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Non-Invasive Venous waveform Analysis (NIVA) correlates with pulmonary capillary wedge pressure (PCWP) and predicts 30-day admission in heart failure patients undergoing right heart catheterization: NIVA Scores correlate with PCWP and predicts 30-day admission.

J Card Fail 2021 Sep 20. Epub 2021 Sep 20.

Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.

Background: Heart failure is the leading cause of hospitalization in the elderly and readmission is common. Clinical indicators of congestion may not precede acute congestion with enough time to prevent hospital admission for heart failure. Thus, there is a large and unmet need for accurate non-invasive assessment of congestion. Read More

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September 2021

Mail-order pharmacy dispensing of mifepristone for medication abortion after in-person clinical assessment.

Contraception 2021 Sep 20. Epub 2021 Sep 20.

Department of Family and Social Medicine, Albert Einstein College of Medicine/Montefiore Medical Center. 3544 Jerome Avenue, Bronx, NY, 10467.

Objective(s): To estimate the effectiveness, acceptability, and feasibility of medication abortion with mifepristone dispensed by a mail-order pharmacy after in-person clinical assessment.

Study Design: This is an interim analysis of an ongoing prospective cohort study conducted at five sites. Clinicians assessed patients in clinic and, if they were eligible for medication abortion and ≤63 days' gestation, electronically sent prescriptions for mifepristone 200 mg orally and misoprostol 800 mcg buccally to a mail-order pharmacy, which shipped medications for next-day delivery. Read More

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September 2021

Cross-Cultural Adaption and Psychometric Evaluation of the German Craniofacial Pain and Disability Inventory (CF-PDI).

Pain Physician 2021 Sep;24(6):E857-E866

Department of Physical Therapy and Rehabilitation science, University of Applied Science Osnabruck, Germany.

Background: The Craniofacial Pain and Disability Inventory (CF-PDI) is a cross-culturally adapted instrument designed from a biopsychosocial perspective to measure pain, disability, and function in orofacial head and neck pain with shown psychometric properties; however, the German cross-cultural adaption is lacking.

Objectives: To carry out a transcultural translation of CF-PDI into German and assess its psychometric properties in patients with painful temporomandibular disorders (TMD) with respect to construct and clinical validity, internal consistency and reproducibility.

Study Design: Multicenter, prospective, cross-sectional design. Read More

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September 2021

Prediction of moxifloxacin concentrations in tuberculosis patient populations by physiologically-based pharmacokinetic modeling.

J Clin Pharmacol 2021 Sep 23. Epub 2021 Sep 23.

Department of Pharmacy, Radboud Institute for Health Sciences & Radboudumc Center for Infectious Diseases, Radboud university medical center, Nijmegen, The Netherlands.

Moxifloxacin has an important role in the treatment of tuberculosis (TB). Unfortunately, co-administration with the cornerstone TB drug rifampicin results in sub-optimal plasma exposure. We aimed to gain insight into the moxifloxacin pharmacokinetics and the interaction with rifampicin. Read More

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September 2021

Depression, anxiety, and fear of COVID-19 in patients with multiple sclerosis in pandemic era: a cross-sectional study.

Neurol Sci 2021 Sep 23. Epub 2021 Sep 23.

Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.

Background: Depression and anxiety are the two important factors determining quality of life of patients with multiple sclerosis (PWMS). In COVID-19 pandemic era, several factors can provoke mental issues of people and patients. In this cross-sectional study, we aim to estimate the new prevalence of anxious and depressive symptoms and their relating factors in PWMS. Read More

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September 2021

Does visuospatial motion perception correlate with coexisting movement disorders in Parkinson's disease?

J Neurol 2021 Sep 23. Epub 2021 Sep 23.

Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.

Postural instability and balance impairment are common in Parkinson's disease (PD). Multiple factors, such as increased tone, bradykinesia, freezing of gait, posture, axial stiffness, and involuntary appendicular movements, can affect balance. The recent studies found that PD patients have abnormal perception of self-motion in vestibular domain. Read More

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September 2021

Impact of Teleconsultation on Subsequent Disease Activity and Flares in Patients with Systemic Lupus Erythematosus.

Rheumatology (Oxford) 2021 Sep 23. Epub 2021 Sep 23.

Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, SINGAPORE.

Objectives: Despite the widespread adoption of teleconsultations amid the COVID-19 pandemic, its safety in systemic lupus erythematosus (SLE) patients has not been evaluated. Here, we examined subsequent disease activity and flares among SLE patients who received teleconsultation vs in-person consultation. To discern differences in physicians' prescription behavior during both forms of consultations, we compared corticosteroid dose adjustments. Read More

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September 2021

Exploratory Economic Evaluation of Buprenorphine Treatment in Opioid Use Disorder.

J Ment Health Policy Econ 2021 Sep;24(3):89-95

National Rehabilitation Centre, PO Box 55001 Abu Dhabi, Shakhboot City, United Arab Emirates,

Background: Burden of opioid use disorder (OUD) is expressed in economic values or health metrics like Disability Adjusted Life Years (DALYs). Disability Weight (DW), a component of DALYs is estimated using economic methods or psychometric tools. Estimating DW at patient level using psychometric tools is an alternative to non-population specific DW overestimated by economic methods. Read More

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September 2021

Met and unmet rehabilitative needs among pediatric patients with moderate to severe TBI.

Brain Inj 2021 Sep 23:1-6. Epub 2021 Sep 23.

Veterans Health Administration Rocky Mountain Mental Illness Research Education and Clinical Center, Aurora, Colorado, USA.

Objective: Estimate the probability of met and unmet post-acute rehabilitative needs among pediatric patients with moderate to severe traumatic brain injury (TBI).

Participants: One hundred and thirty children who received acute and post-acute rehabilitative services at a hospital for children.

Methods: Prospective, observational study. Read More

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September 2021

Recherche sur la fin de vie, la nécessité d’un consensus : premiers résultats.

Sante Publique 2021 Sep;Vol. 33(2):191-198

During the past 15 years, in France, like in many European countries, the attention paid to patients at the end of their lives has continued to grow. But in the meantime, only a few researchers have managed to collect reliable data on End-of-Life Care and to implement scientific studies describing the reality of these situations. This difficulty is due in particular to the lack of a recognized and operational definition of the end of life. Read More

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September 2021

Sleep apnea severity based on estimated tidal volume and snoring features from tracheal signals.

J Sleep Res 2021 Sep 22:e13490. Epub 2021 Sep 22.

KITE, Toronto Rehabilitation Institute-University Health Network, Toronto, ON, Canada.

Sleep apnea can be characterized by reductions in the respiratory tidal volume. Previous studies showed that the tidal volume can be estimated from tracheal sounds and movements called tracheal signals. Additionally, tracheal sounds include the sounds of snoring, a common symptom of obstructive sleep apnea. Read More

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September 2021

High prevalence of long-term olfactory, gustatory, and chemesthesis dysfunction in post-COVID-19 patients: a matched case-control study with one-year follow-up using a comprehensive psychophysical evaluation.

Rhinology 2021 Sep 23. Epub 2021 Sep 23.

Department of Medical, Surgical and Health Sciences, Section of Otolaryngology, University of Trieste, Trieste, Italy.

Background: Using an age and gender matched-pair case-control study, we aimed to estimate the long-term prevalence of psychophysical olfactory, gustatory , and chemesthesis impairment at least one year after SARS-CoV-2 infection considering the background of chemosensory dysfunction in non-COVID-19 population.

Methodology: This case-controlled study included 100 patients who were home-isolated for mildly symptomatic COVID-19 between March and April 2020. One control regularly tested for SARS-CoV-2 infection and always tested negative was matched to each case according to gender and age. Read More

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September 2021

The prognostic value of emergency department measured hypertension: A systematic review and meta-analysis.

Acad Emerg Med 2021 Sep 22. Epub 2021 Sep 22.

Division of Cardiovascular Sciences, University of Manchester, Manchester, UK.

Objectives: The objective was to assess the prognostic value of hypertension detected in the emergency department (ED).

Methods: The ED presents a unique opportunity to predict long-term cardiovascular disease (CVD) outcomes with its potential for high-footfall, and large-scale routine data collection applied to underserved patient populations. A systematic review and meta-analyses were conducted to assess the prognostic performance and feasibility of ED-measured hypertension as a risk factor for long-term CVD outcomes. Read More

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September 2021

DNA Methylation Regulator-Meditated Modification Patterns Define the Distinct Tumor Microenvironment in Lung Adenocarcinoma.

