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A meta-analysis of factors influencing concentrations of brominated flame retardants and organophosphate esters in indoor dust.

Environ Pollut 2021 Apr 29;285:117262. Epub 2021 Apr 29.

School of Geography, Earth, and Environmental Sciences, University of Birmingham, Birmingham, B15 2TT, United Kingdom.

Current assessments of human exposure to flame retardants (FRs) via dust ingestion rely on measurements of FR concentrations in dust samples collected at specific points in time and space. Such exposure assessments are rendered further uncertain by the possibility of within-room and within-building spatial and temporal variability, differences in dust particle size fraction analysed, as well as differences in dust sampling approach. A meta-analysis of peer-reviewed data was undertaken to evaluate the impact of these factors on reported concentrations of brominated flame retardants (BFRs) and organophosphate esters (OPEs) in dust and subsequent human exposure estimates. Read More

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Immunotherapy as Single Treatment for Non-small-cell Lung Cancer Patients with Brain Metastases: a systematic review and meta-analysis - the META-L-BRAIN study.

J Thorac Oncol 2021 May 5. Epub 2021 May 5.

AC Camargo Cancer Center, São Paulo, Brazil.

Introduction: Brain metastases (BM) occur in 40% of lung cancer patients. The activity of immunotherapy in these patients, however, remains controversial, as the cornerstone treatment is radiotherapy (RT). Since RT is associated with adverse events that may impair quality of life, the possibility of substituting it by a single systemic approach is attractive. Read More

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Transcranial Doppler: A Useful Tool to Predict Brain Death Still Not Confirmed by Clinical Assessment.

Transplant Proc 2021 May 4. Epub 2021 May 4.

Department of Neurology, Laboratory for Neurosonology and Cerebral Hemodynamics, Hospital das Clínicas, São Paulo University Medical School, São Paulo, Brazil.

Background: Diagnosing brain death (BD) with accuracy and urgency is of great importance because an early diagnosis may guide the clinical management, optimize hospital beds, and facilitate organ transplantation. The clinical diagnosis of nonreactive and irreversible coma can be confirmed with additional tests. Among the complimentary exams that may testify brain circulatory arrest, transcranial Doppler (TCD) can be an option. Read More

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Monitoring of patients with microdialysis following pancreaticoduodenectomy-the MINIMUM study: study protocol for a randomized controlled trial.

Trials 2021 May 7;22(1):329. Epub 2021 May 7.

Department of Anesthesiology, Division of Emergencies and Critical Care, Oslo University Hospital, Rikshospitalet, Postboks 4950 Nydalen, 0424, Oslo, Norway.

Background: Postoperative pancreatic fistula after pancreatoduodenectomy is a much-feared complication associated with substantial mortality and morbidity. The current standard for diagnosing postoperative pancreatic fistula, besides routine clinical examination, include radiological examinations, analysis of pancreatic drain amylase activity, and routine blood samples. Another promising method is by intraperitoneal microdialysis to monitor intraperitoneal metabolites measured at the pancreaticojejunostomy, thereby detecting what occurs locally, before chemical events can be reflected as measurable changes in systemic blood levels. Read More

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Association of depression, anxiety and menopausal-related symptoms with demographic, anthropometric and body composition indices in healthy postmenopausal women.

BMC Womens Health 2021 May 7;21(1):192. Epub 2021 May 7.

Department of Biology, School of Art and Science, Utica College, Utica, NY, USA.

Background: The termination of the menstrual cycle is correlated with a number of physiological alterations and symptoms that can negatively impact emotion and mood. We aimed to investigate the association of anxiety, depression, and menopausal related symptoms with demographic, anthropometric, and body composition indices in healthy postmenopausal women.

Methods: A total of 320 menopausal women were selected randomly from referrals of health centers between January and June 2018 in Tabriz/Iran. Read More

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Optical Coherence Tomography and Microdialysis for Microneedle-Mediated Penetration Enhancement Study of Paeoniflorin-Loaded Ethosomes.

Skin Pharmacol Physiol 2021 May 6:1-11. Epub 2021 May 6.

School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China.

Background: To understand the cumulative effect of topical formulations after medication, evaluate the therapeutic effect of microneedle-assisted (MN-assisted) paeoniflorin-loaded ethosomes (TGP-E), and explore the potential for deep penetration of drugs, this paper uses microdialysis to systematically study the percutaneous pharmacokinetics of TGP-E.

