10,829 results match your criteria estimated fetal

Swedish intrauterine growth reference ranges for estimated fetal weight.

Sci Rep 2021 Jun 14;11(1):12464. Epub 2021 Jun 14.

Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.

Fetal growth restriction is a strong risk factor for perinatal morbidity and mortality. Reliable standards are indispensable, both to assess fetal growth and to evaluate birthweight and early postnatal growth in infants born preterm. The aim of this study was to create updated Swedish reference ranges for estimated fetal weight (EFW) from gestational week 12-42. Read More

View Article and Full-Text PDF

Blood pressure and cardiac output during caesarean delivery under spinal anaesthesia: a prospective cohort study.

BMJ Open 2021 06 14;11(6):e046102. Epub 2021 Jun 14.

Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.

Objectives: We have previously established a method to measure transfer of nutrients between mother, placenta and fetus in vivo. The method includes measurements of maternal and fetal blood flow by Doppler ultrasound prior to spinal anaesthesia. Spinal anaesthesia affects maternal blood pressure and cardiac output. Read More

View Article and Full-Text PDF

Could Improved Microcirculation Reverse the Effects of Fetal Alcohol Syndrome? A Review.

CNS Spectr 2021 Apr;26(2):173

University of Colorado at Boulder, Boulder, CO, USA.

Fetal alcohol spectrum disorders, (FASDs) are a spectrum of neurodevelopmental and cognitive conditions, caused by the consumption of alcohol in varying amounts in utero that affect an estimated 1 - 5% of the general population in the United States. The effects of the spectrum of disorders are lifelong, resulting in often significant learning difficulties, cognitive deficits, and behavioral issues. It is known that blood flow and microcirculation to the brain are affected by the consumption of alcohol in utero, and that microcirculation and neurology are intimately linked, with changes in the former having drastic effects on the latter. Read More

View Article and Full-Text PDF

Placental growth factor as a diagnostic tool for placental mediated fetal growth restriction.

Pregnancy Hypertens 2021 Jun 6;25:123-128. Epub 2021 Jun 6.

Department of Obstetrics and Gynecology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada; Department of Laboratory Medicine & Pathobiology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.

Objective: Placental growth factor (PlGF) has shown promise in identification of placental fetal growth restriction (FGR). We aimed to investigate the association between PlGF and sonographic markers of placental dysfunction and assess its ability to diagnose FGR secondary to maternal vascular malperfusion (MVM).

Study Design: A retrospective study of singleton pregnancies with small for gestational age (SGA) fetuses, who had PlGF testing at 16-36 weeks. Read More

View Article and Full-Text PDF

Analysis for Data-derived Extrapolation Factors for Procymidone.

Regul Toxicol Pharmacol 2021 Jun 10:104972. Epub 2021 Jun 10.

Australian Pesticides and Veterinary Medicines Authority, Sydney, Australia.

The derivation of Chemical Specific Adjustment Factors (CSAFs) (IPCS, 2005; U.S. EPA, 2014) depends on the choice of appropriate dose metric. Read More

View Article and Full-Text PDF

Maternal phthalate and phthalate alternative metabolites and urinary biomarkers of estrogens and testosterones across pregnancy.

Environ Int 2021 Jun 8;155:106676. Epub 2021 Jun 8.

Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI 48824, USA; Institute for Integrative Toxicology, Michigan State University, East Lansing, MI 48824, USA. Electronic address:

Background/objectives: Pregnant women are ubiquitously exposed to phthalates from food packaging materials and personal care products. Phthalates alter estrogen and testosterone concentrations in experimental models, but their ability to impact these hormones in human pregnancy is not well characterized.

Methods: We recruited women ages 18-40 into the Illinois Kids Development Study (I-KIDS) in early pregnancy. Read More

View Article and Full-Text PDF

Society for Maternal-Fetal Medicine (SMFM) Consult Series #56: Hepatitis C in Pregnancy: Updated Guidelines.

Am J Obstet Gynecol 2021 Jun 8. Epub 2021 Jun 8.

In the United States, it is estimated that 1% to 4% of pregnant women are infected with hepatitis C virus, which carries approximately a 5% risk of transmission from mother to infant. Hepatitis C virus can be transmitted to the infant in utero or during the peripartum period, and infection during pregnancy is associated with an increased risk of adverse fetal outcomes, including fetal growth restriction and low birthweight. The purpose of this document is to discuss the current evidence, provide updated recommendations regarding screening, review treatment, and address management of hepatitis C virus during pregnancy. Read More

View Article and Full-Text PDF

Prenatal exposure to consumer product chemical mixtures and size for gestational age at delivery.

