23,335 results match your criteria established skin

Efficacy and safety of ceftobiprole in patients aged 65 years or older: a  analysis of three Phase III studies.

Future Microbiol 2021 May 7. Epub 2021 May 7.

Basilea Pharmaceutica International Ltd., Basel, Switzerland.

To evaluate the efficacy and safety of ceftobiprole in patients aged ≥65 years. We conducted a analysis of three randomized, double-blind, Phase III studies in patients with acute bacterial skin and skin structure infections, community-acquired pneumonia and hospital-acquired pneumonia. Findings for patients aged ≥65 years (n = 633) were consistent with those for the overall study populations, although a trend toward improved outcomes was reported in some subgroups, for example, patients aged ≥75 years with community-acquired pneumonia were more likely to achieve an early clinical response with ceftobiprole than comparator (treatment difference 16. Read More

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Effectiveness of skin cleanser and protectant regimen on incontinence-associated dermatitis outcomes in acute care patients: A cluster randomised trial.

Int Wound J 2021 May 7. Epub 2021 May 7.

Nursing Research Unit, Tan Tock Seng Hospital, Singapore, Singapore.

Skin cleansers and protectants protect skin from incontinent matter to reduce the risk of incontinence-associated dermatitis (IAD), but their effectiveness treating established IAD in the tropics is unknown. We conducted an open-label cluster randomised trial to compare the effectiveness of a combined regimen of (1) specialised skin cleansers with disposable body wipes and (2) either an acrylic terpolymer (T1) or zinc oxide (T2) skin protectant against disposable body wipes and zinc oxide protectant (control) in promoting IAD healing and reducing the risk of deterioration. Eighty-four patients were recruited in a tertiary hospital in Singapore between April 2019 and January 2020 (T1: n = 23; T2: n = 37; Control: n = 24). Read More

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Psoriasis and Periodontitis: Exploring an association or lack thereof.

Indian Dermatol Online J 2021 Mar-Apr;12(2):281-284. Epub 2021 Feb 22.

Department of Biochemistry, Dr. Harvansh Singh Judge Institute of Dental Sciences and Hospital, Panjab University, Chandigarh, India.

Objectives: Psoriasis is a common, chronic, non-communicable skin disease with no clear etiology or cure. Periodontitis is a chronic inflammatory condition which is now known to significantly influence various systemic diseases as an established risk factor. This study aimed at comparatively evaluating the periodontal status of Psoriatic patients vis. Read More

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February 2021

Physical Exercise is Associated with Glycemic Control among Women with Gestational Diabetes Mellitus: Findings from a Prospective Cohort in Shanghai, China.

Diabetes Metab Syndr Obes 2021 30;14:1949-1961. Epub 2021 Apr 30.

Clinical Research & Innovation Transformation Center, Shanghai Skin Diseases Hospital Affiliated to Tongji University, Shanghai, People's Republic of China.

Objective: Physical exercise during pregnancy is beneficial to women with gestational diabetes mellitus (GDM), but evidence on the association between physical exercise and glycemic control among women with GDM is limited in China. We conducted this study to understand the total exercise times, the percentage of abnormal plasma glucose (PG), and to explore if longer physical exercise is positively associated with a lower percentage of abnormal PG among GDM women.

Methods: During 2019 and 2020, we established a prospective cohort with 1,050 GDM women recruited. Read More

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Antibacterial and antioxidant activities of extracts and isolated compounds from the roots extract of Cucumis prophetarum and in silico study on DNA gyrase and human peroxiredoxin 5.

BMC Chem 2021 May 6;15(1):32. Epub 2021 May 6.

Department of Applied Chemistry, School of Applied Natural Science, Adama Science and Technology University, P.O.Box 1888, Adama, Ethiopia.

Background: Cucumis prophetarum is traditionally used to treat liver and lung disorders, heart failure, diarrhea, gonorrhea, skin infections, intestinal problems and cancer. In the present work, the isolation of two novel compounds along with their antibacterial and antioxidant activities is reported for the first time.

Methods: Silica gel column chromatography was applied to separate constituents of the roots of C. Read More

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Optical Coherence Tomography and Microdialysis for Microneedle-Mediated Penetration Enhancement Study of Paeoniflorin-Loaded Ethosomes.

