559 results match your criteria estimating whole-body

Tissue dose estimation after extravasation of Lu-DOTATATE.

EJNMMI Phys 2021 Mar 31;8(1):33. Epub 2021 Mar 31.

Service de Physique Médicale et Radioprotection, Hospices Civils de Lyon, Lyon, France.

Background: Extravasation of radiopharmaceuticals used for vectorized internal radiotherapy can lead to severe tissue damage (van der Pol et al., Eur J Nucl Med Mol Imaging 44:1234-1243, 2017). Clinical management of these extravasations requires the preliminary estimation of the dose distribution in the extravasation area. Read More

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Molecular imaging and biochemical response assessment after a single cycle of [Ac]Ac-PSMA-617/[Lu]Lu-PSMA-617 tandem therapy in mCRPC patients who have progressed on [Lu]Lu-PSMA-617 monotherapy.

Theranostics 2021 16;11(9):4050-4060. Epub 2021 Feb 16.

Department of Nuclear Medicine, Saarland University - Medical Center, Homburg, Germany.

Despite the promising results of prostate-specific membrane antigen (PSMA)-targeted Lu radioligand therapy in metastatic castration-resistant prostate carcinoma (mCRPC), some patients do not respond and other patients with initially good response develop resistance to this treatment. In this study, we investigated molecular imaging and biochemical responses after a single cycle of [Ac]Ac-PSMA-617/[Lu]Lu-PSMA-617 tandem therapy in patients who had progressed on [Lu]Lu-PSMA-617 monotherapy. Seventeen patients with mCRPC were included in a retrospective, monocenter study. Read More

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February 2021

Whole body potassium as a biomarker for potassium uptake using a mouse model.

Sci Rep 2021 Mar 18;11(1):6385. Epub 2021 Mar 18.

School of Health Sciences, Purdue University, West Lafayette, 47906, USA.

Potassium is known for its effect on modifiable chronic diseases like hypertension, cardiac disease, diabetes (type-2), and bone health. In this study, a new method, neutron generator based neutron activation analysis (NAA), was utilized to measure potassium (K) in mouse carcasses. A DD110 neutron generator based NAA assembly was used for irradiation. Read More

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Bioimpedance analysis as a tool for hemodynamic monitoring: overview, methods and challenges.

Physiol Meas 2021 Feb 19. Epub 2021 Feb 19.

Institute of Biomedical Technologies, Auckland University of Technology, 19 St. Paul Street, AUT, Auckland, Auckland, New Zealand, 1142, NEW ZEALAND.

Recent advances in hemodynamic monitoring have seen the advent of non-invasive methods which offer ease of application and improve patient comfort. Bioimpedance Analysis or BIA is one of the currently employed non-invasive techniques for hemodynamic monitoring. Impedance Cardiography, one of the implementations of BIA, is widely used as a non-invasive procedure for estimating hemodynamic parameters such as stroke volume and cardiac output. Read More

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February 2021

Production and Perception of Intentional and Unintentional Actions.

Mark L Latash

J Hum Kinet 2021 Jan 29;76:51-66. Epub 2021 Jan 29.

Department of Kinesiology. The Pennsylvania State University, University Park, Texas, PA, USA.

Physical approach to biological movement is based on the idea of control with referent spatial coordinates for effectors, from the whole body to single muscles. Within this framework, neural control signals induce changes in parameters of corresponding biology-specific laws of nature, and motor performance emerges as a result of interaction with the external force field. This approach is naturally compatible with the principle of abundance and the uncontrolled manifold hypothesis, which offer the framework for analysis of movement stability. Read More

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January 2021

Adaptive Pixel Mass Recalibration for Mass Spectrometry Imaging Based on Locally Endogenous Biological Signals.

Anal Chem 2021 03 14;93(8):4066-4074. Epub 2021 Feb 14.

Mass Spectrometry Laboratory, MolSys Research Unit, Department of Chemistry, University of Liège, Allée du Six Août, 11, Quartier Agora, Liège 4000, Belgium.

Mass spectrometry imaging (MSI) is a powerful and convenient method for revealing the spatial chemical composition of different biological samples. Molecular annotation of the detected signals is only possible if a high mass accuracy is maintained over the entire image and the / range. However, the change in the number of ions from pixel-to-pixel of the biological samples could lead to small fluctuations in the detected /-values, called mass shift. Read More

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A method for evaluation of patient-specific lean body mass from limited-coverage CT images and its application in PERCIST: comparison with predictive equation.