Environ Health 2021 Jun 10;20(1):68. Epub 2021 Jun 10.

Epidemiology Branch, Division of Intramural Research, National Institute of Environmental Health Sciences, 111 T.W. Alexander Drive, Durham, NC, 27709, USA.

Background: While fetal growth is a tightly regulated process, it is sensitive to environmental exposures that occur during pregnancy. Many commonly used consumer products contain chemicals that can disturb processes underlying fetal growth. However, mixtures of these chemicals have been minimally examined. Read More

View Article and Full-Text PDF

Maternal and Fetal Vascular Lesions of Malperfusion in the Placentas Associated with Fetal and Neonatal Death: Results of a Prospective Observational Study.

Am J Obstet Gynecol 2021 Jun 7. Epub 2021 Jun 7.

Columbia University, New York NY USA.

Background: Fetal death, one of the major adverse pregnancy outcomes, is especially common in low and middle-income countries. Placental lesions may play an important role in the etiology of fetal and possibly neonatal death. Prior research relating placental lesions to fetal death causation was often hindered by the lack of agreement on a placental classification scheme. Read More

View Article and Full-Text PDF

Progress Toward Rubella Elimination - World Health Organization European Region, 2005-2019.

MMWR Morb Mortal Wkly Rep 2021 06 11;70(23):833-839. Epub 2021 Jun 11.

In 2005, the Regional Committee of the World Health Organization (WHO) European Region (EUR) passed a resolution calling for the regional elimination of measles, rubella, and congenital rubella syndrome (CRS) (1). In 2010, all 53 countries in EUR* reaffirmed their commitment to eliminating measles, rubella, and CRS (2); this goal was included in the European Vaccine Action Plan 2015-2020 (3,4). Rubella, which typically manifests as a mild febrile rash illness, is the leading vaccine-preventable cause of birth defects. Read More

View Article and Full-Text PDF

Predicting the need for blood transfusion requirement in postpartum hemorrhage.

J Matern Fetal Neonatal Med 2021 Jun 9:1-6. Epub 2021 Jun 9.

Lis Hospital for Women, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Objective: We aimed to assess the role of lactate and hemoglobin levels as predictors for the need for blood transfusion in post-partum hemorrhage (PPH).

Methods: A retrospective cohort study of women with PPH in a single university-affiliated tertiary medical center between August 2018 and June 2020. PPH was defined as an estimated excessive blood loss (of more than 500 ml following vaginal delivery and 1000 ml following a cesarean delivery) requiring at least one uterotonic drug and fluid resuscitation. Read More

View Article and Full-Text PDF

Birth weight is positively associated with adult osteoporosis risk: observational and Mendelian randomization studies.

J Bone Miner Res 2021 Jun 9. Epub 2021 Jun 9.

Center for Genetic Epidemiology and Genomics, School of Public Health, Medical College of Soochow University, Suzhou, China.

The relationship between birth weight and osteoporosis was inconsistent in previous observational studies. Therefore, we performed a systematic evaluation to determine the inconsistent relationship and further make causal inference based on the UK Biobank datasets (~500,000 individuals) and individual/summary-level genetic datasets. Observational analyses found consistent negative associations either between birth weight and estimated bone mineral density (eBMD) or between genetic risk score (GRS) of birth weight and eBMD in total subjects, and sex-stratified subgroups. Read More

View Article and Full-Text PDF

Diagnostic performance of cerebroplacental and umbilicocerebral ratio in appropriate for gestational age and late growth restricted fetuses attempting vaginal delivery: a multicenter, retrospective study.

J Matern Fetal Neonatal Med 2021 Jun 8:1-7. Epub 2021 Jun 8.

Fetal Medicine Unit, Maternal and Child Health and Development Network, Department of Obstetrics and Gynecology, University Hospital 12 de Octubre, Complutense University of Madrid, Madrid, Spain.

Background: Cerebroplacental Doppler studies have been advocated to predict the risk of adverse perinatal outcome (APO) irrespective of fetal weight.

Objective: To report the diagnostic performance of cerebroplacental (CPR) and umbilicocerebral (UCR) ratios in predicting APO in appropriate for gestational age (AGA) fetuses and in those affected by late fetal growth restriction (FGR) attempting vaginal delivery.