Skin Pharmacol Physiol 2021 May 6:1-11. Epub 2021 May 6.

School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China.

Background: To understand the cumulative effect of topical formulations after medication, evaluate the therapeutic effect of microneedle-assisted (MN-assisted) paeoniflorin-loaded ethosomes (TGP-E), and explore the potential for deep penetration of drugs, this paper uses microdialysis to systematically study the percutaneous pharmacokinetics of TGP-E.

Methods: First, optical coherence tomography (OCT) was used to study the effectiveness of microneedle puncture. Second, a microdialysis method and a UPLC-MS method for determining the amount of paeoniflorin (Pae) in dialysate were established. Read More

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Tattoos - more than just colored skin? Searching for tattoo allergens.

J Dtsch Dermatol Ges 2021 May 6. Epub 2021 May 6.

Department of Dermatology and Allergology, University of Regensburg, Regensburg, Germany.

During tattooing, a high amount of ink is injected into the skin. Tattoo inks contain numerous substances such as the coloring pigments, impurities, solvents, emulsifiers, and preservatives. Black amorphous carbon particles (carbon black), white titanium dioxide, azo or polycyclic pigments create all varieties of color shades in the visible spectrum. Read More

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An update on genetic basis of generalized pustular psoriasis (Review).

Int J Mol Med 2021 Jun 6;47(6). Epub 2021 May 6.

Department of Laboratory Medicine, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China.

Generalized pustular psoriasis (GPP) is a rare and severe auto‑inflammatory skin disease that is characterized by recurrent, acute onset, and generalized pustular eruptions on erythematous, inflamed skin. GPP is traditionally classified as a variant of psoriasis vulgaris, even though recent clinical, histological and genetic evidence suggests that it is a heterogeneous disease and requires a separate diagnosis. In recent years, variants of , , and genes have been identified as causative or contributing to genetic defects in a proportion of patients affected by GPP. Read More

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Development of a risk prediction model of pneumothorax in percutaneous computed tomography guided transthoracic needle lung biopsy.

J Med Imaging Radiat Oncol 2021 May 6. Epub 2021 May 6.

Department of Radiology, Ballarat Base Hospital, Ballarat, Victoria, Australia.

Introduction: To retrospectively evaluate the incidence of and the risk factors for pneumothorax and intercostal catheter insertion (ICC) after CT-guided lung biopsy and to generate a risk prediction model for developing a pneumothorax and requiring an ICC.

Methods: 255 CT-guided lung biopsies performed for 249 lesions in 249 patients from August 2014 to August 2019 were retrospectively analysed using multivariate logistic regression analysis. Risk prediction models were established using backward stepwise variable selection and likelihood ratio tests and were internally validated using split-sample methods. Read More

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Position statement: The need for EU legislation to require disclosure and labelling of the composition of medical devices.

J Eur Acad Dermatol Venereol 2021 May 6. Epub 2021 May 6.

Contact Allergy Unit, Department of Dermatology, University Hospital KU Leuven, Leuven, Belgium.

Background: In recent years, skin reactions secondary to the use of medical devices (MD), such as allergic contact dermatitis have increasingly been observed (e.g. to continuous blood sugar monitoring systems, insulin pumps, wound dressings, medical gloves, etc. Read More

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Role of Ingestible Carotenoids in Skin Protection: A Review of Clinical Evidence.

Photodermatol Photoimmunol Photomed 2021 May 5. Epub 2021 May 5.

IUF - Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany.

Carotenoids, a class of phytonutrients, have been well established to boost skin's innate resistance against Ultraviolet (UV) B-induced erythema (sunburn). Many of the published clinical studies thus far have focused on measurement of erythema as the primary clinical indicator of skin protection against UVB radiation. More recent studies have shown that carotenoid supplementation provides even more skin protection than previously shown as new clinical and molecular endpoints beyond UVB-induced erythema have been reported. Read More

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Primary squamous cell carcinoma, breast: A challenging diagnosis.

Cancer Rep (Hoboken) 2021 May 5:e1391. Epub 2021 May 5.

Department of Endocrine surgery, King George's Medical University, Lucknow, India.

