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Randomized clinical trial of bedtime sublingual cyclobenzaprine (TNX-102 SL) in military-related PTSD and the role of sleep quality in treatment response.

Psychiatry Res 2021 Apr 30;301:113974. Epub 2021 Apr 30.

Tonix Pharmaceuticals, Inc., New York, NY.

Effective posttraumatic stress disorder (PTSD) pharmacotherapy is needed. This 12-week randomized multicenter trial evaluated efficacy and safety of TNX-102 SL, a bedtime sublingual formulation of cyclobenzaprine, in patients with military-related PTSD randomized to TNX-102 SL 2.8 mg or 5. Read More

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Opioid Treatment Deserts: Concept development and application in a US Midwestern urban county.

PLoS One 2021 12;16(5):e0250324. Epub 2021 May 12.

Center for Urban Regional Analysis, The Ohio State University, Columbus, OH, United States of America.

Objectives: An Opioid Treatment Desert is an area with limited accessibility to medication-assisted treatment and recovery facilities for Opioid Use Disorder. We explored the concept of Opioid Treatment Deserts including racial differences in potential spatial accessibility and applied it to one Midwestern urban county using high resolution spatiotemporal data.

Methods: We obtained individual-level data from one Emergency Medical Services (EMS) agency (Columbus Fire Department) in Franklin County, Ohio. Read More

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Conformational Reorganization of Apolipoprotein E Triggered by Phospholipid Assembly.

J Phys Chem B 2021 May 12. Epub 2021 May 12.

Tata Institute of Fundamental Research, Center for Interdisciplinary Sciences, Hyderabad 500107, India.

Apolipoprotein E (apoE), a major determinant protein for lipid metabolism, actively participates in lipid transport in the central nervous system via high-affinity interaction with the low-density lipoprotein receptor (LDLR). Prior evidences indicate that the phospholipids first need to assemble around apoE before the protein can recognize its receptor. However, despite multiple attempts via spectroscopic and biochemical investigations, it is unclear what are the impacts of lipid assembly on the globular structure of apoE. Read More

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RHEDAR Study: Determination of the Risk of gastrointestinal hemorrhage in treatment with dabigatran, acenocoumarol and rivaroxaban.

J Gastroenterol Hepatol 2021 May 12. Epub 2021 May 12.

Department of Gastroenterology, Rey Juan Carlos Hospital, Móstoles, Madrid, Spain.

Background And Aim: Atrial fibrillation is a major cause of death and disability due to stroke. Vitamin K antagonist drugs are effective for prevention, but they have a narrow therapeutic range and multiple pharmacological interactions. In recent years, new therapeutic alternatives have been searched to minimize complications. Read More

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Correlated structure of neuronal firing in macaque visual cortex limits information for binocular depth discrimination.

J Neurophysiol 2021 May 12. Epub 2021 May 12.

Physiology, Anatomy & Genetics, University of Oxford, United Kingdomgrid.4991.5.

Variability in cortical neural activity potentially limits sensory discriminations. Theoretical work shows that information required to discriminate two similar stimuli is limited by the correlation structure of cortical variability. We investigated these information-limiting correlations by recording simultaneously from visual cortical areas V1 and V4 in macaque monkeys, performing a binocular, stereo-depth discrimination task. Read More

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Cortisol levels in blood and hair of unanesthetized grizzly bears (Ursus arctos) following intravenous cosyntropin injection.

Vet Med Sci 2021 May 12. Epub 2021 May 12.

fRI Research, Hinton, AB, Canada.

Hair cortisol concentration (HCC) is being used increasingly to evaluate long-term stress in many mammalian species. Most of the cortisol is assumed to passively diffuse from circulating blood into hair follicles and gradually accumulate in growing hair. However, our research with free-ranging grizzly bears (Ursus arctos) suggests HCC increases significantly within several hours following capture, a time too brief to be explained by this mechanism alone. Read More

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Inhibitory control in children with tic disorder: aberrant fronto-parietal network activity and connectivity.

Brain Commun 2021 9;3(2):fcab067. Epub 2021 Apr 9.

Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA 90095, USA.

Chronic tic disorders, including Tourette syndrome, are typically thought to have deficits in cognitive inhibition and top down cognitive control due to the frequent and repetitive occurrence of tics, yet studies reporting task performance results have been equivocal. Despite similar behavioural performance, individuals with chronic tic disorder have exhibited aberrant patterns of neural activation in multiple frontal and parietal regions relative to healthy controls during inhibitory control paradigms. In addition to these top down attentional control regions, widespread alterations in brain activity across multiple neural networks have been reported. Read More

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Acute Generalized Exanthematous Pustulosis Caused by Erlotinib in a Patient with Lung Cancer.

Case Rep Oncol 2021 Jan-Apr;14(1):599-603. Epub 2021 Mar 29.

Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, Japan.

Acute generalized exanthematous pustulosis (AGEP) is a rare drug-related adverse skin reaction caused mainly by antibiotics. Erlotinib is an epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) used to treat lung cancer. A 69-year-old woman with primary lung cancer (adenocarcinoma, cT3N1M1b, stage IVB) developed erythema and multiple skin pustules on her abdomen and both thighs after 7 weeks of erlotinib treatment. Read More

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Functional and Comparative Analysis of Centromeres Reveals Clade-Specific Genome Rearrangements in and a Chromosome Number Change in Related Species.

mBio 2021 May 11;12(3). Epub 2021 May 11.

Molecular Mycology Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, India

The thermotolerant multidrug-resistant ascomycete rapidly emerged since 2009 causing systemic infections worldwide and simultaneously evolved in different geographical zones. The molecular events that orchestrated this sudden emergence of the killer fungus remain mostly elusive. Here, we identify centromeres in and related species, using a combined approach of chromatin immunoprecipitation and comparative genomic analyses. Read More

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Assessing Hospital Adaptive Resource Allocation Strategies in Responding to Mass Casualty Incidents.

Disaster Med Public Health Prep 2021 May 12:1-11. Epub 2021 May 12.

Emergency Department, Ospedale San Raffaele, Milano, Lombardia, Italy.

Objectives: Hospitals are expected to operate at a high-performance level even under exceptional conditions of peak demand and resource disruptions. This understanding is not mature yet, and there are wide areas of possible improvement. In particular, the fast mobilization and reconfiguration of resources frequently result into the severe disruption of elective activities, worsening the quality of care. Read More

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Endoscopic Management of Staple Line Leak after Bariatric Surgery: Surgeon's Perspective.

Clin Endosc 2021 May 12. Epub 2021 May 12.

Bariatric and Metabolic Surgery Center, H+ Yangji Hospital, Seoul, Korea.

Laparoscopic sleeve gastrectomy (LSG) has become a standalone primary procedure as a bariatric metabolic surgery since the early 2000s. The overall complication rate of LSG is reported to range from 2% to 15%. Staple line leakage (SLL) remains a major adverse event and occurs in approximately 1%-6% of patients. Read More

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A phase 3, randomized study of ofatumumab combined with bendamustine in rituximab-refractory iNHL (COMPLEMENT A + B study).

Br J Haematol 2021 May 10. Epub 2021 May 10.

Wilmot Cancer Institute, University of Rochester Medical Centre, Rochester, NY, USA.

The standard of care for indolent non-Hodgkin lymphoma (iNHL) is rituximab, an anti-CD20 antibody, with/without chemotherapy. However, multiple relapses are common in these patients. This phase 3, randomized study compared outcomes of a combination of ofatumumab (a second-generation anti-CD20 antibody) and bendamustine, with bendamustine alone in patients unresponsive to prior rituximab-based treatment. Read More

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Evaluation of inflammatory acquired demyelinating syndromes in children: a single-center experience.

Acta Neurol Belg 2021 May 10. Epub 2021 May 10.

Department of Pediatric Neurology, Cerrahpasa School of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey.

To evaluate the clinical and neuroimaging features of pediatric acquired demyelinating syndromes (ADS) in a tertiary pediatric neurology clinic in Turkey. All children diagnosed with any subset of ADS between 2013 and 2018 were included in this retrospective cohort study. Forty-two patients (21 female) with a median follow-up period of 30 months were included. Read More

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Population genomics study of Vibrio alginolyticus.

Yi Chuan 2021 Apr;43(4):350-361

State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China.

Vibrio alginolyticus is a Gram-negative bacillus that causes vibriosis to human and aquatic products, including fish, shrimp and shellfish. It poses a threat to public health and causes enormous economic losses to the aquaculture industry. However, research on genetic diversity and pathogenicity-related genetic elements based on whole genome is still lacking. Read More

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RENEB Inter-Laboratory Comparison 2017: limits and pitfalls of ILCs.

Int J Radiat Biol 2021 May 10:1-52. Epub 2021 May 10.

Agenzia Nazionale per le Nuove Tecnologie, L´Energia e lo Sviluppo Economico Sostenibile, Rome, Italy.

Purpose: In case of a mass-casualty radiological event, there would be a need for networking to overcome surge limitations and to quickly obtain homogeneous results (reported aberration frequencies or estimated doses) among biodosimetry laboratories. These results must be consistent within such network. Inter-laboratory comparisons (ILCs) are widely accepted to achieve this homogeneity. Read More

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Resuscitative Effect of Centhaquine (Lyfaquin) in Hypovolemic Shock Patients: A Randomized, Multicentric, Controlled Trial.

Adv Ther 2021 May 10. Epub 2021 May 10.

Pharmazz India Private Limited, Greater Noida, India.