Front Oncol 2021 6;11:734873. Epub 2021 Sep 6.

Department of Forensic Medicine, College of Basic Medicine, Chongqing Medical University, Chongqing, China.

Background: Epigenetic changes of lung adenocarcinoma (LUAD) have been reported to be a relevant factor in tumorigenesis and cancer progression. However, the molecular mechanisms responsible for DNA methylation patterns in the tumor immune-infiltrating microenvironment and in cancer immunotherapy remain unclear.

Methods: We conducted a global analysis of the DNA methylation modification pattern (DMP) and immune cell-infiltrating characteristics of LUAD patients based on 21 DNA methylation regulators. Read More

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September 2021

A Robust Seven-Gene Signature Associated With Tumor Microenvironment to Predict Survival Outcomes of Patients With Stage III-IV Lung Adenocarcinoma.

Front Genet 2021 6;12:684281. Epub 2021 Sep 6.

Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, China.

Background: Due to the relatively insidious early symptoms of lung adenocarcinoma (LUAD), most LUAD patients are at an advanced stage at the time of diagnosis and lose the best chance of surgical resection. Mounting evidence suggested that the tumor microenvironment (TME) was highly correlated with tumor occurrence, progress, and prognosis. However, TME in advanced LUAD remained to be studied and reliable prognostic signatures based on TME in advanced LUAD also had not been well-established. Read More

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September 2021

The Impact of Frailty on Prognosis in Elderly Hemodialysis Patients: A Prospective Cohort Study.

Clin Interv Aging 2021 15;16:1659-1667. Epub 2021 Sep 15.

Department of Geriatrics, Beijing Friendship Hospital, Capital Medical University, Beijing, People's Republic of China.

Purpose: To explore the impact of frailty on adverse outcomes in elderly hemodialysis (HD) patients.

Patients And Methods: An observational and prospective cohort study was conducted in elderly patients (≥60) with HD, with an average 12-month follow-up. Fried frailty phenotype (FFP) was used to define frailty. Read More

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September 2021

Comparing Patient- and Clinician-Administered Near Point of Convergence After Concussion.

J Sport Rehabil 2021 Sep 22:1-4. Epub 2021 Sep 22.

Objective: (1) To compare patient- and clinician-administered measurements of near point of convergence (NPC) distance including the percentage of patients exceeding clinical cutoffs among concussed adolescents and (2) to assess the reliability of patient- and clinician-measured NPC distances.

Methods: A total of 762 patients (mean = 15.51, SD = 3. Read More

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September 2021

Tumor diameter response in patients with metastatic clear cell renal cell carcinoma is associated with overall survival.

Urol Oncol 2021 Sep 19. Epub 2021 Sep 19.

Department of Urology, The University of Texas MD Anderson Cancer Center, Houston, TX; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX. Electronic address:

Objective: Tumor shrinkage of at least 10% after presurgical targeted molecular therapy (TMT) in renal cell carcinoma (RCC) patients has been associated with better overall survival (OS) outcomes. We characterized primary and metastatic tumor diameter response and OS in patients with metastatic clear cell RCC (ccRCC) who received preoperative TMT, immunotherapy, or both followed by deferred cytoreductive nephrectomy (dCN).

Materials And Methods: Patients with metastatic ccRCC (n = 198) who underwent preoperative therapy and dCN from 2005 to 2019 were identified retrospectively. Read More

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September 2021

Evaluation of the costing methodology of published studies estimating costs of surgical site infections: A systematic review.

Infect Control Hosp Epidemiol 2021 Sep 23:1-17. Epub 2021 Sep 23.

Biomedical Informatics & Medical Statistics Department, Medical Research Institute, Alexandria University, Alexandria, Egypt.

