1,370 results match your criteria euthanized histologic

Local RANKL delivery improves socket healing in bisphosphonate treated rats.

Bone 2021 Apr 6:115945. Epub 2021 Apr 6.

Division of Diagnostic and Surgical Sciences, UCLA School of Dentistry, Los Angeles, CA, USA. Electronic address:

Medication related osteonecrosis of the Jaws (MRONJ) is a severe complication of antiresorptive and anti-angiogenic medications. Osteoclast inhibition is central in MRONJ pathogenesis. Here, we investigated if local application of RANKL (a key molecule in osteoclast activation) could enhance osteoclast generation and improve extraction socket healing in the presence of bisphosphonates. Read More

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Peptidoglycan Recognition Peptide 2 Aggravates Weight Loss in a Murine Model of Chemotherapy-Induced Gastrointestinal Toxicity.

Front Oncol 2021 23;11:635005. Epub 2021 Mar 23.

Hans Christian Andersen Children's Hospital, Odense University Hospital, Odense, Denmark.

Chemotherapy-induced gastrointestinal toxicity (CIGT) is a frequent, severe and dose-limiting side effect. Few treatments have proven effective for CIGT. CIGT is characterized by activation of the nuclear factor kappa B pathway which, leads to upregulation of proinflammatory cytokines. Read More

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J Zoo Wildl Med 2021 Apr;52(1):379-388

Oklahoma City Zoo, Oklahoma City, OK 73111, USA,

This case series describes six confirmed cases of mycotic encephalitis and/or mycotic pneumonia in southern pudu (). One case involved a 10.5-yr-old intact female that presented with an inability to stand, eventually progressing to grand mal seizures. Read More

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J Zoo Wildl Med 2021 Apr;52(1):332-336

College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, IL 61802, USA,

Giraffes () are commonly managed in zoos and conservation programs worldwide, but the current understanding of the occurrence and progression of neoplastic disease in this species is limited by the scarcity of published reports. This study collated documented cases of neoplasia on the basis of gross and histologic evaluation of ante- and postmortem samples. In total, 30 giraffes from 22 institutions across the United States were included. Read More

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J Zoo Wildl Med 2021 Apr;52(1):117-125

School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA.

The objective of this pilot study was to examine the histologic effects associated with three known sclerosing agents and their ability to induce fibrosis in the subcutaneous space between the cervicocephalic air sac and skin. In the future, these drugs may prove useful in treating birds experiencing cervicocephalic diverticula rupture. The agents used were 1% polidocanol, absolute ethanol, and doxycycline hyclate. Read More

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J Zoo Wildl Med 2021 Apr;52(1):28-37

Institute of Virology, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland.

Equine sarcoids (ES) were diagnosed in 12 Somali wild asses (SWA) () from 10 different institutions of the SWA European Endangered Species Programme from 1976 to 2019. Samples of surgically excised masses, biopsies, or necropsy samples were submitted for histologic and virologic analysis. In addition, tissue samples from one onager (), one kulan (), and two Hartmann's mountain zebras (HMZ) () were examined. Read More

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Cutaneous seeding of transitional cell carcinoma of the urinary bladder after placement of a subcutaneous ureteral bypass device in a dog with bilateral ureteral obstruction.

J Am Vet Med Assoc 2021 Apr;258(8):877-882

Case Description: A 12-year-old spayed female Jack Russell Terrier was presented with pollakiuria and stranguria.

Clinical Findings: Transitional cell carcinoma (TCC) of the urinary bladder trigone and urethra was diagnosed via CT, cystoscopic, and histologic examinations. Azotemia developed 2 weeks following diagnosis, secondary to bilateral ureteral obstruction. Read More

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Intramuscularly administered A1 adenosine receptor agonists as delayed treatment for organophosphorus nerve agent-induced Status Epilepticus.

Toxicol Appl Pharmacol 2021 Mar 30;419:115515. Epub 2021 Mar 30.

