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Air pollution as a risk factor for Cognitive Impairment no Dementia (CIND) and its progression to dementia: A longitudinal study.

Environ Int 2022 Jan 12;160:107067. Epub 2022 Jan 12.

Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden; Stockholm Gerontology Research Center, Stockholm, Sweden.

Background And Aim: Accumulation of evidence has raised concern regarding the harmful effect of air pollution on cognitive function, but results are diverging. We aimed to investigate the longitudinal association of long-term exposure to air pollutants and cognitive impairment and its further progression to dementia in older adults residing in an urban area.

Methods: Data were obtained from the Swedish National Study on Aging and Care in Kungsholmen (SNAC-K). Read More

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January 2022

Towards a representative reference for MRI-based human axon radius assessment using light microscopy.

Neuroimage 2022 Jan 12:118906. Epub 2022 Jan 12.

Institute of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.

Non-invasive assessment of axon radii via MRI bears great potential for clinical and neuroscience research as it is a main determinant of the neuronal conduction velocity. However, there is a lack of representative histological reference data at the scale of the cross-section of MRI voxels for validating the MRI-visible, effective radius (r). Because the current gold standard stems from neuroanatomical studies designed to estimate the bulk-determined arithmetic mean radius (r) on small ensembles of axons, it is unsuited to estimate the tail-weighted r. Read More

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January 2022

Plutonium isotopes in the northwestern South China Sea: Level, distribution, source and deposition.

Environ Pollut 2022 Jan 12:118846. Epub 2022 Jan 12.

State Key Laboratory of Loess and Quaternary Geology, Xi'an AMS Center, Institute of Earth Environment, Chinese Academy of Sciences, Xi'an, 710061, PR China; Shaanxi Key Laboratory of Accelerator Mass Spectrometry Technology and Application, Xi'an, 710061, PR China; Department of Environmental Engineering, Technical University of Denmark, Risø Campus, Roskilde, 4000, Denmark; Open Studio for Oceanic-Continental Climate and Environment Changes, Pilot National Laboratory for Marine Science and Technology (Qingdao), Qingdao, 266061, PR China. Electronic address:

The spatial distribution of plutonium isotopes (Pu, Pu) in the surface sediments collected from the northwestern South China Sea (SCS) in 2018 was investigated. The Pu concentrations in surface sediments vary from 0.048 to 0. Read More

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January 2022

Associations of variability in body weight and glucose levels with the risk of hip fracture in people with diabetes.

Metabolism 2022 Jan 12:155135. Epub 2022 Jan 12.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea; Department of Medical Informatics, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea. Electronic address:

Background: Diabetes is associated with a high risk of fragility fracture. However, there are controversies regarding the effect of fluctuations in metabolic parameters on the risk of fracture. We aimed to investigate the associations of body weight or glucose variability or their combination with the risk of hip fracture in people with diabetes. Read More

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January 2022

Addressing the Eltonian shortfall with trait-based interaction models.

Ecol Lett 2022 Jan 15. Epub 2022 Jan 15.

Department of Biology, McGill University, Montreal, QC, Canada.

We have very limited knowledge of how species interact in most communities and ecosystems despite trophic relationships being fundamental for linking biodiversity to ecosystem functioning. A promising approach to fill this gap is to predict interactions based on functional traits, but many questions remain about how well we can predict interactions for different taxa, ecosystems and amounts of input data. Here, we built a new traits-based model of trophic interactions for European vertebrates and found that even models calibrated with 0. Read More

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January 2022

Environmental regionalization and endemic plant distribution in the Maghreb.

Environ Monit Assess 2022 Jan 15;194(2):100. Epub 2022 Jan 15.

Ecole Nationale Supérieure Agronomique, El Harrach, Algeria.

Clustering methods based on environmental variables are useful in the planning of conservation strategies for species and ecosystems. However, there is a lack of work on the regionalization of the vast space of North Africa and the distribution of plant species. The current lists of endemic plants are focused mostly on an occurrence at the country level and not on regions with different conditions. Read More

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January 2022

Dipeptidyl-peptidase IV inhibitor (DPP4i) confers increased odds of bullous pemphigoid even years after drug initiation.

Arch Dermatol Res 2022 Jan 15. Epub 2022 Jan 15.

Clalit Health Services, Tel-Aviv, Israel.

