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The examination of biophysical parameters of the skin in Polish Konik horses.

PLoS One 2021 21;16(6):e0250329. Epub 2021 Jun 21.

Department of Internal Medicine and Clinic of Diseases of Horses, Dogs and Cats, Faculty of Veterinary Medicine, Wrocław University of Environmental and Life Sciences, Wrocław, Poland.

This study aimed to assess the biophysical parameters of the skin in Polish Konik horses (Polish primitive horses). According to the authors, this is the first assessment performed on such a wide scale in this group of animals. The evaluation carried out is innovative both with regards to the breed of the animals and the wide scope of the physicochemical skin assessment. Read More

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Assessment of groundwater quality and usability of Salda Lake Basin (Burdur/Turkey) and health risk related to arsenic pollution.

J Environ Health Sci Eng 2021 Jun 11;19(1):681-706. Epub 2021 Mar 11.

Department of Geography, Süleyman Demirel University, Isparta, Turkey.

Purpose: In this study the aim was to analyze the seasonal concentration, groundwater quality, usage areas and arsenic-related health risk of major ions and heavy metals in groundwater samples collected from the Salda Lake basin.

Methods: In this study, 42 groundwater samples were collected from springs and wells in dry and wet seasons in 2015. Hydrogeochemical evaluations were made using different diagrams such as Piper and Gibbs diagrams. Read More

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Adverse Effects Associated With the Use of Antimalarials During The COVID-19 Pandemic in a Tertiary Care Center in Mexico City.

Front Pharmacol 2021 3;12:668678. Epub 2021 Jun 3.

Department of Infectious Diseases, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.

Antimalarial drugs were widely used as experimental therapies against COVID-19 in the initial stages of the pandemic. Despite multiple randomized controlled trials demonstrating unfavorable outcomes in both efficacy and adverse effects, antimalarial drugs are still prescribed in developing countries, especially in those experiencing recurrent COVID-19 crises (India and Brazil). Therefore, real-life experience and pharmacovigilance studies describing the use and side effects of antimalarials for COVID-19 in developing countries are still relevant. Read More

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Prognostic Factors for Long-Term Recovery of Homonymous Visual Field Defects After Posterior Circulation Ischemic Stroke.

J Stroke Cerebrovasc Dis 2021 Jun 16;30(8):105924. Epub 2021 Jun 16.

Stroke Clinic, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City, Mexico; Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City, Mexico. Electronic address:

Objectives: Ischemic stroke (IS) is the main cause of homonymous visual field defects (HVFDs) in adults. Some reports suggest recovery even in late-phase strokes, but data is sparse. This study examines the frequency of long-term recovery from HVFDs in patients with posterior circulation infarction (POCI) and evaluates whether demographic or clinical characteristics are prognostic factors of perimetric recovery. Read More

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GFAP variants leading to infantile Alexander disease: Phenotype and genotype analysis of 135 cases and report of a de novo variant.

Clin Neurol Neurosurg 2021 Jun 10;207:106754. Epub 2021 Jun 10.

Growth and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran; Iranian Comprehensive Hemophilia Care Center, Tehran, Iran. Electronic address:

Objectives: Alexander disease (AxD) is a rare autosomal dominant disorder due to GFAP mutations; infantile AxD is the most common severe form which usually results in death. In this study, phenotype and genotype analysis of all reported cases with IAxD are reported as well as a de novo variant.

Methods: We conduct a comprehensive review on all reported Infantile AxD due to GFAP mutation. Read More

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Periocular rejuvenation using a unique non-ablative long-pulse 2940 nm Er:YAG laser.

Lasers Med Sci 2021 Jun 19. Epub 2021 Jun 19.

LA&HA - Laser and Health Academy, Ljubljana, Slovenia.

The periocular region is challenging for cosmetic laser surgeons. Surgery and laser resurfacing have traditionally been used to correct periorbital lines and wrinkles. Although effective, the associated downtime with these methods has made many people reluctant to decide for such treatments. Read More

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Effects of adipose tissue-derived stromal vascular fraction on osteochondral defects treated by hyaluronic acid-based scaffold: An experimental study.

Jt Dis Relat Surg 2021 11;32(2):347-354. Epub 2021 Jun 11.

Ordu Üniversitesi Eğitim ve Araştırma Hastanesi Ortopedi ve Travmatoloji Kliniği, 52200 Altınordu, Ordu, Türkiye.

