222 results match your criteria eurycoma longifolia


Combined Effects of Exercise and Phytoanabolic Extracts in Castrated Male and Female Mice.

Nutrients 2021 Apr 2;13(4). Epub 2021 Apr 2.

Programa de Pós-Graduação em Medicina e Ciências da Saúde, Escola de Medicina, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS 90619-900, Brazil.

Dry extracts from the Eurasian plants, , , and have been used as anabolic supplements, despite the limited scientific data on these effects. To assess their actions on early sarcopenia signs, male and female castrated mice were supplemented with lyophilized extracts of the three plants, isolated or in association (named TLU), and submitted to resistance exercise. Ovariectomy (OVX) led to body weight increase and non-high-density cholesterol (HDL) cholesterol elevation, which had been restored by exercise plus extract, or by exercise and TLU, respectively. Read More

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LC-PDA-MS/MS-Based Characterization of Key Phytochemicals in Eurycoma Longifolia Roots.

J Chromatogr Sci 2021 Apr 20. Epub 2021 Apr 20.

Biotropics Malaysia Berhad, Lot 21, Jalan U1/19, Section U1, Hicom Glenmarie Industrial Park, 40150 Shah Alam, Selangor.

The objective of the study was to fractionate the crude extract of Eurycoma longifolia (E. longifolia) roots and identify the intense peaks using HPLC-PDA-MS/MS, UPLC-MS/MS and H-NMR. Column chromatography was used to fractionate the crude extract into individual fractions using six solvent systems ranged from ethyl acetate, methanol and water in increasing polarity. Read More

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Investigation of Obesity-Alleviation Effect of on Mice Fed with a High-Fat Diet through Metabolomics Revealed Enhanced Decomposition and Inhibition of Accumulation of Lipids.

J Proteome Res 2021 May 15;20(5):2714-2724. Epub 2021 Apr 15.

Laboratory of Clinical Proteomics and Metabolomics, Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, 88 Keyuan South Road, Hi-Tech Zone, Chengdu 610041, China.

The metabolic and bioactivity effects of () in obesity treatment were studied in mice fed with a high-fat diet using a metabolomics approach. Aqueous extracts of were obtained via grinding, dissolving, and freeze-drying. The hepatic steatosis effect of was characterized by hematoxylin and eosin histological staining. Read More

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Medicinal Plants in COVID-19: Potential and Limitations.

Front Pharmacol 2021 24;12:611408. Epub 2021 Mar 24.

Herbal Medicine Research Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health Malaysia, Shah Alam, Malaysia.

Currently, the search to identify treatments and vaccines for novel coronavirus disease (COVID-19) are ongoing. Desperation within the community, especially among the middle-and low-income groups acutely affected by the economic impact of forced lockdowns, has driven increased interest in exploring alternative choices of medicinal plant-based therapeutics. This is evident with the rise in unsubstantiated efficacy claims of these interventions circulating on social media. Read More

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Comparing the pharmacokinetics of 13α,21-dihydroeurycomanone and eurycomanone exclusively enriched in Eurycoma longifolia extracts and their spermatogenesis enhancement in andrographolide-induced oligospermia in rats.

J Pharm Pharmacol 2021 Mar;73(2):161-168

School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia.

Objectives: The quassinoids eurycomanone (EN) and 13α,21-dihydroeurycomanone (DHY) of Eurycoma longifolia Jack are reported to enhance spermatogenesis. This study aims to profile the pharmacokinetics of DHY, a minor and hitherto unstudied constituent, evaluate its spermatogenesis enhancement property and compare these attributes with that of the predominant EN.

Methods: Crude Eurycoma longifolia extract was chromatographed into a DHY-enriched extract (DHY-F) and an EN-enriched extract (EN-F). Read More

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A review on extraction techniques and therapeutic value of polar bioactives from Asian medicinal herbs: Case study on and .

Saudi Pharm J 2021 Feb 7;29(2):143-165. Epub 2021 Jan 7.

Institute of Bioproduct Development, Universiti Teknologi Malaysia, 81310 Johor Bahru, Johor, Malaysia.

Medicinal plants have gained much interest in the prevention and treatment of common human disease such as cold and fever, hypertension and postpartum. Bioactive compounds from medicinal plants were synthesised using effective extraction methods which have important roles in the pharmaceutical product development. (OA), (EL) and (AP) are among popular medicinal herbs in Southeast Asia. Read More

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February 2021

Unfermented Freeze-Dried Leaf Extract of ( Jack.) Induced Cytotoxicity and Apoptosis in MDA-MB-231 and MCF-7 Breast Cancer Cell Lines.