Study Design: Multicenter, retrospective, nested case-control study between 1 January 2017 and January 2020 involving five referral centers in Italy and Spain. Read More

View Article and Full-Text PDF

Evaluation of Urinary Tract Dilation Classification System for Prediction of Long-Term Outcomes in Isolated Antenatal Hydronephrosis: A Cohort Study.

J Urol 2021 Jun 8:101097JU0000000000001899. Epub 2021 Jun 8.

Pediatric Nephrourology Division, Department of Pediatrics, National Institute of Science and Technology of Molecular Medicine, Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil.

Purpose: The aim of this study was to evaluate the performance of the new classification of urinary tract dilatation (UTD) to predict long-term clinical outcomes in infants with isolated antenatal hydronephrosis (AHN).

Patients And Methods: Between 1989 and 2019, 447 infants diagnosed with isolated severe AHN and were prospectively followed. The main predictive variable for the analysis was the new UTD classification system. Read More

View Article and Full-Text PDF

Evaluation of blood transfusion rates by blood loss estimation techniques.

J Matern Fetal Neonatal Med 2021 Jun 7:1-6. Epub 2021 Jun 7.

Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, MedStar Washington Hospital Center, Washington, DC, USA.

Background: Postpartum hemorrhage is a major cause of maternal morbidity and mortality. Though the American College of Obstetricians and Gynecologists and quality improvement initiatives recommend the use of a quantitative measurement of blood loss, it is not known if the quantitative measurement compared to visual estimation of blood loss improves maternal outcomes.

Objective: To compare rates of red blood cell transfusion between a quantitative measurement and visual estimation of blood loss. Read More

View Article and Full-Text PDF

Individualized growth assessment in pregnancies complicated by fetal gastroschisis.

J Matern Fetal Neonatal Med 2021 Jun 7:1-11. Epub 2021 Jun 7.

Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA, USA.

Objective: Prenatal ultrasound (US) has been shown to overestimate the incidence of suspected fetal growth restriction (FGR) in gastroschisis cases. This is largely because of altered sonographic abdominal circumference (AC) measurements when comparing gastroschisis cases with population nomograms. Individualized Growth Assessment (IGA) evaluates fetal growth using serial US measurements that allow consideration of the growth potential for a given case. Read More

View Article and Full-Text PDF

Automated quantitative evaluation of atrioventricular annular plane systolic excursion in human fetuses.

Ultrasound Obstet Gynecol 2021 Jun 7. Epub 2021 Jun 7.

Department of Clinical Science, Intervention and Technology - CLINTEC, Karolinska Institutet, Stockholm, Sweden.

Objectives: The primary aim of this study was to evaluate the feasibility of measuring fetal atrioventricular plane displacement (AVPD) using an automated analysis software. The secondary objectives were to establish reference ranges for AVPD during the second half of normal pregnancy, assess fetal AVPD in prolonged pregnancies in relation to adverse perinatal outcome and in fetuses with a suspicion of intrauterine growth restriction (IUGR).

Methods: The reference population consisted of women with uncomplicated pregnancies at 18-42 weeks of gestation (n=201). Read More

View Article and Full-Text PDF

Fast Multiple Landmark Localisation Using a Patch-based Iterative Network.

Med Image Comput Comput Assist Interv 2018 26;2018:563-571. Epub 2018 Sep 26.

Biomedical Image Analysis Group Imperial College London UK.

We propose a new Patch-based Iterative Network (PIN) for fast and accurate landmark localisation in 3D medical volumes. PIN utilises a Convolutional Neural Network (CNN) to learn the spatial relationship between an image patch and anatomical landmark positions. During inference, patches are repeatedly passed to the CNN until the estimated landmark position converges to the true landmark location. Read More

View Article and Full-Text PDF
September 2018

Prenatal growth trajectories and birth outcomes after frozen-thawed extended culture embryo transfer and fresh embryo transfer: the Rotterdam Periconception Cohort.

Reprod Biomed Online 2021 Apr 24. Epub 2021 Apr 24.

Department of Obstetrics and Gynecology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.

Research Question: Are there differences in prenatal growth trajectories and birth outcomes between singleton pregnancies conceived after IVF treatment with frozen-thawed extended culture embryo transfer at day 5, fresh embryo transfer at day 3 or naturally conceived pregnancies?