Neuroscience Department, Medical Toxicology Research Division, US Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD 21010-5400, USA. Electronic address:

Exposure to organophosphorus nerve agents (NAs) like sarin (GB) and soman (GD) can lead to sustained seizure activity, or status epilepticus (SE). Previous research has shown that activation of A1 adenosine receptors (A1ARs) can inhibit neuronal excitability, which could aid in SE termination. Two A1AR agonists, 2-Chloro-N6-cyclopentyladenosine (CCPA) and N-Bicyclo(2. Read More

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Retrospective and prospective studies of transmissible viral proventriculitis in broiler chickens in Brazil.

J Vet Diagn Invest 2021 Mar 26:10406387211004106. Epub 2021 Mar 26.

Departments of Veterinary Clinic and Surgery, Veterinary School, Universidade Federal de Minas Gerais-UFMG, Belo Horizonte, Minas Gerais, Brazil.

We investigated the occurrence and pathologic findings of transmissible viral proventriculitis (TVP) associated with the chicken proventricular necrosis virus (CPNV) in commercial broiler chickens in southeastern Brazil. Seventy-three broilers, 25-36 d old, with a history of reduced growth, were referred to our veterinary pathology services from 2013 to 2017. Broilers were clinically examined, weighed, and euthanized for postmortem examination. Read More

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Generation of a Biobank From Two Adult Thoroughbred Stallions for the Functional Annotation of Animal Genomes Initiative.

Front Genet 2021 8;12:650305. Epub 2021 Mar 8.

Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, Davis, CA, United States.

Following the successful creation of a biobank from two adult Thoroughbred mares, this study aimed to recapitulate sample collection in two adult Thoroughbred stallions as part of the Functional Annotation of the Animal Genome (FAANG) initiative. Both stallions underwent thorough physical, lameness, neurologic, and ophthalmic (including electroretinography) examinations prior to humane euthanasia. Epididymal sperm was recovered from both stallions immediately postmortem and cryopreserved. Read More

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Maternal vitamin D deficiency increases the risk of obesity in male offspring mice by affecting the immune response.

Nutrition 2021 Feb 11;87-88:111191. Epub 2021 Feb 11.

Department of Experimental Hematology and Biochemistry, Beijing Institute of Radiation Medicine, Beijing, China. Electronic address:

Objectives: Recently, many epidemiologic and animal studies have indicated that obesity has its origin in early stages of life, including the inappropriate balance of some nutrients. So the objectives of this study were to determine the risk of obesity in male offspring mice as a consequence of maternal vitamin D (VD) deficiency mediating the disordered immune response.

Methods: C57BL/6J female mice 4 wk old were fed VD-deficient or normal reproductive diets during pregnancy and lactation. Read More

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February 2021

Effect and timing of parathyroid hormone analog administration for preventing medication-related osteonecrosis of the jaws in a murine model.

J Craniomaxillofac Surg 2021 Feb 26. Epub 2021 Feb 26.

Department of Oral & Maxillofacial Surgery, School of Dentistry, Kyung Hee University, Seoul, Republic of Korea; Department of Dentistry, Graduate School, Kyung Hee University, Seoul, Republic of Korea. Electronic address:

The aim of this study was to investigate the effect and timing of recombinant human parathyroid hormone analog (PTH) administration for preventing medication-related osteonecrosis of the jaws (MRONJ) using a murine model. After standardized MRONJ induction using zoledronic acid and dexamethasone injections, 48 female Sprague-Dawley rats were divided into four groups according to the timing of PTH administration before or after dental extraction. Rats were euthanized 3 weeks after dental extraction, followed by clinical and histologic analyses. Read More

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February 2021

Experimental re-infected cats do not transmit SARS-CoV-2.

Emerg Microbes Infect 2021 Dec;10(1):638-650

Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA.

SARS-CoV-2 is the causative agent of COVID-19 and responsible for the current global pandemic. We and others have previously demonstrated that cats are susceptible to SARS-CoV-2 infection and can efficiently transmit the virus to naïve cats. Here, we address whether cats previously exposed to SARS-CoV-2 can be re-infected with SARS-CoV-2. Read More

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December 2021

Use of immune repertoire sequencing to resolve discordant microscopic and immunochemical findings in a case of T cell-rich large B cell lymphoma in a young dog.