The timing pattern in which dipeptidyl-peptidase IV inhibitors (DPP4i) confer the risk of bullous pemphigoid (BP) is unknown. To investigate the odds of BP following exposure to DPP4i and to perform a duration-response analysis evaluating the risk of BP in relation to the duration of exposure to the culprit drug. A population-based nested case-control study was performed comparing diabetic patients with BP (n = 1458) with age-, sex- and ethnicity-matched diabetic control subjects (n = 6051) with respect to the prevalence of exposure to DPP4i. Read More

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January 2022

Metacontrast masking reduces the estimated duration of visible persistence.

Atten Percept Psychophys 2022 Jan 14. Epub 2022 Jan 14.

Department of Psychology, Simon Fraser University, 8888 University Drive, Burnaby, BC, V5A 1S6, Canada.

A brief visual display can give rise to a sensation that outlasts the duration of the physical stimulus. The duration of this visible persistence has been estimated with paradigms that require the temporal integration of two brief sequential displays (frames) separated by a blank temporal gap. Temporal integration is said to occur when the visible persistence generated by the first frame is sufficiently long to bridge the inter-frame temporal gap. Read More

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January 2022

A predictive modelling approach to support the overfill volume definition of liquid-in-vial drug products.

PDA J Pharm Sci Technol 2022 Jan 14. Epub 2022 Jan 14.

UCB Pharma, Chemin du Foriest, 1420 Braine-l'Alleud, Belgium.

Liquid-in-vial drug products are typically overfilled to meet the label claim volume specification while taking into account for losses in the container-closure system and withdrawal device. Any overfill volume setting requires justification. The aim of this study was to estimate the overfill volume required for a liquid drug product in a vial using a prediction model. Read More

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January 2022

Improved access to rapid electroencephalography at a community hospital reduces inter-hospital transfers for suspected non-convulsive seizures.

Epileptic Disord 2022 Jan 12. Epub 2022 Jan 12.

Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.

Patients with suspected non-convulsive seizures are optimally evaluated with EEG. However, limited EEG infrastructure at community hospitals often necessitates transfer for long-term EEG monitoring (LTM). Novel point-of-care EEG systems could expedite management of non-convulsive seizures and reduce unnecessary transfers. Read More

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January 2022

Two new pseudocryptic species in the medium-sized common European land snails, Fruticicola Held, 1838; as a result of phylogeographic analysis of Fruticicola fruticum (O. F. Müller, 1774) (Gastropoda: Helicoidea: Camaenidae).

Mol Phylogenet Evol 2022 Jan 11:107402. Epub 2022 Jan 11.

Department of Malacology, Institute of Zoology and Biomedical Research, Jagiellonian University, Gronostajowa 9, 30-387 Kraków, Poland. Electronic address:

Fruticicola fruticum (O. F. Müller, 1774), a medium-sized helicoid snail in the Bradybaenidae, has a wide range in Europe, reaching from the Urals and the Caucasus to the Balkans, and from the southern part of Scandinavia, through Central Europe to eastern and central France and northern Italy. Read More

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January 2022

Patterns of diversification of the operculate land snail genus Cyclophorus (Caenogastropoda: Cyclophoridae) on the Ryukyu Islands, Japan.

Mol Phylogenet Evol 2022 Jan 11:107407. Epub 2022 Jan 11.

Centre of Northeast Asian Studies, Tohoku University, Sendai, Miyagi, Japan; Graduate School of Life Sciences, Tohoku University, Sendai, Miyagi, Japan.

The Ryukyu Islands, an island chain in southwestern Japan, originated from land masses that separated from the Eurasian continent due to the formation of sea barriers about 1.55 million years ago. In this study, we investigated the phylogenetic relationships of the operculate land snail genus Cyclophorus (Caenogastropoda: Cyclophoridae) in the Ryukyu Archipelago and surrounding regions based on DNA sequence data. Read More

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January 2022

Utilization and cost-effectiveness of school and community center AED deployment models in Canadian cities.

Resuscitation 2022 Jan 11. Epub 2022 Jan 11.

Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark; Assistance Publique - Hôpitaux de Paris (AP-HP), Emergency department, Hôpitaux universitaires Henri Mondor, Créteil, France; Department of Emergency Medicine, St Paul's Hospital and the University of British Columbia, Vancouver, BC, Canada; Copenhagen University Hospital - Copenhagen Emergency Medical Services, Denmark.

Background: The optimal locations and cost-effectiveness of placing automated external defibrillators(AEDs) for out-of-hospital cardiac arrest(OHCAs) in urban residential neighbourhoods are unclear.