Objectives: This study aims to evaluate the effect of adipose-derived stromal vascular fraction (SVF) on osteochondral defects treated by hyaluronic acid (HA)-based scaffold in a rabbit model.

Materials And Methods: Eighteen white New Zealand rabbits were randomly grouped into the experimental group (n=9) and control group (n=9). In all groups, osteochondral defects were induced on the weight-bearing surfaces of the right femoral medial condyles, and a HA-based scaffold was applied to the defect area with microfractures (MFs). Read More

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Effects of different vardenafil doses on bone healing in a rat fracture model.

Jt Dis Relat Surg 2021 11;32(2):313-322. Epub 2021 Jun 11.

SBÜ Bağcılar Eğitim ve Araştırma Hastanesi Ortopedi ve Travmatoloji Kliniği, 34200 Bağcılar, İstanbul, Türkiye.

Objectives: We aimed to investigate the radiological, biomechanical, histopathological, histomorphometric, and immunohistochemical effects of different doses of vardenafil on fracture healing.

Materials And Methods: Fifty-one rats were divided into three groups. Group V5 was given 5 mg/kg/day of vardenafil; Group V10 was given 10 mg/kg/day of vardenafil; and the control group was given the same volume of saline. Read More

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Kitchen elbow sign predicts surgical outcomes in adults with spinal deformity: a retrospective cohort study.

Sci Rep 2021 Jun 18;11(1):12859. Epub 2021 Jun 18.

Department of Orthopedic Surgery, Wakayama Medical University, 811-1 Kimiidera, Wakayama City, Wakayama, 641-8510, Japan.

Kitchen elbow sign (KE-Sign) is a skin abnormality on the extensor side of the elbow and forearm that is often observed in patients with adult spinal deformity (ASD). The significance of KE-Sign in surgical cases was investigated. Overall, 114 patients with ASD treated with long spinal fusion were reviewed and divided into KE-Sign positive and negative groups. Read More

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Alumina particle air-abrasion and aging effects: Fatigue behavior of CAD/CAM resin composite crowns and flexural strength evaluations.

J Mech Behav Biomed Mater 2021 May 19;121:104592. Epub 2021 May 19.

MSciD and PhD Post-Graduate Program in Oral Science, Prosthetic Dentistry Unit, Faculty of Dentistry, Federal University of Santa Maria (UFSM), Santa Maria, Rio Grande do Sul State, Brazil. Electronic address:

The aim of this study was to characterize the flexural strength and elastic modulus of CAD/CAM resin composite material and to evaluate the influence of different surface treatments and storage conditions on the fatigue behavior of bonded composite crowns. Bars (flexural strength, n= 30; elastic modulus, n= 5) (1.2 × 4 × 12 mm) were produced for three-point bending test and CAD/CAM milled crowns (n= 5) (thickness= 1 mm) adhesively cemented to an epoxy resin substrate for fatigue tests. Read More

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Bulk-fill versus layering pure ormocer posterior restorations: A randomized split-mouth clinical trial.

Am J Dent 2021 Jun;34(3):143-149

Department of Restorative Dentistry, São Paulo State University (UNESP), Institute of Science and Technology, São Jose dos Campos, SP, Brazil.

Purpose: To evaluate the clinical performance of Class II restorations made with bulk-fill or layering pure ormocer materials, as well as the time necessary to fill the preparations.

Methods: After ethics approval, a randomized controlled split-mouth clinical trial was performed. 30 subjects were selected according to the inclusion/exclusion criteria, and two restorations were randomly performed in each first or second molar that presented caries, fracture, or cosmetic needs. Read More

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The use of intra-articular injection of autologous micro-fragmented adipose tissue as pain treatment for ankle osteoarthritis: a prospective not randomized clinical study.

Int Orthop 2021 Jun 17. Epub 2021 Jun 17.

Department of Orthopaedics, IRCCS Ospedale Sacro Cuore Don Calabria, Negrar di Valpolicella, Italy.

Purpose: The objective of this study was to evaluate the safety and the efficacy of intra-articular injections of autologous micro-fragmented adipose tissue in patients affected by early or moderate ankle osteoarthritis (AOA).

Methods: A total of 31 symptomatic patients, aged 28-71 years, affected by AOA, were treated with 5 ml of autologous micro-fragmented adipose tissue. Clinical evaluations before the treatment and after six, 12, and 24 months were performed through American Orthopaedic Foot and Ankle Society (AOFAS) scale, the Foot and Ankle Disability Index (FADI), and Visual Analogue Scale (VAS) scores. Read More

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Quick and simple test to evaluate severity of acute lateral ankle sprain.

