251,544 results match your criteria evaluated risk


Second trimester prediction of gestational diabetes: maternal analytes as an additional screening tool.

J Perinat Med 2021 Jul 27. Epub 2021 Jul 27.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Hawaii, Honolulu, HI, USA.

Objectives: Early diagnosis of gestational diabetes can lead to greater optimization of glucose control. We evaluated associations between maternal serum analytes (alpha-fetoprotein [AFP], free beta-human chorionic gonadotropin [beta-hCG], inhibin, and estriol) and the development of gestational diabetes mellitus (GDM).

Methods: This retrospective cohort study identified single-ton pregnancies with available second trimester serum analytes between 2009 and 2017. Read More

View Article and Full-Text PDF

Comparative Safety and Efficacy of Therapeutic Options in Resectable and Advanced/Metastatic Pancreatic Cancer: A Systematic Review and Indirect Comparison.

Oncol Res Treat 2021 Jul 27:1-9. Epub 2021 Jul 27.

Department of Pharmacotherapy, College of Pharmacy, University of Utah, Salt Lake City, Utah, USA.

Objectives: FOLFIRINOX, gemcitabine/nab-paclitaxel (gem-nab/P), and gemcitabine-capecitabine (gem-cap) demonstrated superiority over gemcitabine monotherapy for pancreatic cancer (PC). It is still unclear which chemotherapy regimen is the most optimal. This study aimed to conduct a systematic review (SR) and indirect comparison to compare safety and efficacy of FOLFIRINOX versus gem-nab/P and gem-cap in PC. Read More

View Article and Full-Text PDF

The Risk Factors and Clinical Outcomes Associated with Acute Kidney Injury in Patients with COVID-19: Data from a Large Cohort in Iran.

Kidney Blood Press Res 2021 Jul 27:1-9. Epub 2021 Jul 27.

Department of Nephrology Diseases, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Introduction: Kidney involvement, ranging from mild hematuria and proteinuria to acute kidney injury (AKI) in patients with coronavirus disease-2019 (COVID-19), is a recent finding with various incidence rates reported among hospitalized patients with COVID-19. Given the various AKI rates and their associated risk factors, lack of AKI recovery in the majority of patients hospitalized with COVID-19, and limited data regarding AKI in patients with COVID-19 in Iran, we aim to investigate the potential risk factors for AKI development and its incidence in patients hospitalized with COVID-19.

Methods: In this retrospective cohort study, we enrolled adult patients referred to the Sina Hospital, Iran, from February 20 to May 14, 2020, with either a positive PCR test or a highly susceptible chest computed tomography features consistent with COVID-19 diagnosis. Read More

View Article and Full-Text PDF

Highly efficient removal of DEET by UV-LED irradiation in the presence of iron-containing coagulant.

Chemosphere 2021 Jul 20;286(Pt 1):131613. Epub 2021 Jul 20.

School of Environmental Science and Engineering, Suzhou University of Science and Technology, Suzhou, 215009, China.

N,N-Diethyl-3-methyl benzoyl amide (DEET) has been detected as an emerging pollutant in various water bodies because of its widespread use as an insect repellent. In this study, the combination of UV-LED and iron-containing coagulant (FeCl) was used for the elimination of DEET in water. It was found that UV-LED/FeCl (98 %) system presented a favorable removal of DEET compared with UV/FeCl (59 %) and UV-LED/Fe(SO) (81 %) processes at initial pH 3. Read More

View Article and Full-Text PDF

Mild cognitive impairment and abnormal brain metabolic expression in idiopathic REM sleep behavior disorder.

Parkinsonism Relat Disord 2021 Jul 22;90:1-7. Epub 2021 Jul 22.

Department of Neurology and Movement Disorder Center, Parkinson Study Group, Neuroscience Research Institute, College of Medicine, Seoul National University Hospital, Seoul, 03080, Republic of Korea. Electronic address:

Background: Mild cognitive impairment (MCI) is a common feature of isolated rapid-eye-movement sleep behavior disorder (iRBD). Here, we assessed cognitive functions and MCI in a prospective iRBD cohort and investigated their association with disease-specific brain metabolic patterns.

