301,142 results match your criteria etiology severity

AIM2-driven inflammasome activation in heart failure.

Cardiovasc Res 2021 Jun 12. Epub 2021 Jun 12.

Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary.

Aims: Interleukin-1β (IL-1β) is an important pathogenic factor in cardiovascular diseases including chronic heart failure (HF). The CANTOS trial highlighted that inflammasomes as primary sources of IL-1 β are promising new therapeutic targets in cardiovascular diseases. Therefore, we aimed to assess inflammasome activation in failing hearts to identify activation patterns of inflammasome subtypes as sources of IL-1β. Read More

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Clinical Manifestations and Long-Term Outcome of Early Lyme Neuroborreliosis According to EFNS Diagnostic Criteria (Definite versus Possible) in Central Europe. A Retrospective Cohort Study.

Eur J Neurol 2021 Jun 11. Epub 2021 Jun 11.

Institute for Microbiology and Immunology Ljubljana, Faculty of Medicine, University of Ljubljana, Zaloška 4, 1104, Ljubljana, Slovenia.

Background: Characteristics and long-term outcome of Lyme neuroborreliosis (LNB) according to diagnostic certainty (definite versus possible) are incompletely understood.

Methods: In this retrospective cohort study of adults with definite or possible LNB, clinical and microbiologic characteristics and long-term outcome over 12-months were evaluated at a single medical center. Severity of acute disease and long-term outcome were assessed using a composite clinical score encompassing clinical findings and symptoms and by the probability of incomplete recovery. Read More

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Stress and corticotropin releasing factor (CRF) promote necrotizing enterocolitis in a formula-fed neonatal rat model.

PLoS One 2021 10;16(6):e0246412. Epub 2021 Jun 10.

Department of Obstetrics and Gynecology, Center for Reproductive Sciences, University of California San Francisco, San Francisco, California, United States of America.

The etiology of necrotizing enterocolitis (NEC) is not known. Alterations in gut microbiome, mucosal barrier function, immune cell activation, and blood flow are characterized events in its development, with stress as a contributing factor. The hormone corticotropin-releasing factor (CRF) is a key mediator of stress responses and influences these aforementioned processes. Read More

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Genomic Surveillance for SARS-CoV-2 Variants Circulating in the United States, December 2020-May 2021.

MMWR Morb Mortal Wkly Rep 2021 Jun 11;70(23):846-850. Epub 2021 Jun 11.

SARS-CoV-2, the virus that causes COVID-19, is constantly mutating, leading to new variants (1). Variants have the potential to affect transmission, disease severity, diagnostics, therapeutics, and natural and vaccine-induced immunity. In November 2020, CDC established national surveillance for SARS-CoV-2 variants using genomic sequencing. Read More

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Understanding Factors That Cause Tinnitus: A Mendelian Randomization Study in the UK Biobank.

Ear Hear 2021 Jun 8. Epub 2021 Jun 8.

Royal Devon and Exeter NHS Foundation Trust, Barrack Road, Exeter, United Kingdom Genetics of Complex Traits, University of Exeter Medical School, RILD building, Royal Devon and Exeter Hospital, Exeter, United Kingdom Torbay and South Devon NHS Foundation Trust, Newton Road, Torquay, United Kingdom.

Objectives: To investigate the causal role of established risk factors and associated conditions to tinnitus and tinnitus severity in the UK Biobank.

Design: The prospective cohort study with large dataset of >500,000 individuals. The analytical sample of 129,731 individuals in the UK Biobank of European descent. Read More

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Georgian Med News 2021 Apr(313):89-93

V.N. Karazin Kharkiv National University, Department of Infectious Diseases and Clinical Immunology, School of Medicine, Ukraine.

Herpesvirus infections (HI) are the most common HIV-associated diseases. Due to the development of the HIV pandemic, the incidence of HI against the background of HIV infection is steadily increasing, and the implantation of HAART makes certain changes in the course of diseases of this category. The aim of the study was to compare clinical and immunological data in different forms of HI in HIV-positive patients and in patients with normal immune status. Read More

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Georgian Med News 2021 Apr(313):12-20

City Clinical Hospital №4, Dnipro, Ukraine.

