191 results match your criteria ether mpeg

pH-Responsive Amphiphilic Polyether Micelles with Superior Stability for Smart Drug Delivery.

Biomacromolecules 2021 Apr 9. Epub 2021 Apr 9.

Department of Chemistry, Yonsei University, Seoul 03722, Republic of Korea.

Despite widespread interest in the amphiphilic polymeric micelles for drug delivery systems, it is highly desirable to achieve high loading capacity and high efficiency to reduce the side effects of therapeutic agents while maximizing their efficacy. Here, we present a novel hydrophobic epoxide monomer, cyclohexyloxy ethyl glycidyl ether (CHGE), containing an acetal group as a pH-responsive cleavable linkage. A series of its homopolymers, poly(cyclohexyloxy ethyl glycidyl ether)s (PCHGEs), and block copolymers, poly(ethylene glycol)--poly(cyclohexyloxy ethyl glycidyl ether)s (PEG--PCHGE), were synthesized via anionic ring-opening polymerization in a controlled manner. Read More

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Noninvasive Tracking of mPEG-poly(Ala) Hydrogel-Embedded MIN6 Cells after Subcutaneous Transplantation in Mice.

Polymers (Basel) 2021 Mar 13;13(6). Epub 2021 Mar 13.

Department of Chemical Engineering, National Tsing Hua University, Hsinchu 300044, Taiwan.

Recently, we demonstrated the feasibility of subcutaneous transplantation of MIN6 cells embedded in a scaffold with poly(ethylene glycol) methyl ether (mPEG)-poly(Ala) hydrogels. In this study, we further tracked these grafts using magnetic resonance (MR) and bioluminescence imaging. After being incubated overnight with chitosan-coated superparamagnetic iron oxide (CSPIO) nanoparticles and then mixed with mPEG-poly(Ala) hydrogels, MIN6 cells appeared as dark spots on MR scans. Read More

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Water-soluble poly(ethylene glycol) methyl ether-grafted chitosan/alginate polyelectrolyte complex hydrogels.

Int J Biol Macromol 2021 Mar 5;179:353-365. Epub 2021 Mar 5.

Department of Packaging and Materials Technology, Faculty of Agro-Industry, Kasetsart University, Bangkok 10900, Thailand; Center for Advanced Studies in Nanotechnology for Chemical, Food and Agricultural Industries, KU Institute for Advanced Studies, Kasetsart University, Bangkok 10900, Thailand. Electronic address:

This study aimed to fabricate polyelectrolyte complexes from water-soluble poly(ethylene glycol) methyl ether-grafted chitosan (mPEG-g-CTS) and alginate (ALG) in the absence of acetic acid. The complexes formed fibrous network macrogels when mPEG-g-CTS with short mPEG chains (mPEG750-g-CTS and mPEG2000-g-CTS) and mPEG-g-CTS:ALG weight ratios in the range from 1:0.14 to 1:1 were used. Read More

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Micellar Carriers of Active Substances Based on Amphiphilic PEG/PDMS Heterograft Copolymers: Synthesis and Biological Evaluation of Safe Use on Skin.

Int J Mol Sci 2021 Jan 26;22(3). Epub 2021 Jan 26.

Department of Physical Chemistry and Technology of Polymers, Faculty of Chemistry, Silesian University of Technology, 44-100 Gliwice, Poland.

Amphiphilic copolymers containing polydimethylsiloxane (PDMS) and polyethylene glycol methyl ether (MPEG) were obtained via an azide-alkyne cycloaddition reaction between alkyne-functionalized copolymer of MPEG methacrylate and azide-functionalized PDMS. "Click" reactions were carried out with an efficiency of 33-47% increasing grafting degrees. The grafted copolymers were able to carry out the micellization and encapsulation of active substances, such as vitamin C (VitC), ferulic acid (FA) and arginine (ARG) with drug loading content (DLC) in the range of 2-68% (VitC), and 51-89% (FA or ARG). Read More

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January 2021

Photodynamic and Cold Atmospheric Plasma Combination Therapy Using Polymeric Nanoparticles for the Synergistic Treatment of Cervical Cancer.

