107,938 results match your criteria evaluated serum

Clinical And Hemodynamic Outcomes Of Rapid-Deployment Aortic Bioprostheses.

Semin Thorac Cardiovasc Surg 2021 May 9. Epub 2021 May 9.

Division of Cardiac Surgery, University of Padova, Padova, Italy.

Aim of this retrospective, multicenter study was to evaluate early and mid-term clinical and hemodynamic results of patients who underwent surgical aortic valve replacement (SAVR) with Intuity rapid-deployment bioprostheses (RDB) (Edwards Lifesciences, Irvine, CA). We analyzed data from the Italian Registry of Intuity Valve (INTU-ITA registry) that is a national, real-world and independent from the industry registry. Preoperative variables were defined according to EuroSCORE and postoperative outcomes according to Valve Academic Research Consortium (VARC). Read More

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Antioxidants resveratrol and SkQ1 attenuate praziquantel adverse effects on the liver in Opisthorchis felineus infected hamsters.

Acta Trop 2021 May 9:105954. Epub 2021 May 9.

Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, 10 Lavrentiev Ave., Novosibirsk 630090, Russia; Department of Natural Sciences, Novosibirsk State University, 2 Pirogova Str., Novosibirsk 630090, Russia; Institute of Molecular Biology and Biophysics, 2/12, Timakov Str., Novosibirsk, 630117, Russia. Electronic address:

Anthelmintic praziquantel (PZQ) is the drug of the choice for opisthorchiasis, schistosomiasis and other trematodiases therapy for several decades. Despite its good therapeutic performance and effective control of trematode infections, PZQ has some shortcomings; its inability to counteract disease sequelae necessitates novel therapeutic strategies. Testing of antioxidants that have proven themselves in clinical practice, in combination with this anthelmintic drug, offers new opportunities for developing alternatives to PZQ monotherapy. Read More

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The influence on oxidative stress markers, inflammatory factors and intestinal injury-related molecules in Wahui pigeon induced by lipopolysaccharide.

PLoS One 2021 12;16(5):e0251462. Epub 2021 May 12.

College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, 330045, Jiangxi, China.

Introduction: The intestinal structure is the foundation for various activities and functions in poultry. An important question concerns the changes in the intestinal status under endotoxin stimulation. This study aimed to investigate the mechanism of intestinal injury induced by lipopolysaccharide (LPS) in Wahui pigeons. Read More

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SGLT2 inhibitors improve plasma atherogenic biomarkers in patients with type 2 diabetes: a real world retrospective observational study.

Minerva Endocrinol (Torino) 2021 May 12. Epub 2021 May 12.

Endocrinology and Metabolism, Marmara University School of Medicine, Istanbul, Turkey -

Introduction: There are cost-effective, non-invasive, and predictive tools used to predict the CVD risk in patients with diabetes such as the "atherogenic index of plasma (AIP)" which is defined as the logarithm to the base 10 of the ratio of fasting plasma TG (mg/dL) to HDL-C [log (TG/HDL-C)], triglyceride to high density lipoprotein (TG-to-HDL-C) ratio and the triglyceride glucose (TyG) index which is calculated as Ln (fasting TG (mg/dL) × fasting blood glucose (mg/dL)/2). These tools are indirect markers of atherosclerosis. Dapagliflozin and empagliflozin have exhibited cardiovascular beneficial effects and this study evaluated the effects of sodium glucose cotransporter 2 inhibitors (SGLT2i) on AIP, TyG index and TG-to-HDL-C ratio in patients with type 2 diabetes. Read More

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IgG4-related disease in pediatric patients: a single-center experience.

Rheumatol Int 2021 May 12. Epub 2021 May 12.

Department of Pediatric Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey.

Objective: Immunoglobulin G4-related disease (IgG4-RD) is a systemic, immune-mediated, and fibroinflammatory disease that can affect almost any organ system. We aimed to present our single-center experience of pediatric patients with IgG4-RD, a rare disease in children.

Methods: Pediatric patients diagnosed with IgG4-RD at the Hacettepe University between June 2014 and September 2020 were evaluated retrospectively. Read More

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Predictive Value of Small Dense Low-Density Lipoprotein in Coronary Heart Disease in the Chinese Population.

Clin Lab 2021 May;67(5)

Background: Coronary heart disease (CHD) is a global public health concern, and CHD risk assessment remains a major challenge. Therefore, in this study, the ability of small dense low-density lipoprotein (sdLDL) alone to sufficiently predict CHD risk in the Chinese population was evaluated.