Design: From a prospective hospital-based cohort, 859 singleton pregnancies were selected, including 133 conceived after IVF with frozen-thawed embryo transfer, 276 after fresh embryo transfer, and 450 naturally conceived pregnancies. Longitudinal 3D ultrasound scans were performed at 7, 9 and 11 weeks of gestation for offline crown-rump length (CRL) and embryonic volume measurements. Second trimester estimated fetal weight was based on growth parameters obtained during the routine fetal anomaly scan at 20 weeks of gestation. Read More

View Article and Full-Text PDF

Neuropathological hallmarks of fetal hydrocephalus linked to CCDC88C pathogenic variants.

Acta Neuropathol Commun 2021 Jun 6;9(1):104. Epub 2021 Jun 6.

UNIROUEN, Inserm U1245 and Rouen University Hospital, Department of Genetics and Reference Center for Developmental Disorders, Normandy Center for Genomic and Personalized Medicine, Normandie Univ, 76000, Rouen, France.

The prevalence of congenital hydrocephalus has been estimated at 1.1 per 1000 infants when including cases diagnosed before 1 year of age after exclusion of neural tube defects. Classification criteria are based either on CSF dynamics, pathophysiological mechanisms or associated lesions. Read More

View Article and Full-Text PDF

Associations between prenatal exposure to cadmium and lead with neural tube defect risks are modified by single-nucleotide polymorphisms of fetal MTHFR and SOD2: a case-control study.

Environ Health 2021 Jun 5;20(1):66. Epub 2021 Jun 5.

Institute of Reproductive and Child Health/Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China, Peking University, Beijing, China.

Background: Prenatal exposure to heavy metals is implicated in the etiology of birth defects. We investigated whether concentrations of cadmium (Cd) and lead (Pb) in umbilical cord tissue are associated with risk for neural tube defects (NTDs) and whether selected genetic variants of the fetus modify their associations.

Methods: This study included 166 cases of NTD fetuses/newborns and 166 newborns without congenital malformations. Read More

View Article and Full-Text PDF

Estimated glomerular filtration rate and cardiometabolic risk factors in a longitudinal cohort of children.

Sci Rep 2021 Jun 3;11(1):11702. Epub 2021 Jun 3.

Maternal-Fetal Metabolic Research Group, Girona Biomedical Research Institute (IDIBGI), Parc Hospitalari Martí I Julià, Edifici M2, 17190, Salt, Spain.

Associations between glomerular filtration rate (GFR) and cardiometabolic risk factors have been reported in adult and pediatric patients with renal disease. We aimed to assess the relationship between the estimated GFR (eGFR) and cardiometabolic risk factors in apparently healthy children. A longitudinal study in 401 asymptomatic Caucasian children (mean age 8 years) followed up after 4 years (mean age 12 years). Read More

View Article and Full-Text PDF

Interval growth across gestation in pregnancies with fetal gastroschisis.

Am J Obstet Gynecol MFM 2021 May 31:100415. Epub 2021 May 31.

Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco.

Background: Gastroschisis is frequently complicated by fetal growth restriction, preterm delivery, and prolonged neonatal hospitalization. Prenatal management and delivery decisions are often based upon estimated fetal weight and interval growth, however appropriate interval growth from week to week across gestation for these fetuses is poorly understood.

Objectives: To determine the median increase in overall estimated fetal weight and individual biometric measurements across each week of gestation in pregnancies with fetal gastroschisis, and to assess if lower in utero fetal weight gain is predictive of postnatal growth or adverse neonatal outcomes. Read More

View Article and Full-Text PDF

Antibiotic Prescriptions among China Ambulatory Care Visits of Pregnant Women: A Nationwide Cross-Sectional Study.

Antibiotics (Basel) 2021 May 19;10(5). Epub 2021 May 19.

Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.

Background: Antibiotic use in pregnant women at the national level has rarely been reported in China.

Objectives: We aimed to investigate antibiotic prescriptions during pregnancy in ambulatory care settings in China.

Methods: Data of 4,574,961 ambulatory care visits of pregnant women from October 2014 to April 2018 were analyzed. Read More

View Article and Full-Text PDF

Methods for managing miscarriage: a network meta-analysis.

Cochrane Database Syst Rev 2021 Jun 1;6:CD012602. Epub 2021 Jun 1.

Tommy's National Centre for Miscarriage Research, Institute of Metabolism and Systems Research (IMSR), WHO Collaborating Centre for Global Women's Health Research, University of Birmingham, Birmingham, UK.