Int J Mol Sci 2021 Jan 25;22(3). Epub 2021 Jan 25.

Department of Biomedical Engineering, Daegu Catholic University, Gyeongsan 38430, Korea.

Integrating multi-modal therapies into one platform could show great promise in overcoming the drawbacks of conventional single-modal therapy and achieving improved therapeutic efficacy in cancer. In this study, we prepared pheophorbide a (Pheo a)/targeting ligand (epitope analog of oncoprotein E7, EAE7)-conjugated poly(γ-glutamic acid) (γ-PGA)/poly(lactide-co-glycolide)-block-poly(ethylene glycol) methyl ether (MPEG-PLGA)/hyaluronic acid (PPHE) polymeric nanoparticles via self-assembly and encapsulation method for the photodynamic therapy (PDT)/cold atmospheric plasma (CAP) combinatory treatment of human papillomavirus (HPV)-positive cervical cancer, thereby enhancing the therapeutic efficacy. The synthesized PPHE polymeric nanoparticles exhibited a quasi-spherical shape with an average diameter of 80. Read More

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January 2021

A New Approach to Developing Long-Acting Injectable Formulations of Anti-HIV Drugs: Poly(Ethylene Phosphoric Acid) Block Copolymers Increase the Efficiency of Tenofovir against HIV-1 in MT-4 Cells.

Int J Mol Sci 2020 Dec 30;22(1). Epub 2020 Dec 30.

Chemistry Department, M.V. Lomonosov Moscow State University, 1-3 Leninskie Gory, 119991 Moscow, Russia.

Despite the world's combined efforts, human immunodeficiency virus (HIV), the causative agent of AIDS, remains one of the world's most serious public health challenges. High genetic variability of HIV complicates the development of anti-HIV vaccine, and there is an actual clinical need for increasing the efficiency of anti-HIV drugs in terms of targeted delivery and controlled release. Tenofovir (TFV), a nucleotide-analog reverse transcriptase inhibitor, has gained wide acceptance as a drug for pre-exposure prophylaxis or treatment of HIV infection. Read More

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December 2020

Synthesis Characterization of Platinum (IV) Complex Curcumin Backboned Polyprodrugs: In Vitro Drug Release Anticancer Activity.

Polymers (Basel) 2020 Dec 26;13(1). Epub 2020 Dec 26.

Institute of Food Safety and Environment Monitoring, College of Chemistry, Fuzhou University, Fuzhou 350108, China.

The conventional mono-chemotherapy still suffers from unsatisfied potency for cancer therapy due to tumor heterogeneity and the occurrence of drug resistance. Combination chemotherapy based on the nanosized drug delivery systems (nDDSs) has been developed as a promising platform to circumvent the limitations of mono-chemotherapy. In this work, starting from cisplatin and curcumin (Cur), we prepared a dual drug backboned shattering polymeric nDDS for synergistic chemotherapy. Read More

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December 2020

Controlled-release behavior of ciprofloxacin from a biocompatible polymeric system based on sodium alginate/poly(ethylene glycol) mono methyl ether.

Int J Biol Macromol 2020 Dec 29;165(Pt A):1047-1054. Epub 2020 Sep 29.

Centre for Genetics and Inherited Diseases (CGID), Taibah University, Madinah AlMunawwarah 42318, Saudi Arabia. Electronic address:

In this study, a facile drug release system was developed through a solution casting technique using a combination of sodium alginate (SA), poly(ethylene glycol)monomethyl ether (mPEG) and ciprofloxacin hydrochloride (CPX). The structure of the membranes was characterized using ATR-FTIR, AFM and the static contact angle (SCA) was determined to find surface nature of membranes. ATR-FTIR confirmed the existence of intermolecular hydrogen bonding between SA/mPEG in bio-polymeric membranes. Read More

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December 2020

The pH-triggered polyglutamate brush co-delivery of MDR1 and survivin-targeting siRNAs efficiently overcomes multi-drug resistance of NSCLC.

