42 results match your criteria eumycetoma sites


Two simultaneous eumycetomas in different sites of same patient with discharge of black and white grains - First case in India.

Indian J Med Microbiol 2021 Apr 2;39(2):256-258. Epub 2020 Nov 2.

Department of Dermatology, Institute of Post-Graduate Medical Education & Research, 244 AJC Bose Road, Kolkata, 700020, India.

Simultaneous double mycetoma is a rare presentation. Worldwide only three to four cases are found in literature. Here we report such an unusual case, to the best of our knowledge first documented case from India, where a 60 years old male farmer presented with double eumycetoma in different sites of same limb with discharge of black and white grains, which conventionally diagnosed as Madurella grisea from foot and Acremonium falciformi from buttock respectively. Read More

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Invasive, aggressive mastoid bone eumycetoma: a treatment challenge.

Trans R Soc Trop Med Hyg 2021 04;115(4):431-435

Mycetoma Research Centre, University of Khartoum, Khartoum, Sudan.

Mycetoma is a chronic granulomatous disease that significant affects the subcutaneous tissue and deep structures. Mycetoma is caused by certain fungi (eumycetoma) or higher bacteria (actinomycetoma). The clinical presentation is variable and depends on the causative agent. Read More

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Massive complicated secondary inguinal mycetoma: a case series.

Trans R Soc Trop Med Hyg 2021 04;115(4):420-425

Mycetoma Research Centre, University of Khartoum, Khartoum, Sudan.

Mycetoma is a chronic subcutaneous granulomatous disease of the soft tissue and extremities. Herein we report four cases of mycetoma caused by different agents, two caused by Madurella mycetomatis, with Actinomadura madurae and Streptomyces somaliensis affecting the others. These lesions originated at different sites but eventually spread to the inguinal region. Read More

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Cyto-morphological and clinical approach to infections presenting with discharging sinuses mimicking malignancy.

Diagn Cytopathol 2020 Dec 17;48(12):1265-1272. Epub 2020 Aug 17.

Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

Introduction: Discharging sinuses is a form of chronic unhealed infection that can present at any site due to a variety of infectious organisms. These discharging sinuses may be associated with mass lesions and lymphadenopathy to mimic some neoplastic processes. Identifying these infections with accuracy and promptness is essential, as the treatment regimens are specific. Read More

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December 2020

Frequency distribution of IL-17A G197A (rs2275913) and IL-17F A7488G (rs763780) polymorphisms among healthy Sudanese population.

BMC Res Notes 2020 Jul 2;13(1):317. Epub 2020 Jul 2.

Department of Molecular Biology, Institute of Parasitology, University of Leipzig, Leipzig, Germany.

Objectives: IL-17A G197A and IL-17F A7488G polymorphisms has been identified to be associated with the susceptibility to many diseases. This study aimed to investigate the frequency distribution of IL-17A G197A and IL-17F A7488G polymorphisms among healthy Sudanese population. A descriptive cross-sectional hospital-based molecular study conducted in different sites throughout Sudan. Read More

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Diversity and geographic distribution of soil streptomycetes with antagonistic potential against actinomycetoma-causing Streptomyces sudanensis in Sudan and South Sudan.

BMC Microbiol 2020 02 12;20(1):33. Epub 2020 Feb 12.

Department of Soil Ecology, Helmholtz-Centre for Environmental Research GmbH - UFZ, Theodor-Lieser-Str. 4, 06120, Halle, Germany.

Background: Production of antibiotics to inhibit competitors affects soil microbial community composition and contributes to disease suppression. In this work, we characterized whether Streptomyces bacteria, prolific antibiotics producers, inhibit a soil borne human pathogenic microorganism, Streptomyces sudanensis. S. Read More

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February 2020

Genetic polymorphism of the N-terminal region in circumsporozoite surface protein of Plasmodium falciparum field isolates from Sudan.

Malar J 2019 Oct 1;18(1):333. Epub 2019 Oct 1.

Department of Parasitology and Medical Entomology, Faculty of Medical Laboratory Sciences, Alzaiem Alazhari University, Khartoum, Sudan.

Background: Malaria caused by Plasmodium falciparum parasite is still known to be one of the most significant public health problems in sub-Saharan Africa. Genetic diversity of the Sudanese P. falciparum based on the diversity in the circumsporozoite surface protein (PfCSP) has not been previously studied. Read More

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October 2019

Mycetoma: The Spectrum of Clinical Presentation.

Trop Med Infect Dis 2018 Sep 4;3(3). Epub 2018 Sep 4.

The International Foundation for Dermatology, London W1P 5HQ, UK.