Evid Based Complement Alternat Med 2021 30;2021:8811236. Epub 2021 Jan 30.

Faculty of Science and Natural Resources, Universiti Malaysia Sabah, Jalan UMS, Kota Kinabalu, Sabah 88400, Malaysia.

The present study was conducted to determine the cytotoxicity effect of (Jack.) leaf extracts and also its possible anticancer mechanism of action against breast cancer cell lines: non-hormone-dependent MDA-MB-231 and hormone-dependent MCF-7. The leaves of were processed into unfermented and fermented batches before drying using freeze and microwave-oven drying techniques. Read More

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January 2021

Herbal-Based Formulation Containing and Aqueous Extracts: Safe for Consumption?

Pharmaceuticals (Basel) 2021 Feb 10;14(2). Epub 2021 Feb 10.

Herbal Medicine Research Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health Malaysia, Shah Alam 40170, Selangor Darul Ehsan, Malaysia.

A combined polyherbal formulation containing tongkat ali () and kacip fatimah () aqueous extracts was evaluated for its safety aspect. A repeated dose 28-day toxicity study using Wistar rats was conducted where the polyherbal formulation was administered at doses 125, 500 and 2000 mg/kg body weight to male and female treatment groups daily via oral gavage, with rats receiving only water as the control group. In-life parameters measured include monitoring of food and water consumption and clinical and functional observations. Read More

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February 2021

The effect of Eurycoma Longifolia on the regulation of reproductive hormones in young males.

Andrologia 2021 May 9;53(4):e14001. Epub 2021 Feb 9.

Centre for Sport and Exercise Sciences, University of Malaya, Kuala Lumpur, Malaysia.

Eurycoma longifolia supplementation increases testosterone levels in humans via activation of the hypothalamic-pituitary-gonadal axis and/or the hypothalamic-pituitary-adrenal axis mainly in older adults and nonhealthy populations. This study aimed to assess the impact of Eurycoma longifolia on the hypothalamic-pituitary-gonadal and hypothalamic-pituitary-adrenal axes in healthy young males since this might promote functional testosterone prowess. Thirty-two males (24. Read More

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A 6-month, double-blind, placebo-controlled, randomized trial to evaluate the effect of Eurycoma longifolia (Tongkat Ali) and concurrent training on erectile function and testosterone levels in androgen deficiency of aging males (ADAM).

Maturitas 2021 Mar 10;145:78-85. Epub 2020 Dec 10.

University of Santa Catarina State, Universidade do Estado de Santa Catarina Florianopolis, Santa Catarina, Brazil.

Background: Androgen deficiency of aging males (ADAM) largely manifests as sexual symptoms. Erectile dysfunction is one of the most common symptoms of ADAM.

Aim: To ascertain the effect of concurrent training and supplementation with Eurycoma longifolia on erectile function and testosterone levels in men with ADAM, and the association of erectile function with levels of total testosterone. Read More

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Dietary Supplement Intake and Its Association with Cognitive Function, Physical Fitness, Depressive Symptoms, Nutritional Status and Biochemical Indices in a 3-Year Follow-Up Among Community Dwelling Older Adults: A Longitudinal Study.

Clin Interv Aging 2021 26;16:161-175. Epub 2021 Jan 26.

Center for Healthy Aging and Wellness (H-Care), Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.

Purpose: Use of dietary supplements by older adults has been increasing for improving micronutrient deficiencies, cognitive function, and overall health status. Thus, the objective of this secondary investigation is to explore the longitudinal association of baseline supplement intake in improving cognitive function, biochemical parameters, anthropometric variables and physical fitness among older adults.

Methods: Towards Useful Aging (TUA) is a three-year longitudinal study conducted at baseline (2013-2014) and at follow-up (2015-2017) surveys. Read More

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January 2021

Exercise associated or not to the intake of Eurycoma longifolia improves strength and cardiorespiratory fitness in men with androgen deficiency.

Complement Ther Clin Pract 2021 Feb 5;42:101301. Epub 2021 Jan 5.

Professor of the Department of Physical Education and Post-Graduation Program in Human Movement Sciences at the Health and Sports Sciences Center of the State University of Santa Catarina, Brazil.