Drug Dev Ind Pharm 2020 Nov 21;46(11):1862-1872. Epub 2020 Sep 21.

Department of Pharmacy, Yan'an Hospital Affiliated to Kunming Medical University, Kunming, PR China.

Multi-drug resistance (MDR) is one of the major challenges in the successful chemotherapy of non-small cell lung cancer (NSCLC). Although RNA interference (RNAi) has been widely used to silence resistance-related genes, the effect remains unsatisfactory. In this study, we attempted to overcome MDR of NSCLC by simultaneously interfering with two RNAs that have different functions. Read More

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November 2020

TME-Responsive Polyprodrug Micelles for Multistage Delivery of Doxorubicin with Improved Cancer Therapeutic Efficacy in Rodents.

Adv Healthc Mater 2020 09 20;9(18):e2000387. Epub 2020 Aug 20.

Department of Neurobiology, School of Life Sciences, China Medical University, Shenyang, 110001, P. R. China.

It is of great significance to develop multifunctional biomaterials to effectively deliver anticancer drug to tumor cells for cancer therapy. Here, inspired by the specific tumor microenvironment (TME) cues, a unique multistage pH/redox-responsive polyprodrug composed of amphiphilic pH-sensitive diblock copolymer poly(ethylene glycol) methyl ether-b-poly(β-amino esters) conjugated with doxorubicin (DOX) via redox-sensitive disulfide bonds (mPEG-b-PAE-ss-DOX) is designed and developed. This polyprodrug can self-assemble into micelles (DOX-ss@PMs) at low concentration with high serum stability, indicating that DOX-ss@PMs have prolonged circulation time. Read More

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September 2020

Thiol-ene photoclick reaction: An eco-friendly and facile approach for preparation of MPEG-g-keratin biomaterial.

Eng Life Sci 2020 Jan 9;20(1-2):17-25. Epub 2019 Oct 9.

Key Laboratory of Eco-Textiles Ministry of Education Jiangnan University Wuxi P. R. China.

Wool keratin is a natural material with excellent properties, which is considered as scaffold biomaterial for tissue engineering. Polyethylene glycol can improve the mechanical properties of keratin materials because of its excellent biocompatibility and plasticity. In the present work, poly (ethylene glycol) methyl ether methacrylate (MPEGMA) was grafted onto keratin by thiol-ene photoclick reaction. Read More

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January 2020

Charge-conversional polyethylenimine-entrapped gold nanoparticles with I-labeling for enhanced dual mode SPECT/CT imaging and radiotherapy of tumors.

Biomater Sci 2020 Jul 18;8(14):3956-3965. Epub 2020 Jun 18.

School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing 211816, People's Republic of China.

Novel theranostic nanosystems demonstrate great potential to achieve timely diagnosis and effective therapy at the same time. However, due to the relatively low accumulation of theranostic nanosystems at the tumor site, the theranostic efficiency is limited. In this study, a novel theranostic nanosystem with a pH-responsive charge conversion property was constructed to improve the cellular uptake towards cancer cells for enhanced single photon emission computed tomography (SPECT)/computed tomography (CT) dual mode imaging and radiotherapy of tumors. Read More

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Self-assembled dihydroartemisinin nanoparticles as a platform for cervical cancer chemotherapy.

Drug Deliv 2020 Dec;27(1):876-887

Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, China.

Dihydroartemisinin (DHA) is a potent anti-cancer drug that has limited clinical applications due to poor water solubility and low bioavailability. We designed a biodegradable poly(ethylene glycol) methyl ether-poly(ε-caprolactone) (MPEG-PCL) micelle carrier for DHA using the self-assembly method. The DHA/MPEG-PCL nanoparticles were spherical with an average particle size of 30. Read More

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December 2020

Partially Oxidized Cellulose grafted with Polyethylene Glycol mono-Methyl Ether (m-PEG) as Electrolyte Material for Lithium Polymer Battery.