Mycetoma is a chronic infection, newly designated by the World Health Organization (WHO) as a neglected tropical disease, which is endemic in tropical and subtropical regions. It follows implantation of infectious organisms, either fungi (eumycetomas) or filamentous bacteria (actinomycetomas) into subcutaneous tissue, from where infection spreads to involve skin, bone and subcutaneous sites, leading to both health related and socioeconomic problems. In common with other NTDs, mycetoma is most often seen in rural areas amongst the poorest of people who have less access to health care. Read More

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September 2018

Giant cell tumour of tendon sheath: A 10-year study from a tertiary care centre.

Cytopathology 2018 06 25;29(3):288-293. Epub 2018 Mar 25.

Department of Cytology and Gynecological Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Introduction: Cytology of giant cell tumour of tendon sheath (GCTTS) is often sufficient to diagnose this lesion and has been previously described in small series. The present study was undertaken to evaluate detailed cytomorphological features and differential diagnostic entities and pitfalls in the diagnosis.

Methods: All the cases of GCTTS reported on FNAC were retrieved from July 2007 to June 2017. Read More

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Predictors of Post-operative Mycetoma Recurrence Using Machine-Learning Algorithms: The Mycetoma Research Center Experience.

PLoS Negl Trop Dis 2016 Oct 31;10(10):e0005007. Epub 2016 Oct 31.

The Mycetoma Research Center, University of Khartoum, Khartoum, Sudan.

Post-operative recurrence in mycetoma after adequate medical and surgical treatment is common and a serious problem. It has health, socio-economic and psychological detrimental effects on patients and families. It is with this in mind, we set out to determine the predictors of post-operative recurrence in mycetoma. Read More

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October 2016

[Multiple sites extrapodal actinomycetoma: Favorable outcome to treatment with a combination of cotrimoxazole and NSAI].

J Mycol Med 2015 Dec 5;25(4):297-302. Epub 2015 Nov 5.

Service de parasitologie-mycologie de l'institut supérieur des sciences de la santé, université polytechnique de Bobo-Dioulasso, Bobo-Dioulasso, Burkina Faso.

Mycetoma is a bacteriological or fungal infectious disease affecting the skin and/or soft tissues, which can be complicated by bone involvement. The most common feature is a tumor of the foot, but extrapodal localizations have been described. We report one case of a 47-year-old man who presented with tumefaction of a leg with multiple skin fistulae. Read More

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December 2015

Mycetoma in the Sudan: an update from the Mycetoma Research Centre, University of Khartoum, Sudan.

PLoS Negl Trop Dis 2015 Mar 27;9(3):e0003679. Epub 2015 Mar 27.

Faculty of Mathematical Sciences, University of Khartoum, Khartoum, Sudan.

This communication reports on the Mycetoma Research Centre of the University of Khartoum, Sudan experience on 6,792 patients seen during the period 1991-2014.The patients were predominately young (64% under 30 years old) males (76%). The majority (68%) were from the Sudan mycetoma belt and 28% were students. Read More

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Tuberculous granuloma: a rare cause of a non-healing ulcer.

BMJ Case Rep 2014 Nov 19;2014. Epub 2014 Nov 19.

Derriford Hospital, Plymouth, Devon, UK.

A 78-year-old woman on ciclosporin for aplastic anaemia presented to her general practitioner with a 2 cm cystic swelling on the right side of her forehead. After a period of 8 months the lesion ruptured and, despite good wound care, failed to heal over a period of seven further months. Imaging demonstrated an invasive process and a biopsy was taken, which showed granulomatous inflammation that stained positively for mycobacteria. Read More

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November 2014

[Epidemiological transition of mycosis diseases in sub-Saharan Africa: from surface to depth].

Bull Soc Pathol Exot 2015 Feb 5;108(1):41-5. Epub 2014 Jul 5.

Parasitologie-mycologie-médecine tropicale, CHRU, 37000, Tours, France.

Fungi are schematically responsible for three distinct kinds of infections: superficial mycoses, subcutaneous and deep ones. The current socio-epidemiological transition observed in sub-Saharan Africa does not actually lead to similar consequences regarding these three categories of fungal entities. For instance, it has long been known that superficial mycoses are very prevalent in tropical areas, since they are partly due to the warm climate and the promiscuity. Read More

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February 2015

A Rare Presentation of Concurrent Scedosporium apiospermum and Madurella grisea Eumycetoma in an Immunocompetent Host.

Case Rep Pathol 2012 22;2012:154201. Epub 2012 Oct 22.

Department of Orthopaedic, Ealing Hospital NHS Trust, Uxbridge Road, Southall UB1 3HW, UK ; HPA Mycology Reference Laboratory, Myrtle Road, Bristol BS2 8EL, UK.