EJNMMI Phys 2021 Feb 8;8(1):12. Epub 2021 Feb 8.

Department of Nuclear Medicine and PET/CT-MRI Center, The First Affiliated Hospital of Jinan University, No. 613 West Huangpu Road, Guangzhou, 510630, China.

Background: Standardized uptake value (SUV) normalized by lean body mass ([LBM] SUL) is recommended as metric by PERCIST 1.0. The James predictive equation (PE) is a frequently used formula for LBM estimation, but may cause substantial error for an individual. Read More

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February 2021

Sweat rate and sweat composition following active or passive heat re-acclimation: A pilot study.

Temperature (Austin) 2020 Oct 11;8(1):90-104. Epub 2020 Oct 11.

Department of Human Movement Sciences, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, The Netherlands.

The purpose of this study was to investigate local sweat rate (LSR) and sweat composition before and after active or passive heat re-acclimation (HRA). Fifteen participants completed four standardized heat stress tests (HST): before and after ten days of controlled hyperthermia (CH) heat acclimation (HA), and before and after five days of HRA. Each HST consisted of 35 min of cycling at 1. Read More

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October 2020

Impedance plethysmography-based method in the assessment of subclinical atherosclerosis.

Atherosclerosis 2021 02 12;319:101-107. Epub 2021 Jan 12.

Finnish Cardiovascular Research Center - Tampere, Arvo Ylpön Katu 34 (33520 Tampere), P.O. Box 100, FI-33014 Tampere University, Finland; Faculty of Medicine and Health Technology, Arvo Ylpön Katu 34 (33520 Tampere) P.O. Box 100, FI-33014 Tampere University, Finland; Vascular Centre, Tampere University Hospital, Elämänaukio 2 (33520 Tampere), P.O. Box 2000, Tampere, 33521, Finland. Electronic address:

Background And Aims: The aim of this study was to examine an association of individual and combined pulse waveform parameters derived from bioimpedance measurements, that is pulse waves from a distal impedance plethysmographic (IPG), a whole-body impedance cardiographic (ICG) and transformed distal impedance plethysmographic (tIPG) signals, with markers of subclinical atherosclerosis, i.e. carotid intima-media thickness (cIMT), brachial artery flow-mediated dilation (FMD) and carotid artery distensibility (Cdist). Read More

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February 2021

Applications of the Critical Power Model to Dynamic Constant External Resistance Exercise: A Brief Review of the Critical Load Test.

Sports (Basel) 2021 Jan 21;9(2). Epub 2021 Jan 21.

Department of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.

The study and application of the critical power (CP) concept has spanned many decades. The CP test provides estimates of two distinct parameters, CP and W', that describe aerobic and anaerobic metabolic capacities, respectively. Various mathematical models have been used to estimate the CP and W' parameters across exercise modalities. Read More

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January 2021

Non-Contact Respiratory Measurement Using a Depth Camera for Elderly People.

Sensors (Basel) 2020 Dec 3;20(23). Epub 2020 Dec 3.

Laboratory of Welfare Technology-Telehealth and Telerehabilitation, Department of Health Science and Technology, Aalborg University, 9220 Aalborg Ost, Denmark.

Measuring respiration at home for cardiac patients, a simple method that can detect the patient's natural respiration, is needed. The purpose of this study was to develop an algorithm for estimating the tidal volume (TV) and respiratory rate (RR) from the depth value of the chest and/or abdomen, which were captured using a depth camera. The data of two different breathing patterns (normal and deep) were acquired from both the depth camera and the spirometer. Read More

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December 2020

Bayesian models of human navigation behaviour in an augmented reality audiomaze.

Eur J Neurosci 2020 Nov 25. Epub 2020 Nov 25.

Swartz Center for Neural Computation, Institute for Neural Computation, University of California San Diego, San Diego, CA, USA.

