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Bone Metabolism in the Healing Process of Lumbar Interbody Fusion-Temporal changes of bone turnover markers.

Spine (Phila Pa 1976) 2021 Apr 19. Epub 2021 Apr 19.

Spine Center, Hakodate Central General Hospital, Hakodate, Japan Department of Orthopaedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.

Study Design: Prospective longitudinal study.

Objective: The aim of this study was to evaluate temporal changes of bone turnover markers (BTMs) after lumbar spinal fusion in patients without osteoporosis.

Summary Of Background Data: Radiological studies are the standard method to monitor bony fusion, but they do not allow a timely assessment of bone healing. Read More

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The Evaluation of Different Treatments of Incipient Caries Lesions: An in Situ Study of Progression Using Fluorescence-based Methods.

Oper Dent 2021 Jan;46(1):87-99

Clinical Relevance: Effective methods to control incipient caries lesions are needed. In this investigation, several methods provide encouraging results.

Summary: This study aimed to evaluate in situ the inhibition of incipient caries lesion progression using different treatment protocols and to evaluate the effectiveness of fluorescence-based methods (DIAGNOdent, DIAGNOdent pen, and VistaProof fluorescence camera [FC]) in monitoring this process. Read More

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January 2021

Adaptive Data Structure Regularized Multiclass Discriminative Feature Selection.

IEEE Trans Neural Netw Learn Syst 2021 Apr 21;PP. Epub 2021 Apr 21.

Feature selection (FS), which aims to identify the most informative subset of input features, is an important approach to dimensionality reduction. In this article, a novel FS framework is proposed for both unsupervised and semisupervised scenarios. To make efficient use of data distribution to evaluate features, the framework combines data structure learning (as referred to as data distribution modeling) and FS in a unified formulation such that the data structure learning improves the results of FS and vice versa. Read More

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Comparative analysis of spatial genetic structures in sympatric populations of two riparian plants, Saxifraga acerifolia and Saxifraga fortunei.

Am J Bot 2021 Apr 21. Epub 2021 Apr 21.

Graduate School of Human and Environmental Studies, Kyoto University, Yoshida Nihonmatsu-cho, Sakyo-ku, Kyoto, Kyoto, 606-8501, Japan.

Premise: The genetic structure between plant populations is facilitated by the spatial population arrangement and limited dispersal of seed and pollen. Saxifraga acerifolia, a local endemic species in Japan, is a habitat specialist that is confined to waterfalls in riparian environments. Its sister species, Saxifraga fortunei, is a generalist that is widely distributed along riverbanks. Read More

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Social Learning and Innovation in Adolescence : A Comparative Study of Aka and Chabu Hunter-Gatherers of Central and Eastern Africa.

Bonnie Hewlett

Hum Nat 2021 Apr 21. Epub 2021 Apr 21.

College of Arts and Sciences, Washington State University, Vancouver, 14204 NE Salmon Creek Ave., Vancouver, WA, 98686, USA.

This paper examines how innovative skills and knowledge are transmitted and acquired among adolescents in two hunter-gatherer communities, the Aka of southern Central African Republic and the Chabu of southwestern Ethiopia. Modes of transmission and processes of social learning are addressed. Innovation as well as social learning have been hypothesized to be key features of human cumulative culture, enhancing the fitness and survival of individuals in diverse environments. Read More

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Reduction of sulfur oxides emissions via adsorptive desulfurization of transportation fuels using novel silica-based adsorbent.

Environ Sci Pollut Res Int 2021 Apr 21. Epub 2021 Apr 21.

Department of Chemistry, Faculty of Science, Helwan University, Cairo, Egypt.

Transportation fuels with high sulfur content are one of the primary contributors to air pollution because they emit massive quantities of sulfur oxides upon combustion. The emitted sulfur oxides undoubtedly contribute to global warming and climate change. Therefore, they should be minimized. Read More

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Leveraging digital transformation to empower clinical governance: enhancement in intermediate clinical endpoints and patients' survival after implementation of a continuous quality improvement program in a large dialysis network.

Nephrol Dial Transplant 2021 Apr 21. Epub 2021 Apr 21.

Clinical & Data Intelligence Systems - Advanced Analytics, Fresenius Medical Care Deutschland GmbH, Vaiano Cremasco (CR), Italy.