Carbohydr Polym 2020 Jul 25;240:116339. Epub 2020 Apr 25.

Helmholtz Institute Ulm (HIU), Helmholtzstrasse 11, 89081 Ulm, Germany; Karlsruhe Institute of Technology (KIT), P.O. Box 3640, 76021 Karlsruhe, Germany.

Herein, a novel cellulose derivative has been synthesized and investigated as a nature-derived solid polymer electrolyte for lithium batteries. Cellulose is oxidized in a two-step process to dicarboxylic acid cellulose to allow for grafting low molecular weight poly(ethylene glycol) monomethyl ether (550 g mol) via Fischer-Speier esterification at the thus obtained carboxyl groups. The chemical structure of the synthesized materials is confirmed by Fourier-transform infrared (FT-IR) and nuclear magnetic resonance (NMR) spectroscopy as well as X-ray diffraction. Read More

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Solid solid phase change (SSPC) chitosan-g-mPEG fiber with improved mechanical performance via in-situ wet spinning process.

Carbohydr Polym 2020 Jul 19;240:116313. Epub 2020 Apr 19.

School of Textile and Materials Engineering, Dalian Polytechnic University, #1 Qinggongyuan, Ganjingzi, Dalian 116034, Liaoning, PR China. Electronic address:

Nowadays, environment-friendly and sustainable polymers have aroused great research attention, due to serious pollution caused by nondegradable and nonrenewable polymer waste. In this paper, chitosan (CS) grafted polyethylene glycol monomethyl ether (mPEG) (CS-g-mPEG) fiber, with solid-solid phase change (SSPC) behavior and improved mechanical performance, were prepared successfully by in-situ wet spinning process. The tensile strength of CS-g-mPEG fiber reached 1. Read More

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Thio-Bromo "Click" Reaction Derived Polymer-Peptide Conjugates for Their Self-Assembled Fibrillar Nanostructures.

Macromol Biosci 2020 06 13;20(6):e2000048. Epub 2020 Apr 13.

Macromolecular Chemistry, Faculty of Natural Science II (Chemistry, Physics and Mathematics), Institute of Chemistry, Martin Luther University Halle-Wittenberg, Von-Danckelmann-Platz 4, Halle (Saale), D-06120, Germany.

The synthesis and self-assembly of peptide-polymer conjugates into fibrillar nanostructures are reported, based on the amyloidogenic peptide KLVFF. A strategy for rational synthesis of polymer-peptide conjugates is documented via tethering of the amyloidogenic peptide segment LVFF (Aβ ) and its modified derivative FFFF to the hydrophilic poly(ethylene glycol) monomethyl ether (mPEG) polymer via thio-bromo based "click" chemistry. The resultant conjugates mPEG-LVFF-OMe and mPEG-FFFF-OMe are purified via preparative gel permeation chromatography technique (with a yield of 61% and 64%, respectively), and are successfully characterized via combination of spectroscopic and chromatographic methods, including electrospray ionization time-of-flight mass spectrometry. Read More

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Triclosan-loaded pH-responsive copolymer to target bacteria and to have long bacteriostatic efficacy.

Eur J Pharm Sci 2020 May 31;148:105320. Epub 2020 Mar 31.

College of Polymer Science and Engineering, Sichuan University, Chengdu 610065, PR China; State Key Lab of Polymer Materials Engineering, Sichuan University, Chengdu 610065, PR China. Electronic address:

It is important to reduce side effects and to explore novel usage for hydrophobic broad-spectrum antibacterial agent triclosan (TCS). In this study, a new amphiphilic copolymer with tertiary amine groups, monomethyl ether poly(ethylene glycol)-b-poly{α-[4-(diethylamino)methyl-1,2,3-triazol]-caprolactone-co-caprolactone} (mPEG-PDCL) was designed and synthesized, and its micelles were applied as carries of TCS to enhance antimicrobial and bacteriostatic action. mPEG-PDCL and its contrastive copolymer mPEG-PCL could form uniform spherical micelles with sizes 50-110 nm. Read More

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A Dendrimer-Based Dual Radiodense Element-Containing Nanoplatform for Targeted Enhanced Tumor Computed Tomography Imaging.