Methods: We used prospectively collected data from 2016 to 2018 from the British Columbia OHCA Registry to examine the utilization and cost-effectiveness of hypothetical AED deployment in municipalities with a population of over 100 000. We geo-plotted OHCA events using seven hypothetical deployment models where AEDs were placed at the exteriors of public schools and community centers and fetched by bystanders. Read More

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January 2022

Nocturia and Chronic Kidney Disease: Systematic Review and Nominal Group Technique Consensus on Primary Care Assessment and Treatment.

Eur Urol Focus 2022 Jan 11. Epub 2022 Jan 11.

Nuffield Department of Medicine, University of Oxford, Oxford, UK; Oxford Kidney Unit, Churchill Hospital, Oxford, UK.

Context: Reduced renal function impairs salt and water homeostasis, which can drive nocturnal or 24-h polyuria. Nocturia can arise early in chronic kidney disease (CKD). Evidence-based recommendations can facilitate management outside nephrology clinics. Read More

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January 2022

Altered task-modulated functional connectivity during emotional face processing in euthymic bipolar patients: A whole-brain psychophysiological interaction study.

J Affect Disord 2022 Jan 11. Epub 2022 Jan 11.

School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, 518060, China; Guangdong Provincial Key Laboratory of Biomedical Measurements and Ultrasound Imaging, Shenzhen, 518060, China; Peng Cheng Laboratory, Shenzhen, 518055, China. Electronic address:

Background: Patients with bipolar disorder (BD) show deficits of facial emotion processing even in the euthymic phase. However, the large-scale functional brain network mechanism underlying the emotional deficit of BD remains unclear. Specifically, it is of importance to understand how the task-modulated functional connectivity (FC) was alternated over distributed brain networks in BD. Read More

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January 2022

Optimizing use of L-asparaginase-based treatment of adults with acute lymphoblastic leukemia.

Blood Rev 2021 Nov 12:100908. Epub 2021 Nov 12.

Hematology Adolescent and Young Adult Unit, Saint Louis Hospital, URP-3518, Université de Paris, Paris, France. Electronic address:

Acute lymphoblastic leukemia (ALL) is a malignancy of lymphoid progenitor cells occurring at an annual incidence rate of approximately 1.1 to 2.1 per 100,000 person-years globally. Read More

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November 2021

Validation of Heart Failure-Specific Risk Equations in 1.3 Million Israeli Adults and Usefulness of Combining Ambulatory and Hospitalization Data from a Large Integrated Health Care Organization.

Am J Cardiol 2022 Jan 11. Epub 2022 Jan 11.

Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

Heart failure (HF) prevalence is increasing worldwide and is associated with significant morbidity and mortality. Guidelines emphasize prevention in those at-risk, but HF-specific risk prediction equations developed in United States population-based cohorts lack external validation in large, real-world datasets outside of the United States. The purpose of this study was to assess the model performance of the pooled cohort equations to prevent HF (PCP-HF) within a contemporary electronic health record for 5- and 10-year risk. Read More

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January 2022

Do Cost-Effectiveness Analyses Account for Drug Genericization? A Literature Review and Assessment of Implications.

Value Health 2022 Jan 12;25(1):59-68. Epub 2021 Nov 12.

Center for the Evaluation of Value and Risk in Health, Tufts Medical Center, Boston, MA, USA.

Objectives: We investigated how health technology assessment (HTA) organizations around the world have handled drug genericization (an allowance for future generic drug entry and subsequent drug price declines) in their guidelines for cost-effectiveness analyses (CEAs). We also analyzed a large sample of published CEAs to examine prevailing practices in the field.

Methods: We reviewed 43 HTA guidelines to determine whether and how they addressed drug genericization in their CEAs. Read More

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January 2022

Cost of integrating assisted partner services in HIV testing services in Kisumu and Homa Bay counties, Kenya: a microcosting study.

BMC Health Serv Res 2022 Jan 14;22(1):69. Epub 2022 Jan 14.

Department of Global Health, University of Washington, 325 9th Avenue, Box 359909, Seattle, WA, 98104, USA.

Background: HIV assisted partner services (aPS), or provider notification and testing for sexual and injecting partners of people diagnosed with HIV, is shown to be safe, effective, and cost-effective and was scaled up within the national HIV testing services (HTS) program in Kenya in 2016. We estimated the costs of integrating aPS into routine HTS within an ongoing aPS scale-up project in western Kenya.

Methods: We conducted microcosting using the payer perspective in 14 facilities offering aPS. Read More

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January 2022

Protein Biophotosensitizer-Based IGZO Photo-thin Film Transistors for Monitoring Harmful Ultraviolet Light.

ACS Appl Bio Mater 2019 Jul 21;2(7):3030-3037. Epub 2019 Jun 21.