Methods: First, optical coherence tomography (OCT) was used to study the effectiveness of microneedle puncture. Second, a microdialysis method and a UPLC-MS method for determining the amount of paeoniflorin (Pae) in dialysate were established. Read More

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The use of digital texture image analysis in determining the masticatory efficiency outcome.

PLoS One 2021 6;16(5):e0250936. Epub 2021 May 6.

Clinic for Prosthetic Dentistry, Faculty of Dental Medicine, University of Belgrade, Belgrade, Serbia.

The mixture level of gum samples consisting of two colours can be assessed visually, using the electronic colorimetric method, employing digital image processing techniques and specially designed software. The study investigates the possibility of an alternative method called "digital texture image analysis" (DTIA) to assess improvement of masticatory efficiency in denture wearers. The objectives were i) to evaluate whether DTIA discriminates changes in the colour mixing ability within a group over time; ii) to determine whether DTIA can be used to detect improvement in chewing ability; iii) to select the most appropriate DTIA feature that sufficiently describes masticatory efficiency in CDs wearers. Read More

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Investigation of SARS-CoV-2 in hospital indoor air of COVID-19 patients' ward with impinger method.

Environ Sci Pollut Res Int 2021 May 6. Epub 2021 May 6.

Health & Environment Research Center, Ilam University of Medical Sciences, Ilam, Iran.

In December 2019, all nations learnt about the emergence of a pandemic of coronavirus disease (COVID-19), induced by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is a member of the β-coronavirus group. As SARS-CoV-2 has the potentiality of leading to life-threatening respiratory failure, its transmission routes need to be characterized. Yet, the possibility of airborne transmission is still debated. Read More

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Barriers to Access to Treatment for Hypertensive Patients in Primary Health Care of Less Developed Northwest China: A Predictive Nomogram.

Int J Hypertens 2021 14;2021:6613231. Epub 2021 Apr 14.

Hypertension Center of People's Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Hypertension Institute, National Health Committee Key Laboratory of Hypertension Clinical Research, Urumqi, Xinjiang, China.

Background: This study aims to evaluate the risk factors associated with untreated hypertension and develop and internally validate untreated risk nomograms in patients with hypertension among primary health care of less developed Northwest China.

Methods: A total of 895 eligible patients with hypertension in primary health care of less developed Northwest China were divided into a training set ( = 626) and a validation set ( = 269). Untreated hypertension was defined as not taking antihypertensive medication during the past two weeks. Read More

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Synchrotron total-scattering data applicable to dual-space structural analysis.

IUCrJ 2021 May 6;8(Pt 3):387-394. Epub 2021 Mar 6.

Department of Chemistry, Aarhus University, Langelandsgade 140, Aarhus C, 8000, Denmark.

Synchrotron powder X-ray diffraction (PXRD) is a well established technique for investigating the atomic arrangement of crystalline materials. At modern beamlines, X-ray scattering data can be collected in a total-scattering setting, which additionally opens up the opportunity for direct-space structural analysis through the atomic pair distribution function (PDF). Modelling of PXRD and PDF data is typically carried out separately, but employing a concurrent structural model to both direct- and reciprocal-space data has the possibility to enhance total-scattering data analysis. Read More

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α-synuclein aggregates induce c-Abl activation and dopaminergic neuronal loss by a feed-forward redox stress mechanism.

Prog Neurobiol 2021 May 2:102070. Epub 2021 May 2.

Department of Neurology, University of California San Francisco, United States; Neurology Service, San Francisco Veterans Affairs Health Care System, United States. Electronic address:

Oxidative stress and α-synuclein aggregation both drive neurodegeneration in Parkinson's disease, and the protein kinase c-Abl provides a potential amplifying link between these pathogenic factors. Suppressing interactions between these factors may thus be a viable therapeutic approach for this disorder. To evaluate this possibility, pre-formed α-synuclein fibrils (PFFs) were used to induce α-synuclein aggregation in neuronal cultures. Read More

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A nonrandomised pilot study to examine the feasibility and acceptability of reflexology in patients undergoing hospital-based haemodialysis (solitude study).

J Ren Care 2021 May 5. Epub 2021 May 5.

School of Nursing and Midwifery, Queen's University, Belfast, UK.