We investigated Bayesian modelling of human whole-body motion capture data recorded during an exploratory real-space navigation task in an "Audiomaze" environment (see the companion paper by Miyakoshi et al. in the same volume) to study the effect of map learning on navigation behaviour. There were three models, a feedback-only model (no map learning), a map resetting model (single-trial limited map learning), and a map updating model (map learning accumulated across three trials). Read More

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November 2020

Estimating time to reinjury among Washington State injured workers by degree of permanent impairment: Using state wage data to adjust for time at risk.

Am J Ind Med 2021 01 18;64(1):13-25. Epub 2020 Nov 18.

Institute for Work and Health, Ontario, Toronto, Canada.

Background: Many injured workers are reinjured, but reinjury risk is challenging to quantify. Because many injured workers face delayed return-to-work, or return to part-time or intermittent jobs, a calendar timescale may overestimate actual work-time at risk, yielding underestimated reinjury rates. Objectives included determining: (1) reinjury risk by degree of permanent impairment and other factors, and (2) how choice of timescale affects reinjury estimates. Read More

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January 2021

Relationships Between Level and Change in Sarcopenia and Other Body Composition Components and Adverse Health Outcomes: Findings from the Health, Aging, and Body Composition Study.

Calcif Tissue Int 2021 Mar 15;108(3):302-313. Epub 2020 Nov 15.

MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.

We investigated how baseline values and rates of decline in components of sarcopenia and other body composition parameters relate to adverse clinical outcomes using the Health, Aging, and Body Composition Study. 2689 participants aged 70-79 years were studied. Appendicular lean mass, whole body fat mass, and total hip BMD were ascertained using DXA; muscle strength by grip dynamometry; and muscle function by gait speed. Read More

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Precise Prediction of Total Body Lean and Fat Mass From Anthropometric and Demographic Data: Development and Validation of Neural Network Models.

J Diabetes Sci Technol 2020 Nov 16:1932296820971348. Epub 2020 Nov 16.

Department of Health Science and Technology, Aalborg University, Denmark.

Background: Estimating body composition is relevant in diabetes disease management, such as drug administration and risk assessment of morbidity/mortality. It is unclear how machine learning algorithms could improve easily obtainable body muscle and fat estimates. The objective was to develop and validate machine learning algorithms (neural networks) for precise prediction of body composition based on anthropometric and demographic data. Read More

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November 2020

Estimating the whole-body effective dose and health risks as well as introducing a new easy method for eye lens dosimetry in interventional cardiology procedures.

MethodsX 2020 10;7:101097. Epub 2020 Oct 10.

Medical Physics and Medical Engineering Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

This study aimed to introduce a new method for eye lens thermo-luminescent dosimetry and also estimate the dose associated with induced cancer risk due to the ionizing radiation exposure received by physicians and other staff cooperating in interventional cardiology (IC) procedures. The measurements were performed with six TLDs (thermoluminescent dosimeters): four TLDs for eye lens dosimetry (2 positioned on respiratory/surgical mask under the eye region as the new method; and 2 near the outside border of the eye as the common method) and two TLDs for whole-body dosimetry. Whole-body doses were used to calculate the cancer risks induced by IC procedures. Read More

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October 2020

Calculating and estimating second cancer risk from breast radiotherapy using Monte Carlo code with internal body scatter for each out-of-field organ.

J Appl Clin Med Phys 2020 Dec 30;21(12):62-73. Epub 2020 Oct 30.

Graduate School of Medical Care and Technology, Teikyo University, 2-11-1 Kaga, Itabashi-ku, Tokyo, 173-8605, Japan.

Out-of-field organs are not commonly designated as dose calculation targets during radiation therapy treatment planning, but they might entail risks of second cancer. Risk components include specific internal body scatter, which is a dominant source of out-of-field doses, and head leakage, which can be reduced by external shielding. Our simulation study quantifies out-of-field organ doses and estimates second cancer risks attributable to internal body scatter in whole-breast radiotherapy (WBRT) with or without additional regional nodal radiotherapy (RNRT), respectively, for right and left breast cancer using Monte Carlo code PHITS. Read More

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December 2020

Feasibility of lower trapezius transfer extended by the infraspinatus fascia for restoration of external rotation in irreparable posterosuperior rotator cuff tears: an anatomical study.

Eur J Orthop Surg Traumatol 2020 Oct 24. Epub 2020 Oct 24.

Clinique Bizet, Paris Shoulder Unit, 22 bis rue Georges Bizet, 75116, Paris, France.

