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Treatment components in behavioral versus nondirective telephone-assisted self-help interventions for parents of children with externalizing behavior problems.

J Clin Psychol 2021 Sep 24. Epub 2021 Sep 24.

Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.

Background: The aim of this study was to analyze treatment differentiation in a behavioral and a nondirective telephone-assisted self-help intervention for parents of children with externalizing behavior problems, including the development and evaluation of a rating scale.

Methods: In a randomized controlled trial, 149 parents of children aged 4-11 years with externalizing behavior problems were allocated to a behavioral or a nondirective guided self-help intervention. Parents in both conditions received eight self-help booklets and ten telephone consultations. Read More

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September 2021

Improving quality of PrEP counseling for adolescent girls and young women in Kenya with standardized patient actors: a dose-response analysis.

J Acquir Immune Defic Syndr 2021 Sep 23. Epub 2021 Sep 23.

Department of Global Health, University of Washington, Seattle, WA, USA Department of Epidemiology, University of Washington, Seattle, WA, USA Department of Research and Programs, Kenyatta National Hospital, Nairobi, Kenya Policy Development & Evaluation Unit, Public Health Seattle/King County, Seattle, WA, USA Howard University, Washington, DC, USA Department of Biobehavioral Nursing and Health Informatics, University of Washington, Seattle, WA, USA Department of Biostatistics, University of Washington, Seattle, WA, USA Department of Medicine, University of Washington, Seattle, WA, USA Department of Pediatrics, University of Washington, Seattle, WA, USA Department of Child, Family, and Population Health Nursing, University of Washington, Seattle, WA, USA.

Background: Health care worker (HCW) training using standardized patient actors (SPs) is an evidence-based approach for improving patient-provider interactions. We evaluated whether SP training among HCWs in Western Kenya improved quality of PrEP counseling for adolescent girls and young women (AGYW).

Methods: We conducted a 2-day SP training intervention among HCWs providing PrEP counseling for AGYW. Read More

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September 2021

Application of Various Methods to Evaluate the Postoperative Characteristics of Expanded Pedicled Deltopectoral Flap for Large Facial Scars.

J Craniofac Surg 2021 Sep 22. Epub 2021 Sep 22.

Xijing 986 Hospital Department Department of Plastic and Reconstructive Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, China.

Abstract: The expanded pedicled deltopectoral flap (EPDF) has been widely used to repair large facial scars. Although doctors and patients are usually satisfied with the outcomes, the actual functional recovery and cosmetic effects of EPDF are still unknown. It is, therefore, necessary to objectively investigate the effect of transferred EPDF by using a variety of methods. Read More

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September 2021

Gender differences in prevalence and clinical correlates of anxiety symptoms in first-episode and drug-naïve patients with major depressive disorder.

Compr Psychiatry 2021 Sep 17;111:152275. Epub 2021 Sep 17.

CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China. Electronic address:

Aim: Gender differences in major depressive disorder (MDD) are commonly reported; however, gender differences in first-episode and drug-naïve (FEDN) patients with major depressive disorder remain unclear. This study aimed to examine potential gender differences in the prevalence and clinical correlates of comorbid anxiety in FEDN patients with MDD.

Methods: A cross-sectional study was conducted with1718 FEDN patients with MDD. Read More

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September 2021

Diffusion weighted imaging for evaluation of breast lesions: Comparison between high b-value single-shot and routine readout-segmented sequences at 3 T.

Magn Reson Imaging 2021 Sep 21. Epub 2021 Sep 21.

Department of Medical Imaging, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525GA Nijmegen, the Netherlands; Department of Radiology, the Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066, CX, Amsterdam, the Netherlands.

Purpose: In this study, we compare readout-segmented echo-planar imaging (rs-EPI) Diffusion Weighted Imaging (DWI) to a work-in-progress single-shot EPI with modified Inversion Recovery Background Suppression (ss-EPI-mIRBS) sequence at 3 T using a b-value of 2000 s/mm on image quality, lesion visibility and evaluation time.

Method: From September 2017 to December 2018, 23 women (one case used for training) with known breast cancer were included in this study, after providing signed informed consent. Women were scanned with the conventional rs-EPI sequence and the work-in-progress ss-EPI-mIRBS during the same examination. Read More

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September 2021

Screening for Psychological Distress in Vietnamese Cancer Patients: An Evaluation of the Distress Thermometer.

Cancer Med 2021 Sep 24. Epub 2021 Sep 24.