This study aims to analyze the effects of a concurrent training (CT) associated with Eurycoma longifolia (EL) supplementation on the muscle strength, cardiorespiratory fitness, and symptomatology score of men with the androgen deficiency of aging male (ADAM). Forty-five subjects (47.6 ± 5. Read More

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February 2021

The botanical eurycomanone is a potent growth regulator of the diamondback moth.

Ecotoxicol Environ Saf 2021 Jan 18;208:111647. Epub 2020 Nov 18.

Key Laboratory of South Subtropical Fruit Biology and Genetic Resource Utilization (MOA), Guangdong Province Key Laboratory of Tropical and Subtropical Fruit Tree Research, Institute of Fruit Tree Research, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China. Electronic address:

Eurycomanone is a quassinoid compound that is derived from Eurycoma longifolia, and it is often used as an indicator to evaluate the active ingredients of Eurycoma longifolia. However, Eurycomanone has rarely been reported to have biological activity toward pests. In this study, we evaluated the antifeedant activity of eurycomanone against the diamondback moth(Plutella xylostella), with a non-selective AFC(the concentration that corresponds to 50% antifeedant action) value and selective AFC of 17. Read More

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January 2021

In Vitro Element Bioavailability Studies of Some Underutilized Seeds in Southeast Nigeria.

Biol Trace Elem Res 2020 Nov 23. Epub 2020 Nov 23.

Department of Dental Surgery, Kwara State College of Technology, Offa, Nigeria.

Elemental and antinutritional compositions of three underutilized seeds (Mucuna sloanei, Brachystegia eurycoma and Detarium microcarpum) were analysed to elucidate their safety and wholesomeness as human food supplements or condiments using standard analytical methods. Results showed that there were significant differences in the concentration levels of the elements and the antinutrient contents of the seeds. The toxic element concentration levels clearly indicated that they exhibited acceptable values when compared with the recommended standards. Read More

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November 2020

[Qualitative and quantitative analysis of quassinoid diterpenoids from Eurycoma longifolia by UPLC-Q-TOF-MS combined with UPLC-QQQ-MS/MS].

Zhongguo Zhong Yao Za Zhi 2020 Oct;45(19):4667-4676

Fujian Provincial Key Laboratory of Screening for Novel Microbial Products, Fujian Institute of Microbiology Fuzhou 350007, China.

In this work, a sensitive and efficient method was established and validated for qualitative and quantitative analysis of major quassinoid diterpenoids constituents from the extract of Eurycoma longifolia by ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry(UPLC-Q-TOF-MS) and ultra-performance liquid chromatography coupled with a triple quadrupole mass spectrometry(UPLC-QQQ-MS/MS). The UPLC-Q-TOF-MS analysis was performed on an Agilent Eclipse Plus C_(18) RRHD(2.1 mm×100 mm,1. Read More

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October 2020

Medicinal plants as a potential source of Phosphodiesterase-5 inhibitors: A review.

J Ethnopharmacol 2021 Mar 1;267:113536. Epub 2020 Nov 1.

Chemical Sciences and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology (NIIST), Thiruvananthapuram, India. Electronic address:

Ethnopharmacological Relevance: The prevalence and distress caused by erectile dysfunction (ED) to both male and female partners are increasing at a steady rate. ED has now become the most treated sexual disorder for men among young and old age groups due to varying physical and psychological factors. The treatment with synthetic Phosphodiesterase-5 (PDE5) inhibitors are cost-effective but due to adverse effects such as priapism, loss of vision, heart attack and syncope, the daily life patterns of these patients are distressed and hence the need for alternative medicaments or sources are of utmost important. Read More

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Pharmacology of Herbal Sexual Enhancers: A Review of Psychiatric and Neurological Adverse Effects.

Pharmaceuticals (Basel) 2020 Oct 14;13(10). Epub 2020 Oct 14.

Unit of Forensic Toxicology, Section of Legal Medicine, Department of Excellence of Biomedical Sciences and Public Health, Marche Polytechnic University, 60126 Ancona, Italy.

Sexual enhancers increase sexual potency, sexual pleasure, or libido. Substances increasing libido alter the concentrations of specific neurotransmitters or sex hormones in the central nervous system. Interestingly, the same pathways are involved in the mechanisms underlying many psychiatric and neurological disorders, and adverse reactions associated with the use of aphrodisiacs are strongly expected. Read More

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October 2020

-Infused Coffee-An Oral Toxicity Study.

Nutrients 2020 Oct 13;12(10). Epub 2020 Oct 13.