Mycetoma is a disfiguring, chronic granulomatous infection which affects the skin and the underlying subcutaneous tissue. We present an atypical case of recurrent mycetoma without ulceration, in a 35-year-old immunocompetent male caused by Scedosporium apiospermum sensu stricto and Madurella grisea, occurring at two separate anatomical sites. Read More

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November 2012

Abundance of Pseudallescheria/Scedosporium species in the Australian urban environment suggests a possible source for scedosporiosis including the colonization of airways in cystic fibrosis.

Med Mycol 2010 Nov;48 Suppl 1:S70-6

Centre for Infectious Diseases and Microbiology, Westmead Hospital, Westmead Millennium Institute, The University of Sydney, Australia.

Members of the Pseudallescheria/Scedosporium species complex are emerging opportunistic fungal pathogens which have the capacity to colonize patients with damaged airways, including those with cystic fibrosis (CF). Assuming human infection is acquired via inhalation of fungal spores from the environment, we performed a qualitative environmental survey encompassing 25 urban, semirural and rural sites in the greater Sydney region to determine the prevalence of Pseudallescheria/Scedosporium species. Soil sampling revealed an abundance of Pseudallescheria/Scedosporium, particularly in locations associated with high human activity. Read More

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November 2010

Successful treatment of Scedosporium apiospermum soft tissue abscess with caspofungin and voriconazole in a severely immunocompromised patient with acute myeloid leukemia.

Transpl Infect Dis 2010 Dec;12(6):538-42

Department of Hematology and Oncology, University of Regensburg, Regensburg, Germany.

We report the case of a 53-year-old female patient with refractory acute myeloid leukemia developing a necrotic, soft tissue abscess on the right forearm caused by Scedosporium apiospermum during prolonged severe neutropenia (absolute white blood cell count <500/μL for 49 days). In the context of the severely immunocompromised state of the patient and her need for allogeneic hematopoietic stem cell transplantation (HSCT), surgical treatment options were not favored. Therefore, combined antifungal therapy with voriconazole and caspofungin was started, based on the results of the in vitro testing (minimum inhibitory concentrations of voriconazole, posaconazole, and amphotericin B: 1, 4, and >2mg/L, respectively). Read More

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December 2010

Infections caused by Scedosporium spp.

Clin Microbiol Rev 2008 Jan;21(1):157-97

Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA.

Scedosporium spp. are increasingly recognized as causes of resistant life-threatening infections in immunocompromised patients. Scedosporium spp. Read More

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January 2008

Scedosporiosis in patients with acute leukemia: a retrospective multicenter report.

Haematologica 2008 Jan;93(1):104-10

Istituto di Ematologia, Università Cattolica del Sacro Cuore, Largo Francesco Vito, I-00168 Rome, Italy.

We retrospectively analyzed 542 proven/probable mould infections registered, in the course of 2 studies, in 8,633 patients with acute leukemia, focusing on scedosporiosis. We aimed to define scedosporiosis incidence and mortality rate over a 15-year period. Only 5 cases of scedosporiosis were identified, all of them involving patients with acute myeloid leukemia (AML). Read More

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January 2008

Primary cutaneous nocardiosis: a case study and review.

Indian J Dermatol Venereol Leprol 2003 Nov-Dec;69(6):386-91

Department of Dermatology, Venereology & Leprosy, BLDEA's SBMP Medical College, Hospital & Research Centre, Bijapur.

Background: Primary cutaneous nocardiosis is an uncommon entity. It usually occurs among immunocompetent but occupationally predisposed individuals.

Aim: To study clinical profile of patients with primary cutaneous nocardiosis in a tertiary care hospital and to review the literature. Read More

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Abdominal wall mycetoma presented as obstructed incisional hernia of cesarean section in eastern Sudan.

Infect Dis Obstet Gynecol 2009 7;2009:74643. Epub 2007 Mar 7.

New Halfa Teaching Hospital, P.O. Box 61, New Halfa, Sudan.

Mycetoma a worldwide disease frequently occurs in the tropics with the highest prevalence being in Africa. Madurella mycetomatis is the main causative organism of human eumycetoma in Sudan. The legs and feet were commonly the sites of the infection. Read More

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October 2009

[Maxillary sinus infection with emphysema of the head as a "red herring" in steroid associated colon perforation].

Ther Umsch 2006 Dec;63(12):763-6

Medizinische Klinik, Spital Zollikerberg, Zollikerberg.

Steroid therapy increases the risk of bowel perforation. Bowel perforation may occur at any time of steroid therapy, but the first weeks appear to hold the greatest potential for perforation. However, clinical findings after perforation may be misleading under steroids, and peritonitis may be absent. Read More

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December 2006

[Clinical and microbiological study of mycetomas at the Muñiz hospital of Buenos Aires between 1989 and 2004].