Jeonju Center, Korea Basic Science Institute, Jeonju, Jeollabuk-do 54907, Republic of Korea.

The development of health monitoring devices to prevent skin cancers or various diseases arising from exposure to harmful light has attracted increasing scientific interest and has led to the exploration of hybrid inorganic-biological systems through the incorporation of biomolecules. Here, ultraviolet (UV) photodetectors based on transistors incorporating green fluorescent protein (GFP) molecules on multilayer-stacked indium-gallium-zinc-oxide (IGZO) thin films are studied, where the top layer of the IGZO films has different surface properties. Light-sensitive GFP can play a role as a biophotosensitizer due to light-induced electron transfer during photoexcitation. Read More

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Site-Selective Interaction of Human Serum Albumin with 4-Chloro-7-nitro-1,2,3-benzoxadiazole Modified Olanzapine Derivative and Effect of β-Cyclodextrin on Binding: In the Light of Spectroscopy and Molecular Docking.

ACS Appl Bio Mater 2019 Aug 30;2(8):3551-3561. Epub 2019 Jul 30.

Department of Chemistry, Jadavpur University, 188, Raja S. C. Mullick Road, Kolkata 700 032, India.

Here, we present a detailed investigation on the interaction of 4-chloro-7-nitro-1,2,3-benzoxadiazole (NBD) embedded olanzapine derivative (OLA-NBD) with a model transport protein, human serum albumin (HSA). The thermodynamic parameters, Δ, Δ, and Δ, as evaluated by considering the van't Hoff relationship imply the major contribution of electrostatic/ionic interactions for the HSA-OLA-NBD association. The OLA-NBD induced quenching of HSA emission occurs through static quenching mechanism, indicating a 1:1 association, as portrayed from Benesi-Hildebrand plot, with ∼10 M association constant value, and it is in good harmony with the value estimated from anisotropy experiment. Read More

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Long-term consumption of a mediterranean diet or a low-fat diet on kidney function in coronary heart disease patients: The CORDIOPREV randomized controlled trial.

Clin Nutr 2022 Jan 6;41(2):552-559. Epub 2022 Jan 6.

Unidad de Gestión Clinica Medicina Interna, Lipids and Atherosclerosis Unit, Maimonides Institute for Biomedical Research in Córdoba, Reina Sofia University Hospital, 14004 University of Córdoba, Córdoba, Spain; CIBER Physiopathology of Obesity and Nutrition (CIBEROBN), Institute of Health Carlos III, Madrid, Spain. Electronic address:

Background & Aims: Lifestyle and dietary habits influence kidney function, playing an important role in the prevention and development of chronic kidney disease (CKD). The effectiveness of the Mediterranean diet in preserving kidney function has been seen in primary prevention. However, no scientific evidence is currently available to determine which dietary pattern is more effective in the management of CKD in secondary cardiovascular disease prevention. Read More

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January 2022

Layered SnS/porous nickel foil based Schottky junction: An excellent ammonia sensor at room temperature.

J Hazard Mater 2022 Jan 10;428:128252. Epub 2022 Jan 10.

Materials Processing & Microsystem Laboratory, CSIR-Central Mechanical Engineering Research Institute, Durgapur 713209, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, Uttar Pradesh, India. Electronic address:

In recent years, layered materials has gained immense attention in the field of gas sensing owing to their extraordinary electrical, optical and catalytic properties. Their gas sensing performance can further be improved by switching from ohmic to schottky based sensor due to exponential change of conductance in analyte environment. In most of the Schottky based gas sensor, the surface of the sensing material is covered by metal electrode which reduces the sensing performance. Read More

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January 2022

Multi-dimensional factors related to participation in a population-wide mass COVID-19 testing program among Hong Kong adults: A population-based randomized survey.

Soc Sci Med 2021 Dec 30;294:114692. Epub 2021 Dec 30.

Centre for Health Behaviours Research, JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China.

Rationale: Mass testing is considered as an important policy response to the COVID-19 pandemic, and high population coverage is pivotal to its effectiveness. A range of factors derived from health behaviour theories were hypothesized to be associated with public uptake of mass testing, including illness representations of COVID-19, perceived susceptibility to COVID-19, perceived efficacy of the testing program, and general trust toward governmental measures for controlling COVID-19.

Objective: This study aimed to investigate the multi-dimensional factors associated with participation in a free and voluntary population-wide mass COVID-19 testing program. Read More

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December 2021

An evaluation of the serum carbon isotope ratio as a candidate predictive biomarker for dietary animal protein ratio (animal protein/total protein) in a 15-d controlled feeding study of US adults.