Vietnam National Cancer Hospital, Hanoi, Vietnam.

Background: Psychological distress is prevalent in patients with cancer, negatively affecting their treatment and quality of life. Clinical guidelines recommended screening all cancer patients routinely for psychological problems using simple measures such as the Distress Thermometer (DT) and Problem List (PL). This study is the first research in Vietnam to identify the optimal DT cutoff point to screen distress and the relationship with PL items among cancer patients. Read More

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September 2021

Comparison of Mid- to Long-term follow-up of Patient-Reported Outcomes Measures after Single-level Lumbar Total Disc Arthroplasty, Multi-level Lumbar Total Disc Arthroplasty, and the Lumbar Hybrid Procedure for the Treatment of Degenerative Disc Disease.

Spine (Phila Pa 1976) 2021 Sep 22. Epub 2021 Sep 22.

Gold Coast Spine, Gold Coast, QLD AUSTRALIA 4229 Faculty of Health Science & Medicine, Bond University, Gold Coast, QLD AUSTRALIA 4229 Department of Orthopaedic Surgery, Cairns Hospital, Cairns North, QLD AUSTRALIA 4870.

Study Design: Prospective Cohort Study.

Objective: The aim of this paper is to compare the mid- to long-term patient-reported outcome measures (PROMs) between single-level total disc arthroplasty (TDA), multi-level TDA, and hybrid constructs (combination of TDA and anterior lumbar interbody fusion (ALIF) across multiple levels) for symptomatic degenerative disc disease (DDD).

Summary Of Background Data: The treatment of single-level DDD is well documented using TDA. Read More

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September 2021

Prospective adverse event risk evaluation in clinical trials.

Health Care Manag Sci 2021 Sep 24. Epub 2021 Sep 24.

Department of Industrial, Manufacturing and Systems Engineering, Texas Tech University, Lubbock, TX, USA.

Proactive and objective regulatory risk management of ongoing clinical trials is limited, especially when it involves the safety of the trial. We seek to prospectively evaluate the risk of facing adverse outcomes from standardized and routinely collected protocol data. We conducted a retrospective cohort study of 2860 Phase 2 and Phase 3 trials that were started and completed between 1993 and 2017 and documented in ClinicalTrials. Read More

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September 2021

Clinical performance of rheumatoid arthritis impact of disease score: a real-life evidence from the multicenter nationwide registry BioStaR.

Rheumatol Int 2021 Sep 24. Epub 2021 Sep 24.

Rheumatology Clinic, Aydin State Hospital, Aydın, Turkey.

The rheumatoid arthritis impact of disease (RAID) score was developed as a patient-derived composite response index for the evaluation of the disease impact on cases with rheumatoid arthritis (RA). The aim of this study was to evaluate the psychometric properties and performance of RAID score in the real-life settings. Cases with RA from our multi-center, nationwide registry called Biologic and targeted Synthetic antirheumatic drugs Registry RA (BioStaR RA) were included in this cross-sectional observational study. Read More

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September 2021

Discordance in Patient and Physician Global Assessment in Relapsing Polychondritis.

Rheumatology (Oxford) 2021 Sep 24. Epub 2021 Sep 24.

Systemic Autoimmunity Branch, National Institutes of Health, NIAMS, Bethesda, MD, USA.

Objectives: Relapsing polychondritis (RP) is a rare, heterogeneous, systemic inflammatory disease that targets cartilage. Patient-reported outcome measures may differ from physician assessment. This study compared patient global assessment (PtGA) and physician global assessment (PhGA) scores in a prospective cohort of patients with RP. Read More

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September 2021

Subcutaneous golimumab induced and maintained clinical response in a child with a biological-experienced steroid-refractory flare of ulcerative colitis: A case report.

Medicine (Baltimore) 2021 Sep;100(38):e27283

Gastroenterology Department, Damascus Hospital, Damascus, Syria.

Introduction: Golimumab is a fully human antitumor necrosis monoclonal antibody that can be administered by either subcutaneous injection or intravenous infusion. Golimumab is approved for the treatment of the adults with rheumatic diseases, and ulcerative colitis, Whereas in children, golimumab is indicated only for the treatment of active polyarticular juvenile idiopathic arthritis. We have written on the off-label use of subcutaneous golimumab, which helped to induce and maintain remission on a low-weight biologically experienced child with steroid-refractory ulcerative colitis flare. Read More

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September 2021

Afterload-related cardiac performance predicts prognosis in critical ill patients with sepsis: A prospective observational pilot study.