Methods: Patients with CHD (139) and healthy controls (58) were included in this study. Read More

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Efficacy of Ayurvedic treatment protocol in gouty arthritis - a clinical study.

J Complement Integr Med 2021 May 11. Epub 2021 May 11.

Department of Kayachikitsa, Amrita School of Ayurveda, Amritapuri, Amrita Vishwa Vidyapeetham, Kollam, India.

Objectives: Gout is an inflammatory response to the Monosodium urate crystals formed secondary to hyperuricaemia. The prevalence of gout has increased in recent years. The current conventional medical management aims at symptomatic management. Read More

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Production of polyclonal antibody against the recombinant PirB protein of Vibrio parahaemolyticus.

J Genet Eng Biotechnol 2021 May 11;19(1):70. Epub 2021 May 11.

University of Science, 227 Nguyen Van Cu Street, Ward 4, District 5, Ho Chi Minh City, Vietnam.

Background: Acute hepatopancreatic necrosis disease (AHPND) is caused by toxin-producing strains of Vibrio parahaemolyticus which contain deadly binary toxins PirA and PirB encoded in pVA1 plasmid. The polyclonal antibodies against PirB protein could be used to develop immunochromatographic test strip for in-field diagnosis of AHPND.

Results: In this study, PirB gene was amplified, cloned, and expressed in E. Read More

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Combining Serum DNA Methylation Biomarkers and Protein Tumor Markers Improved Clinical Sensitivity for Early Detection of Colorectal Cancer.

Int J Genomics 2021 21;2021:6613987. Epub 2021 Apr 21.

Department of Clinical Laboratory, Nanjing Integrated Traditional Chinese and Western Medicine Hospital, Nanjing, Jiangsu 210014, China.

Background: Colorectal cancer (CRC) is one of the leading causes of cancer deaths worldwide and in China. Early CRC screening is the best approach to reduce its incidence and mortality rates. The ColoDefense test, a multiplex qPCR assay simultaneously detecting both methylated and genes, has demonstrated improved clinical performance on either methylation biomarker alone for CRC screening with both blood and stool samples. Read More

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Association between transient appetite loss and vitamin B1 deficiency in elderly patients with suspected deficiency.

J Gen Fam Med 2021 May 17;22(3):128-133. Epub 2020 Nov 17.

Internal Medicine Unnan City Hospital Unnan Japan.

Background: There is scarce evidence associating vitamin B1 levels and appetite loss duration in elderly patients with suspected B1 deficiency. We aimed to investigate this association in elderly hospitalized patients with suspected vitamin B1 deficiency in rural Japan.

Methods: This cross-sectional study evaluated 309 elderly patients (aged ≥ 65 years) admitted to one rural Hospital between April 2017 and March 2019. Read More

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Erectile function in SRY positive 46,XX males with normal phenotype.

Cent European J Urol 2021 11;74(1):95-98. Epub 2021 Mar 11.

Ufuk University Faculty of Medicine, Department of Obtetrics and Gynecology, Ankara, Turkey.

Introduction: The 46,XX male syndrome is a rare disorder of sex development and has two different forms, depending on the sex-determining region's presence on the Y chromosome (SRY) gene. The SRY positive 46,XX males are usually diagnosed during infertility workup. We evaluated the erectile function of 46,XX SRY positive males and compared it with healthy males. Read More

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Effects of Transcutaneous Electrical Acupoint Stimulation on Postoperative Cognitive Decline in Elderly Patients: A Pilot Study.

Clin Interv Aging 2021 3;16:757-765. Epub 2021 May 3.

Department of Anesthesiology, The Third Hospital of Hebei Medical University, Shijiazhuang City, Hebei, People's Republic of China.

Background: Postoperative cognitive decline (POCD) in the old ages seriously delays the rapid recovery. Here, we aimed to investigate the effects of transcutaneous electrical acupoint stimulation (TEAS) against POCD in elderly patients undergoing laparoscopic radical colon cancer surgery, as well as the potential mechanism.

Methods: A prospective, single-center, parallel-group, randomized trial was designed. Read More

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Protective Effects of Silymarin Against D-Gal/LPS-Induced Organ Damage and Inflammation in Mice.

Drug Des Devel Ther 2021 4;15:1903-1914. Epub 2021 May 4.

Chongqing Collaborative Innovation Center for Functional Food, Chongqing University of Education, Chongqing, 400067, People's Republic of China.