Objectives: Surgical site infections (SSIs) are associated with increased length of hospitalization and costs. Epidemiologists and infection control practitioners, who are in charge of implementing infection control measures, have to assess the quality and relevance of the published SSI cost estimates before using them to support their decisions. In this review, we aimed to determine the distribution and trend of analytical methodologies used to estimate cost of SSIs, to evaluate the quality of costing methods and the transparency of cost estimates, and to assess whether researchers were more inclined to use transferable studies. Read More

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September 2021

Cost-effectiveness of tiotropium versus omalizumab for uncontrolled allergic asthma.

J Asthma 2021 Sep 22:1-8. Epub 2021 Sep 22.

Department of Pharmacology and Toxicology, University of Antioquia Faculty of Medicine, Medellin, Colombia.

In patients with uncontrolled asthma, despite management with high doses of inhaled corticosteroids, the additional use of omalizumab and tiotropium is recommended. Omalizumab is an expensive medication and doubts arise as to whether the benefit of this drug outweighs the additional expense of the drug. The purpose of this study was to assess the cost-effectiveness of tiotropium versus omalizumab as add-on therapies to ICS + LABA for patients with uncontrolled allergic asthma. Read More

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September 2021

Prevalence, determinants, and outcomes of SARS-COV-2 infection among cancer patients. A population-based study in northern Italy.

Cancer Med 2021 Sep 22. Epub 2021 Sep 22.

Friuli Venezia Giulia Regional Health Coordination Agency, Udine, Italy.

Background: It is well established that cancer patients infected with SARS-CoV-2 are at particularly elevated risk of adverse outcomes, but the comparison of SARS-CoV-2 infection risk between cancer patients and cancer-free individuals has been poorly investigated on a population-basis.

Methods: A population-based study was thus conducted in Friuli Venezia Giulia region, northeastern Italy, to estimate prevalence and determinants of SARS-CoV-2 infection among cancer patients, as compared to cancer-free individuals, and to evaluate adverse outcomes of SARS-CoV-2 infection. The study included 263,042 individuals tested for SARS-CoV-2 in February-December 2020 with cancer history retrieved through the regional cancer registry. Read More

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September 2021

Quantifying the impact of COVID-19 non-pharmaceutical interventions on influenza transmission in the United States.

J Infect Dis 2021 Sep 22. Epub 2021 Sep 22.

Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA.

Background: Nonpharmaceutical interventions (NPIs) have been implemented to suppress the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Evidence indicates that NPIs against COVID-19 may also have effects on the transmission of seasonal influenza.

Methods: In this study, we use an absolute humidity-driven susceptible-infectious-recovered-susceptible (SIRS) model to quantify the reduction of influenza incidence and transmission in the US and HHS (the US Department of Health and Human Services) regions after implementation of NPIs in 2020. Read More

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September 2021

[Assessing occipital nerve stimulation efficacy for chronic refractory headaches].

Rev Med Suisse 2021 Sep;17(751):1624-1626

Unité de neurologie, Département des neurosciences cliniques, CHUV, 1011 Lausanne.

We prospectively followed a cohort of 26 subjects for an average period of 41 months who benefited from occipital nerve stimulation (ONS) in the context of chronic refractory headaches. In 17 patients treated, the frequency of headache decreased, and quality of life scores improved significantly. Among these patients, the "very good" response rate was 34 %. Read More

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September 2021

Assessing couples' preferences for fresh or frozen embryo transfer: a discrete choice experiment.

Hum Reprod 2021 Sep 22. Epub 2021 Sep 22.

Aberdeen Fertility Centre, NHS Grampian, Aberdeen, UK.

Study Question: What are couples' preferences for fresh embryo transfer versus freezing of all embryos followed by frozen embryo transfer and the associated clinical outcomes that may differentiate them?

Summary Answer: Couples' preferences are driven by anticipated chances of live birth, miscarriage, neonatal complications, and costs but not by the differences in the treatment process (including delay of embryo transfer linked to frozen embryo transfer and risk of ovarian hyperstimulation syndrome (OHSS) associated with fresh embryo transfer).

What Is Known Already: A policy of freezing all embryos followed by transfer of frozen embryos results in livebirth rates which are similar to or higher than those following the transfer of fresh embryos while reducing the risk of OHSS and small for gestational age babies: it can, however, increase the risk of pre-eclampsia and large for gestational age offspring. Hence, the controversy continues over whether to do fresh embryo transfer or freeze all embryos followed by frozen embryo transfer. Read More

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September 2021

High prevalence of thyroid carcinoma in patients with insulin resistance: a meta-analysis of case-control studies.