Background: Patients with end-stage kidney disease, receiving haemodialysis can experience complications-hypotension, headache, muscle cramp, chest pain, nausea and vomiting. Patients who experience all or some of these symptoms will often report reduced health-related quality of life (HRQOL) and poor sleep quality, which may lead to increased morbidity and mortality.

Objective: The objective of this pilot study is to evaluate the feasibility of a larger randomised controlled trial to determine the effect of foot reflexology on a cohort of patients undergoing hospital-based haemodialysis. Read More

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Rhododendrol-induced leukoderma update II: Pathophysiology, mechanisms, risk evaluation, and possible mechanism-based treatments in comparison with vitiligo.

J Dermatol 2021 May 5. Epub 2021 May 5.

Department of Integrative Medical Science for Allergic Disease, Fujita Health University School of Medicine, Nagoya, Japan.

A small proportion of individuals utilizing cosmetics containing rhododendrol developed leukoderma with various pathological conditions, in some cases indistinguishable from vitiligo. In this review, we investigate and evaluate the major considerations for developing rhododendrol-induced leukoderma based on data from original or review articles published in the literature to provide a wide range of information regarding the pathophysiology, mechanisms, risk evaluation, and possible mechanism-based treatments. We compile and discuss the latest information, including data related to the cytotoxicity of rhododendrol, cytoprotective functions, and involvement of the immune system, and consider the possibility of novel treatments based on the differences between individual patients and on the mechanism underlying the onset of the condition. Read More

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Communicating multiple tubular enteric duplication with toxic megacolon in an infant: A case report.

Medicine (Baltimore) 2021 May;100(18):e25772

Department of Surgery, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea.

Rationale: Gastrointestinal tract duplication is a rare congenial anomaly which can be found anywhere along the gastrointestinal tract. While many patients are incidentally diagnosed during operation, in some cases it can present with severe gastrointestinal symptoms. In this case report, the patient presented with signs of toxic megacolon leading to rapid aggravation of inflammatory shock. Read More

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Can the exposure system adopted influence the results of the atrazine toxicity in hepatic tissue of fish?

J Exp Zool A Ecol Integr Physiol 2021 May 5. Epub 2021 May 5.

Laboratório de Processamento de Tecidos - LAPROTEC, Universidade Federal de São João Del Rei, Divinópolis, Minas Gerais, Brazil.

The widespread use of atrazine, a herbicide used to control weeds, has contributed to the increased contamination of aquatic environments. To assess the toxicological effects of a xenobiotic on a nontarget organism in the laboratory, different models of toxicological exposure systems have been widely used. Therefore, the aim of this study was to evaluate and compare the action of sublethal concentrations of atrazine on the hepatic histology of Oreochromis niloticus, considering two models of exposure: static (where atrazine was only added once) and semi-static (where atrazine was periodically renewed). Read More

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PCR-RFLP and FTIR-based detection of high-risk human papilloma virus for cervical cancer screening and prevention.

Biochem Biophys Rep 2021 Jul 15;26:100993. Epub 2021 Apr 15.

Laboratório de Biologia Molecular do Câncer, Universidade do Vale do Paraíba, UNIVAP, Instituto de Pesquisa e Desenvolvimento, Avenida Shishima Hifumi 2911, Urbanova, São José dos Campos, 12244-000, São Paulo, SP, Brazil.

Background: Approximately 70% of cervical carcinoma cases show the presence of high-risk Human Papilloma Virus (HPV), especially HPV-16 and HPV-18, and can be used to stratify high risk patients from low risk and healthy. Currently, molecular biology techniques such as polymerase chain reaction (PCR) are used to identify the presence of virus in patient samples. While the methodology is highly sensitive, it is labor intensive and time-consuming. Read More

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Reversible dementia due to vitamin B12 deficiency in a lung cancer patient: Relevance of preoperative evaluation.

Palliat Support Care 2021 May 5:1-3. Epub 2021 May 5.

Department of Psycho-oncology, Saitama Medical University International Medical Center, Saitama, Japan.

Objective: Cognitive dysfunction has a negative effect on cancer treatment; however, in a cancer setting, specific treatments can restore cognitive function. Such conditions are known as reversible dementia, with one of these being vitamin B12 (VB12) deficiency. However, there have been no reports of VB12 deficiency identified by preoperative evaluation in cancer patients. Read More

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Amphetamine-Decreased Progesterone and Estradiol Release in Rat Granulosa Cells: The Regulatory Role of cAMP- and Ca-Mediated Signaling Pathways.

