Cancer Sci 2021 May 8. Epub 2021 May 8.
Faculty of Human Culture and Science, Department of Health Sciences, Prefectural University of Hiroshima, 1-1-71 Ujinahigashi, Minami-ku, Hiroshima, Japan.
Macrophages are an essential component of antitumor activity; however, the role of tumor-associated macrophages (TAMs) in colorectal cancer (CRC) remains controversial. Here, we elucidated the role of TAMs in CRC progression, especially at the early stage. We assessed the TAM number, phenotype, and distribution in 53 patients with colorectal neoplasia, including intramucosal neoplasia, submucosal invasive colorectal cancer (SM-CRC), and advanced cancer, using double immunofluorescence for CD68 and CD163. Read More