Introduction: Centhaquine (Lyfaquin) showed significant efficacy as a resuscitative agent in animal models of haemorrhagic shock. Its safety and tolerability were confirmed in healthy human volunteers. In this study, our primary objective was to determine the safety, and the secondary objective was to assess the efficacy of centhaquine in patients with hypovolemic shock. Read More

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Functional joint models for chronic kidney disease in kidney transplant recipients.

Stat Methods Med Res 2021 May 10:9622802211009265. Epub 2021 May 10.

Division of Nephrology, University of Nebraska Medical Center, NE, USA.

This functional joint model paper is motivated by a chronic kidney disease study post kidney transplantation. The available kidney organ is a scarce resource because millions of end-stage renal patients are on the waiting list for kidney transplantation. The life of the transplanted kidney can be extended if the progression of the chronic kidney disease stage can be slowed, and so a major research question is how to extend the transplanted kidney life to maximize the usage of the scarce organ resource. Read More

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Multicenter Interventional Phase IV Study for the Assessment of the Effects on Patient's Satisfaction of Peg IFN Beta-1a (Pre-filled Pen) in Subjects With Relapsing-Remitting Multiple Sclerosis Unsatisfied With Other Injectable Subcutaneous Interferons (PLATINUM Study).

Front Neurol 2021 22;12:637615. Epub 2021 Apr 22.

Biogen Italia, Milan, Italy.

Subcutaneous (SC) interferons beta (IFN-beta) are effective therapies for the treatment of relapsing-remitting multiple sclerosis (RRMS). Factors such as dosing schedule, needle intolerance/fatigue, and side effects may impact patient satisfaction with treatment. Improvement of patient satisfaction may increase the adherence to treatment and the patient quality of life. Read More

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Estimation of covariate effects on net survivals in the relative survival progressive illness-death model.

Stat Methods Med Res 2021 May 8:9622802211003608. Epub 2021 May 8.

Aix-Marseille Univ, INSERM, IRD, SESSTIM, Sciences Economiques et Sociales de la Santé et Traitement de l'Information Médicale, Hop Timone, BioSTIC, Biostatistique et Technologies de l'Information et de la communication, Marseille, France.

Recently, there has been a lot of development in relative survival field. In the absence of data on the cause of death, the research has tended to focus on the estimation of survival probability of a cancer (as a disease of interest). In many cancers, one nonfatal event that decreases the survival probability can occur. Read More

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Implications of mosaicism in variant interpretation: A case of a de novo homozygous NF1 variant.

Eur J Med Genet 2021 May 6:104236. Epub 2021 May 6.

Department of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.

Neurofibromatosis type 1 is a common multisystem autosomal dominant syndrome caused by pathogenic heterozygous variants in the neurofibromin gene (NF1). It is associated with a substantially increased cancer risk. Mosaicism for NF1 has been clinically well-established for "second hit" variants in skin lesions and tumor tissues. Read More

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Ginsenosides in vascular remodeling: cellular and molecular mechanisms of their therapeutic action.

Pharmacol Res 2021 May 5:105647. Epub 2021 May 5.

The Second Xiangya Hospital of Central South University Shenzhen Hospital, Shenzhen, Guangdong 518067, China. Electronic address:

Evidence is mounting that abnormal vascular remodeling (VR) is a vital pathological event that precedes many cardiovascular diseases (CVD). This provides us with a new research perspective that VR can be a pivotal target for CVD treatment and prevention. However, the current drugs for treating CVD does not fundamentally reverse VR and repair vascular function. Read More

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Disparity in Context: Understanding how monocular image content interacts with disparity processing in human visual cortex.

Neuroimage 2021 May 5:118139. Epub 2021 May 5.

Wu Tsai Neurosciences Institute, 290 Jane Stanford Way, Stanford, CA 94305. Electronic address:

Horizontal disparities between the two eyes' retinal images are the primary cue for depth. Commonly used Random dot stereograms (RDS) intentionally camouflage the disparity cue, breaking the correlations between monocular image structure and the depth map that are present in natural images. Because of the nonlinear nature of visual processing, it is unlikely that simple computational rules derived from RDS will be sufficient to explain binocular vision in natural environments. Read More

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Pharmacological SARM1 inhibition protects axon structure and function in paclitaxel-induced peripheral neuropathy.

Brain 2021 May 8. Epub 2021 May 8.

Disarm Therapeutics, a wholly owned subsidiary of Eli Lilly & Co., Cambridge MA 02142, USA.

Axonal degeneration is an early and ongoing event that causes disability and disease progression in many neurodegenerative disorders of the peripheral and central nervous systems. Chemotherapy-induced peripheral neuropathy (CIPN) is a major cause of morbidity and the main cause of dose reductions and discontinuations in cancer treatment. Preclinical evidence indicates that activation of the Wallerian-like degeneration pathway driven by SARM1 is responsible for axonopathy in CIPN. Read More

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A varying-coefficient model for gap times between recurrent events.