Asia Pac J Sports Med Arthrosc Rehabil Technol 2021 Jul 30;25:30-34. Epub 2021 May 30.

Fujita Orthopedic & Sports Clinic, Japan.

Background/objective: For early return to sports after a lateral ankle sprain (LAS) and recurrence prevention, effective rehabilitation and gradual return to sports should be initiated while predicting the return time based on the appropriate severity evaluation immediately after injury. However, since severity evaluations performed in previous studies required large space and stairs and involved high-revel activity, their use as a test and index to evaluate severity after LAS was not appropriate considering convenience and risk of re-injury. Therefore, a quick and simple test was developed to evaluate the severity of acute LAS. Read More

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3D Non-Rigid Alignment of Low-Dose Scans Allows to Correct for Saturation in Lower Extremity Cone-Beam CT.

IEEE Access 2021 11;9:71821-71831. Epub 2021 May 11.

Division of Mechanical and Biomedical Engineering, Graduate Program in System Health Science and Engineering, Ewha Womans University, Seoul 03760, South Korea.

Detector saturation in cone-beam computed tomography occurs when an object of highly varying shape and material composition is imaged using an automatic exposure control (AEC) system. When imaging a subject's knees, high beam energy ensures the visibility of internal structures but leads to overexposure in less dense border regions. In this work, we propose to use an additional low-dose scan to correct the saturation artifacts of AEC scans. Read More

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Safety assessment of Bong. Steud leaves extract: acute, sub-acute toxicity, antioxidant, and antihemolytic evaluations.

Toxicol Res (Camb) 2021 May 29;10(3):613-626. Epub 2021 May 29.

Laboratório de Neuroendocrinologia e Metabolismo, Departamento de Fisiologia e Farmacologia, Centro de Biociências, Universidade Federal de Pernambuco, Avenida Prof. Moraes Rego, 1235, 50670-901, Recife, Pernambuco, Brasil.

(Fabaceae), known popularly as pata-de-vaca and mororó has been largely recommended treating several diseases in folk medicine. However, information on safe doses and use is still scarce. The goal was to evaluate antioxidant and antihemolytic and also acute and sub-acute toxicity effects of hydroalcoholic extract from leaves (HaEBcl). Read More

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Baseline intracardiac echocardiography predicts haemodynamic changes and Doppler velocity patterns during follow-up after percutaneous pulmonary valve implantation.

Cardiol Young 2021 Jun 18:1-7. Epub 2021 Jun 18.

The Heart Institute, Children's Hospital Colorado, Aurora, Colorado, USA.

Background: Intracardiac echocardiography Doppler-derived gradients have previously been shown to correlate with post-procedure echocardiographic evaluations when compared with invasive gradients measured during percutaneous pulmonary valve implantation, suggesting that intracardiac echocardiography could offer an accurate and predictable starting point to estimate valve function after percutaneous pulmonary valve implantation.

Methods: We performed a retrospective chart review of 51 patients who underwent percutaneous pulmonary valve implantation between September 2018 and December 2019 in whom intracardiac echocardiography was performed immediately after valve implantation. We evaluated the correlation between intracardiac echocardiography gradients and post-procedural Doppler-derived gradients. Read More

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Revascularized Pyelo-Uretero-Cystoplasty in Patients with Chronic Bladder Outlet Obstruction Due to Ectopic Ureterocele: A Safe Surgical Technique with Superior Continence Outcomes.

J Invest Surg 2021 Jun 17:1-8. Epub 2021 Jun 17.

Pediatric Urology and Regenerative Medicine Research Center, Section of Tissue Engineering and Stem Cells Therapy, Children's Hospital Medical Center, Tehran University of Medical Sciences, Tehran, Iran.

Purpose: To present the outcomes of revascularized pyeloureterocystoplasty with ureterocele unroofing in end stage bladder patients with duplex system and ureterocele.

Methods: Thirteen patients with obstruction of intrauterine outlet from an ectopic obstructive ureterocele were included. Fourteen units of duplex systems underwent upper pole partial nephrectomy in conjunction with augmentation revascularized pyeloureterocystoplaty and ureterocele unroofing. Read More

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Outcome Comparison of Latissimus Dorsi Transfer and Pectoralis Major Transfer for Irreparable Subscapularis Tendon Tear: A Systematic Review.