Methods: Forty-four patients with polysomnography-confirmed iRBD performed a standardized battery of neuropsychological examinations every two years. Read More

View Article and Full-Text PDF

Single and ternary competitive adsorption-desorption and degradation of amphenicol antibiotics in three agricultural soils.

J Environ Manage 2021 Jul 24;297:113366. Epub 2021 Jul 24.

National Reference Laboratory of Veterinary Drug Residues (HZAU) and MOA Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, Hubei, 430070, China; MOA Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products, Hubei, 430070, China; National Laboratory for Veterinary Drug Safety Evaluation, Huazhong Agriculture University, Wuhan, 430070, China; College of Veterinary Medicine, Huazhong Agriculture University, Wuhan, 430070, China. Electronic address:

The widespread usage of veterinary antibiotics results in antibiotic contamination and increases environmental risks. This study was evaluated the single and ternary competitive adsorption-desorption and degradation of three amphenicol antibiotics (AMs): chloramphenicol (CAP), thiamphenicol (TAP), and florfenicol (FF) in three agricultural soils. The adsorption capacity of amphenicol antibiotics in the soil was weak, and the K value was in the range of 0. Read More

View Article and Full-Text PDF

Effect of physical activity and BMI SDS on bone metabolism in children and adolescents.

Bone 2021 Jul 24:116131. Epub 2021 Jul 24.

Department of Pediatric Surgery, University Hospital Leipzig, Leipzig, Germany. Electronic address:

Objective: Children with obesity are known to have reduced bone density and are at a higher risk for fractures. This may be caused by decreased physical activity or a metabolic phenomenon. In this study, we evaluated associations of physical activity with bone metabolism in children and adolescents with and without obesity. Read More

View Article and Full-Text PDF

Effect and feasibility of wearable physical activity trackers and pedometers for increasing physical activity and improving health outcomes in cancer survivors: A systematic review and meta-analysis.

J Sport Health Sci 2021 Jul 24. Epub 2021 Jul 24.

Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia.

Background: The purpose of this systematic review and meta-analysis was to evaluate the effect of wearable devices for improving physical activity and health-related outcomes in cancer survivors.

Methods: CINAHL, Cochrane, Ebscohost, MEDLINE, Pubmed, ProQuest Health and Medical Complete, ProQuest Nursing and Allied Health Source, ScienceDirect, and SPORTDiscus databases were searched for randomized controlled trials published before September 1, 2020, that evaluated interventions involving wearable devices in cancer survivors. Standardized mean differences (SMDs) were calculated to assess effects on physical activity and health-related outcomes. Read More

View Article and Full-Text PDF

Machine learning analysis of multispectral imaging and clinical risk factors to predict amputation wound healing.

J Vasc Surg 2021 Jul 24. Epub 2021 Jul 24.

Baylor Scott & White The Heart Hospital; Plano, TX. Electronic address:

Objective: Prediction of amputation wound healing is challenging due to the multifactorial nature of critical limb ischemia and lack of objective assessment tools. Up to one-third of amputations require revision to a more proximal level within one year. We tested a novel wound imaging system to predict amputation wound healing at initial evaluation. Read More

View Article and Full-Text PDF

Comparing visual inspection and performance observation for evaluation of hospital cleanliness.

Am J Infect Control 2021 Jul 24. Epub 2021 Jul 24.

Infection Control Center, Taichung Veterans General Hospital, Taichung, Taiwan. Electronic address:

Background: Environmental cleaning is an effective measure to prevent infections. However, performance observation has been rarely delineated. This study aimed to compare correlations among visual inspection, performance observation and effectiveness by using adenosine triphosphate bioluminescence (ATP bioluminescence) as a comparator to find out which method is better to assess hospital cleanliness. Read More

View Article and Full-Text PDF

Aging-related severe hypertension induces detrusor underactivity in rats.