Biomedicines 2021 Apr 29;9(5). Epub 2021 Apr 29.

Institute of Sports Sciences, University of Taipei, Taipei City 112, Taiwan.

The purpose of this study is to evaluate the amphetamine effects on progesterone and estradiol production in rat granulosa cells and the underlying cellular regulatory mechanisms. Freshly dispersed rat granulosa cells were cultured with various test drugs in the presence of amphetamine, and the estradiol/progesterone production and the cytosolic cAMP level were measured. Additionally, the cytosolic-free Ca concentrations ([Ca]i) were measured to examine the role of Ca influx in the presence of amphetamine. Read More

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Combination fixed-dose beta agonist and steroid inhaler as required for adults or children with mild asthma.

Cochrane Database Syst Rev 2021 05 4;5:CD013518. Epub 2021 May 4.

Respiratory Medicine Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

Background: Asthma affects 350 million people worldwide including 45% to 70% with mild disease. Treatment is mainly with inhalers containing beta₂-agonists, typically taken as required to relieve bronchospasm, and inhaled corticosteroids (ICS) as regular preventive therapy. Poor adherence to regular therapy is common and increases the risk of exacerbations, morbidity and mortality. Read More

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Planning for End of Life.

Am J Hosp Palliat Care 2021 May 4:10499091211014166. Epub 2021 May 4.

Division of Pulmonary & Critical Care Medicine, The University of Utah, Salt Lake City, UT, USA.

Background: Oncology provider discussions of treatment options, outcomes of treatment, and end of life planning are essential to care for patients with advanced malignancies. Studies have shown that despite this, many patients do not have adequate care planning, including end of life planning. It is thought that the accessibility of information outside of clinical encounters and individual factors and/or beliefs may influence the patient's perception of disease. Read More

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Arthroscopic Internal Drainage with Cyst Wall Resection and Arthroscopic Internal Drainage with Cyst Wall Preservation to Treat Unicameral Popliteal Cysts: A Retrospective Case-Control Study.

Orthop Surg 2021 May 4. Epub 2021 May 4.

Department of Orthopedics, The Second Hospital of Shanxi Medical University, Taiyuan, China.

Objective: To compare the clinical efficacy and safety of arthroscopic internal drainage for the treatment of unicameral popliteal cysts with or without cyst wall resection.

Methods: This was a retrospective case-control study of 73 patients diagnosed with unicameral popliteal cysts from January 2012 to January 2019 who received arthroscopic treatment. The study included 38 cases with cyst wall resection (CWR group) and 35 cases with cyst wall preservation (CWP group). Read More

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Bayes shrinkage estimator for consistency assessment of treatment effects in multi-regional clinical trials.

Pharm Stat 2021 May 3. Epub 2021 May 3.

School of Statistics, East China Normal University, Shanghai, China.

The primary objective of a multi-regional clinical trial is to investigate the overall efficacy of the drug across regions and evaluate the possibility of applying the overall trial result to some specific region. A challenge arises when there is not enough regional sample size. We focus on the problem of evaluating applicability of a drug to a specific region of interest under the criterion of preserving a certain proportion of the overall treatment effect in the region. Read More

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[Pancreas divisum and pancreatitis].

Radiologe 2021 May 3. Epub 2021 May 3.

Klinik für Diagnostische & Interventionelle Radiologie, Universitätsklinikum Heidelberg, Im Neuenheimer Feld 420, 69120, Heidelberg, Deutschland.

Clinical/methodological Issue: Diagnostic and clinical relevance of pancreas divisum.

Standard Radiological Methods: Ultrasonography (US), magnetic resonance cholangiopancreatography (MRCP), magnetic resonance imaging (MRI), computed tomography (CT), endoscopic retrograde cholangiopancreatography (ERCP).

Performance: Pancreas divisum is an anatomic variation of pancreatic duct system with an incidence in general population of about 10%. Read More

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Over-utilization of computed tomography angiography in extremity trauma.

OTA Int 2019 Dec 2;2(4):e030. Epub 2019 Aug 2.

The Florida Orthopaedic Institute and University of South Florida.

