19,371 results match your criteria evaluated possibility

No Detectable Alteration of Inorganic Allogeneic Bone Matrix Colonizing Mesenchymal Cells: A Step Towards Personalized Bone Grafts.

J Bone Metab 2021 May 31;28(2):161-169. Epub 2021 May 31.

Université Clermont Auvergne, CHU Clermont-Ferrand, GECOM, CRB Auvergne, Clermont-Ferrand, France.

Background: During major bone substance loss, secured allogeneic bone matrix (ABM) is normally utilized for bone repair. Here, we propose a method to colonize ABM using autologous mesenchymal cells (MCs) to improve their integration. Moreover, in this study, the consequences of in vitro colonization on MCs have been evaluated. Read More

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Influence of current and previous smoking on current phenotype in Parkinson's disease.

J Neurol Sci 2021 Jun 8;427:117534. Epub 2021 Jun 8.

Department of Clinical Neuroscience and Therapeutics, Hiroshima University, Graduate School of Biomedical and Health Sciences, Hiroshima, Japan; Epilepsy Center, Hiroshima University Hospital, Hiroshima, Japan.

Introduction: Although an inverse correlation between smoking and Parkinson's disease (PD) has been reported, research into the effect of smoking on current clinical progression remains limited for PD patients. Elucidation of a specific PD population who would benefit from smoking is challenging.

Methods: We evaluated 110 consecutive PD patients (mean age; 71. Read More

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Feature engineering and machine learning for causality assessment in pharmacovigilance: Lessons learned from application to the FDA Adverse Event Reporting System.

Comput Biol Med 2021 Jun 8;135:104517. Epub 2021 Jun 8.

The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine Baltimore, MD, USA. Electronic address:

Background: Our objective was to support the automated classification of Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) reports for their usefulness in assessing the possibility of a causal relationship between a drug product and an adverse event.

Method: We used a data set of 326 redacted FAERS reports that was previously annotated using a modified version of the World Health Organization-Uppsala Monitoring Centre criteria for drug causality assessment by a group of SEs at the FDA and supported a similar study on the classification of reports using supervised machine learning and text engineering methods. We explored many potential features, including the incorporation of natural language processing on report text and information from external data sources, for supervised learning and developed models for predicting the classification status of reports. Read More

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Evaluation of efficacy and safety of combined rosuvastatin and atorvastatin in treating with coronary heart disease: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 Jun;100(24):e26340

Department of Hematology, the Affiliated Hospital of Qinghai University, Xining, Qinghai.

Background: Globally, coronary heart disease (CHD) is a primary cause of morbidity leading to disabilities and mortality. Modern clinical practice adopts several pharmacological methods to treat CHD. Angina pectoris refers to sever chest pain due to CHD, it has a profound impact on the wellbeing of patients. Read More

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Upregulation of antigen presentation function and inflammation in chondrocytes by induction of proteoglycan aggrecan peptides (P16-31 and P263-280).

Clin Exp Rheumatol 2021 Jun 8. Epub 2021 Jun 8.

Immunology Division, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, and Skeletal Disorders Research Unit, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand.

Objectives: A central hallmark of osteoarthritis (OA) is cartilage destruction. Chondrocytes not only control cartilage metabolism, but are capable of immunogenic responses. The role of chondrocytes in the pathogenesis of OA is still unclear. Read More

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RNAi of a Putative Grapevine Susceptibility Gene as a Possible Downy Mildew Control Strategy.

Front Plant Sci 2021 28;12:667319. Epub 2021 May 28.

Dipartimento di Scienze Agrarie ed Ambientali, Università degli Studi di Milano, Milan, Italy.

Downy mildew, caused by the oomycete , is one of the diseases causing the most severe economic losses to grapevine () production. To date, the application of fungicides is the most efficient method to control the pathogen and the implementation of novel and sustainable disease control methods is a major challenge. RNA interference (RNAi) represents a novel biotechnological tool with a great potential for controlling fungal pathogens. Read More

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Long-Term Deutetrabenazine Treatment Is Associated With Continued Improvement in Tardive Dyskinesia in the Completed 3-Year Open-Label Extension Study.