Purpose: Lower trapezius (LT) transfer using Achilles tendon allograft or semitendinosus autograft is effective in restoring external rotation in massive irreparable posterosuperior rotator cuff tears (RCT). The purpose of this study was to evaluate if the infraspinatus fascia (IF) could be used in LT transfer to extend the LT tendon.

Methods: Eight fresh-frozen whole-body cadavers were dissected using both shoulders, beach chair position. Read More

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October 2020

Diagnostic accuracy of FeNO [fractional exhaled nitric oxide] and asthma symptoms increased when evaluated with a superior reference standard.

J Clin Epidemiol 2021 Jan 8;129:86-96. Epub 2020 Oct 8.

Institute of General Practice and Health Services Research, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany. Electronic address:

Objectives: The objective of the study is to determine the impact of changing reference standards (RS), namely spirometry vs. whole-body plethysmography (WBP), on estimation of the diagnostic accuracy of fractional exhaled nitric oxide (FeNO) and clinical signs and symptoms (CSS) as index tests regarding asthma diagnosis.

Study Design And Setting: This was a diagnostic study conducted in 393 patients attending a private practice of pneumologists with complaints suspicious of asthma. Read More

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January 2021

Monte carlo method for estimating whole-body injury metrics from pedestrian impact simulation results.

Accid Anal Prev 2020 Nov 18;147:105761. Epub 2020 Sep 18.

Center for Applied Biomechanics, University of Virginia, Charlottesville, VA, USA.

The goal of the current study was to develop a method to estimate whole-body injury metrics (WBIMs), which measure the overall impact of injuries, using stochastic injury prediction results from a computational human surrogate. First, hospitalized pedestrian data was queried to identify injuries sustained by pedestrians and their frequencies. Second, with consideration for an understanding of injury mechanisms and the capability of the computational human surrogate, the whole-body was divided into 17 body regions. Read More

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November 2020

Estimating partial-body ionizing radiation exposure by automated cytogenetic biodosimetry.

Int J Radiat Biol 2020 Nov 6;96(11):1492-1503. Epub 2020 Oct 6.

CytoGnomix Inc., London, Canada.

Purpose: Inhomogeneous exposures to ionizing radiation can be detected and quantified with the dicentric chromosome assay (DCA) of metaphase cells. Complete automation of interpretation of the DCA for whole-body irradiation has significantly improved throughput without compromising accuracy, however, low levels of residual false positive dicentric chromosomes (DCs) have confounded its application for partial-body exposure determination.

Materials And Methods: We describe a method of estimating and correcting for false positive DCs in digitally processed images of metaphase cells. Read More

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November 2020

Whole-body heat exchange in women during constant- and variable-intensity work in the heat.

Eur J Appl Physiol 2020 Dec 9;120(12):2665-2675. Epub 2020 Sep 9.

Human and Environmental Physiology Research Unit, School of Human Kinetics, University of Ottawa, 125 University Private, Room 367 Montpetit Hall, Ottawa, ON, K1N 6N5, Canada.

Purpose: Time-weighted averaging is used in occupational heat stress guidelines to estimate the metabolic demands of variable-intensity work. However, compared to constant-intensity work of the same time-weighted average metabolic rate, variable-intensity work may cause decrements in total heat loss (dry + evaporative heat loss) that exacerbate heat storage in women. We therefore used direct calorimetry to assess whole-body total heat loss and heat storage (metabolic heat production minus total heat loss) in women and men during constant- and variable-intensity work of equal average intensity. Read More

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December 2020

Formulae for calculating body surface area in modern U.S. Army Soldiers.

J Therm Biol 2020 Aug 30;92:102650. Epub 2020 Jun 30.

Biophysics and Biomedical Modeling Division, U.S. Army Research Institute of Environmental Medicine (USARIEM), 10 General Greene Avenue, Bldg 42, Natick, MA, 01760, USA. Electronic address:

Purpose: Body surface area (BSA) is an important measurement for many thermophysiological, pharmaceutical, toxicological, environmental, and military applications. Unfortunately, BSA is difficult to quantify, and existing prediction methods are not optimized for contemporary populations.