Background: Treatment of end-stage kidney disease patients is extremely challenging given the inter-connected functional derangements and comorbidities characterizing the disease. Continuous Quality Improvement (CQI) in healthcare is a structured clinical governance process helping physicians adhere to best clinical practices. The digitization of patient medical records and data warehousing technologies has standardized and enhanced the efficiency of the CQÍs evidence generation process. Read More

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Chatbot-Based Assessment of Employees' Mental Health: Design Process and Pilot Implementation.

JMIR Form Res 2021 Apr 21;5(4):e21678. Epub 2021 Apr 21.

Vitalk, TNH Health, São Paulo, Brazil.

Background: Stress, burnout, and mental health problems such as depression and anxiety are common, and can significantly impact workplaces through absenteeism and reduced productivity. To address this issue, organizations must first understand the extent of the difficulties by mapping the mental health of their workforce. Online surveys are a cost-effective and scalable approach to achieve this but typically have low response rates, in part due to a lack of interactivity. Read More

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Enhancing models of social and strategic decision making with process tracing and neural data.

Wiley Interdiscip Rev Cogn Sci 2021 Apr 20:e1559. Epub 2021 Apr 20.

Department of Economics, Zurich Center for Neuroeconomics (ZNE), University of Zurich.

Every decision we take is accompanied by a characteristic pattern of response delay, gaze position, pupil dilation, and neural activity. Nevertheless, many models of social decision making neglect the corresponding process tracing data and focus exclusively on the final choice outcome. Here, we argue that this is a mistake, as the use of process data can help to build better models of human behavior, create better experiments, and improve policy interventions. Read More

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[Preparation and evaluation of fused deposition modeling 3D printed verapa-mil hydrochloride gastric floating formulations].

Beijing Da Xue Xue Bao Yi Xue Ban 2021 Mar;53(2):348-354

Department of Pharmaceutics, Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems, Peking University School of Pharmaceutical Sciences, Beijing 100191, China.

Objective: To explore the feasibility of preparing gastric floating formulations by fused de-position modeling (FDM) 3D printing technology, to evaluate the properties of the prepared FDM 3D printed gastric floating formulations, and to compare the influence of different external shapes of the formulation with their properties.

Methods: Verapamil hydrochloride and polyvinyl alcohol (PVA) were used as the model drug and the excipient, respectively. The capsule-shaped and hemisphere-shaped gastric floating formulations were then prepared by FDM 3D printing. Read More

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Production and properties of non-cytotoxic pyomelanin by laccase and comparison to bacterial and synthetic pigments.

Sci Rep 2021 Apr 20;11(1):8538. Epub 2021 Apr 20.

Mediterranean Institute of Oceanology (MIO), Aix-Marseille Université, 163 avenue de Luminy, 13288, Marseille Cedex 9, France.

Pyomelanin is a polymer of homogentisic acid synthesized by microorganisms. This work aimed to develop a production process and evaluate the quality of the pigment. Three procedures have been elaborated and optimized, (1) an HGA-Mn chemical autoxidation (Pyo yield 0. Read More

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Association between cardiovascular risk factors and degenerative disc disease of the thoracolumbar spine in the general population: results from the KORA MRI Study.

Acta Radiol 2021 Apr 20:2841851211010391. Epub 2021 Apr 20.

Department for Diagnostic and Interventional Radiology, Eberhard Karls University Tuebingen, University Hospital Tuebingen, Tübingen, Germany.

Background: Little is known about the associations between cardiovascular risk factors (CRF) and disc degeneration (DD).

Purpose: To evaluate the potential association between CRFs and intervertebral DD in a population-based sample.

Methods: A total of 400 participants from the community-based KORA-study were assessed in terms of CRFs, specifically obesity, hypertension, diabetes, elevated LDL-c, low HDL-c, elevated triglycerides, smoking status, and alcohol consumption. Read More

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Nanosecond pulsed fiber laser irradiation for enhanced zirconia crown adhesion: Morphological, chemical, thermal and mechanical analysis.

J Photochem Photobiol B 2021 Apr 15;219:112189. Epub 2021 Apr 15.

CNR-IMEM Institute, Parco delle Scienze 37a, I-43100 Parma, Italy.