Objective - to study the character of possible postoperative complications and to define the reason and frequency of postoperative hemorrhage as a complication of partial nephrectomy. From January 2008 to December 2019 were performed 175 partial nephrectomy (PN) by a single surgeon in a high volume center. 41 operations were laparoscopic partial nephrectomy (LPN), 134 - open partial nephrectomy (OPN). Read More

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[Preliminary analysis of intestinal microflora in patients with different severity of OSAHS].

Zhonghua Jie He He Hu Xi Za Zhi 2021 Jun;44(6):543-549

Department of Respiratory and Critical Care Medicine, the Second Hospital of Shanxi Medical University, Taiyuan 030001, China.

To analyze the diversity, abundance and structural composition of intestinal microflora in patients with different severity of OSAHS, and to explore their potential role in the occurrence and development of OSAHS. A total of 27 healthy volunteers(N) [male 19, female 8, age 22-78(44.4±2. Read More

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Coagulation factors and the incidence of COVID-19 severity: Mendelian randomization analyses and supporting evidence.

Signal Transduct Target Ther 2021 06 7;6(1):222. Epub 2021 Jun 7.

The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin Medical University, Tianjin, China.

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Association of thromboelastography profile with severity of liver cirrhosis and portal venous system thrombosis.

BMC Gastroenterol 2021 Jun 7;21(1):253. Epub 2021 Jun 7.

Liver Cirrhosis Study Group, Department of Gastroenterology, General Hospital of Northern Theater Command (formerly General Hospital of Shenyang Military Area), No. 83 Wenhua Road, Shenyang, 110840, Liaoning Province, China.

Background And Aim: Hemostasis profile is often complicated in liver cirrhosis. Thromboelastography is a global viscoelastic test recommended by the current practice guideline and consensus. This cross-sectional study aimed to evaluate the association of thromboelastography profile with severity of liver cirrhosis and presence of portal venous system thrombosis (PVST). Read More

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Creatinine-lactate score predicts mortality in non-acetaminophen-induced acute liver failure in patients listed for liver transplantation.

BMC Gastroenterol 2021 Jun 7;21(1):252. Epub 2021 Jun 7.

Laboratorio de Investigaçao Medica 37, Departamento de Gastroenterologia, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo - HCFMUSP, Sao Paulo, SP, Brazil.

Background: The aim of this study was to analyze prognostic indicators of in-hospital mortality among patients listed for urgent liver transplantation (LT) for non-acetaminophen (APAP)-induced acute liver failure (ALF).

Methods: ALF patients listed for LT according to the King's College Criteria were retrospectively reviewed. Variables were recorded from medical records and electronic databases (HCMED and RedCap). Read More

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[Risk factors and clinical prognosis analysis of carbapenem-resistant bacteria nosocomial infection].

Zhonghua Yi Xue Za Zhi 2021 Jun;101(21):1572-1582

Department of Laboratory Medicine, Peking University People's Hospital, Beijing 100044, China.

To explore the risk factors for carbapenem-resistant (CRE) infection and death. A case-control analysis of 482 inpatients in 18 secondary or tertiary hospitals in Beijing in 2018 was conducted. Patients infected by CRE were selected as the case group (247), and infected by carbapenem susceptible (CSE) as the control group (235). Read More

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[Preliminary study on the relationship between different blood glucose levels and periodontitis in patients with diabetes mellitus type 2].

Zhonghua Kou Qiang Yi Xue Za Zhi 2021 Jun;56(6):517-524

Department of Periodontology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine & College of Stomatology, Shanghai Jiao Tong University & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Shanghai Key Laboratory of Stomatology, Shanghai 200011, China.

To determine the correlation between the diabetes mellitus control and periodontitis. This study was a cross-sectional survey using stratified system sampling model design. The target population was the patients with diabetes investigated from May to July 2018 in Huangpu District of Shanghai. Read More

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Reactive Oxygen Species Mediate Low Back Pain by Upregulating Substance P in Intervertebral Disc Degeneration.

Oxid Med Cell Longev 2021 14;2021:6681815. Epub 2021 May 14.