Am J Sports Med 2021 Jun 17:3635465211018216. Epub 2021 Jun 17.

Department of Sports Medicine, Fudan University Huashan Hospital Huashan Hospital, Shanghai, China.

Background: Latissimus dorsi transfer (LDT) and pectoralis major transfer (PMT) were developed to treat an irreparable subscapularis tendon tear (ISScT); however, the difference in their outcomes remains unclear.

Purpose: To systematically review and compare the outcomes of LDT and PMT for ISScT.

Study Design: Systematic review; Level of evidence, 4. Read More

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Losartan modifies mesh integration after abdominal wall repair: an experimental study.

Hernia 2021 Jun 17. Epub 2021 Jun 17.

Department of Surgery, Hospital Alemán of Buenos Aires, Av. Pueyrredón 1640, 1118, Buenos Aires, CP, Argentina.

Purpose: Angiotensin II (AT II) receptor blockers have previously shown to reduce inflammatory response in many settings. We aimed to assess the effects of ATII receptor blocker (Losartan) on mesh integration after abdominal wall repair in a rat model.

Methods: A total of 16 Wistar-Kyoto (WKY) and 16 previously hypertensive (SHRSP) rats were isolated. Read More

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Effect of Subcutaneous Topical Ozone Therapy on Second-Degree Burn Wounds in Rats: An Experimental Study.

J Burn Care Res 2021 Jun 16. Epub 2021 Jun 16.

Baskent University, Department of General Surgery, Ankara, Turkey.

Burns are one of the most severe traumas, causing coagulative destruction of the skin. The use of various products that accelerate wound healing in patients with burns may affect rates of patient survival and reduce complications. We studied the effects of subcutaneous ozone injection on second-degree burn wounds in animal model. Read More

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Phytochemical profiles of lemon verbena ( H.B.K.) and its potential application to cookie enrichment.

Food Sci Nutr 2021 Jun 29;9(6):3100-3113. Epub 2021 Mar 29.

Department of Food Safety and Hygiene School of Public Health Shahid Sadoughi University of Medical Science Yazd Iran.

In this research, phytochemical properties of lemon verbena and oxidative stability of the fat component in cookies (contain lemon verbena powder and EO) were investigated. The essential oil (EO) profile and polyphenol compounds were identified by GC/MS and HPLC, respectively. Different concentrations of lemon verbena powder and EO were added to the cookies in comparison with TBHQ. Read More

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Effects of topical Coenzyme Q10, Xanthan Gum and Sodium Hyaluronate on corneal epithelial wound healing.

Clin Exp Optom 2021 Jun 16:1-7. Epub 2021 Jun 16.

Department of Ophthalmology, Başkent University Faculty of Medicine, Ankara, Turkey.

: Effective treatment of corneal epithelial defects is crucial to prevent secondary infectious keratitis and visual impairment due to loss of corneal transparency. Therefore, it is important to determine the effect of different topical agents on corneal wound healing response.: The aim was to compare the effects of three different eye drops on corneal epithelial wound healing in an experimental model. Read More

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Autologous Osteochondral Transplantation for Young Patients with Postcollapse Osteonecrosis of the Knee: A Retrospective Cohort Study with an Average 7-Year Follow-Up.

Cartilage 2021 Jun 17:19476035211023566. Epub 2021 Jun 17.

Department of Orthopaedic Surgery, Center for Osteonecrosis and Joint Preserving & Reconstruction, China-Japan Friendship Hospital, Beijing, China.

Background: Only a few studies exist that have assessed the efficacy of autologous osteochondral transplantation (AOT) treatment of osteonecrosis (ON) of the knee. The purpose of this study was to clarify the clinical and radiographic results of AOT performed on young patients with postcollapse ON of the knee.

Methods: This retrospective study included 14 young patients (6 men, 8 women, mean age 34. Read More

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Exacerbation of Background Nuclear Cataracts in Sprague-Dawley Rats in Embryo-Fetal Development Studies With JNJ-42165279, a Fatty Acid Amide Hydrolase Inhibitor.

Toxicol Pathol 2021 Jun 15:1926233211010444. Epub 2021 Jun 15.

Janssen Research & Development, LLC, San Diego, CA, USA.