Objectives: Widespread availability of computed tomography angiography (CTA) for diagnosing arterial injury in injured extremities has created the possibility of overuse. The objective of this study was to evaluate CTA utilization, indications, ordering personnel, and rate of significant findings for blunt or penetrating extremity trauma at a level I trauma center.

Methods: We performed a retrospective chart review of 1440 consecutive CTAs of upper and lower extremities from 2010 to 2012 at a large level I trauma center, and included only those done for acute trauma. Read More

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December 2019

Initial assessment of suitability of MCF-7 and HepG2 cancer cell lines for AQP3 research in cancer biology.

Acta Histochem 2021 Apr 29;123(4):151716. Epub 2021 Apr 29.

Department of Histology and Developmental Biology, Pomeranian Medical University, Żołnierska 48, 71-210, Szczecin, Poland.

Cancer cell lines are widely used as in vitro models to elucidate biological processes in cancer, and as a tool to evaluate anticancer agents. In fact, the use of an appropriate cancer cell line in cancer research is crucial for investigating new, potential factors involved in carcinogenesis. One of them is aquaporin-3 (AQP3), which is a small, hydrophobic, integral membrane protein with a predominant role in water and glycerol transport. Read More

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A survey among German-speaking radiation oncologists on PET-based radiotherapy of prostate cancer.

Radiat Oncol 2021 May 1;16(1):82. Epub 2021 May 1.

Department of Radiation Oncology, Klinikum rechts der isar, Technical University of Munich (TUM), Ismaninger Strasse 22, 81675, Munich, Germany.

Background: Positron emission tomography-(PET) has evolved as a powerful tool to guide treatment for prostate cancer (PC). The aim of this survey was to evaluate the acceptance and use of PET-especially with prostate-specific membrane antigen (PSMA) targeting tracers-in clinical routine for radiotherapy (RT) and the impact on target volume definition and dose prescription.

Methods: We developed an online survey, which we distributed via e-mail to members of the German Society of Radiation Oncology (DEGRO). Read More

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Construction and evaluation of red blood cells-based drug delivery system for chemo-photothermal therapy.

Colloids Surf B Biointerfaces 2021 Apr 26;204:111789. Epub 2021 Apr 26.

Department of Pharmacy, Xiamen Xianyue Hospital, Xiamen, 361012, PR China.

In this study, a novel tumor-targeting drug delivery system (DDS) based on red blood cells (RBCs) were fabricated for combinational chemo-phototherapy against cancer. Cyclic peptide (cRGD) and indocyanine green (ICG) were applied to the surface of RBCs to increase the targeting and photothermal effect, respectively. Doxorubicin (DOX) as a model drug was loaded into RBCs by the hypotonic dialysis method. Read More

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Preliminary development of a bystander intervention scale for depression and the examination of socio-demographic correlates amongst Singapore university students.

BMC Psychol 2021 Apr 30;9(1):67. Epub 2021 Apr 30.

Research Division, Institute of Mental Health, Buangkok Green Medical Park, 10 Buangkok View, Singapore, 539747, Singapore.

Background: Despite peer involvement having a positive impact on help-seeking behavior, there is a lack of a scale quantifying the possibility of an individual intervening upon noticing peers who show signs of depression. The aims of this study were to (1) develop a bystander intervention scale for depression that assesses the likelihood of university students intervening when a peer shows signs of depression based on the theory of bystander intervention, (2) identify the underlying factors contributing to the behavior, and (3) explore the socio-demographic correlates of the scale.

Methods: The proposed scale, the Bystander Intervention Scale for Depression (BISD), is a 17-item self-reported questionnaire that was developed based on existing bystander intervention theory and inputs from mental health experts. Read More

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Investigating the dynamic eco-efficiency in agriculture sector of the European Union countries.

Environ Sci Pollut Res Int 2021 Apr 30. Epub 2021 Apr 30.

Department of Economics, Faculty of Economics and Management, Czech University of Life Science Prague, Prague, Czech Republic.

One of the main aims of European Common Agricultural Policy (CAP) has been established on a considerable reduction of greenhouse gas (GHG) emissions without any decline in productivity by 2030. This introduces some challenges in the assessment of agricultural technical efficiency. In particular, we can formulate at least two problems that are worth to be addressed: (i) possibility of treating undesirable outputs and (ii) panel data analysis of agricultural technical efficiency enriched by eco-efficiency assessment. Read More

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