Medicine (Baltimore) 2021 Sep;100(38):e27235

Department of Intensive Care Unit, The Fourth Hospital of Hebei Medical University, 12 Jiankang Road, Shijiazhuang, People's Republic of China.

Abstract: To investigate the usefulness of afterload-related cardiac performance (ACP) for assessing cardiac impairment and predicting prognosis in septic patients.Adult patients with sepsis in the intensive care unit were included. Cardiac output, cardiac index, cardiac power index, and ACP were calculated at the time of admission (D0) and 48-72 h after admission (D3). Read More

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September 2021

Chinese herbal medicine for mild cognitive impairment using mini-mental state examination: A systematic review and meta-analysis.

Medicine (Baltimore) 2021 Sep;100(38):e27034

Shaanxi University of Traditional Chinese Medicine, Xianyang, Shaanxi Province, China.

Introduction: The prevalence of mild cognitive impairment (MCI) in the elderly population aged 60 to 84 years ranges from 6.7% to 25.2%, and the effective prevention and reversal of MCI progression to Alzheimer disease (AD) is crucial. Read More

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September 2021

Introducing clinical pharmacy specialists into interprofessional primary care teams: Assessing pharmacists' team integration and access to care for rural patients.

Medicine (Baltimore) 2021 Sep;100(38):e26689

Center for Healthcare Organization and Implementation Research, VA Bedford Healthcare System, Bedford, MA.

Abstract: Clinical pharmacy specialists (CPS) were deployed nationally to improve care access and relieve provider burden in primary care.The aim of this study was to assess CPS integration in primary care and the Clinical Pharmacy Specialist Rural Veteran Access (CRVA) initiative's effectiveness in improving access.Concurrent embedded mixed-methods evaluation of participating CRVA CPS and their clinical team members (primary care providers, others). Read More

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September 2021

Comparative life cycle assessment of aerobic treatment units and constructed wetlands as onsite wastewater treatment systems in Australia.

Water Sci Technol 2021 Sep;84(6):1527-1540

School of Engineering and Built Environment, Griffith University, Nathan, QLD 4111 Australia E-mail:

Life Cycle Assessment was used to evaluate onsite wastewater treatment systems (OWTS): aerobic treatment unit (ATU) with reinforced concrete (C.ATU) and HDPE (H.ATU) tank; and constructed wetland (CW) with three biochar concentrations in the substrate (0%; 10, and 20% v:v), dubbed CW. Read More

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September 2021

The Effects of Lifestyle Intervention Using the Modified Beliefs, Attitude, Subjective Norms, Enabling Factors Model in Hypertension Management: Quasi-Experimental Study.

JMIR Cardio 2021 Sep 24;5(2):e20297. Epub 2021 Sep 24.

Université du Québec à Montréal, Montréal, QC, Canada.

Background: Hypertension is a serious health issue and a significant risk factor for cardiovascular disease and stroke. Although various health education models have been used to improve lifestyle in patients with hypertension, the findings have been inconsistent.

Objective: This study aims to assess the effects of a lifestyle intervention program using a modified Beliefs, Attitude, Subjective Norms, Enabling Factors (BASNEF) model among nonadherent participants with hypertension in managing elevated blood pressure (BP) levels. Read More

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September 2021

Role of auricular laser acupuncture and psychological counseling in reducing nicotine dependence due to smoking: A randomized controlled trial.

Indian J Public Health 2021 Jul-Sep;65(3):243-249

Professor and Head, Department of Public Health Dentistry, Dayanand Sagar College of Dental Sciences, Bengaluru, Karnataka, India.

Background: Low level laser therapy is a novel noninvasive technology used to stimulate the acupoints recognized for tobacco cessation.

Objective: To compare the effect of laser auricular acupuncture, psychological counseling, and combination of laser acupuncture and psychological counseling in reducing nicotine dependence due to smoking.

Methods: Smokers (n = 150) fulfilling the eligibility criteria were randomly allocated to three interventional groups. Read More

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September 2021

One-stop preoperative assessment of renal vessels for living donors with 3.0 T non-contrast-enhanced magnetic resonance angiography: compared with computerized tomography angiography and surgical results.

Br J Radiol 2021 Sep 24:20210589. Epub 2021 Sep 24.

Department of Radiology, Tianjin First Center Hospital, Tianjin, China.