Langmuir 2020 03 20;36(12):3096-3103. Epub 2020 Mar 20.

Key Laboratory of Science & Technology of Eco-Textile, Ministry of Education, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, People's Republic of China.

The exploration of original computed tomography (CT) imaging contrast agents with enhanced sensitivity and specificity is currently one of the major challenging tasks for precision medicine. Herein, we develop an innovative nanoprobe of dendrimer-stabilized gold nanoparticles (Au DSNs) linked with folic acid (FA) as a targeting ligand and diatrizoic acid (DTA) for specific enhanced tumor CT imaging. In current work, poly(amidoamine) (PAMAM) dendrimers of generation 5 (G5) with amine termini were adopted to entrap Au NPs through a stepwise complexation/reduction method to achieve a higher Au loading than the conventional one-step complexation/reduction method. Read More

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Immobilized metal affinity chromatography matrix modified by poly (ethylene glycol) methyl ether for purification of angiotensin I-converting enzyme inhibitory peptide from casein hydrolysate.

J Chromatogr B Analyt Technol Biomed Life Sci 2020 Apr 25;1143:122042. Epub 2020 Feb 25.

Guangxi Key Laboratory of Petrochemical Resource Processing and Process Intensification Technology, School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, China. Electronic address:

Purification of small bioactive peptides from complex biological samples is a difficult task due to the interference of concentrated large biomolecules. In this study, a magnetic immobilized metal affinity chromatography matrix modified by poly (ethylene glycol) methyl ether (IMACM@mPEG) was prepared and applied for the rapid purification of angiotensin I-converting enzyme (ACE) inhibitory peptides from casein hydrolysate. The proposed IMACM@mPEG considerably reduced the non-specific adsorption of large proteins and exhibited improved purification efficiency towards ACE inhibitory peptides. Read More

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Design and Synthesis of Polymer Prodrugs for Improving Water-Solubility, Pharmacokinetic Behavior and Antitumor Efficacy of TXA9.

Pharm Res 2020 Mar 12;37(3):66. Epub 2020 Mar 12.

School of Traditional Chinese Material, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang, 110016, China.

Purpose: TXA9, a novel cardiac glycoside, has a potent anti-proliferative effect against A549 human lung cancer cells, however, possesses a poor water-solubility and a rapid metabolic rate in vivo which limited the further development of TXA9. To overcome the shortcomings of TXA9, four polymer prodrugs of TXA9 were designed and synthesized.

Methods: Poly (ethylene glycol) monomethyl ether (mPEG) and α-tocopherol polyethylene glycol succinate (TPGS) were applied to modify TXA9 via carbonate ester and glycine linkers respectively to obtain four polymer prodrugs. Read More

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Surface modification of superparamagnetic iron oxide (SPION) and comparison of cytotoxicity effect of mPEG2000-PEI-SPION and mPEG750-PEI-SPION on the human embryonic carcinoma stem cell, NTERA2 cell line.

Hum Antibodies 2020 ;28(2):159-167

National Institute of Genetic Engineering and Biotechnology, Tehran, Iran.

Non-viral carriers based on nanoparticles are promising vectors for drug and gene delivery into the target cells. The data provided in this article are related to research entitled "Efficiency of surface modified SPION". In this article the surface of superparamagnetic iron oxide (SPION) (core) coated with poly (ethylene glycol)-grafted polyethylenimine (mPEG-co-PEI) shell. Read More

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January 2020

Rationally Designed Polymer Conjugate for Tumor-Specific Amplification of Oxidative Stress and Boosting Antitumor Immunity.