Aim: Silymarin contains various flavonoids and exhibits antioxidative, anti-inflammatory, and anticancer effects, in addition to other pharmacological properties. This study explored the alleviating effect of silymarin on multiple-organ damage induced by D-galactose/lipopolysaccharide in Kunming mice.

Methods: Kunming mice were injected intraperitoneally with D-galactose (30 mg/kg·BW)/LPS (3 μg/kg·BW) and then treated using silymarin with different doses (75 mg/kg·bw and 150 mg/kg·bw) via intragastric administration. Read More

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Distinguishing active from quiescent disease in ANCA-associated vasculitis using attenuated total reflection Fourier-transform infrared spectroscopy.

Sci Rep 2021 May 11;11(1):9981. Epub 2021 May 11.

Biocel UK Ltd, Hull, UK.

The current lack of a reliable biomarker of disease activity in anti-neutrophil cytoplasmic autoantibody (ANCA) associated vasculitis poses a significant clinical unmet need when determining relapsing or persisting disease. In this study, we demonstrate for the first time that attenuated total reflection Fourier-transform infrared (ATR-FTIR) spectroscopy offers a novel and functional candidate biomarker, distinguishing active from quiescent disease with a high degree of accuracy. Paired blood and urine samples were collected within a single UK centre from patients with active disease, disease remission, disease controls and healthy controls. Read More

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Sex and body mass index dependent associations between serum 25-hydroxyvitamin D and pulse pressure in middle-aged and older US adults.

Sci Rep 2021 May 11;11(1):9989. Epub 2021 May 11.

Department of Preventive Medicine, Gachon University College of Medicine, 155 Gaetbeol-ro, Yeonsu-gu, Incheon, 21999, Republic of Korea.

High pulse pressure (PP) is a valid indicator of arterial stiffness. Many studies have reported that vitamin D concentration is inversely associated with vascular stiffening. This association may differ depending on sex and body mass index (BMI). Read More

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Efficacy of flash glucose monitoring in pregnant women with poorly controlled pregestational diabetes (FlashMom): A randomized pilot study.

Nutr Metab Cardiovasc Dis 2021 Mar 24. Epub 2021 Mar 24.

Department of Clinical and Experimental Medicine, Endocrinology Section, University of Catania Medical School, Catania, Italy.

Background And Aims: Good glycemic control is crucial to reduce the risk of adverse pregnancy outcomes. Our aim was to evaluate the efficacy of Flash Glucose Monitoring (FGM) on glucose control in women with pregestational diabetes.

Methods And Results: Forty women with inadequately controlled type 1 (T1D, n = 34) and type 2 (T2D, n = 6) diabetes at conception were randomly assigned to two arms: the Flash Glucose group (FG, n = 21) using FGM, and the control group (CG, n = 19) using self-monitoring of blood glucose (SMBG). Read More

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Clinical significance of heart rate variability for the monitoring of cardiac autonomic neuropathy in end-stage renal disease patients.

Nutr Metab Cardiovasc Dis 2021 Mar 26. Epub 2021 Mar 26.

Division of Nephrology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea. Electronic address:

Background And Aims: The aim of this study is to determine whether the measurement of continuous heart rate variability (HRV) is useful in the evaluation of cardiac autonomic neuropathy (CAN) in end-stage renal disease (ESRD) patients.

Methods And Results: This cross-sectional study was performed at Seoul St. Mary's hospital between June 2017 and February 2018. Read More

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Determination of ultra-trace levels of titanium in human serum using inductively coupled plasma tandem mass spectrometry based on O/H reaction gas.

Anal Chim Acta 2021 Jun 24;1165:338564. Epub 2021 Apr 24.

Hunan Academy of Chinese Medicine, Hunan University of Chinese Medicine, Changsha, 410013, PR China.

This study proposes a new strategy to determine ultra-trace Ti in human serum using inductively coupled plasma tandem mass spectrometry (ICP-MS/MS). The human serum samples were diluted with 1% (v/v) HNO, followed by the determination of ultra-trace Ti using ICP-MS/MS. In the MS/MS mode, a small amount of H was mixed with O (the reaction gas) in a collision reaction cell (CRC) to form an O/H reaction mixture, and then, the conversion of Ti to TiO was determined by the O mass shift method. Read More

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Hsa Circ 001839 Promoted Inflammation in Renal Ischemia-Reperfusion Injury Through NLRP3 by miR-432-3p.