Objective: The study was to investigate the feasibility and accuracy of assessment for living renal donors before transplantation by using 3.0 T non-contrast-enhanced magnetic resonance angiography (NCE-MRA).

Methods: Thirty renal donors were investigated and underwent computed tomography angiography (CTA) and 3. Read More

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September 2021

Effects of multimedia-based fall prevention education on the knowledge, attitudes, or behaviors of patients.

Jpn J Nurs Sci 2021 Sep 24:e12455. Epub 2021 Sep 24.

Health Evaluation Center, St. Martin De Porres Hospital, Chiayi City, Taiwan.

Objectives: Patient safety is regarded as a critical quality monitoring indicator for medical institutions. The effects of a multimedia-based patient education intervention on knowledge, attitudes, and behaviors regarding fall prevention were observed.

Methods: The study had a quasi-experimental research design and enrolled 140 participants. Read More

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September 2021

A Useful Approach to I-Shaped Crooked Nose Correction: Cross-Spreader Graft Technique.

Aesthetic Plast Surg 2021 Sep 23. Epub 2021 Sep 23.

Department of Otolaryngology, Faculty of Medicine, Bozok University, Atatürk Yolu 7. Km, 66100, Yozgat, Turkey.

Objectives: Correction of crooked nose with long-term functional and aesthetic success remains a great challenge for rhinoplasty surgeons. The aim of this study was to present the aesthetic and functional results of the cross-spreader graft technique applied for the correction of I-shaped crooked nose.

Methods: A retrospective examination was made of 25 patients applied with open technique rhinoplasty using cross-spreader graft for the correction of I-shaped crooked nose between March 2016 and June 2019. Read More

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September 2021

Impaired hand function and performance in activities of daily living in systemic lupus erythematosus, even in patients achieving lupus low disease activity state (LLDAS).

Rheumatol Adv Pract 2021 5;5(2):rkab029. Epub 2021 May 5.

First Department of Propaedeutic Internal Medicine, Joint Rheumatology Program, Medical School, National and Kapodistrian University of Athens, Athens.

Objective: The aim was to examine hand function and performance in activities of daily living (ADL) in patients with SLE healthy controls, and any associations with demographic and disease-related characteristics.

Methods: Hand function (grip strength, pinch strength and dexterity) and ADL performance were evaluated in 240 patients with SLE and 122 age- and biological sex-matched healthy controls. Grip strength, pinch strength and dexterity were measured by Jamar dynamometer, pinch gauge and Purdue pegboard test, respectively. Read More

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Social Behavior Observer Checklist: Patterns of Spontaneous Behaviors Differentiate Patients With Neurodegenerative Disease From Healthy Older Adults.

Front Neurol 2021 7;12:683162. Epub 2021 Sep 7.

Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, United States.

Neurodegenerative disease syndromes often affect personality and interpersonal behavior in addition to cognition, but there are few structured observational measures of altered social demeanor validated for this population. We developed the Social Behavior Observer Checklist (SBOCL), a 3-min checklist tool, to facilitate identification of patterns of interpersonal behavior that are diagnostically relevant to different neurodegenerative syndromes. Research assistants without formal clinical training in dementia used the SBOCL to describe participants' behavior, including 125 healthy older adults and 357 patients diagnosed with one of five neurodegenerative disease syndromes: 135 behavioral variant frontotemporal dementia (bvFTD), 57 semantic variant primary progressive aphasia (svPPA), 51 non-fluent variant PPA (nfvPPA), 65 progressive supranuclear palsy (PSP), and 49 amyloid-positive Alzheimer's disease syndrome (AD), all of whom had concurrent 3D T1 MRI scans available for voxel-based morphometry analysis. Read More

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September 2021

Memory Deficit in Patients With Temporal Lobe Epilepsy: Evidence From Eye Tracking Technology.

Front Neurosci 2021 7;15:716476. Epub 2021 Sep 7.

Key Laboratory of Spectral Imaging Technology, Xi'an Institute of Optics and Precision Mechanics of the Chinese Academy of Sciences, Xi'an, China.

To explore quantitative measurements of the visual attention and neuroelectrophysiological relevance of memory deficits in temporal lobe epilepsy (TLE) by eye tracking and electroencephalography (EEG). Thirty-four TLE patients and twenty-eight healthy controls were invited to complete neurobehavioral assessments, cognitive oculomotor tasks, and 24-h video EEG (VEEG) recordings using an automated computer-based memory assessment platform with an eye tracker. Visit counts, visit time, and time of first fixation on areas of interest (AOIs) were recorded and analyzed in combination with interictal epileptic discharge (IED) characteristics from the bilateral temporal lobes. Read More

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September 2021

Teaching the Neurologic Examination: A Prospective, Controlled Study to Compare a Blended Learning Approach With Face-to-Face Instruction.