Life Sci 2021 Jul 24:119855. Epub 2021 Jul 24.

Department of Pharmacology, Kochi Medical School, Kochi University, Nankoku, Japan. Electronic address:

Aims: Aging is an obvious risk factor for detrusor underactivity. We investigated the effects of aging on bladder function in spontaneously hypertensive rats.

Main Methods: Male spontaneously hypertensive rats and Wistar Kyoto rats (used as normotensive controls) at the ages of 18, 36, 54, or 72 weeks were used. Read More

View Article and Full-Text PDF

Epidemiology of Idiopathic Pulmonary Fibrosis Among U.S. Veterans, 2010 - 2019.

Ann Am Thorac Soc 2021 Jul 27. Epub 2021 Jul 27.

San Francisco VA Medical Center, 19980, San Francisco, California, United States.

Rationale: The development of novel therapies for idiopathic pulmonary fibrosis (IPF) has brought increased attention to the population burden of disease. However, little is known about the epidemiology of IPF among United States Veterans.

Objectives: This study examines temporal trends in incidence and prevalence, patient characteristics, and risk factors associated with IPF among a national cohort of United States Veterans. Read More

View Article and Full-Text PDF

Rivaroxaban for Extended Thromboprophylaxis in Acutely Ill Medical Patients 75 Years of Age or Older.

J Thromb Haemost 2021 Jul 27. Epub 2021 Jul 27.

The Feinstein Institute for Medical Research and Zucker School of Medicine at Hofstra/Northwell, Department of Medicine, Anticoagulation and Clinical Thrombosis Services Northwell Health at Lenox Hill Hospital, New York, NY, USA.

Background: Although older patients are at increased risk for venous thromboembolism (VTE), thromboprophylaxis is underutilized because of bleeding concerns. The MARINER trial evaluated whether rivaroxaban reduced symptomatic post-discharge VTE in acutely ill medical patients. We hypothesized that rivaroxaban would have a favorable benefit/risk profile in patients ≥75 years of age. Read More

View Article and Full-Text PDF

Adverse COVID-19 Outcomes in Immune Deficiencies; Inequality Exists Between Subclasses.

Allergy 2021 Jul 27. Epub 2021 Jul 27.

Faculty of Medicine, Division of Pediatric Allergy-Immunology, Marmara University, Istanbul, Turkey.

Background: Genetic deficiencies of immune system, referred to as inborn errors of immunity (IEI), serve as a valuable model to study human immune responses. In a multicenter prospective cohort, we evaluated the outcome of SARS-CoV-2 infection among IEI subjects and analyzed genetic and immune characteristics that determine adverse COVID-19 outcomes.

Materials And Methods: We studied 34 IEI patients (19M/15F, 12 (min:0. Read More

View Article and Full-Text PDF

Characterizing the Chemical Profile of Incidental Ultrafine Particles for Toxicity Assessment Using an Aerosol Concentrator.

Ann Work Expo Health 2021 Jul 27. Epub 2021 Jul 27.

ITC, Castellón, Spain.

Incidental ultrafine particles (UFPs) constitute a key pollutant in industrial workplaces. However, characterizing their chemical properties for exposure and toxicity assessments still remains a challenge. In this work, the performance of an aerosol concentrator (Versatile Aerosol Concentration Enrichment System, VACES) was assessed to simultaneously sample UFPs on filter substrates (for chemical analysis) and as liquid suspensions (for toxicity assessment), in a high UFP concentration scenario. Read More

View Article and Full-Text PDF

Evaluation of Unscheduled Return Visits to the Pediatric Emergency Department and Risk Factors for Admission After Return Visit.

Pediatr Emerg Care 2021 Jul 27. Epub 2021 Jul 27.