Nephron 2021 May 11:1-13. Epub 2021 May 11.

College of Sports, Southwest Medical University, Luzhou, China.

Background: In recent years, increasing discovery of the extremely important regulatory effects of circular RNAs on biological development, angiogenesis, tumor genesis, and development, as well as stem cell proliferation and differentiation has provided new opportunities for investigating regulation mechanism in angiogenesis.

Objectives: This study explored the expression of circ 001839 in renal ischemia-reperfusion injury (RI-RI) rats and whether its upstream microRNA-432-3p (miR-432-3p) affects inflammation in both RI-RI rats and NRK52E cells.

Methods: Rat model of RI-RI was made, and circ 001839 was identified by the gene-chip analysis in RI-RI rats. Read More

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Assessing the role of a tissue-based assay in the diagnostic algorithm of autoimmune encephalitis.

J Neuroimmunol 2021 Apr 30;356:577601. Epub 2021 Apr 30.

Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, Rome, Italy; UOC Neurologia, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy. Electronic address:

Tissue-based assay (TBA) is a widely-used method to detect neural autoantibodies, but the diagnostic accuracy for autoimmune encephalitis (AE) has not yet been adequately measured. We retrospectively evaluated the sensitivity and specificity of an indirect immunofluorescence TBA (IIF-TBA) in 159 patients with suspected AE. Serum and cerebrospinal fluid (CSF) specimens were collected and tested from December 2012 to September 2020. Read More

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Effects of Bacillus Coagulans on growth performance, antioxidant capacity, immunity function, and gut health in broilers.

Poult Sci 2021 Mar 27;100(6):101168. Epub 2021 Mar 27.

Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, Zhejiang Provincial Engineering Laboratory for Animal Health and Internet Technology, College of Animal Science and Technology, Zhejiang Agriculture & Forestry University, Hangzhou 311300, China. Electronic address:

This study evaluated the effects of Bacillus coagulans (B. coagulans) as an alternative to antibiotics on growth performance, antioxidant capacity, immunity function and gut health in broilers. A total of 480 one-day-old broilers were randomly divided into 3 treatments with 8 replicates comprising 20 broilers each. Read More

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Comparative evaluation of single or combined anticoccidials on performance, antioxidant status, immune response, and intestinal architecture of broiler chickens challenged with mixed Eimeria species.

Poult Sci 2021 Mar 26;100(6):101162. Epub 2021 Mar 26.

Biological Applications Department, Nuclear Research Center, Egyptian Atomic Energy Authority, Abu-Zaabal 13759, Egypt. Electronic address:

Poultry production faces several threats and challenges, one of the most important of which is avian coccidiosis which causes annual losses exceeding US$ 3 billion. Discovering new drugs or combinations of existing anticoccidials has become inevitable to overcome the emergence of coccidiosis resistance. This study evaluated a new combination of maduramicin and diclazuril in comparison to the well-known product Maxiban72 which consisted of narasin and nicarbazin, and the single effect of monensin as treatments for avian coccidiosis. Read More

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Analysis of the diagnostic and prognostic value of miR-9-5p in carotid artery stenosis.

Bosn J Basic Med Sci 2021 Apr 19. Epub 2021 Apr 19.

Department of Neurosurgery, Zhucheng People's Hospital, Weifang, China.

More and more evidence shows that microRNAs (miRNAs) play an important role in the diagnosis and prognosis of human diseases. In this study, we investigated the diagnostic value of miR-9-5p for asymptomatic carotid artery stenosis (CAS) and its predictive value for future cerebrovascular events within 5 years. A total of 88 asymptomatic CAS patients and 86 healthy individuals were recruited. Read More

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Extrapolation and dosing recommendations for raxibacumab in children from birth to < 18 years of age.

Br J Clin Pharmacol 2021 May 11. Epub 2021 May 11.

Clinical Pharmacology and Therapeutics Group, University College London, UK.

Aim: The US Food and Drug Administration's Animal Rule allows for the approval of drugs when human efficacy studies are not ethical. While the therapeutic doses of raxibacumab, a monoclonal antibody for the prophylaxis and treatment of inhalational anthrax, have been based on pharmacokinetic data from adult subjects, its disposition in children has not been evaluated in clinical trials. Here we evaluate the effect of demographic covariates on the pharmacokinetic disposition of raxibacumab and explore opportunities for the optimization of the paediatric doses. Read More

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Utility of remission criteria for the renal prognosis of IgA nephropathy.