CNS Spectr 2021 Apr;26(2):162

Georgetown University, Washington, DC, USA.

Background: The 12-week ARM-TD and AIM-TD studies in tardive dyskinesia (TD) patients showed statistically significant improvements in TD symptoms with deutetrabenazine. The completed open-label extension (OLE) study (SD-809-C-20) evaluated long-term efficacy and safety of deutetrabenazine in TD.

Methods: Patients who completed ARM-TD or AIM-TD enrolled in the OLE study, with deutetrabenazine dose titrated based on dyskinesia control and tolerability. Read More

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Evaluation of Computer-Aided Nodule Assessment and Risk Yield (CANARY) in Korean patients for prediction of invasiveness of ground-glass opacity nodule.

PLoS One 2021 14;16(6):e0253204. Epub 2021 Jun 14.

Department of Thoracic and Cardiovascular Surgery, Yonsei University College of Medicine, Seoul, Korea.

Differentiating the invasiveness of ground-glass nodules (GGN) is clinically important, and several institutions have attempted to develop their own solutions by using computed tomography images. The purpose of this study is to evaluate Computer-Aided Analysis of Risk Yield (CANARY), a validated virtual biopsy and risk-stratification machine-learning tool for lung adenocarcinomas, in a Korean patient population. To this end, a total of 380 GGNs from 360 patients who underwent pulmonary resection in a single institution were reviewed. Read More

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Exploring the electronic states of the hydroxyl dication OH: thermodynamic (meta)stability, bound-free emission spectra, and charge transfer processes.

Phys Chem Chem Phys 2021 Jun 14. Epub 2021 Jun 14.

Universidade de São Paulo, Instituto de Química, Departamento de Química Fundamental, Av. Prof. Lineu Prestes, 748, São Paulo, São Paulo, 05508-000, Brazil.

Accurate potential energy curves were constructed for a manifold of electronic states of the hydroxyl dication using a highly correlated electronic structure approach (SA-CASSCF/MRCI+Q/aug-cc-pV5Z). The existence of a bound (meta)stable ground state and bound low-lying states for OH2+ are ruled out, but do not exclude the possibility of its transient formation and dissociation along the repulsive ground state potential energy curve. Our results do not support the conclusion reported for the observation of OH2+ by electron ionization from ground state OH+. Read More

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Metabolite Profiling of Pig Seminal Plasma Identifies Potential Biomarkers for Sperm Resilience to Liquid Preservation.

Front Cell Dev Biol 2021 28;9:669974. Epub 2021 May 28.

Biotechnology of Animal and Human Reproduction (TechnoSperm), Institute of Food and Agricultural Technology, University of Girona, Girona, Spain.

Metabolomic approaches allow the study of downstream gene expression events since metabolites are considered as the products of cell signaling pathways. For this reason, many studies in humans have already been conducted to determine the influence of the metabolites present in seminal plasma (SP) on sperm physiology, and to identify putative biomarkers. However, in livestock species, these relationships are yet to be uncovered. Read More

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Sézary Syndrome with CD4/CD8 Double-Negative Neoplastic T Cells in Peripheral Blood.

Case Rep Hematol 2021 1;2021:5527725. Epub 2021 Jun 1.

Department of Hematology, Yokkaichi Municipal Hospital, 2-2-37 Shibata, Yokkaichi 510-8567, Japan.

Sézary syndrome is a rare leukemic type of cutaneous T-cell lymphoma characterized by the presence of neoplastic T cells with cerebriform nuclei (Sézary cells) in the skin, lymph nodes, and peripheral blood. Typical Sézary cells have a CD3CD4CD8 phenotype; however, in cases of the aberrant loss of antigens on Sézary cells, especially the loss of critically important T-cell antigens such as CD4, there is a possibility of misdiagnosing the disease or underestimating the tumor burden of the disease. Here, we report a rare case of Sézary syndrome with CD4/CD8 double-negative Sézary cells in the peripheral blood. Read More

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Two-year weight trajectories following completion of a behavioral weight loss maintenance intervention.

Obes Sci Pract 2021 Jun 6;7(3):321-325. Epub 2021 Mar 6.

Center for Health Services Research in Primary Care Durham VA Health Care System Durham North Carolina USA.