The increasing demand for aesthetics, together with advancements in technology, have contributed to the rise in popularity of all-ceramic restorations. In the last two decades, the continuous progression in ceramic materials science for dental applications has permitted the fabrication of high-strength materials. Amongst these, zirconia-based ceramics have improved in terms of fracture resistance and long-term viability in comparison with other silica-based materials. Read More

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Managing the risk of a COVID-19 outbreak from border arrivals.

J R Soc Interface 2021 Apr 21;18(177):20210063. Epub 2021 Apr 21.

Manaaki Whenua, Lincoln, New Zealand.

In an attempt to maintain the elimination of COVID-19 in New Zealand, all international arrivals are required to spend 14 days in government-managed quarantine and to return a negative test result before being released. We model the testing, isolation and transmission of COVID-19 within quarantine facilities to estimate the risk of community outbreaks being seeded at the border. We use a simple branching process model for COVID-19 transmission that includes a time-dependent probability of a false-negative test result. Read More

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Epidemiological characteristics of uropatogenic isolates of Escherichia coli in hospitals.

Klin Lab Diagn 2021 Apr;66(4):248-256

Institute of Ecology and Genetic of Microorganisms Ural Branch Russian Academy of Sciences.

The aim of the study was to evaluate the genetic affinity of uropathogenic E. coli cultures (UPEC) and to identify the major types of extended spectrum beta-lactamases (ESBL) found among nosocomial isolates. A molecular typing of UPEC (n=93) isolated from patients with urinary tract infections (UTI) who were hospitalised in nine medical facilities (MO) in Perm was performed. Read More

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Process Humidity Affects Salmonella Lethality at the Surface and Core of Impingement-Cooked Meat and Poultry Products.

J Food Prot 2021 Apr 20. Epub 2021 Apr 20.

Michigan State University 524 S. Shaw Ln UNITED STATES East Lansing 48824 1-517-432-7703.

Recent revisions to USDA FSIS compliance and safe harbor guidelines for ready-to-eat meat and poultry products addressed process humidity requirements. Given the lack of prior data for impingement-cooked products, this project aimed to evaluate the impact of process humidity on Salmonella lethality at the product core and surface, and compliance of the results with USDA FSIS lethality performance standards. Whole muscle beef strips, ground beef patties, whole muscle chicken breast fillets, and breaded ground chicken patties were inoculated with an 8-serovar cocktail of Salmonella. Read More

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American Academy of Orthopaedic Surgeons Clinical Practice Guideline Summary for Limb Salvage or Early Amputation.

J Am Acad Orthop Surg 2021 Apr 16. Epub 2021 Apr 16.

From the Walter Reed National Military Medical Center-Uniformed Services University of Health Sciences, Bethesda, MD (Potter), and Department of Orthopaedics, Atrium Health, Carolinas Medical Center, Charlotte, NC (Bosse).

Clinical Practice Guideline for Limb Salvage or Early Amputation is based on a systematic review of current scientific and clinical research. The purpose of this clinical practice guideline is to address treatment for severe lower limb trauma below the distal femur by either amputation or limb salvage by providing evidence-based recommendations for key decisions that affect the management of patients with lower extremity trauma. This guideline contains 11 recommendations to evaluate the decision factors important for limb salvage versus early amputation. Read More

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Towards Perceptually Optimized Adaptive Video Streaming -A Realistic Quality of Experience Database.

IEEE Trans Image Process 2021 Apr 20;PP. Epub 2021 Apr 20.

Measuring Quality of Experience (QoE) and integrating these measurements into video streaming algorithms is a multi-faceted problem that fundamentally requires the design of comprehensive subjective QoE databases and objective QoE prediction models. To achieve this goal, we have recently designed the LIVE-NFLX-II database, a highly-realistic database which contains subjective QoE responses to various design dimensions, such as bitrate adaptation algorithms, network conditions and video content. Our database builds on recent advancements in content-adaptive encoding and incorporates actual network traces to capture realistic network variations on the client device. Read More

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Integrating Dairy Manure for Enhanced Resource Recovery at a WRRF: Environmental Life Cycle and Pilot-scale Analyses.

Water Environ Res 2021 Apr 20. Epub 2021 Apr 20.

Department of Civil and Environmental Engineering, University of Idaho, Moscow, ID, USA, 83844-1022.