Background: Primary squamous cell carcinoma of the breast is an extremely rare malignancy constituting less than 0.1% of all breast cancers with very few cases reported in literature. It is an aggressive, triple-hormone negative tumor, and its appropriate management is still debated. Read More

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The influence of sham feedback on physiological processing during fear-driven stimulation.

PLoS One 2021 5;16(5):e0251211. Epub 2021 May 5.

Department of General Psychology, Ulm University, Ulm, Germany.

Biofeedback constitutes a well-established, non-invasive method to voluntary interfere in emotional processing by means of cognitive strategies. However, treatment durations exhibit strong inter-individual variations and first successes can often be achieved only after a large number of sessions. Sham feedback constitutes a rather untapped approach by providing feedback that does not correspond to the participant's actual state. Read More

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Delineation of temperature-humidity index (THI) as indicator of heat stress in riverine buffaloes (Bubalus bubalis) of a sub-tropical Indian region.

Cell Stress Chaperones 2021 May 5. Epub 2021 May 5.

Division of Livestock Production and Management, Sher-e-Kashmir University of Agricultural Sciences and Technology of Jammu (SKUAST-Jammu), R. S. Pura, Jammu, Jammu and Kashmir, 181102, India.

The erstwhile developed temperature-humidity index (THI) has been popularly used to indicate heat stress in dairy cattle and often in buffaloes. However, scientific literature suggests differences in thermotolerance and physiological responses to heat stress between cattle and buffalo. Therefore, THI range used to indicate degree of heat stress (mild, moderate, and severe) in cattle should be recalibrated for indicating heat stress in buffaloes. Read More

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A novel histopathological scoring system to distinguish urticarial vasculitis from chronic spontaneous urticaria.

Clin Transl Allergy 2021 Apr;11(2):e12031

Dermatological Allergology, Allergie-Centrum-Charité, Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Background: Urticarial vasculitis (UV) is defined by long-lasting urticarial lesions combined with the histopathologic findings of leukocytoclastic vasculitis. As one of the major unmet needs in UV, diagnostic criteria are rather vague and not standardized. Moreover, there seems to be considerable overlap with chronic spontaneous urticaria (CSU), particularly for the normocomplementemic variant of UV. Read More

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SETD2 epidermal deficiency promotes cutaneous wound healing via activation of AKT/mTOR Signalling.

Cell Prolif 2021 May 5:e13045. Epub 2021 May 5.

State Key Laboratory of Oncogenes and Related Genes, School of Medicine and School of Biomedical Engineering, Renji Med-X Clinical Stem Cell Research Center, Ren Ji Hospital, Shanghai Jiao Tong University, Shanghai, China.

Objectives: Cutaneous wound healing is one of the major medical problems worldwide. Epigenetic modifiers have been identified as important players in skin development, homeostasis and wound repair. SET domain-containing 2 (SETD2) is the only known histone H3K36 tri-methylase; however, its role in skin wound healing remains unclear. Read More

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Contact-Free Pulse Signal Extraction from Human Face Videos: A Review and New Optimized Filtering Approach.

Adv Exp Med Biol 2021 ;1317:181-202

Aberystwyth University, Aberystwyth, UK.

In this chapter, we review methods for video-based heart monitoring, from classical signal processing approaches to modern deep learning methods. In addition, we propose a new method for learning an optimal filter that can overcome many of the problems that can affect classical approaches, such as light reflection and subject's movements, at a fraction of the training cost of deep learning approaches. Following the usual procedures for region of interest extraction and tracking, robust skin color estimation and signal pre-processing, we introduce a least-squares error optimal filter, learnt using an established training dataset to estimate the photoplethysmographic (PPG) signal more accurately from the measured color changes over time. Read More

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A Two-Pore Physiologically Based Pharmacokinetic Model to Predict Subcutaneously Administered Different-Size Antibody/Antibody Fragments.

AAPS J 2021 May 3;23(3):62. Epub 2021 May 3.

Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, The State University of New York at Buffalo, 455 Pharmacy Building, Buffalo, New York, 14214, USA.