Introduction: Long-term effects of behavioral weight loss maintenance interventions need to be assessed in order to understand their durability of effects. This can be evaluated with the use of weights recorded in the electronic medical record. The goal of this study was to use electronic health record (EHR)-recorded weight to examine outcomes 2 years beyond the completion of a trial in which participants were randomized to receive a weight maintenance intervention or usual care after required initial weight loss. Read More

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Scalable Bio Marker Combinations for Early Stroke Diagnosis: A Systematic Review.

Front Neurol 2021 28;12:638693. Epub 2021 May 28.

The Clinical Hospital of Chengdu Brain Sciences Institute, University Electronic Sciences and Technology of China UESTC, Chengdu, China.

Acute stroke treatment is a time-critical process in which every minute counts. Laboratory biomarkers are needed to aid clinical decisions in the diagnosis. Although imaging is critical for this process, these biomarkers may provide additional information to distinguish actual stroke from its mimics and monitor patient condition and the effect of potential neuroprotective strategies. Read More

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Incidence of Olfactory Dysfunction and Associated Factors: A Nationwide Cohort Study From South Korea.

Ear Nose Throat J 2021 Jun 12:1455613211012906. Epub 2021 Jun 12.

Department of Otorhinolaryngology, National Health Insurance Service Ilsan Hospital, Goyang, South Korea.

Objectives: Olfactory dysfunction, a reduced or complete loss of the ability to smell, is gaining attention because of its substantial impact on an individual's quality of life and the possibility that it is an important sign of underlying disease. However, olfactory dysfunction is underdiagnosed in the general population due to diagnostic difficulty and unpredictable prognosis. This study aimed to evaluate the prevalence of clinically diagnosed olfactory dysfunction in South Korea by using well-organized, nationwide, population-based cohort data, and the associations between olfactory dysfunction and risk of neurodegenerative disorders. Read More

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Low seroprevalence of SARS-CoV-2 antibodies in a liver transplant cohort.

Transpl Int 2021 Jun 14. Epub 2021 Jun 14.

Liver Unit. Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute (VHIR). Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain.

Solid organ transplant recipients might be at greater risk for acquisition and mortality due to SARS-CoV-2. There is no data regarding SARS-CoV-2 seroprevalence among liver transplant (LT) recipients, and whether it is different from that of the general population or other immunosuppressed groups. We evaluated the prevalence of IgG SARS-CoV-2 antibodies among LT recipients to estimate the frequency of asymptomatic SARS-CoV-2 infection using serological assays in our outpatient clinic. Read More

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Distinct Contribution of Hyperbaric Oxygen Therapy to Human Neutrophil Function and Antibiotic Efficacy against Staphylococcus aureus.

APMIS 2021 Jun 12. Epub 2021 Jun 12.

Department of Clinical Microbiology, Rigshospitalet, 2200, Copenhagen Ø, Denmark.

Staphylococcus aureus (SA) causes superficial and severe endovascular infections. The present in vitro study investigates the anti-SA mechanisms of hyperbaric oxygen therapy (HBOT) on direct bacterial killing, antibiotic potentiation and polymorphonuclear leukocyte (PMN) enhancement. SA was exposed to isolated human PMNs, tobramycin, ciprofloxacin or benzylpenicillin. Read More

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Influence of loneliness and social isolation on the diagnosis and treatment of Japanese patients with advanced lung cancer: a prospective cohort study.

Ann Palliat Med 2021 Jun 2. Epub 2021 Jun 2.

Center for Innovative Research for Communities and Clinical Excellence, Fukushima Medical University, Fukushima, Fukushima, Japan; Department of General Internal Medicine, Fukushima Medical University, Fukushima, Fukushima, Japan.

Background: Social determinants of health (SDHs) are social factors that affect human health; loneliness and social isolation are core SDH factors. There is a possibility that SDHs are related to passive decisionmaking. However, few studies have evaluated SDHs, especially social isolation and loneliness, among lung cancer patients. Read More

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The effectiveness of preoperative stoma site marking on patient outcomes: A systematic review and meta-analysis.

J Adv Nurs 2021 Jun 12. Epub 2021 Jun 12.