From the Division of Pediatric Emergency Medicine, Ankara Child Health and Diseases Hematology Oncology Training and Research Hospital, University of Health Sciences Division of Pediatric Emergency Medicine, Hacettepe University Faculty of Medicine Department of Pediatrics, Ankara Child Health and Diseases Hematology Oncology Training and Research Hospital, University of Health Sciences, Ankara, Turkey.

Objective: Unscheduled return visits to the emergency department (unscheduled RTED) increase both the workload and overcrowding in the emergency department. The aim in the present study is to identify the patient groups that require more careful and closer follow-up to reduce the rates of unscheduled RTED and hospital admissions after a return visit.

Methods: Among the patients admitted to the emergency department of our hospital between 2016 and 2017, those who made an unscheduled RTED within 72 hours after their first visit to the emergency department were evaluated retrospectively. Read More

View Article and Full-Text PDF

Exercise improves cardiorespiratory fitness but not arterial health after spinal cord injury: The CHOICES trial.

J Neurotrauma 2021 Jul 27. Epub 2021 Jul 27.

The University of British Columbia International Collaboration on Repair Discoveries, 507272, Vancouver, British Columbia, Canada.

Arterial stiffness, as measured by carotid-femoral pulse wave velocity (cfPWV), is elevated after spinal cord injury (SCI). In the uninjured population, exercise training has been shown to reduce arterial stiffness. In a randomized, clinical multicenter trial, we evaluated the impact of two exercise interventions on cardiovascular disease risk factors in individuals with chronic SCI. Read More

View Article and Full-Text PDF

Ecotoxicological Effects of Bimetallic PdNi/MWCNT and PdCu/MWCNT Nanoparticles onto DNA Damage and Oxidative Stress in Earthworms.

Biol Trace Elem Res 2021 Jul 27. Epub 2021 Jul 27.

Department of Medical Services and Techniques, Tuzluca Vocational School, University of Igdır, Igdır, Turkey.

Bimetallic nanoparticles are synthesized using two different metal elements and used recently in many fields. However, limited studies related to the ecotoxic effects of nanoparticles available in the literature. The purpose of this study is to synthesize and characterize bimetallic PdCu/MWCNT and PdNi/MWCNT NPs and investigate their ecotoxic effects on earthworms. Read More

View Article and Full-Text PDF

Association between rs3088440 (G > A) polymorphism at 9p21.3 locus with the occurrence and severity of coronary artery disease in an Iranian population.

Mol Biol Rep 2021 Jul 27. Epub 2021 Jul 27.

Department of Pathology and Laboratory Medicine, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.

Background: Several genome-wide association studies showed that a series of genetic variants located at the chromosome 9p21 locus are strongly associated with coronary artery disease (CAD).

Rationale And Purpose Of The Study: In the present study, the relationship of rs3088440 (G > A) in cyclin-dependent kinase inhibitor 2A (CDKN2A) gene site with the presence of coronary artery disease (CAD) and its severity was evaluated in an Iranian population.

Methods And Results: The presence of rs3088440 (G > A) genotypes was assessed by polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP) technique in 324 CAD patients and 148 normal controls. Read More

View Article and Full-Text PDF

Risk stratification of anastomotic leakage using eGFR and FIB-4 index in patients undergoing esophageal cancer surgery.

Langenbecks Arch Surg 2021 Jul 27. Epub 2021 Jul 27.

Department of Gastrointestinal Surgery, Jikei University School of Medicine, 3-25-8 Nishishimbashi, Minato-ku, Tokyo, 105-8461, Japan.

Purpose: Renal insufficiency and liver cirrhosis are identified as independent risk factors for anastomotic leakage (AL) after esophagectomy. However, research evaluating the incidence of AL using quantitative data to measure renal function and liver fibrosis remain to be limited. Therefore, this study was conducted to evaluate postoperative AL after esophagectomy using estimated glomerular filtration rate (eGFR) and fibrosis-4 (FIB-4) index. Read More

View Article and Full-Text PDF

Associations Between Human Milk Oligosaccharides at One Month and Infant Development Throughout the First Year of Life in a Brazilian Cohort.