Herbal Medicine Research Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health Malaysia, Setia Alam, Shah Alam 40170, Malaysia.

Coffee infused with the additive , also known as Tongkat ali (TA), has become widely available in the Malaysian market. Safety evaluations for consumption of the products have been called for due to the herbal addition. This study investigates the acute, subacute and chronic effects of a commercial TA coffee in Sprague Dawley rats when given in a single, repeated and prolonged dosage. Read More

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October 2020

HPLC-UV-based simultaneous determination of canthin-6-one alkaloids, quassinoids,and scopoletin: the active ingredients in Eurycoma Longifolia Jack and Eurycoma Harmandiana Pierre, and their anti-inflammatory activities.

J AOAC Int 2020 Oct 16. Epub 2020 Oct 16.

Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen, Thailand.

Background: Quassinoids and canthin-6-one alkaloids are bioactive markers of Eurycoma longifolia (EL) and E. harmandiana (EH) and have been commercially utilized to treat inflammation and male infertility.

Objectives: This study aims to reveal the contents of bioactive compounds and to compare anti-inflammatory activities of these two species. Read More

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October 2020

Efficacy of and standardised extracts on hot flushes, quality of life, hormone and lipid profile of peri-menopausal and menopausal women: a randomised, placebo-controlled study.

Food Nutr Res 2020 3;64. Epub 2020 Sep 3.

KGK Science, London, ON, Canada.

Background: Interest in herbal medicines and non-hormonal therapies for the treatment of menopausal symptoms has increased since the publication of adverse effects of estrogen replacement therapy. Vasomotor symptoms are the most characteristic and notable symptoms of menopause.

Objective: To investigate the changes in the frequency and severity of hot flush and associated vasomotor symptoms experienced by peri-menopausal and menopausal women supplemented with the herbal formulation (Nu-femme™) comprising (SLP+) and (Physta) or placebo. Read More

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September 2020

Physical properties of , , and .

Heliyon 2020 Sep 19;6(9):e04885. Epub 2020 Sep 19.

Department of Agricultural and Bioresources Engineering, University of Nigeria, Nsukka, Nigeria.

A culinary enhancer is a substance that enhances the flavor and other properties of soups, stews and foods. Normally in flour form, culinary enhancers are used to enhance the proximate composition, viscosity, flavor and some other rheological and functional properties of soups and convenience foods. Physical properties of culinary seeds are utilized in the development of their handling, storage and processing facilities. Read More

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September 2020

Inactivation of AKT/NF‑κB signaling by eurycomalactone decreases human NSCLC cell viability and improves the chemosensitivity to cisplatin.

Oncol Rep 2020 Oct 31;44(4):1441-1454. Epub 2020 Jul 31.

Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.

The high activation of protein kinase B (AKT)/nuclear factor‑κB (NF‑κB) signaling has often been associated with the induction of non‑small cell lung cancer (NSCLC) cell survival and resistance to cisplatin, which is one of the most widely used chemotherapeutic drugs in the treatment of NSCLC. The inhibition of AKT/NF‑κB can potentially be used as a molecular target for cancer therapy. Eurycomalactone (ECL), a quassinoid from Eurycoma longifolia Jack, has previously been revealed to exhibit strong cytotoxic activity against the human NSCLC A549 cell line, and can inhibit NF‑κB activity in TNF‑α‑activated 293 cells stably transfected with an NF‑κB luciferase reporter. Read More

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October 2020

Differentially expressed genes on the growth of mouse Leydig cells treated with standardised Eurycoma longifolia extract.

Mol Med Rep 2020 Nov 2;22(5):3645-3658. Epub 2020 Sep 2.

School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Penang, Malaysia.

Eurycoma (E.) longifolia Jack (Tongkat Ali) is a widely applied medicine that has been reported to boost serum testosterone and increase muscle mass. However, its actual biological targets and effects on an in vitro level remain poorly understood. Read More

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November 2020

The Powdered Root of Jack Improves Beta-Cell Number and Pancreatic Islet Performance through PDX1 Induction and Shows Antihyperglycemic Activity in db/db Mice.

Nutrients 2020 Jul 16;12(7). Epub 2020 Jul 16.

Department of Physiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.

Non-insulin-dependent diabetes mellitus (NIDDM) is a common metabolic disorder worldwide. In addition to the chief feature of long-standing hyperglycemia, dyslipidemia, hyperinsulinemia, and a number of complications develop in parallel. It is believed that an adequate control of blood glucose levels can cause these complications to go into remission. Read More

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Anti-inflammatory canthin-6-one alkaloids from the roots of Thailand Eurycoma longifolia Jack.