Department of Nursing, Yonsei Cancer Center, Yonsei University Health System, Seoul, Republic of Korea.

Aims: This study systematically reviews the literature regarding preoperative stoma site marking and discusses the effectiveness of the procedure on complication rates, self-care deficits and health-related quality of life (HRQOL).

Design: Systematic review and meta-analysis.

Data Source: Our review was conducted following the PRISMA guidelines. Read More

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The Effect of Gamma and Microwave Radiation Sterilization on Periodontological Grafts for Microbiological Evaluation.

APMIS 2021 Jun 12. Epub 2021 Jun 12.

Hacettepe University, Faculty of Dentistry, Department of Periodontology, 06100, Sıhhiye Ankara, Turkey.

Purpose: Periodontological grafts are materials used in dentistry to regenerate lost gingival soft tissues or bone parts. In the case of direct contact with blood, the possibility of disease transmission from the source to the patient is high. This source can be an animal or a human. Read More

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Usefulness of postoperative surveillance MR for women after breast-conservation therapy: Focusing on MR features of early and late recurrent breast cancer.

PLoS One 2021 11;16(6):e0252476. Epub 2021 Jun 11.

Departments of Radiology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Purpose: To investigate the imaging characteristics of early and late recurrent breast cancer and the detectability of mammography, ultrasonography, and breast magnetic resonance imaging (MRI) in patients who underwent breast-conservation therapy (BCT).

Materials And Methods: Total of 1312 women with 2026 surveillance breast MRI after BCT between January 2014 and September 2018 were studied. Early recurrence was defined as newly diagnosed breast cancer and/or axillary metastasis within 12 months of surgery. Read More

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End-to-End Automatic Morphological Classification of Intracranial Pressure Pulse Waveforms Using Deep Learning.

IEEE J Biomed Health Inform 2021 Jun 11;PP. Epub 2021 Jun 11.

Objective: Mean intracranial pressure (ICP) is commonly used in the management of patients with intracranial pathologies. However, the shape of the ICP signal over a single cardiac cycle, called ICP pulse waveform, also contains information on the state of the craniospinal space. In this study we aimed to propose an end-to-end approach to classification of ICP waveforms and assess its potential clinical applicability. Read More

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Safety of dupilumab in patients with atopic dermatitis. Expert opinion.

Expert Opin Drug Saf 2021 Jun 11. Epub 2021 Jun 11.

Div. Allergy and Immunology, Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Dermatology, Venereology and Allergology, Charitéplatz 1, 10117 Berlin, Germany.

Introduction: Dupilumab, the first biologic drug to be approved for the treatment of moderate to severe atopic dermatitis in adolescents and adults, has shown efficacy and safety in clinical trials. Data on long-term safety is limited but crucial for pharmacovigilance. Therefore, we performed this review to evaluate available real-world data on the long-term safety of dupilumab in atopic dermatitis. Read More

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Human monocytes store and secrete preformed CCL5, independent of de novo protein synthesis.

J Leukoc Biol 2021 Jun 11. Epub 2021 Jun 11.

Department of Biological Sciences, University of Toronto Scarborough, Toronto, Ontario, Canada.

Monocytes are a subset of circulating peripheral blood mononuclear cells with diverse roles in immunity, including sentinel roles in cytokine secretion. Conventionally, cytokines require an inductive stimulus for their expression and secretion, resulting in a time lag from the time of stimulation to when the proteins are packaged and secreted. Because cytokines are the main communicators in the immune system, their temporal expression is a key factor in coordinating responses to efficiently resolve infection. Read More

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A prospective study of dietary flavonoid intake and risk of glioma in US men and women.

Am J Clin Nutr 2021 Jun 10. Epub 2021 Jun 10.

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

Background: Flavonoids are a diverse group of plant constituents with demonstrated neuroprotective and anti-tumor effects. Flavonoid intake may decrease the risk of glioma, but the possibility of an association has not yet been investigated in humans.

Objectives: We evaluated the association between dietary flavonoid consumption and the risk of glioma. Read More

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Screening for Sarcopenia (Physical Frailty) in the COVID-19 Era.

Int J Endocrinol 2021 21;2021:5563960. Epub 2021 May 21.

Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan.

Although the numbers of aged populations have risen considerably in the last few decades, the current coronavirus disease 2019 (COVID-19) has revealed an extensive vulnerability among these populations. Sarcopenia is an age-related disorder that increases hospitalization, dependencies, and mortality in older adults. It starts to develop in midlife or even earlier as a result of unbalanced diet/poor nutrition and low levels of physical activity, in addition to chronic disorders such as obesity and diabetes mellitus. Read More

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Factors Associated With Ruminative Thinking in Individuals With Gender Dysphoria.

Front Psychiatry 2021 25;12:602293. Epub 2021 May 25.

Transdisciplinary Gender Identity Program, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.

This study aimed to examine psychosocial factors and medical history as well as symptoms of depression, anxiety, and stress associated with ruminative thinking in transgender people with gender dysphoria (GD) before undergoing gender affirmation surgery (GAS). This study evaluated 189 participants with GD (111 trans women and 78 trans men) from a specialized service for GAS in southern Brazil. Semi-structured interviews were conducted, and participants were asked to complete self-report questionnaires. Read More

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The significance of red cell distribution width and homocysteine values in STEMI patients undergoing PCI in the population of Bosnia and Herzegovina.

Eur Rev Med Pharmacol Sci 2021 May;25(10):3791-3797

Department of Laboratory Medicine, University Clinical Hospital Mostar, Mostar, Bosnia and Herzegovina.

Objective:   We aimed to confirm whether serum on admission homocysteine level (HCY) and red cell distribution width (RDW) value are independent risk factors for MACE incidence in patients with STEMI myocardial infarction treated by percutaneous coronary intervention (PCI), as well as the possibility of their joint assessment in order to enhance the risk stratification for major adverse cardiac events (MACE).

Patients And Methods: A total of 80 patients with acute myocardial infarction (AMI) were included in the study and tested for blood HCY and RDW values. Patients were followed up for six months after discharge and evaluated for MACE occurrence. Read More

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Repurposing of Anti-Diabetic Agents as a New Opportunity to Alleviate Cognitive Impairment in Neurodegenerative and Neuropsychiatric Disorders.

Front Pharmacol 2021 24;12:667874. Epub 2021 May 24.

Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, China.

Cognitive impairment is a shared abnormality between type 2 diabetes mellitus (T2DM) and many neurodegenerative and neuropsychiatric disorders, such as Alzheimer's disease (AD) and schizophrenia. Emerging evidence suggests that brain insulin resistance plays a significant role in cognitive deficits, which provides the possibility of anti-diabetic agents repositioning to alleviate cognitive deficits. Both preclinical and clinical studies have evaluated the potential cognitive enhancement effects of anti-diabetic agents targeting the insulin pathway. Read More

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Pelvic antropometric measurement in 3D CT for placement of two unilateral iliosacral S1 - 7.3 mm screws.

Int Orthop 2021 Jun 8. Epub 2021 Jun 8.

Department of Orthopaedics and Trauma Surgery, Medical Faculty Mannheim of Heidelberg University, University Medical Center Mannheim, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.

Purpose: Stability of the dorsal pelvic ring is important for patient mobilisation and can be restored using several surgical procedures after fracture. Placement of percutaneous iliosacral screws is a reliable and minimal-invasive technique to achieve stabilisation of the dorsal pelvic ring by placement of two screws in the first sacral vertebra. Aim of this study was to evaluate 3D CT scans regarding the anatomical possibility to place two 7. Read More

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Using the Computer-based Health Evaluation System (CHES) to Support Self-management of Symptoms and Functional Health: Evaluation of Hematological Patient Use of a Web-Based Patient Portal.

J Med Internet Res 2021 Jun 8;23(6):e26022. Epub 2021 Jun 8.

University Hospital of Psychiatry II, Medical University of Innsbruck, Innsbruck, Austria.

Background: Patient portals offer the possibility to assess patient-reported outcome measures (PROMs) remotely, and first evidence has demonstrated their potential benefits.

Objective: In this study, we evaluated patient use of a web-based patient portal that provides patient information and allows online completion of PROMs. A particular focus was on patient motivation for (not) using the portal. Read More

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