BMC Vet Res 2021 Feb 18;17(1):85. Epub 2021 Feb 18.

Department of Pathobiology, University of Guelph, Guelph, Ontario, Canada.

Background: Lymphocytic neoplasms with frequent reactive lymphocytes are uncommonly reported in dogs, and can pose a diagnostic challenge. Different diagnostic modalities such as cytology, flow cytometry, histopathology, immunohistochemistry, and clonality testing, are sometimes required for a diagnosis. This report illustrates the value of using a multi-modal diagnostic approach to decipher a complex lymphocytic tumor, and introduces immune repertoire sequencing as a diagnostic adjunct. Read More

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February 2021

The Enhancement Effect of Acetylcholine and Pyridostigmine on Bone-Tendon Interface Healing in a Murine Rotator Cuff Model.

Am J Sports Med 2021 03 16;49(4):909-917. Epub 2021 Feb 16.

Department of Sports Medicine, Xiangya Hospital, Central South University, Changsha, China.

Background: How to improve rotator cuff healing remains a challenge. Little is known about the effect of the parasympathetic transmitter acetylcholine (ACh) and the acetylcholinesterase inhibitor pyridostigmine (PYR), both of which have anti-inflammatory properties, in the healing process of rotator cuff injury.

Hypothesis: ACh and PYR could enhance bone-tendon interface healing in a murine model of rotator cuff repair. Read More

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Angioinvasive lymphoma (lymphomatoid granulomatosis) in a cat, with cutaneous and ocular metastasis.

J Vet Diagn Invest 2021 Mar 10;33(2):340-344. Epub 2021 Feb 10.

Kansas State Veterinary Diagnostic Laboratory, College of Veterinary Medicine, Kansas State University, Manhattan, KS.

Lymphomatoid granulomatosis (LYG) is a rare variant of an angioinvasive T-cell lymphoproliferative disorder that primarily affects the lungs, with common sites of metastasis including the skin and subcutis. In humans, it is a B-cell lymphoproliferative disorder associated with Epstein-Barr virus infection. Our case is a 7-y-old, spayed female, domestic longhair cat that decompensated and was euthanized following an initial diagnosis of angioinvasive lymphoma from a skin biopsy. Read More

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Periodontal wound healing/regeneration of two-wall intrabony defects following reconstructive surgery with cross-linked hyaluronic acid-gel with or without a collagen matrix: a preclinical study in dogs.

Quintessence Int 2021 ;0(0):308-316

Objectives: In-vitro data have shown that cross-linked hyaluronic acid (HA) enhances the proliferative and migratory properties of cells involved in periodontal wound healing/regeneration, stabilizes the blood clot, reduces the inflammatory response, and facilitates angiogenesis. The aim of this study was to histologically evaluate the effects of cross-linked HA alone or combined with a collagen matrix (CM) on the periodontal wound healing/regeneration in intrabony defects.

Method And Materials: Two-wall intrabony defects (5 mm wide, 5 mm deep) were surgically created at the distal and mesial aspects of mandibular premolars in six beagle dogs. Read More

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February 2021

Long-Term Effects of Sulfadiazine-Trimethoprim Medicated Diet on Cardiac Function, Hematology, and Weight Gain in Hsd:ICR (CD1) and Tac:SW Mice.

Comp Med 2021 Feb 29;71(1):66-75. Epub 2021 Jan 29.

Animal Resources Center, The University of Chicago, Chicago, Illinois; Department of Surgery, The University of Chicago, Chicago, Illinois.

With the alarming increase in heart disease and heart failure, the need for appropriate and ethical animal models of cardiac dysfunction continues to grow. Currently, many animal models of cardiomyopathy require either invasive procedures or genetic manipulation, both of which require extensive expertise, time, and cost. Serendipitous findings at our institution revealed a possible correlation between sulfadiazine-trimethoprim (SDZ-TMP) medicated diet and the development of cardiomyopathy in IcrTac:ICR mice. Read More

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February 2021

Dietary supplementation with multi-strain formula of probiotics modulates inflammatory and immunological markers in apical periodontitis.