Am J Clin Nutr 2022 Jan 14. Epub 2022 Jan 14.

College of Health Solutions, Arizona State University, Phoenix, AZ.

Background: The serum natural abundance carbon isotope ratio (CIR) was recently identified as a candidate biomarker of animal protein intake in postmenopausal women. Such a biomarker would help clarify the relationship between dietary protein source (plant vs. animal) and chronic disease risk. Read More

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January 2022

Riemannian classification of single-trial surface EEG and sources during checkerboard and navigational images in humans.

PLoS One 2022 14;17(1):e0262417. Epub 2022 Jan 14.

Laboratory of Neurophysiology and Movement Biomechanics, Neuroscience Institute, Université Libre de Bruxelles (ULB), Brussels, Belgium.

Objective: Different visual stimuli are classically used for triggering visual evoked potentials comprising well-defined components linked to the content of the displayed image. These evoked components result from the average of ongoing EEG signals in which additive and oscillatory mechanisms contribute to the component morphology. The evoked related potentials often resulted from a mixed situation (power variation and phase-locking) making basic and clinical interpretations difficult. Read More

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January 2022

Evaluation of a parasite-density based pooled targeted amplicon deep sequencing (TADS) method for molecular surveillance of Plasmodium falciparum drug resistance genes in Haiti.

PLoS One 2022 14;17(1):e0262616. Epub 2022 Jan 14.

Division of Parasitic Diseases and Malaria, Malaria Branch, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, GA, United States America.

Sequencing large numbers of individual samples is often needed for countrywide antimalarial drug resistance surveillance. Pooling DNA from several individual samples is an alternative cost and time saving approach for providing allele frequency (AF) estimates at a population level. Using 100 individual patient DNA samples of dried blood spots from a 2017 nationwide drug resistance surveillance study in Haiti, we compared codon coverage of drug resistance-conferring mutations in four Plasmodium falciparum genes (crt, dhps, dhfr, and mdr1), for the same deep sequenced samples run individually and pooled. Read More

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January 2022

Facile Method to Determine the Molecular Weight of Polymer Grafts Grown from Cellulose Nanocrystals.

Biomacromolecules 2022 Jan 14. Epub 2022 Jan 14.

Adolphe Merkle Institute, University of Fribourg, Chemin des Verdiers 4, 1700 Fribourg, Switzerland.

One of the main challenges associated with the modification of cellulose nanocrystals (CNCs) with polymers by surface-initiated polymerization is the characterization of the resulting products, notably the molecular weight of the grafts. The solid nature of the (modified) CNC nanoparticles limits the possibility to apply solution-based characterization techniques, and the cleavage of the macromolecules from the surface of the CNCs to enable their characterization using solution-based techniques is intricate. Here, we report that H NMR spectroscopy of the supernatant of the heterogeneous reaction mixture can be used to approximate the molecular weight of poly(hexyl methacrylate) grafts grown from the surface of CNCs surface-initiated atom transfer radical polymerization. Read More

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January 2022

Hypothyroidism risk associated with rheumatoid arthritis: A population-based retrospective cohort study.

Medicine (Baltimore) 2022 Jan;101(1):e28487

Division of Immunology and Rheumatology, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan.

Abstract: Studies on the thyroid disease risk in patients with rheumatoid arthritis (RA) associated with comorbidities are limited. This population-based retrospective cohort study investigated the hypothyroidism risk in patients with RA and the role of comorbidities.We used Taiwan National Health Insurance Research Database to identify 16,714 RA patients newly diagnosed in 2000 to 2008 and 66,856 control persons without RA, frequency matched by sex, age, and index year. Read More

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January 2022

Response and multiscenario simulation of trade-offs/synergies among ecosystem services to the Grain to Green Program: a case study of the Chengdu-Chongqing urban agglomeration, China.

Environ Sci Pollut Res Int 2022 Jan 14. Epub 2022 Jan 14.

Chongqing Institute of Surveying and Monitoring for Planning and Natural Resources, Chongqing, 401121, People's Republic of China.

As a policy tool for advancing ecological progress, the Grain to Green Program (GTGP) has been operating for 20 years and has played an important role in improving ecosystem service value. However, there are few studies on the trade-off/synergy changes in ecosystem services during the implementation of the GTGP and how to select the optimal scheme for regional ecological security based on these trade-offs. Thus, we took the Chengdu-Chongqing urban agglomeration (CCUA) in southwestern China as the study area and estimated the regional food production, carbon sequestration, water yield, soil conservation, and habitat quality services. Read More

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January 2022