Henan Luoyang Orthopedic Hospital (Henan Provincial Orthopedic Hospital), Henan Provincial Orthopedic Institute, Zhengzhou 450000, China.

Reactive oxygen species (ROS) are thought to have a strong correlation with a number of intervertebral disc (IVD) diseases. Here, we aimed to determine whether ROS represent an etiology of low back pain (LBP) during IVD degeneration. Thirty degenerated intervertebral disc samples were obtained from patients, and ROS levels were quantified using dihydroethidium (DHE) staining. Read More

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Association Between Environmental Factors and Asthma Using Mendelian Randomization: Increased Effect of Body Mass Index on Adult-Onset Moderate-to-Severe Asthma Subtypes.

Front Genet 2021 20;12:639905. Epub 2021 May 20.

Department of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University, Seoul, South Korea.

Although asthma is one of the most common chronic diseases throughout all age groups, its etiology remains unknown, primarily due to its heterogeneous characteristics. We examined the causal effects of various environmental factors on asthma using Mendelian randomization and determined whether the susceptibility to asthma due to the causal effect of a risk factor differs between asthma subtypes, based on age of onset, severity of asthma, and sex. We performed Mendelian randomization analyses (inverse variance weighted, weighted median, and generalized summary-data-based Mendelian randomization) using UK Biobank data to estimate the causal effects of 69 environmental factors on asthma. Read More

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Can Resveratrol-Inhaled Formulations Be Considered Potential Adjunct Treatments for COVID-19?

Front Immunol 2021;12:670955. Epub 2021 May 19.

Department of Public Health and Infectious Diseases, Microbiology Section, University of Rome "Sapienza", Rome, Italy.

The pandemic caused by severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) has led to an extraordinary threat to the global healthcare system. This infection disease, named COVID-19, is characterized by a wide clinical spectrum, ranging from asymptomatic or mild upper respiratory tract illness to severe viral pneumonia with fulminant cytokine storm, which leads to respiratory failure. To improve patient outcomes, both the inhibition of viral replication and of the unwarranted excessive inflammatory response are crucial. Read More

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Nasopharyngeal Type-I Interferon for Immediately Available Prophylaxis Against Emerging Respiratory Viral Infections.

Front Immunol 2021 19;12:660298. Epub 2021 May 19.

Webb-Waring Center, University of Colorado School of Medicine, Aurora, CO, United States.

In addition to SARS-CoV-2 and its variants, emerging viruses that cause respiratory viral infections will continue to arise. Increasing evidence suggests a delayed, possibly suppressed, type 1 interferon (IFN-I) response occurs early during COVID-19 and other viral respiratory infections such as SARS and MERS. These observations prompt considering IFN-β as a prophylactic or early intervention for respiratory viral infections. Read More

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Calming the Agitated Patient: Providing Strategies to Support Clinicians.

Medsurg Nurs 2021 Jan-Feb;30(1):9-13

School of Nursing, Miami University, Coral Gables, FL.

Agitation is a symptom of many medical and psychiatric disorders that can manifest along a spectrum of severity. Agitation often delays treatment onset, potentially impacting morbidity and mortality, and may require emergency interventions. Management of acute agitation centers around three main goals: early recognition and treatment of the underlying etiology, rapid control of the behavior, and prevention of harm to the patient and personnel. Read More

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January 2022

Development and validation of a prognostic model for patients with hepatorenal syndrome: A retrospective cohort study.

World J Gastroenterol 2021 May;27(20):2615-2629

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China.

Background: Hepatorenal syndrome (HRS) is a severe complication of cirrhosis with high mortality, which necessitates accurate clinical decision. However, studies on prognostic factors and scoring systems to predict overall survival of HRS are not enough. Meanwhile, a multicenter cohort study with a long span of time could be more convincing. Read More

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Lamotrigine and Stevens-Johnson Syndrome Prevention.