J Nutr 2021 Jul 27. Epub 2021 Jul 27.

Nutritional Epidemiology Observatory, Josué de Castro Nutrition Institute, Rio de Janeiro Federal University. Avenida Carlos Chagas Filho 373/CCS, bloco J, 2º andar, sala 29. Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ, 21941-902, Brazil.

Background: Human milk oligosaccharides (HMOs) are unconjugated glycans associated with infant health and development.

Objective: To investigate the associations between HMO concentrations at one month and infant development throughout the first year of life.

Methods: A prospective cohort of Brazilian women between 18-40 years of age and their infants was studied from baseline (between 28-35 gestational weeks) and followed at one (n = 73), six (n = 51), and twelve months (n = 45). Read More

View Article and Full-Text PDF

Neurite Imaging Reveals Widespread Alterations in Gray and White Matter Neurite Morphology in Healthy Aging and Amnestic Mild Cognitive Impairment.

Cereb Cortex 2021 Jul 27. Epub 2021 Jul 27.

Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94304, USA.

Aging is the major risk factor for neurodegenerative diseases and affects neurite distributions throughout the brain, yet underlying neurobiological mechanisms remain unclear. Multi-shell diffusion-weighted imaging and neurite orientation dispersion and density imaging (NODDI) now provide in vivo biophysical measurements that explain these biological processes in the cortex and white matter. In this study, neurite distributions were evaluated in the cortex and white matter in healthy older adults and patients with amnestic mild cognitive impairment (aMCI) that provides fundamental contributions regarding healthy aging and neurodegeneration. Read More

View Article and Full-Text PDF

Digital chest radiography enhances screening efficiency for pulmonary tuberculosis in primary health clinics, South Africa.

Clin Infect Dis 2021 Jul 27. Epub 2021 Jul 27.

The Aurum Institute, Johannesburg, South Africa.

Background: Optimized tuberculosis (TB) screening in high burden settings is essential for case finding. We evaluated digital chest x-ray with computer-aided detection (CAD) software (d-CXR) for identifying undiagnosed TB in three primary health clinics in South Africa.

Methods: The cross-sectional study consented adults who were sequentially screened for TB using the World Health Organization (WHO) four symptom questionnaire and d-CXR. Read More

View Article and Full-Text PDF

Association of lifestyle factors with osteoporosis and fracture in postmenopausal women: a Japanese cohort study.

Menopause 2021 Jul 26. Epub 2021 Jul 26.

Department of Psychosomatic Medicine, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka-shi, Fukuoka, Japan Department of Psychosomatic Medicine, International University of Health and Welfare Narita Hospital, Narita City, Chiba, Japan Department of General Internal Medicine, Kyushu University Hospital, Fukuoka-shi, Fukuoka, Japan Taihaku Avenue Clinic, Hakata-ku, Fukuoka, Japan.

Objective: Osteoporosis is a major risk factor for fracture later in life; however, few studies have examined the association of lifestyle factors with osteoporosis and fracture. This study aimed to identify factors associated with osteoporosis and fracture in postmenopausal women.

Methods: We evaluated the association between baseline characteristics and outcomes (diagnosis of osteoporosis or incidence of fracture) in 4,427 postmenopausal women who participated in the Kyushu University Fukuoka Cohort Study on lifestyle-related diseases (baseline: February 2004 to August 2007; follow-up: February 2010 to December 2012). Read More

View Article and Full-Text PDF

Hormone therapy formulation, dose, route of delivery, and risk of hypertension: findings from the Women's Health Initiative Observational Study (WHI-OS).

Menopause 2021 Jul 26. Epub 2021 Jul 26.

Department of Obstetrics and Gynecology, Biostatistics and Epidemiology, Family and Preventive Medicine University of Oklahoma Health Sciences Center, Oklahoma City, OK Statistical Research Associate, Fred Hutchinson Cancer Research Center, Seattle, WA Department of Medicine, David Geffen School of Medicine at the University of California at Los Angeles, Los Angeles, CA Department of Family Medicine, University of California San Diego School of Medicine, La Jolla, CA The North American Menopause Society Emeritus, Cleveland, OH Barbra Streisand Women's Heart Center, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA.