Methods: The present study analyzed data body measurements from 5603 male and female participants of a US Army Anthropometric Survey to determine optimal methods for estimating BSA in modern US Army Soldiers. Read More

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The effects of incidental findings from whole-body MRI on the frequency of biopsies and detected malignancies or benign conditions in a general population cohort study.

Eur J Epidemiol 2020 Oct 29;35(10):925-935. Epub 2020 Aug 29.

Department SHIP-KEF, Institute for Community Medicine, Greifswald University Medical Center, Walther Rathenau Str. 48, 17475, Greifswald, Germany.

Magnetic resonance imaging (MRI) yields numerous tumor-related incidental findings (IFs) which may trigger diagnostics such as biopsies. To clarify these effects, we studied how whole-body MRI IF disclosure in a population-based cohort affected biopsy frequency and the detection of malignancies. Laboratory disclosures were also assessed. Read More

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October 2020

Cross-validation of equations to predict whole-body sweat sodium concentration from regional measures during exercise.

Physiol Rep 2020 08;8(15):e14524

Gatorade Sports Science Institute, PepsiCo R&D Life Sciences, Barrington, IL, USA.

We have previously published equations to estimate whole-body (WB) sweat sodium concentration ([Na ]) from regional (REG) measures; however, a cross-validation is needed to corroborate the applicability of these prediction equations between studies. The purpose of this study was to determine the validity of published equations in predicting WB sweat [Na ] from REG measures when applied to a new data set. Forty-nine participants (34 men, 15 women; 75 ± 12 kg) cycled for 90 min while WB sweat [Na ] was measured using the washdown technique. Read More

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Estimating resting energy expenditure from dual-energy X-ray absorptiometry: A cross-sectional study in healthy young adults.

Am J Hum Biol 2021 03 14;33(2):e23466. Epub 2020 Jul 14.

University of São Paulo at Ribeirão Preto, College of Nursing (EERP-USP), Ribeirão Preto, São Paulo, Brazil.

Objective: To qualify a 3C approach model of dual-energy X-ray absorptiometry (DXA) to estimate multicomponent resting energy expenditure (REE) referenced by indirect calorimetry (IC).

Methods: A sample of 155 college students, of both sexes (18-30 years old) was evaluated. Anthropometric measures, REE by IC, and whole-body DXA-scans were performed. Read More

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Development of a simple method to measure masseter muscle mass.

Gerodontology 2020 Dec 13;37(4):383-388. Epub 2020 Jul 13.

Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.

Objective: To develop a simple method to estimate masseter muscle mass.

Background: The masseter muscle is important for optimal oral function. A decrease in the masseter muscle mass may affect the oral and physical function of the whole body; therefore, it is an important entity to measure. Read More

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December 2020

Accuracy of surrogate methods to estimate skeletal muscle mass in non-dialysis dependent patients with chronic kidney disease and in kidney transplant recipients.

Clin Nutr 2021 Jan 26;40(1):303-312. Epub 2020 May 26.

Department of Applied Nutrition, Nutrition Institute, Rio de Janeiro State University, Rio de Janeiro, 20550-900, Brazil. Electronic address:

Background & Aims: Bioelectrical impedance analysis (BIA) and anthropometric predictive equations have been proposed to estimate whole-body (SMM) and appendicular skeletal muscle mass (ASM) as surrogate for dual energy X-ray absorptiometry (DXA) in distinct population groups. However, their accuracy in estimating body composition in non-dialysis dependent patients with chronic kidney disease (NDD-CKD) and kidney transplant recipients (KTR) is unknown. The aim of this study was to investigate the accuracy and reproducibility of BIA and anthropometric predictive equations in estimating SMM and ASM compared to DXA, in NDD-CKD patients and KTR. Read More

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January 2021

Deconvolution of bulk blood eQTL effects into immune cell subpopulations.

BMC Bioinformatics 2020 Jun 12;21(1):243. Epub 2020 Jun 12.

Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

Background: Expression quantitative trait loci (eQTL) studies are used to interpret the function of disease-associated genetic risk factors. To date, most eQTL analyses have been conducted in bulk tissues, such as whole blood and tissue biopsies, which are likely to mask the cell type-context of the eQTL regulatory effects. Although this context can be investigated by generating transcriptional profiles from purified cell subpopulations, current methods to do this are labor-intensive and expensive. Read More

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