The Twin Falls, Idaho wastewater treatment plant (WWTP) currently operates solely to achieve regulatory permit compliance. Research was conducted to evaluate conversion of the WWTP to a water resource recovery facility (WRRF) and to assess the WRRF environmental sustainability; process configurations were evaluated to produce five resources - reclaimed water, biosolids, struvite, biogas, and bioplastics (polyhydroxyalkanoates, PHA). PHA production occurred using fermented dairy manure. Read More

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Effects of non-thermal atmospheric pressure plasma on palatal wound healing of free gingival grafts: a randomized controlled clinical trial.

Clin Oral Investig 2021 Apr 20. Epub 2021 Apr 20.

Department of Periodontology, Izmir Katip Celebi University, 35640, Cigli, Izmir, Turkey.

Objective: The aim of this trial was to evaluate the effects of non-thermal atmospheric pressure plasma (NAPP) on wound healing, epithelization, local pain, bleeding, and alteration of sensation in palatal donor site.

Materials And Methods: Forty patients with inadequate attached gingiva were included in the study. Patients were divided into two groups: (i) NAPP group (Free gingival graft [FGG] + NAPP) and (ii) control group (FGG alone). Read More

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Evaluation of a urology specialist therapeutic radiographer implemented radiotherapy pathway for prostate cancer patients.

Radiography (Lond) 2021 May 24;27(2):430-436. Epub 2020 Oct 24.

The Royal Marsden NHS Foundation Trust, UK; The Institute of Cancer Research, UK. Electronic address:

Introduction: The role of the Urology Specialist Therapeutic Radiographer (USTR) was introduced to support a busy NHS uro-oncology practice. Key objectives were to improve patient preparedness for and experience of radiotherapy, focussed on prostate cancer. Pre-radiotherapy information seminars were developed, and on-treatment patient review managed by the USTRs. Read More

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Prognostic value of sternal lymphadenopathy on malignancy and survival in dogs undergoing splenectomy.

Vet Comp Oncol 2021 Apr 20. Epub 2021 Apr 20.

VCA Animal Specialty and Emergency Center, 1535 S Sepulveda Blvd, Los Angeles, CA, 90025.

The purpose of this retrospective cohort study was to determine prevalence of sternal lymphadenopathy in a population of dogs undergoing splenectomy, and to evaluate if the prevalence was associated with splenic malignancy. In addition, the study investigated if survival in dogs diagnosed with hemangiosarcoma (HSA) differed between those with or without sternal lymphadenopathy at the time of surgery. Digital radiographs and medical records for dogs who underwent splenectomy from 2013 to 2016 where retrospectively reviewed. Read More

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Electrochemical process for simultaneous removal of chemical and biological contaminants from drinking water.

Environ Sci Pollut Res Int 2021 Apr 20. Epub 2021 Apr 20.

Government College University, Punjab, 54000, Lahore, Pakistan.

Simultaneous management of chemical and biological contaminants in drinking water has been presented through modification in conventional electrocoagulation (EC) process. Traditional EC process using iron and aluminum electrodes removed metals but did not affect microbiological contaminants to a greater extent. Iron anode composition was amended by addition of zinc for desired antimicrobial output. Read More

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Investigating Factors at Play in Hepatopancreatobiliary Fellowship Selection: Beliefs versus Reality.

World J Surg 2021 Apr 19. Epub 2021 Apr 19.

Department of Surgery, Methodist Richardson Medical Center, 2805 E President George Bush Hwy, Richardson, TX, 75082, USA.

Background: Selection biases affecting candidate matches to fellowship programs directly influence diversity within the surgical community. The review of selection bias has never been distinctively investigated in the Hepatopancreatobiliary (HPB) surgery community. This study seeks to (i) evaluate factors affecting selection of candidates to HPB fellowships, (ii) examine explicit biases among program directors and faculty of HPB programs in North America, and (iii) compare the demography of the HPB faculty and recently graduated fellows to general surgery residents. Read More

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Updating atomic charge parameters of aliphatic amino acids: a quest to improve the performance of molecular modeling via sequential molecular dynamics and DFT-GIAO-NMR calculations.

Phys Chem Chem Phys 2021 Apr 25;23(14):8413-8425. Epub 2021 Mar 25.

Departamento de Física, CEPAE, Universidade Federal de Goiás, 74690-900, Goiânia, GO, Brazil.

