognize and remember faces of their same race. Angry faces have been shown to facilitate processes that promote face recognition as reflected in the proportion of remembered faces after study. The other-race effect may be diminished when other-race faces display negative expressions, but no event-related potential studies have examined whether this improvement in other-race face recognition occurs during facial encoding or recognition. Read More

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Kinematic Boundary Cues Modulate 12-month-old Infants' Segmentation of Action Sequences: An ERP Study.

Neuropsychologia 2021 Jun 15:107916. Epub 2021 Jun 15.

Department of Psychology, Cognitive Sciences, University of Potsdam, Karl-Liebknecht-Str. 24-25, 14476 Potsdam, Germany.

Human infants can segment action sequences into their constituent actions already during the first year of life. However, work to date has almost exclusively examined the role of infants' conceptual knowledge of actions and their outcomes in driving this segmentation. The present study examined electrophysiological correlates of infants' processing of lower-level perceptual cues that signal a boundary between two actions of an action sequence. Read More

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Modelling of hypothetical SARS-CoV-2 point of care tests for routine testing in residential care homes: rapid cost-effectiveness analysis.

Health Technol Assess 2021 Jun;25(39):1-74

Personalised Medicine and Health, University of Leeds, Leeds, UK.

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus that causes coronavirus disease 2019 (COVID-19), which at the time of writing (January 2021) was responsible for more than 2.25 million deaths worldwide and over 100,000 deaths in the UK. SARS-CoV-2 appears to be highly transmissible and could rapidly spread in residential care homes. Read More

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