Menopause 2021 Jul 26. Epub 2021 Jul 26.
Department of Obstetrics and Gynecology, Biostatistics and Epidemiology, Family and Preventive Medicine University of Oklahoma Health Sciences Center, Oklahoma City, OK Statistical Research Associate, Fred Hutchinson Cancer Research Center, Seattle, WA Department of Medicine, David Geffen School of Medicine at the University of California at Los Angeles, Los Angeles, CA Department of Family Medicine, University of California San Diego School of Medicine, La Jolla, CA The North American Menopause Society Emeritus, Cleveland, OH Barbra Streisand Women's Heart Center, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA.
Objective: Using data from the Women's Health Initiative Observational Study (WHI-OS), to determine the role of estrogen formulation, dose, route of delivery, and its combination with different progestogens on the risk for hypertension in the WHI-OS.
Methods: After excluding women with diagnosed hypertension, receiving antihypertensive medication, presenting with elevated blood pressure ( ≥ 140/90), and those not taking menopausal hormone therapy at baseline, 19,986 women remained eligible for the analyses. Using hierarchal modeling, proportional hazard rate calculation, and linear and logistic regression analyses, we evaluated incident treated hypertension and mean systolic and diastolic blood pressure changes at 3 years. Read More