Background: Miscarriage, defined as the spontaneous loss of a pregnancy before 24 weeks' gestation, is common with approximately 25% of women experiencing a miscarriage in their lifetime. An estimated 15% of pregnancies end in miscarriage. Miscarriage can lead to serious morbidity, including haemorrhage, infection, and even death, particularly in settings without adequate healthcare provision. Read More

View Article and Full-Text PDF

The frequency of severe Fetal Alcohol Spectrum Disorders in the neonatal period using data from the French hospital discharge database between 2006 and 2013.

Drug Alcohol Depend 2021 May 21;225:108748. Epub 2021 May 21.

Santé publique France, French National Public Health Agency, F-94415 Saint-Maurice, France.

Backgrounds: At birth, only complete Fetal Alcohol Syndrome (FAS) can be properly diagnosed. However, other Consequences of prenatal Alcohol Exposure (CAE) can also be recorded. Our objective was to describe the frequency of diagnoses highly suggestive of "potential Fetal Alcohol Syndrome Disorder" (pFASD, i. Read More

View Article and Full-Text PDF

Patient Characteristics Associated with Complications of External Cephalic Version.

Am J Obstet Gynecol MFM 2021 May 28:100411. Epub 2021 May 28.

Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago IL, USA.

Background: Patient characteristics associated with external cephalic version success are well documented; however, the association between patient characteristics and the chance of external cephalic version complications is poorly understood.

Objective: To assess frequency of and patient characteristics associated with complications leading to unanticipated delivery during external cephalic version.

Study Design: This retrospective study included pregnant individuals at least 18 years of age with singleton gestations who underwent an external cephalic version between 2006-2016 at a single quaternary care center. Read More

View Article and Full-Text PDF

Should prenatal chromosomal microarray analysis be offered for isolated fetal growth restriction? A French multicenter study.

Am J Obstet Gynecol 2021 May 29. Epub 2021 May 29.

Department of Obstetrics and Gynaecology, Antoine Béclère Hospital, AP-HP, Paris Saclay University, Clamart, France.

Background: Compared with standard karyotype, chromosomal microarray analysis improves the detection of genetic anomalies and is thus recommended in many prenatal indications. However, evidence is still lacking on the clinical utility of chromosomal microarray analysis in cases of isolated fetal growth restriction.

Objective: This study aimed to estimate the proportion of copy number variants detected by chromosomal microarray analysis and the incremental yield of chromosomal microarray analysis compared with karyotype in the detection of genetic abnormalities in fetuses with isolated fetal growth restriction. Read More

View Article and Full-Text PDF

Association between AMPKα1 gene polymorphisms and gestational diabetes in the Chinese population: A case-control study.

Diabet Med 2021 May 30:e14613. Epub 2021 May 30.

Department of Epidemiology, School of Public Health, Center of Clinical Epidemiology and Evidence Based Medicine, Shanxi Medical University, Taiyuan, China.

Aim: The aim is to examine the association between seven candidate single nucleotide polymorphisms in AMPKα1 and gestational diabetes in Chinese people.

Method: We used a matched nested case-control study design, individuals including 334 participants with gestational diabetes and 334 healthy pregnant women. Confirmed 334 gestational diabetes cases and maternal age and district of residence matched controls (1:1) were enrolled. Read More

View Article and Full-Text PDF

Placental chemical elements concentration in small fetuses and its relationship with Doppler markers of placental function.

Placenta 2021 May 14;110:1-8. Epub 2021 May 14.

Department of Forensic and Legal Medicine. University of Murcia, Spain.

Introduction: In this study, we aimed at quantifying placental concentrations of 22 chemical elements in small fetuses (SGA) as compared with normally grown fetuses (AGA), and to assess the relationship with Doppler markers of placental function.

Methods: Prospective cohort study, including 71 SGA fetuses (estimated fetal weight < 10th percentile) and 96 AGA fetuses (estimated fetal weight > 10th percentile), recruited in the third trimester of gestation. The placental concentration of 22 chemical elements was determined by inductively coupled plasma optical emission spectrophotometer (ICP-OES, ICAP 6500 Duo Thermo): aluminum (Al), beryllium (Be), bismuth (Bi), calcium (Ca), cadmium (Cd), cobalt (Co), chrome (Cr), copper (Cu), magnesium (Mg), manganese (Mn), molybdenum (Mo), nickel (Ni), phosphorus (P), lead (Pb), rubidium (Rb), sulfur (S), strontium (Sr), titanium (Ti), thallium (Tl), antimony (Sb), selenium (Se), and zinc (Zn). Read More

View Article and Full-Text PDF