J Appl Oral Sci 2021 25;29:e20210483. Epub 2021 Jan 25.

Universidade Estadual Paulista (UNESP), Faculdade de Odontologia de Araçatuba, Departamento de Odontologia Preventiva e Restauradora, Araçatuba, Brasil.

Objective: The aim of this study was to evaluate whether probiotics multi-strain formula affects the development of apical periodontitis (AP) induced in rats.

Methodology: 16 Wistar rats were divided in two groups (n=8): rats with AP fed with regular diet (Control-C (CG)); rats with AP, fed with regular diet and supplemented with multi-strain formula (one billion colony-forming units (CFU)): GNC Probiotic Complex (PCG) ( Lactobacillus acidophilus, Lactobacillus salivaris, Lactobacillus plantarum, Lactobacillus rhamnosus, Bifidobacterium bifidum, Bifidobacterium animalis subs. lactis and Streptococcus thermofilus ). Read More

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January 2021


J Zoo Wildl Med 2021 Jan;51(4):958-969

Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.

An increase in cases of metabolic bone disease (MBD) in chicks of six species of heron and egret (family Ardeidae) was identified at a wildlife rehabilitation center in the spring and summer of 2018. The outbreak affected 34.3% of birds in care for four or more days during the first 3 mo of the study and was the most common reason for euthanasia during that time. Read More

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January 2021

Safety and efficacy of cold atmospheric plasma for the sterilization of a -contaminated subcutaneously implanted foreign body in rabbits.

Am J Vet Res 2021 Feb;82(2):118-124

Objective: To determine whether a stainless steel implant sterilized with a novel cold atmospheric plasma sterilization (CAPS) device adversely affects local tissues in rabbits and whether CAPS was as effective as steam sterilization with an autoclave to inactivate

Animals: 31 healthy New Zealand White rabbits.

Procedures: Steam-autoclaved stainless steel implants inoculated with underwent a second steam autoclave sterilization (AIA) or CAPS (AICAPS). One AIA implant and 3 AICAPS implants were randomly placed subcutaneously at 4 sites in 21 rabbits (84 implants). Read More

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February 2021

The effect of synthetic bone graft substitutes on bone formation in rabbit calvarial defects.

J Mater Sci Mater Med 2021 Jan 21;32(1):14. Epub 2021 Jan 21.

Department of Cranio-Maxillofacial Surgery, Faculty of Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

The aim of this study was to evaluate the influence of the intensity of the biomimetic hydroxyapatite (HA) coating of α-tricalcium phosphate (α-TCP) on biomaterial degradation and bone formation. Twenty-four female NZW rabbits of approximately 12 weeks of age were used. Critical size defects were randomly treated with 3%:97% HA:α-TCP (BBCP1), 12%:88% HA:α-TCP (BBCP2), and 23%:77% HA:α-TCP (BBCP3), respectively or sham. Read More

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January 2021

Pre-clinical evaluation of the effect of a volume-stable collagen matrix on periodontal regeneration in two-wall intrabony defects.

J Clin Periodontol 2021 Jan 20. Epub 2021 Jan 20.

Department of Periodontology, School of Dental Medicine, University of Bern, Bern, Switzerland.

Aim: To histologically evaluate the effect of a new collagen matrix on periodontal regeneration.

Materials And Methods: Two-wall intrabony defects were surgically created bilaterally distally to the maxillary first and third pre-molars in beagle dogs. The defects were randomly allocated to open flap debridement either with (test) or without (control) a volume-stable collagen matrix (VCMX). Read More

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January 2021

Lesions associated with -like bacterium infection in a free-ranging, young-of-the-year raccoon from Prince Edward Island, Canada.

J Vet Diagn Invest 2021 Mar 19;33(2):362-365. Epub 2021 Jan 19.