Nano Lett 2020 04 4;20(4):2514-2521. Epub 2020 Mar 4.

Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.

The crosstalk between tumor and stroma cells is a central scenario in the tumor microenvironment (TME). While the predominant effect of tumor cells on immune cells is establishing an immunosuppressive context, tumor cell death at certain conditions will boost antitumor immunity. Herein, we report a rationally designed tumor specific enhanced oxidative stress polymer conjugate (TSEOP) for boosting antitumor immunity. Read More

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All-in-One Hydrogel Realizing Adipose-Derived Stem Cell Spheroid Production and In Vivo Injection via "Gel-Sol" Transition for Angiogenesis in Hind Limb Ischemia.

ACS Appl Mater Interfaces 2020 Mar 28;12(10):11375-11387. Epub 2020 Feb 28.

Department of Polymer Materials, School of Materials Science and Engineering, Shanghai University, Shanghai 200444, PR China.

Adipose-derived stem cell (ASC) spheroids exhibit enhanced angiogenic efficacy toward ischemia treatment. Thus, it is necessary to develop an all-in-one platform that enables efficient spheroid production, collection, and injectable implantation in vivo. The present study fabricated a poly(l-glutamic acid) (PLGA)-based porous hydrogel that can not only produce ASC spheroids but also conveniently collect spheroids for in vivo implantation via minimally invasive injection to treat hind limb ischemia. Read More

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Interface crosslinked mPEG-b-PAGE-b-PCL triblock copolymer micelles with high stability for anticancer drug delivery.

Colloids Surf B Biointerfaces 2020 May 1;189:110830. Epub 2020 Feb 1.

Key Laboratory of Environment-Friendly Polymeric Materials of Anhui Province, School of Chemistry and Chemical Engineering, Anhui University, Hefei 230601, China.

The stability of polymeric micelles is a key property for anticancer drug delivery. In this study, a novel amphiphilic triblock copolymer, methoxy poly(ethylene glycol)-b-poly(allyl glycidyl ether)-b-poly(ε-caprolactone) (mPEG-b-PAGE-b-PCL), with different hydrophobic lengths was designed and synthesized using the combination of two successive ring-opening polymerizations. The products were characterized using H NMR and gel permeation chromatography (GPC). Read More

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Hypoxia-sensitive supramolecular nanogels for the cytosolic delivery of ribonuclease A as a breast cancer therapeutic.

J Control Release 2020 04 16;320:83-95. Epub 2020 Jan 16.

Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China; Jilin Biomedical Polymers Engineering Laboratory, Changchun 130022, PR China.

As the most common malignancy in women, breast cancer causes >40,000 deaths annually. Ribonuclease A (RNase), a new anti-cancer agent, has attracted intense interest due to its high efficacy and specificity. However, RNase suffers from instability, a short half-life in the circulation and poor membrane penetration. Read More

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Preparation of mixed micelles carrying folates and stable radicals through PLA stereocomplexation for drug delivery.

Mater Sci Eng C Mater Biol Appl 2020 Mar 20;108:110464. Epub 2019 Nov 20.

Institute of Materials Research and Engineering, A*STAR (Agency for Science, Technology and Research), 2 Fusionopolis Way, Innovis, #08-03138634, 138634, Singapore. Electronic address:

Multifunctional mixed micelles possessing targeting folates on the periphery and stable radicals in the core were prepared from the mixture of folate-poly(ethylene glycol)-block-poly(d-lactide) (FA-PEG-b-PDLA) and poly(ethylene glycol) methyl ether-block-poly(l-lactide)- 2,2,6,6-tetramethylpiperidine-1-oxyl (mPEG-b-PLLA-TEMPO). FA-PEG-b-PDLA and mPEG-b-PLLA-TEMPO were prepared by combining ring-opening polymerization (ROP) of lactide with a series of conversion of the end functional groups. The synthesized block copolymers and their intermediates were well characterized by gel permeation chromatography (GPC) and H nuclear magnetic resonance (H NMR) spectroscopy. Read More

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Resistive Water Sensors Based on PEDOT:PSS--PEGME Copolymer and Laser Treatment for Water Ingress Monitoring Systems.