Lifetime Data Anal 2021 May 8. Epub 2021 May 8.

Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA, 30322, USA.

Recurrent events often arise in follow-up studies where a subject may experience multiple occurrences of the same type of event. Most regression models for recurrent events consider the time scale measured from the study origin and assume constant effects of covariates. In many applications, however, gap times between recurrent events are of natural interest and moreover the effects may actually vary over time. Read More

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A Randomized Phase 1 Safety, Pharmacokinetic and Pharmacodynamic Study of the Novel Myostatin Inhibitor Apitegromab (SRK-015): A Potential Treatment for Spinal Muscular Atrophy.

Adv Ther 2021 May 8. Epub 2021 May 8.

Medpace Clinical Pharmacology, Cincinnati, OH, USA.

Introduction: Apitegromab (SRK-015) is an anti-promyostatin monoclonal antibody under development to improve motor function in patients with spinal muscular atrophy, a rare neuromuscular disease. This phase 1 double-blind, placebo-controlled study assessed safety, pharmacokinetic parameters, pharmacodynamics (serum latent myostatin), and immunogenicity of single and multiple ascending doses of apitegromab in healthy adult subjects.

Methods: Subjects were administered single intravenous ascending doses of apitegromab of 1, 3, 10, 20, 30 mg/kg or placebo, and multiple intravenous ascending doses of apitegromab of 10, 20, 30 mg/kg or placebo. Read More

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The Role of the Lateral Habenula in Inhibitory Learning from Reward Omission Experiences.

eNeuro 2021 May 7. Epub 2021 May 7.

Universidad Iberoamericana

The lateral habenula (LHb) is a phylogenetically primitive brain structure that plays a key role in learning to inhibit distinct responses to specific stimuli. This structure is activated by primary aversive stimuli, cues predicting an imminent aversive event, unexpected reward omissions, and cues associated with the omission of an expected reward. The most widely described effect of LHb activation is acutely suppressing midbrain dopaminergic signaling. Read More

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Acute hemolytic transfusion reaction caused by anti-Yt.

Immunohematology 2021 Mar;37(1):13-17

Department of Transfusion Medicine and Transplantation Biology, University Clinical Hospital Zagreb , Zagreb , Croatia .

Many patients with anti-Yt receive multiple transfusions of Yt(a+) red blood cells (RBCs) with no ill effects. However, anti-Yt has been implicated in hemolytic transfusion reactions. Antibody identification typically determines specificity of antibodies and their clinical significance to justify blood requirements for antigen-negative blood when clinically significant antibodies are involved. Read More

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Silent corticotroph pituitary adenomas: clinical characteristics, long-term outcomes, and management of disease recurrence.

J Neurosurg 2021 May 7:1-8. Epub 2021 May 7.

Departments of1Neurological Surgery.

Objective: Silent corticotroph adenomas (SCAs) are a distinct subtype of nonfunctioning pituitary adenomas (NFAs) that demonstrate positive immunohistochemistry for adrenocorticotropic hormone (ACTH) without causing Cushing's disease. SCAs are hypothesized to exhibit more aggressive behavior than standard NFAs. The authors analyzed their institution's surgical experience with SCAs in an effort to characterize rates of invasion, postoperative clinical outcomes, and patterns of disease recurrence and progression. Read More

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Identifying the predictors of turnover intention based on psychosocial factors of nurses during the COVID-19 outbreak.

Nurs Open 2021 May 7. Epub 2021 May 7.

Department of Nursing, School of Nursing and Midwifery, Ardabil University of Medical Sciences, Ardabil, Iran.

Aims: Because of the direct contact nurses have with patients, they are exposed to more stressful events during the outbreak of infectious diseases, which increases their turnover intention, highly impacting not only nurses, but also patients and organizations. The present study aimed to identify the predictors of turnover intention based on psychosocial factors in nurses of Ardabil pre-hospital emergency and educational and medical centres during the COVID-19 outbreak.

Design: The present descriptive-analytical study was conducted in June, 2020. Read More

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Associations Between Adverse Childhood Experiences and Trauma Among Young People Who Offend: A Systematic Literature Review.

Trauma Violence Abuse 2021 May 7:15248380211013132. Epub 2021 May 7.

University of Melbourne, Melbourne, Victoria, Australia.

This systematic review synthesized current knowledge about the prevalence of adverse childhood experiences (ACEs) among young people known to have offended and examined evidence of associations between ACEs, trauma symptoms, and offending behavior. A systematic search of English-language, peer-reviewed studies published from the year 2000 onwards was conducted. A final pool of 124 studies that reported quantitative data were included in the review. Read More

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