Psychopharmacol Bull 2021 Mar;51(2):96-114

Edinoff, MD, Nguyen, MD, Gerald, MD, Louisiana State University Health Science Center Shreveport, Department of Psychiatry and Behavioral Medicine, Shreveport, LA. Crane, BS, Lewis, BS, St Pierre, BS, Louisiana State University Shreveport School of Medicine, Shreveport, LA. Alan D. Kaye, MD, PhD, Louisiana State University New Orleans, Department of Anesthesiology, New Orleans, LA, Louisiana State University Shreveport, Department of Anesthesiology, Shreveport, LA. Gennuso, MD, Louisiana State University Shreveport, Department of Anesthesiology, Shreveport, LA. Adam M. Kaye, PharmD, Jessica S. Kaye, Thomas J. Long School of Pharmacy and Health Sciences, University of the Pacific, Department of Pharmacy Practice, Stockton, CA. Rachel J. Kaye, BA, Medical College of South Carolina, Charleston, SC. Varrassi, MD, PhD, FIPP, Paolo Procacci Foundation, Via Tacito 7, Roma, Italy. Viswanath, MD, Louisiana State University Shreveport, Department of Anesthesiology, Shreveport, LA, University of Arizona College of Medicine-Phoenix, Phoenix, AZ, Creighton University School of Medicine, Department of Anesthesiology, Omaha, NE, Valley Anesthesiology and Pain Consultants-Envision Physician Services, Phoenix, AZ. Urits, MD, Louisiana State University Shreveport, Department of Anesthesiology, Shreveport, LA, Southcoast Health, Southcoast Physicians Group Pain Medicine, Wareham, MA.

Stevens-Johnson Syndrome (SJS) is a rare life-threatening condition characterized by severe mucocutaneous epidermal necrolysis and detachment of the epidermis. The condition centers around a delayed-type hypersensitivity reaction with a complex etiology stemming from a variety of causes. The number one cause is medication-related-common ones including sulfonamides, antiepileptics, allopurinol, and nonsteroidal anti-inflammatory drugs. Read More

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Madelung-type deformity in a female individual from the Merovingian Period in Central Germany: A rare finding or a rare disease?

Int J Paleopathol 2021 Jun 3;34:1-11. Epub 2021 Jun 3.

Georg-August University of Göttingen, Institute of Anatomy and Embryology, University Medical Centre, Germany; University of Hildesheim, Institute of Biology and Chemistry, Germany.

Objective: This paper presents a probable case of Madelung-type deformity of the right lower arm in an individual from the Merovingian burial ground (7th and 8 th century CE) from Gotha-Boilstädt (Germany).

Materials: A female individual with an age-at-death of 40-50 years was investigated.

Methods: Macroscopic, osteometric and radiographic analyses were performed using standard methods. Read More

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Determinants of treatment-seeking behavior during self-reported febrile illness episodes using the socio-ecological model in Kilombero District, Tanzania.

BMC Public Health 2021 Jun 5;21(1):1075. Epub 2021 Jun 5.

Sokoine University of Agriculture, Morogoro, Tanzania.

Background: Febrile diseases in Sub-Saharan Africa cause acute and chronic illness. Co-infections are common and these diseases have a complex etiology that includes zoonoses. For the implementation of appropriate treatment and control strategies, determinants of lay treatment-seeking behavior by the affected communities need to be understood. Read More

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Comparison of renin-angiotensin-aldosterone system inhibitors with other antihypertensives in association with coronavirus disease-19 clinical outcomes.

BMC Infect Dis 2021 Jun 5;21(1):527. Epub 2021 Jun 5.

School of Pharmacy and Pharmacology, University of Tasmania, Private Bag 26, Hobart, TAS, 7001, Australia.

Background: Reports on the effects of renin-angiotensin-aldosterone system (RAAS) inhibitors on the clinical outcomes of coronavirus disease-19 (COVID-19) have been conflicting. We performed this meta-analysis to find conclusive evidence.

Methods: We searched published articles through PubMed, EMBASE and medRxiv from 5 January 2020 to 3 August 2020. Read More

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Wiad Lek 2021 ;74(5):1245-1249


Objective: The aim: To investigate theimpact of asthma co-morbidity on the susceptibility and clinical course of COVID-19 in asthma patients.

Patients And Methods: Materials and methods: Electronic databases of Pubmed and Google Scholar were searched using keyword searches.