ACS Sens 2019 12 13;4(12):3291-3297. Epub 2019 Dec 13.

School of Advanced Materials Science & Engineering , Sungkyunkwan University , Suwon 440-745 , Republic of Korea.

Water sensors are a type of level sensor that can be used in various applications requiring the sensing of water levels, such as in dams, nuclear power plants, water pipes, water tanks, and dehumidifiers. In particular, water sensors in water ingress monitoring systems (WIMS) protect lives and property from disasters caused by water leakage and flooding. Here, a resistive water sensor for WIMS that incorporates poly(3,4-ethylenedioxythinophene):poly(styrene sulfonate) (PEDOT:PSS) grafted with poly(ethylene glycol) methyl ether (PEGME) (PEDOT:PSS--PEGME copolymer) as high-conductivity electrodes and laser-treated PEDOT:PSS--PEGME copolymer as the low-conductivity resistive component is reported. Read More

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December 2019

Oxygen-Rich Polymers as Highly Effective Positive Tribomaterials for Mechanical Energy Harvesting.

ACS Nano 2019 Nov 30;13(11):12787-12797. Epub 2019 Oct 30.

Wisconsin Institute for Discovery , University of Wisconsin-Madison , Madison , Wisconsin 53715 , United States.

Triboelectric nanogenerators (TENGs) are a potential solution to the depleted state of fossil fuels, on the condition that the energy conversion efficiency can be further improved. Tribomaterials are important not only for improving the output performance of TENGs but also for extending their applications. In this work, a poly-ε-caprolactone (PCL) electrospun membrane is proposed as a highly effective positive tribomaterial, paired with an expanded polytetrafluoroethylene (ePTFE) membrane, to fabricate TENGs (PCL/ePTFE TENGs). Read More

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November 2019

Fabrication Of Dual pH/redox-Responsive Lipid-Polymer Hybrid Nanoparticles For Anticancer Drug Delivery And Controlled Release.

Int J Nanomedicine 2019 3;14:8001-8011. Epub 2019 Oct 3.

Department of Thoracic Surgery, The First Affiliated Hospital of China Medical University, Shenyang 110001, People's Republic of China.

Background: The development of biocompatible nanocarriers that can efficiently encapsulate and deliver anticancer drug to the tumor site and provide controlled release of cargos in response to the specific cues for cancer therapy is of great significance.

Methods: In this work, dual pH/redox-responsive fabrication of hybrid lipid-polymer nanoparticles (LPNPs) self-assembled from amphiphilic polymer poly(ethylene glycol) methyl ether-grafted disulfide-poly(-amino esters) (PBAE-ss-mPEG) and PEGylated lipid were prepared and used as drug delivery carriers. The optimization of PEGylated lipid modification was confirmed by analysis of particle size, polydispersity index (PDI), cellular uptake, serum stability, and drug loading capacity. Read More

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December 2019

Tc-Labeled Polyethylenimine-Entrapped Gold Nanoparticles with pH-Responsive Charge Conversion Property for Enhanced Dual Mode SPECT/CT Imaging of Cancer Cells.

Langmuir 2019 10 3;35(41):13405-13412. Epub 2019 Oct 3.

College of Chemistry, Chemical Engineering and Biotechnology , Donghua University , Shanghai 201620 , People's Republic of China.

Development of tumor dual mode contrast agents is still a great challenge due to the relative low accumulation at tumor site, which result in the poor imaging efficiency. In this study, we constructed functional technetium-99m (Tc) labeled polyethylenimine (PEI)-entrapped gold nanoparticles (Au PENs) with pH-responsive charge conversion property for enhanced single photon emission computed tomography (SPECT)/computed tomography (CT) dual mode imaging of cancer cells. PEI with amine functional groups (PEI. Read More

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October 2019