Aging (Albany NY) 2021 Sep 22;13(undefined). Epub 2021 Sep 22.

Division of Endocrinology, Department of Internal Medicine, Qilu Hospital of Shandong University, Jinan 250012, China.

The association between insulin resistance and thyroid carcinoma is controversial. We conducted this meta-analysis of association between insulin resistance and thyroid carcinoma. There were 14 studies included in this meta-analysis. Read More

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September 2021

[Causal relationship between physical exercise and risk of ischemic stroke recurrence based on the potential outcome theory].

Nan Fang Yi Ke Da Xue Xue Bao 2021 Aug;41(8):1191-1197

Department of Epidemiology and Health Statistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China.

Objective: To explore the causal relationship between physical exercise and ischemic stroke recurrence using a multiple imputation approach based on the potential outcomes framework.

Methods: We collected data from 636 patients who were diagnosed with first-ever ischemic stroke between July, 2010 and December, 2018 at West China Hospital, Sichuan University.All the patients had motor ability and were followed up at least for 1 year. Read More

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Risk of atrial fibrillation is increased in patients with exfoliation syndrome: the Utah project on exfoliation syndrome (UPEXS).

Acta Ophthalmol 2021 Sep 21. Epub 2021 Sep 21.

Einhorn Clinical Research Center, New York Eye and Ear Infirmary of Mount Sinai, New York, NY, USA.

Purpose: Exfoliation syndrome, a systemic disorder with ocular manifestations, is associated with lysyl oxidase-like gene variants. Along with transforming growth factor beta-1, lysyl oxidase-like 1 is a key enzyme in stabilizing extracellular matrix and remodelling collagen/elastin. Given the role that transforming growth factor beta-1, lysyl oxidase-like gene variants and fibrosis play in atrial fibrillation, an association with exfoliation syndrome was investigated. Read More

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September 2021

Relationship between malnutrition and the presence of symptoms of anxiety and depression in hospitalized cancer patients.

Support Care Cancer 2021 Sep 21. Epub 2021 Sep 21.

Unidad de Gestión Clínica de Endocrinología y Nutrición, Hospital Regional Universitario de Málaga, Málaga, Spain.

Background: Anxiety and depression are a common issue in patients with cancer, yet understudied among hospitalized patients. The aim of this study was to estimate the prevalence of anxiety and depression symptomatology in cancer inpatients and its relationship with malnutrition.

Methods: Cross-sectional study in hospitalized cancer patients. Read More

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September 2021

Impact of Age, Frailty, and Dementia on Prescribing for Type 2 Diabetes at Hospital Discharge 2012-2016.

J Frailty Aging 2021 ;10(4):343-349

Stephen Wood, Centre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University Melbourne, Australia, 3052, Tel: +61 423301741, E-mail:

Background: The risks of intensive blood glucose lowering may outweigh the benefits in vulnerable older people.

Objectives: Our primary aim was to determine whether age, frailty, or dementia predict discharge treatment types for patients with type 2 diabetes (T2D) and related complications. Secondly, we aimed to determine the association between prior hypoglycemia and discharge treatment types. Read More

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September 2021

Real-World Analysis of the Efficacy and Safety of a Novel Irreversible HER2 Tyrosine Kinase Inhibitor Pyrotinib in Patients with HER2-Positive Metastatic Breast Cancer.

Cancer Manag Res 2021 14;13:7165-7174. Epub 2021 Sep 14.

Department of Medical Oncology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong Province, People's Republic of China.

Background: As a novel irreversible pan-ErbB inhibitor recently approved in China, pyrotinib has exhibited promising anticancer efficacy and acceptable safety profile in HER2-positive metastatic breast cancer (mBC). The aim of this retrospective study was to estimate the efficacy and safety of pyrotinib treatment in Chinese mBC patients.

Methods: We retrospectively reviewed the real-world clinicopathological and treatment data of HER2-positive mBC patients receiving pyrotinib-based treatment from August 2018 to July 2019 in Qilu Hospital of Shandong University and other medical centers of Shandong Province in China. Read More

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September 2021