Conclusion: Conclusions: Despite previous concerns about the increased risk of Covid-19 among asthmatics, most studies have not shown an increase in Covid-19 incidence among asthmatics compared to the general population. Read More

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Rupture of a Vulnerable Plaque in a Hazy Angiographic Culprit Lesion During Acute Coronary Syndrome.

J Invasive Cardiol 2021 Jun;33(6):E487-E488

Cardiovascular Department, ASST Santi Paolo e Carlo, Milano, Italy.

In the presence of an equivocal culprit lesion in the context of an acute coronary syndrome, the optical coherence tomography (OCT) scan defines the severity and composition of the plaque, elucidating (as in this pathognomonic case) the mechanism related to plaque rupture. Furthermore, OCT analysis allowed stent implantation with adequate sizing and length, and subsequent final optimization of the result. In the presence of non-unequivocal lesions, in the context of acute coronary syndrome, the use of OCT imaging defined the etiology and mechanism of plaque instability, reducing cardiovascular events. Read More

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Right paraduodenal hernia accompanying superior mesenteric vein thrombosis: a rare case.

BMJ Case Rep 2021 Jun 4;14(6). Epub 2021 Jun 4.

General Surgery Department, Koç University Hospital, Istanbul, Turkey.

A 59-year-old man with abdominal pain was admitted to the emergency department. Investigations had revealed a right-sided paraduodenal hernia and superior mesenteric vein (SMV) twisting around the superior mesenteric artery in rotation, the 'whirlpool sign'. Owing to the increasing severity of abdominal pain and the presence of SMV thrombosis complicated with strangulated paraduodenal herniation associated with high mortality rates, diagnostic laparoscopy was performed. Read More

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Cytokine and interleukin profile in patients with headache and COVID-19: A pilot, CASE-control, study on 104 patients.

J Headache Pain 2021 Jun 4;22(1):51. Epub 2021 Jun 4.

Institute of Health Sciences of Castile and Leon (ICSCYL), Santa Clara Square, 42002, Soria, Spain.

Background: The presence of headache during the acute phase of COVID-19 could be associated with the innate response and the cytokine release. We aim to compare the cytokine and interleukin profile in hospitalized COVID-19 patients at the moment of admission with and without headache during the course of the disease.

Methods: An observational analytic study with a case control design was performed. Read More

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Angiotensin-converting enzyme-1 gene insertion/deletion polymorphism may be associated with COVID-19 clinical severity: a prospective cohort study.

Ann Saudi Med 2021 May-Jun;41(3):141-146. Epub 2021 Jun 1.

From the Department of Internal Medicine, Section of Rheumatology, Samsun Education and Research Hospital, Samsun, Turkey.

Background: Angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism may play a role in the pathogenesis of coronavirus-19 disease (COVID-19).

Objectives: Investigate the relationship between ACE I/D polymorphism and the clinical severity of COVID-19.

Design: Prospective cohort study. Read More

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Hearing loss among patients with type 2 diabetes mellitus: a cross-sectional study.

Ann Saudi Med 2021 May-Jun;41(3):171-178. Epub 2021 Jun 1.

From the Department of Registry, King Saud University, Riyadh, Saudi Arabia.

Background: Hearing loss is an underestimated comorbid condition in type 2 diabetes.

Objectives: Investigate hearing loss as a comorbidity associated with type 2 diabetes mellitus and evaluate the factors associated with hearing loss.

Design: Cross-sectional. Read More

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Anti-COVID-19 measurements for hidradenitis suppurativa patients.

Exp Dermatol 2021 06;30 Suppl 1:18-22

European Hidradenitis Suppurativa Foundation e.V., Dessau, Germany.

The reported incidence of COVID-19 among cohorts of patients with inflammatory bowel and skin diseases under treatment with biologicals is low. Treatment may further modify disease severity as some biological modifiers, such as anakinra, are also proposed for the management of COVID-19 patients potentially providing HS patients with an advantage. The above preliminary evidence suggests that hidradenitis suppurativa (HS) does probably not provide an increased susceptibility for COVID-19 and that any susceptibility is unlikely to be modified negatively by treatment with biologicals. Read More

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