Neurology 2021 Sep 23. Epub 2021 Sep 23.

Clinic of Neurology and Neurophysiology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.

Objective: To compare a blended learning approach with traditional face-to-face instruction in terms of their individual effectiveness in imparting neurological examination (NE) skills in medical students.

Methods: We conducted a prospective controlled study of 4-year medical students (n=163) who were pseudo-randomly distributed into two groups. Group A (n=87) was subjected to a traditional teaching method comprising two face-to-face sessions. Read More

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September 2021

Fractal analysis and periapical index evaluation of multivisit nonsurgical endodontic retreatment: A retrospective study.

Oral Surg Oral Med Oral Pathol Oral Radiol 2021 Aug 30. Epub 2021 Aug 30.

Assistant Professor, Department of Oral and Maxillofacial Radiology, Faculty of Dentistry, Pamukkale University, Denizli, Turkey.

Objective: This retrospective study compared changes in periapical trabecular patterns using fractal analysis and the periapical index (PAI) on the periapical radiographs of patients who underwent multivisit nonsurgical endodontic retreatment of persistent periapical disease.

Study Design: In total, 50 participants were included in the study. For each patient, baseline periapical radiographs were acquired just before retreatment and postoperative radiographs were acquired 1 year later. Read More

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Machine Learning Identifies Clinical Parameters to Predict Mortality in Patients Undergoing Transcatheter Mitral Valve Repair.

JACC Cardiovasc Interv 2021 Sep;14(18):2027-2036

Department of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany. Electronic address:

Objectives: The aim of this study was to develop a machine learning (ML)-based risk stratification tool for 1-year mortality in transcatheter mitral valve repair (TMVR) patients incorporating metabolic and hemodynamic parameters.

Background: The lack of appropriate, well-validated, and specific means to risk-stratify patients with mitral regurgitation complicates the evaluation of prognostic benefits of TMVR in clinical trials and practice.

Methods: A total of 1,009 TMVR patients from 3 university hospitals within the Heart Failure Network Rhineland were included; 1 hospital (n = 317) served as external validation. Read More

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September 2021

Health questionnaire on back care knowledge and spine disease prevention for 6-10 years old children: development and psychometric evaluation.

BMC Musculoskelet Disord 2021 Sep 23;22(1):820. Epub 2021 Sep 23.

Faculty of Health Sciences, University of Pécs, Institute of Physiotherapy and Sport Science, Vörösmarty street 4, Pécs, 7621, Hungary.

Background: Back school programs, that improve back care and spine disease prevention knowledge are recommended at the age of 4-14 years. There is Health Questionnaire on Back Care Knowledge in the literature for children aged 14-17 years. At other ages, there is no questionnaire examining this knowledge. Read More

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September 2021

Evaluation of the Quality of Safety and Health Services with SERVPERF and Multi-Attribute Decision-Making Methods.

Int J Occup Saf Ergon 2021 Sep 24:1-0. Epub 2021 Sep 24.

Yildiz Technical University, Department of Industrial Engineering, Istanbul, Turkey,

Evaluating the quality of Occupational Safety and Health (OSH) services by experts is essential for both employee health and workplace productivity. In this study, first, the quality of OSH services is evaluated with a questionnaire by using the SERVPERF method. Then, the questionnaire prepared according to the Analytic Hierarchy Process (AHP) method is applied to the OSH experts and the relative importance of the main dimensions and items in the SERVPERF method are determined. Read More

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September 2021

Perioperative Aspirin Use is Associated with Bleeding Complications During Robotic Partial Nephrectomy.

J Urol 2021 Sep 23:101097JU0000000000002240. Epub 2021 Sep 23.

Beth Israel Deaconess Medical Center, Boston, Massachusetts.

Introduction And Objective: Daily aspirin use following cardiovascular intervention is commonplace and creates concern regarding bleeding risk in patients undergoing surgery. Despite its cardio-protective role, aspirin is often discontinued 5-7 days prior to major surgery due to bleeding concerns. Single institution studies have investigated perioperative outcomes of aspirin use in robotic partial nephrectomy (RPN). Read More

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September 2021