Southeastern Cooperative Wildlife Disease Study and Warnell School of Forestry and Natural Resources, The University of Georgia, Athens, GA.

A young-of-the year, female raccoon was presented with clinical signs of weakness and tremors. The raccoon was euthanized, and autopsy findings included poor body condition, diffuse lymphadenopathy, and pale, firm kidneys with petechial hemorrhages throughout the renal cortex. Histologic lesions included systemic fibrinoid vascular necrosis and severe renal lesions, including lymphoplasmacytic interstitial nephritis and fibrinosuppurative glomerulonephritis. Read More

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Feasibility of long-term continuous flow total heart replacement in calves.

Int J Artif Organs 2021 Jan 11:391398820987851. Epub 2021 Jan 11.

Cardiovascular Surgical Research Laboratory, Texas Heart Institute, Houston, TX, USA.

Introduction: Implementation of continuous flow (CF) technology in modern ventricular assist devices (VAD) has afforded a wealth of engineering and design advantages in the development of a total artificial heart (TAH). However, clinical application of CF has created a unique physiologic state, the consequences of which remain largely unknown. We sought to evaluate clinical and biochemical markers of end-organ function in calves supported with biventricular CF VADs for more than 30 days. Read More

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January 2021

Curcumin Chemoprevention Reduces the Incidence of Braf Mutant Colorectal Cancer in a Preclinical Study.

Dig Dis Sci 2021 Jan 2. Epub 2021 Jan 2.

QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.

Background: Colorectal cancer is a leading cause of cancer-related death worldwide and approximately 20% of cases can be attributed to a mutation in the BRAF oncogene. Curcumin is a promising chemopreventive agent with various anti-cancer benefits. Although curcumin has been reported to have poor bioavailability, this limitation has been overcome by the formulation of nano-carriers. Read More

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January 2021

Study Comparing Platform Wound Dressing, a Negative-Pressure Device without a Filler, with Three Conventional Negative-Pressure Wound Therapy Systems in the Treatment of Excisional and Incisional Wounds.

Plast Reconstr Surg 2021 Jan;147(1):76-86

From Applied Tissue Technologies LLC.

Background: All common negative-pressure wound therapy systems include a material, usually foam or gauze, at the wound/device interface. In this preclinical study, the authors have compared the effects on different wound healing parameters in the three most common negative-pressure wound therapy systems (i.e. Read More

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January 2021

Ex vivo comparison of ultrasonographic intestinal wall layering with histology in horses: A feasibilty study.

Vet Radiol Ultrasound 2020 Dec 27. Epub 2020 Dec 27.

Department of Clinical Studies, New Bolton Center, University of Pennsylvania, Kennett Square, Pennsylvania.

Ultrasonography is increasingly being used as a clinical and research method for evaluating the gastrointestinal tract in horses, however published studies comparing ultrasonographic and histologic characteristics of equine intestinal wall layers are currently lacking. Objectives of this prospective, observational, methods comparison, case series study were to compare the layering pattern and thickness of the intestinal wall layers determined using ex vivo and in vivo ultrasonography with those determined using histology. For the ex vivo study, twelve horses were euthanized for reasons unrelated to gastrointestinal disease, and samples of the duodenum, jejunum, ileum, cecum, right dorsal colon, and small colon were collected and imaged sonographically ex vivo in an isotonic bath within 1 hour of euthanasia. Read More

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December 2020

Extrahepatic bile duct reconstruction in pigs with heterogenous animal-derived artificial bile ducts: A preliminary experience.

World J Gastroenterol 2020 Dec;26(46):7312-7324

Department of Hepatopancreatobiliary Surgery, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing 102200, China.

Background: Extrahepatic biliary duct injury (BDI) remains a complicated issue for surgeons. Although several approaches have been explored to address this problem, the high incidence of complications affects postoperative recovery. As a nonimmunogenic scaffold, an animal-derived artificial bile duct (ada-BD) could replace the defect, providing good physiological conditions for the regeneration of autologous bile duct structures without changing the original anatomical and physiologic conditions. Read More

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December 2020