Objective: Using data from the Women's Health Initiative Observational Study (WHI-OS), to determine the role of estrogen formulation, dose, route of delivery, and its combination with different progestogens on the risk for hypertension in the WHI-OS.

Methods: After excluding women with diagnosed hypertension, receiving antihypertensive medication, presenting with elevated blood pressure ( ≥ 140/90), and those not taking menopausal hormone therapy at baseline, 19,986 women remained eligible for the analyses. Using hierarchal modeling, proportional hazard rate calculation, and linear and logistic regression analyses, we evaluated incident treated hypertension and mean systolic and diastolic blood pressure changes at 3 years. Read More

View Article and Full-Text PDF

Comparative venous thromboembolic safety of oral and transdermal postmenopausal hormone therapies among women Veterans.

Menopause 2021 Jul 26. Epub 2021 Jul 26.

Division of Angiology and Hemostasis, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland Seattle Epidemiologic Research and Information Center, Department of Veterans Affairs Office of Research and Development, Seattle, WA Department of Epidemiology, University of Washington, Seattle, WA Department of Medicine, University of Washington, Seattle, WA Kaiser Permanente Washington Health Research Institute, Seattle, WA Department of Health Systems Science, Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, CA Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.

Objective: Hormone therapy (HT) is used by menopausal women to treat vasomotor symptoms. Venous thromboembolism (VTE) is an important risk of HT use, and more knowledge on the comparative safety of different estrogenic compounds is useful for women who use HT for these symptoms. The objective was to compare the risk of VTE among users of oral conjugated equine estrogen (CEE), oral estradiol (E2), and transdermal E2, in a cohort of women veterans. Read More

View Article and Full-Text PDF

No Associations Between Regular Use of Proton Pump Inhibitors and Risk of All-Cause and Cause-Specific Mortality: A Population-Based Cohort of 0.44 Million Participants.

Am J Gastroenterol 2021 Jul 27. Epub 2021 Jul 27.

Big Data Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, China.

Introduction: The association between proton pump inhibitors' (PPIs) use and mortality remains unclear.

Methods: This was a prospective analysis of 440,840 UK residents and 13,154 deaths. We evaluated the associations with multivariate Cox regression. Read More

View Article and Full-Text PDF

Effectiveness of eHealth Interventions in Improving Medication Adherence for Patients With Chronic Obstructive Pulmonary Disease or Asthma: Systematic Review.

J Med Internet Res 2021 Jul 27;23(7):e29475. Epub 2021 Jul 27.

Department of Clinical, Neuro- and Developmental Psychology, Vrije Universiteit, Amsterdam, Netherlands.

Background: Poor treatment adherence in patients with chronic obstructive pulmonary disease (COPD) or asthma is a global public health concern with severe consequences in terms of patient health and societal costs. A potentially promising tool for addressing poor compliance is eHealth.

Objective: This review investigates the effects of eHealth interventions on medication adherence in patients with COPD or asthma. Read More

View Article and Full-Text PDF

Management of patients with asymptomatic carotid stenosis may need to be individualized: a multidisciplinary call for action.

Int Angiol 2021 Jul 27. Epub 2021 Jul 27.

Department of Neurology & Stroke Program, University of Maryland School of Medicine, Baltimore, MD, USA.

The optimal management of patients with asymptomatic carotid stenosis (ACS) is the subject of extensive debate. According to the 2017 European Society for Vascular Surgery guidelines, carotid endarterectomy should (Class IIa; Level of Evidence: B) or carotid artery stenting may be considered (Class IIb; Level of Evidence: B) in the presence of one or more clinical/imaging characteristics that may be associated with an increased risk of late ipsilateral stroke (e.g. Read More

View Article and Full-Text PDF