Quantitative modeling of the subcutaneous absorption processes of protein therapeutics is challenging. Here we have proposed a "two-pore" PBPK model that is able to simultaneously characterize plasma PK of different-size protein therapeutics in mice. The skin compartment is evolved to mechanistically account for the absorption pathways through lymph and blood capillaries, as well as local degradation at the SC injection site. Read More

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Phase 1 study of single-agent WNT974, a first-in-class Porcupine inhibitor, in patients with advanced solid tumours.

Br J Cancer 2021 May 3. Epub 2021 May 3.

Department of Investigational Cancer Therapeutics (Phase 1 Clinical Trials Program), The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Background: This Phase 1 study assessed the safety and efficacy of the Porcupine inhibitor, WNT974, in patients with advanced solid tumours.

Methods: Patients (n = 94) received oral WNT974 at doses of 5-30 mg once-daily, plus additional dosing schedules.

Results: The maximum tolerated dose was not established; the recommended dose for expansion was 10 mg once-daily. Read More

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The effectiveness of botulinum toxin type A (BTX-A) in the treatment of facial skin oily seborrhea, enlarged pores, and symptom complex of post-acne.

Int J Dermatol 2021 May 3. Epub 2021 May 3.

Department of Dermatology and Venereology, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation.

Background: This study aimed to examine the effectiveness of botulinum toxin type A (BTX-A) in the treatment of acne.

Methods: The study was conducted in 2018 on 12 patients, 10 females and two males, aged 35 years on average. The injections with BTX-A were given during 2 weeks into the face skin in a dosage of 0. Read More

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Skin cancer in women of color: Epidemiology, pathogenesis and clinical manifestations.

Int J Womens Dermatol 2021 Mar 2;7(2):127-134. Epub 2021 Feb 2.

Callender Dermatology and Cosmetic Center, Glenn Dale, MD, United States.

Malignant melanoma and nonmelanoma skin cancers (NMSC), which include basal cell carcinoma and squamous cell carcinoma, account for 40% of all neoplasms in white patients, making these cancers the most common malignancy in the United States. Given the large number of NMSC cases in white patients, there is a correspondingly large body of literature addressing various aspects of epidemiology, pathogenesis, and treatment. The incidence of both malignant melanoma and NMSC is well established and remains significantly lower in patients with skin of color (SoC) when compared with white patients. Read More

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Autocrine and Paracrine Effects of Vascular Endothelial Cells Promote Cutaneous Wound Healing.

Biomed Res Int 2021 10;2021:6695663. Epub 2021 Apr 10.

Department of Plastic Surgery, The First Affiliated Hospital of Jinan University, Key Laboratory of Regenerative Medicine, Ministry of Education, Guangzhou, Guangdong Province 510630, China.

Background: When vascular endothelial cells are subjected to external stimuli, paracrine hormones and cytokines act on adjacent cells. The regulation of the biological behaviour of cells is closely related to the maintenance of organ function and the occurrence and development of disease. However, it is unclear whether vascular endothelial cells affect the biological behaviour of cells involved in wound repair through autocrine and paracrine mechanisms and ultimately play a role in wound healing. Read More

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Molecular Biomarkers for Melanoma Screening, Diagnosis and Prognosis: Current State and Future Prospects.

Front Med (Lausanne) 2021 16;8:642380. Epub 2021 Apr 16.

Department of Dermatology, University of Utah, Salt Lake City, UT, United States.

Despite significant progress in the development of treatment options, melanoma remains a leading cause of death due to skin cancer. Advances in our understanding of the genetic, transcriptomic, and morphologic spectrum of benign and malignant melanocytic neoplasia have enabled the field to propose biomarkers with potential diagnostic, prognostic, and predictive value. While these proposed biomarkers have the potential to improve clinical decision making at multiple critical intervention points, most remain unvalidated. Read More

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Snake Bite Management: A Scoping Review of the Literature.

Plast Reconstr Surg Glob Open 2021 Apr 29;9(4):e3506. Epub 2021 Apr 29.

Department of Plastic and Reconstructive Surgery, The Ohio State University College of Medicine, Columbus, Ohio.

Background: Around the world, snake bite envenomation remains an underreported human health hazard. Envenomation can cause local and systemic complications, especially when there is a lack of antivenom availability. Although there are established guidelines regarding snake bite management acute care, there is a paucity of data regarding surgical intervention and the plastic surgeon's role treating this unique patient population. Read More

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Effect of feed additive "Ceobalyk" on the biological and microbiological parameters of African sharptooth catfish ().