Clin Exp Nephrol 2021 May 11. Epub 2021 May 11.

Department of Nephrology, Juntendo University Faculty of Medicine, Hongo 2-1-1, Bunkyo-Ku, Tokyo, 113-8421, Japan.

Background: Novel criteria for the remission of Immunoglobulin A nephropathy (IgAN) based on an opinion survey of Japanese nephrologists and literature review were proposed in 2013. This single-center, longitudinal retrospective cohort study was conducted to validate this criteria.

Methods: Present study included the IgAN patients diagnosed between 2001 and 2005 in the Juntendo University Hospital. Read More

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Bone marrow adiposity in premenopausal women with type 2 diabetes with observations on peri-trabecular adipocytes.

J Clin Endocrinol Metab 2021 May 11. Epub 2021 May 11.

Endocrine Division (SEMPR), Department of Internal Medicine, Federal University of Parana, Curitiba, Brazil.

Context: No study has evaluated the relationships among of bone marrow adiposity(BMA), bone histomorphometry(BH) and glycemic control in premenopausal women with type 2 diabetes(T2DM).

Objectives: Assess the effect of glycemic control on BMA;correlate the parameters of BH with BMA and correlate BMA with the use of hypoglycemic agents and with BMD.

Design, Settings And Patients: This was a cross-sectional study that evaluated 26 premenopausal women with T2DM were divided into groups with HbA1c<7% (GC,n=10) and HbA1c>7% (PC,n=16). Read More

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Levels of angiotensin-converting enzyme 1 and 2 in serum and urine of children with Sickle Cell Disease.

J Bras Nefrol 2021 May 3. Epub 2021 May 3.

Universidade Federal de São Paulo, Escola Paulista de Medicina, Departamento de Pediatria, Disciplina de Hematologia, São Paulo, SP, Brasil.

Introduction: Sickle cell nephropathy begins in childhood and presents early increases in glomerular filtration, which, over the long term, can lead to chronic renal failure. Several diseases have increased circulating and urinary angiotensin-converting enzyme (ACE) activity, but there is little information about changes in ACEs activity in children with sickle cell disease (SCD).

Objective: We examined circulating and urinary ACE 1 activity in children with SCD. Read More

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Preoperative CT for Characterization of Aggressive Macrotrabecular-Massive Subtype and Vessels That Encapsulate Tumor Clusters Pattern in Hepatocellular Carcinoma.

Radiology 2021 May 11:203614. Epub 2021 May 11.

From the Departments of Radiology (Z.F., H.L., H.Z., Y.J., Q.L., W.W., P.R.) and Pathology (Q.C.), The Third Xiangya Hospital of Central South University, No. 138 Tongzipo Road, Changsha 410013, China.

Background Macrotrabecular-massive (MTM) subtype and vessels encapsulating tumor clusters (VETC) pattern of hepatocellular carcinoma (HCC) are associated with unfavorable prognosis. Purpose To estimate the potential of preoperative CT in the prediction of MTM subtype and VETC pattern. Materials and Methods Patients who underwent surgical resection or liver transplant and preoperative CT for HCC between January 2015 and June 2018 were retrospectively included in the primary cohort. Read More

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Bisphenol A decreases expression of insulin-like factor 3 and induces histopathological changes in testes of rat.

Toxicol Ind Health 2021 May 11:7482337211014097. Epub 2021 May 11.

Department of Histology and Embryology, Faculty of Medicine, Cukurova University, Adana, Turkey.

Bisphenol A (BPA) is a chemical agent known to have detrimental reproductive and developmental effects. The tissue-specific impacts of BPA exposures and target tissues sensitiveness to BPA are still unclear. The aim of this study was to determine the short- and long-term dose-dependent toxic effects of BPA on rat testes. Read More

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An independent indicator of erectile dysfunction is C-reactive protein/albumin ratio.

Andrologia 2021 May 10:e14073. Epub 2021 May 10.

Department of Urology, Van Training and Research Hospital, Edremit, Turkey.

Research has found that, instead of passive lipid-accumulated vascular damage, atherosclerosis which is the primary cause of erectile dysfunction (ED) can be seen as an active inflammatory cycle and that inflammation has a central role in the entire atherosclerotic process. As an inflammatory marker, serum C-reactive protein (CRP)/albumin ratio (CAR) may link to ED and ED severity. The CAR, demographic features and other criteria of 198 patients with ED who visited our outpatient clinic during March 2019-April 2020 were prospectively evaluated. Read More

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