J Nat Med 2020 Sep 8;74(4):804-810. Epub 2020 Jul 8.

Tianjin Key Laboratory of TCM Chemistry and Analysis, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin, 301617, China.

Two new canthin-6-one alkaloids, 4,9-dimethoxy-5-hydroxycanthin-6-one (1) and 9-methoxy-(R/S)-5-(1-hydroxyethyl)-canthin-6-one (2), together with fifteen known ones were isolated from the roots of Thailand Eurycoma longifolia Jack. Among the known canthin-6-one alkaloids, compounds 9 and 16 were isolated from the Eurycoma genus for the first time. Meanwhile, the nitric oxide (NO) inhibitory activities of all isolates were examined in lipopolysaccharide (LPS)-stimulated RAW264. Read More

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September 2020

Evaluating the locally sourced materials as fluid loss control additives in water-based drilling fluid.

Heliyon 2020 May 30;6(5):e04091. Epub 2020 May 30.

Department of Chemical and Petroleum Engineering, University of Uyo, Nigeria.

In the exploration for hydrocarbons, a successful drilling operation to the desired depth hinges on the effective performance of the formulated drilling fluid. Apart from carrying drill cuttings to the surface, another major function of the fluid is to seal off the walls of the wellbore to prevent fluids from coming into and out of the wellbore while drilling a well. Numerous commercial fluid loss additives: carboxymethyl cellulose (CMC), polyanionic cellulose (PAC), among others have been in existence with their drawbacks and effect on the total drilling cost. Read More

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14,15β-dihydroxyklaineanone inhibits HepG2 cell proliferation and migration through p38MAPK pathway.

J Pharm Pharmacol 2020 Sep 17;72(9):1165-1175. Epub 2020 May 17.

College of Light Industry and Food Engineering, Guangxi University, Nanning, China.

Objectives: Eurycoma longifolia Jack (Simaroubaceae) is commonly distributed in the Southeast Asia and Indo China, which has been shown to possess antianxiety, antibacterial, anticancer, antifungal, anti-inflammatory, antimalarial and antioxidant biological activities. 14,15β-dihydroxyklaineanone is a diterpene isolated from E. longifolia Jack, which is cytotoxic against human lung cancer and human breast cancer cell lines. Read More

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September 2020

A systematic review and evidence-based analysis of ingredients in popular male testosterone and erectile dysfunction supplements.

Int J Impot Res 2021 Apr 1;33(3):311-317. Epub 2020 May 1.

Department of Urology, Miller School of Medicine, University of Miami, Miami, FL, USA.

The objective was to study available evidence for ingredients of popular over-the-counter testosterone and erectile dysfunction (ED) supplements. The top 16 male testosterone and 16 ED supplements in the USA were identified from the most popular online retailers: A1 Supplements, Amazon, Vitamin Shoppe, and Walmart. In total, 37 ingredients were identified and PUBMED online database was reviewed for randomized-controlled trials (RCT) studying their efficacy. Read More

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Unprecedented Quassinoids from : Biogenetic Evidence and Antifeedant Effects.

J Nat Prod 2020 05 20;83(5):1674-1683. Epub 2020 Apr 20.

Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou, Guangdong 510632, People's Republic of China.

Six new quassinoids (-) were isolated from the roots of , and their structures with absolute configurations were determined unambiguously by spectroscopic analyses and single-crystal X-ray crystallographic experiments. Compounds and are the first members of a new class of quassinoids with an unusual C carbon skeleton. Compound features a C cage-like scaffold with an unprecedented densely functionalized 2,5-dioxatricyclo[5. Read More

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Selection of Thai Medicinal Plants with Anti-Obesogenic Potential via In Vitro Methods.

Pharmaceuticals (Basel) 2020 Mar 29;13(4). Epub 2020 Mar 29.

Division of Fundamental AgriScience and Research, Research Faculty of Agriculture, Hokkaido University, Kita-ku, Sapporo, Hokkaido 060-8589, Japan.

The prevalence of obesity is increasing globally. Despite the availability of a variety of anti-obesogenic drugs, including therapies under clinical development, these treatments are often indicated for patients with severe obesity, making them unsuitable for patients with mild obesity or for preventative use. In Thailand, traditional remedies employing medicinal plants are widely used to maintain health and treat disease. Read More

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