In this work, we observe the behavior of the dipole moment, atomic charges, solute-solvent interactions and NMR spectroscopy of aliphatic amino acids in a water solution via the computational simulations of classical molecular dynamics and DFT quantum calculations. Our results indicate that the convergence of the atomic charge of the solute, from an iterative process, together with the dipole moment of the amino acid, alters the lifetime of hydrogen bonds present in the first solvation shell, resulting in the modification of its structure and dynamics. Using GIAO-DFT-NMR calculations, we assessed the impact of these structural solute-solvent modifications on the magnetic shielding constants of the solute carbon atoms. Read More

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Development and virtual validation of a novel digital workflow to rehabilitate palatal defects by using smartphone-integrated stereophotogrammetry (SPINS).

Sci Rep 2021 Apr 19;11(1):8469. Epub 2021 Apr 19.

College of Dentistry, Jouf University, Sakaka, Kingdom of Saudi Arabia.

Palatal defects are rehabilitated by fabricating maxillofacial prostheses called obturators. The treatment incorporates taking deviously unpredictable impressions to facsimile the palatal defects into plaster casts for obturator fabrication in the dental laboratory. The casts are then digitally stored using expensive hardware to prevent physical damage or data loss and, when required, future obturators are digitally designed, and 3D printed. Read More

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Nurse/Resident Reciprocal Shadowing to Improve Interprofessional Communication.

Hosp Pediatr 2021 Apr 19. Epub 2021 Apr 19.

Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio.

Objectives: Poor communication is a major contributor to sentinel events in hospitals. Suboptimal communication between physicians and nurses may be due to poor understanding of team members' roles. We sought to evaluate the impact of a shadowing experience on nurse-resident interprofessional collaboration, bidirectional communication, and role perceptions. Read More

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Fermentation of Coffea canephora inoculated with yeasts: Microbiological, chemical, and sensory characteristics.

Food Microbiol 2021 Sep 17;98:103786. Epub 2021 Mar 17.

Department of Food Engineering, Federal University of Espirito Santo, Alegre, ES, 29500-000, Brazil. Electronic address:

This work aimed to evaluate Coffea canephora's microbiological, chemical, and sensory characteristics at 300 and 600 m elevation plantations processed by the natural method inoculated with yeasts. The coffee was spread on suspended terraces and sprayed with approximately 10 cfu/mL of Meyerozyma caribbica CCMA 1738 or Pichia kluyveri CCMA 1743, separately. Cherries containing bark and parchment were collected during fermentation for microbial groups counting, qPCR, quantification of organic acids, and sugars (HPLC). Read More

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September 2021

A novel method for clinical risk prediction with low-quality data.

Artif Intell Med 2021 Apr 17;114:102052. Epub 2021 Mar 17.

School of Computer Science, The University of Sydney, Australia. Electronic address:

In real-world data, predictive models for clinical risks (such as adverse drug reactions, hospital readmission, and chronic disease onset) are constantly struggling with low-quality issues, namely redundant and highly correlated features, extreme category imbalances, and most importantly, a large number of missing values. In most existing work, each patient is represented as a value vector with the fixed-length from some feature space, and missing values are forced to be imputed, which introduces much noise for prediction if the data set is highly incomplete. Besides, other challenges are either remaining unresolved or only partially solved when modeling, but without a systematic approach. Read More

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Performance Enhancement of Actual Wastewater Treatment and Electricity Generation Through Surface Modified TiO₂ Nanotube Arrays Based Photoanode Photocatalytic Fuel Cell.

J Nanosci Nanotechnol 2021 Oct;21(10):5188-5195

Beijing Key Laboratory of Functional Materials for Building Structure and Environment Remediation, Beijing University of Civil Engineering and Architecture, Beijing, 100044, China.

Herein, we report a surface modified TiO₂ nanowire arrays (NAs) photoanode based photocatalytic fuel cell (PFC) towards simultaneous enhancement of actual wastewater treatment and electricity generation under visible light irradiation. TiO₂ NAs were facile fabricated via two-step anodization process in ethylene glycol and glycerin solution, respectively. Actual wastewater samples were directly applied to evaluate the PFC performance in terms of wastewater degradation and electricity generation through the as-prepared TiO₂ NAs photoanode without loading noble-metals or semiconductors. Read More

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October 2021