Rev Argent Microbiol 2006 Jan-Mar;38(1):13-8

Unidad Micología, Hospital Francisco Javier Muñiz. Uspallata 2272, (1282) Buenos Aires, Argentina.

This work presents clinical, microbiological and outcome data collected from 76 patients with mycetomas at the Muñiz Hospital from 1989 to 2004. Forty-nine patients were male and 27 female; the mean age was 43.4 years. Read More

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September 2006

[Cranial and cervical vertebral mycetoma. Report of three cases].

Neurochirurgie 2005 Nov;51(5):471-5

Service de Neurochirurgie, Centre Hospitalier National de Fann-Dakar, Dakar, Sénégal.

Mycetomas inflammatory-like tumors presenting as fistulas found in the skin and soft tissues. Inoculation, generally in tropical areas, occurs by skin injury. The foot is the main infection site. Read More

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November 2005

Eumycotic mycetoma caused by Cladophialophora bantiana in a patient with systemic lupus erythematosus.

J Am Acad Dermatol 2005 May;52(5 Suppl 1):S114-7

Department of Dermatology at UT Southwestern Medical Center, Dallas, Texas, USA.

We present the case of a 31-year-old patient who developed widespread mycetoma across her back and shoulders caused by Cladophialophora bantiana 16 years after injury to those sites from tornado debris. The patient also had a history of systemic lupus erythematosus treated with systemic steroids. Systemic antifungal treatment with fluconazole and itraconazole proved ineffective, and surgical debridement was required. Read More

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[Histopathological diagnosis of mycoses in veterinary pathology].

Authors:
L Carrasco J Pérez

Rev Iberoam Micol 2000 Mar;17(1):S18-22

Departamento de Anatomía y Anatomía Patológica Comparadas. Facultad de Veterinaria. Córdoba, España.

Histopathological analysis demonstrates the morphology of the fungi and shows their relationship with tissue lesions, which is a valuable information in the diagnosis of veterinary mycoses, especially in superficial infections where reservoirs make difficult the diagnosis using other techniques. On the other hand, histopathological analysis should be complementary to other methods such as culture, immunohistochemistry, serology, PCR, etc. In this work, the most relevant histopathological features of some of the most common mycoses of domestic animals, some of which have zoonotic potential, are described and their differential diagnosis is discussed. Read More

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Pathological fractures in mycetoma.

Trans R Soc Trop Med Hyg 2003 Sep-Oct;97(5):582-4

Department of Radiology, Faculty of Medicine, University of Khartoum, Khartoum, Sudan.

Pathological fractures in mycetoma are a rarity and only 1 patient was reported in the literature. We report an unexpectedly high incidence of pathological fractures in mycetoma seen at the Mycetoma Research Centre, Khartoum, Sudan over a 10-year period. Plain radiographs of 517 patients with confirmed mycetoma in various body sites were reviewed and correlated with the clinical presentation of the patients. Read More

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November 2004

Madurella mycetomatis strains from mycetoma lesions in Sudanese patients are clonal.

J Clin Microbiol 2003 Oct;41(10):4537-41

Mycetoma Research Group, Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan.

Molecular diversity among clinical isolates of Madurella mycetomatis, the prime fungal agent of human mycetoma in Sudan, could possibly explain the diverse clinical presentations of this severely debilitating infectious disease. In addition, culture-independent DNA-mediated typing tests need to be developed for this organism, since M. mycetomatis DNA, but not the organism itself, can be identified in soil, the material from which infections are thought to originate. Read More

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October 2003

Scedosporium apiospermum keratitis treated with itraconazole.

Med Mycol 2003 Apr;41(2):111-4

Division of Medical Mycology, Department of Microbiology and Clinical Microbiology, Gulhane Military Medical Academy and School of Medicine, 06018 Etlik Ankara, Turkey.

Mycotic keratitis usually occurs in conjunction with trauma to the cornea. Scedosporium apiospermum, a dematiaceous fungus linked to the teleomorph Pseudallescheria boydii is not a common agent of mycotic keratitis. A 22-year old male patient with mycotic keratitis due to S. Read More

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Corneal co-infection with Scedosporium apiospermum and Acanthamoeba after sewage-contaminated ocular injury.

Cornea 2001 Jan;20(1):112-6

Department of Ophthalmology, Western Galilee, Nahariya Medical Center, Israel.

Purpose: To describe a corneal co-infection with the fungus Scedosporium apiospermum and Acanthamoeba that result in spontaneous corneal perforation.

Methods: A 27-year-old man presented due to severe ocular pain in his left eye caused by a corneal ulcer. The patient was injured 7 days before presentation by metallic thread contaminated by sewage. Read More

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January 2001