Fetal examinations in embryo-fetal developmental (EFD) studies are based on macroscopic and dissecting microscopic evaluations, and histopathology is rarely performed other than to confirm macroscopic findings. Fetal lens examination is therefore generally limited to the presence, size, shape, and color of any abnormality. In a Sprague-Dawley rat EFD study with the fatty acid amide hydrolase (FAAH) inhibitor JNJ-42165279, an unusually high incidence of macroscopic granular foci was noted within the lens of gestation day 21 fetuses across all groups including controls, with higher incidence in the high-dose group. Read More

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Evaluation of Molly model predictions of ruminal fermentation, nutrient digestion, and performance by dairy cows consuming ryegrass-based diets.

J Dairy Sci 2021 Jun 11. Epub 2021 Jun 11.

Department of Dairy Science, Virginia Polytechnic Institute and State University, Blacksburg 24061. Electronic address:

Several studies have been conducted to improve grazing management and supplementation in pasture-based systems. However, it is necessary to develop tools that integrate the available information linking the representation of biological processes with animal performance for use in decision making. The objective of this study was to evaluate the precision and accuracy of the Molly cow model predictions of ruminal fermentation, nutrient digestion, and animal performance by cows consuming pasture-based diets to identify model strengths and weaknesses, and to derive new digestive parameters when relevant. Read More

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Automated classification of coronary atherosclerotic plaque in optical frequency domain imaging based on deep learning.

Atherosclerosis 2021 Jun 7;328:100-105. Epub 2021 Jun 7.

Division of Cardiology, Department of Medicine II, Kansai Medical University, Hirakata, Japan.

Background And Aims: We developed a deep learning (DL) model for automated atherosclerotic plaque categorization using optical frequency domain imaging (OFDI) and performed quantitative and visual evaluations.

Methods: A total of 1103 histological cross-sections from 45 autopsy hearts were examined to compare the ex vivo OFDI scans. The images were segmented and annotated considering four histological categories: pathological intimal thickening (PIT), fibrous cap atheroma (FA), fibrocalcific plaque (FC), and healed erosion/rupture (HER). Read More

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Evaluation through outbreak simulation exercise points to the need for considerable improvement in the capacity of peripheral health workers for outbreak detection and response, South India, 2018.

J Family Med Prim Care 2021 Apr 29;10(4):1587-1591. Epub 2021 Apr 29.

SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu, India.

Background: Outbreaks are emergencies, requiring skilled peripheral health workers in the health system. Given the lack of evaluation of the knowledge and practices of peripheral health workers regarding outbreak investigation and response, we surveyed to estimate the performance level of health workers in outbreak detection and response.

Methods: We developed a simulation exercise based on hepatitis and fever outbreak to ascertain knowledge and skills in outbreak detection and response. Read More

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Dermoscopic Predictors of Tumor Thickness in Cutaneous Melanoma: A Retrospective Analysis of 245 Melanomas.

Dermatol Pract Concept 2021 May 20;11(3):e2021059. Epub 2021 May 20.

Department of Dermatology, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

Introduction: The literature regarding the association of dermoscopic structures with Breslow thickness in melanoma is scarce, limited to small case series, and mostly outdated.

Objective: This study determined the dermoscopic patterns, colors and structures that are associated with melanoma in situ, thin melanomas (<0.8 mm) and thick melanomas potentially requiring sentinel lymph node biopsy according to current guidelines (≥0. Read More

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Duplication of the Pituitary Gland (DPG)-Plus Syndrome Associated With Midline Anomalies and Precocious Puberty: A Case Report and Review of the Literature.

Front Endocrinol (Lausanne) 2021 26;12:685888. Epub 2021 May 26.

Pediatric Clinic, Department of Medicine and Surgery, University of Parma, Parma, Italy.

Duplication of the pituitary gland (DPG)-plus syndrome is a very rare developmental disorder with few cases described in the literature and characterized by multiple midline and central nervous system malformations. The hypothalamus and hypophysis involvement may be clinically associated with endocrine abnormalities. A 5. Read More

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Distribution of endemic angiosperm species in Brazil on a municipality level.

Biodivers Data J 2021 3;9:e66043. Epub 2021 Jun 3.

Instituto de Pesquisas do Jardim Botânico do Rio de Janeiro, Rio de Janeiro, Brazil Instituto de Pesquisas do Jardim Botânico do Rio de Janeiro Rio de Janeiro Brazil.

Background: Herbarium collections and the data they hold are the main sources of plant biodiversity information. These collections contain taxonomical and spatial data on living and extinct species; consequently, they are the fundamental basis for temporal and spatial biogeographical studies of plants. Mega projects focused on providing digital and free access to accurate biodiversity data have transformed plant science research, mainly in the past two decades. Read More

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