Vet World 2021 Mar 19;14(3):669-677. Epub 2021 Mar 19.

Kazakh National Agrarian University, 8 Abay Avenue, Almaty, 050010, Republic of Kazakhstan.

Aim: This study aimed to analyze biological and microbiological parameters of bred at Chundzha natural hot spring in the Almaty region of Kazakhstan, a new feed additive, namely, the prebiotic "Ceobalyk."

Materials And Methods: Two groups (50 heads each) of fish of the same age were established and kept in specialized rectangular pools of AsylTasEngineering LLP. The experiment lasted 61 days. Read More

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Recommendations of the Mexican College of Rheumatology for the management of psoriatic arthritis.

Reumatol Clin 2021 Apr 27. Epub 2021 Apr 27.

Facultad de Medicina y Ciencias Biomédicas, Universidad Autónoma de Chihuahua, Chihuahua, México. Electronic address:

Psoriatic arthritis is a chronic systemic inflammatory disease that affects the skin, musculoskeletal structures and other organs and systems compromising functionality, quality of life and reducing the life expectancy of patients. It is a complex disease that requires specialist and timely care and management. The alternatives for treating the manifestations of psoriatic arthritis have increased and the effect of the different agents on specific manifestations has been clarified in recent studies. Read More

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Evidence-based clinical practice guideline: Reconstruction after skin cancer resection.

J Am Acad Dermatol 2021 Apr 26. Epub 2021 Apr 26.

University of Connecticut; The Skin Surgery Center; University Hospitals Cleveland Medical Center/Case Western Reserve University; Kaiser Permanente; Duke University Medical Center; American Society of Plastic Surgeons; Galaria Plastic Surgery and Dermatology; Veterans Affairs Medical Center; Florida Center for Dermatology; Department of Dermatology, University of Pennsylvania Perelman School of Medicine; Private practice; Cooper Medical Center, Rowan University; University of South Florida; University of Central Florida; University of California, Irvine; Piedmont Plastic Surgery and Dermatology; Pennsylvania State University; Rush University Medical Center; University of Illinois at Chicago; R. L. Roudebush Veterans Affairs Medical Center; University of California, Davis, Medical Center; University of Iowa Hospitals & Clinics; Private practice; Northwestern University.

A multi-disciplinary work group involving stakeholders from various backgrounds and societies was convened to develop guidelines for the management of reconstruction after skin cancer resection. The goal was to identify areas of common ground and provide evidence-based recommendations to improve patient care. Given the heterogeneity of reconstructive techniques and clinical scenarios, investigation centered around common elements in the process. Read More

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Aatrilal (Ammi majus L.), an important drug of Unani system of medicine: A review.

J Ethnopharmacol 2021 Apr 27;276:114144. Epub 2021 Apr 27.

Dept. of Tahafuzi wa Samaji Tib, Preventive and Social Medicine, National Institute of Unani Medicine, Kottigepalaya, Magadi Main Road, Bengaluru, 91, India. Electronic address:

Ethnopharmacological Relevance: Ammi majus L. (Aatrilal) a member of the family Apiaceae, is native to Egypt and widely distributed in Europe, the Mediterranean, and West Asia. It has been used for the treatment of various dermatological disorders particularly vitiligo in the Unani system of Medicine for ages. Read More

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Impact of an unannounced standardized veteran program on access to community-based services for veterans experiencing homelessness.

J Public Health (Oxf) 2021 Apr 30. Epub 2021 Apr 30.

Wilmington VA Medical Center, Wilmington, DE 19805, USA.

Background: The United States Department of Veterans Affairs established a program in which actors incognito portray veterans experiencing homelessness with pre-determined needs to identify barriers to access and services at community-based organizations.

Methods: From 2017 to 2019, actors who varied in gender, skin color and age portrayed one of three scripts at all VA Community-Based Resource and Referral Centers (CRRCs) serving veterans experiencing homelessness in 30 cities and completed an evaluative survey. They carried authentic VA identification and were registered in a VA patient database for each identity. Read More

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Combined immune checkpoint blockade and radiotherapy induces durable remission in relapsed natural killer/T-cell lymphoma: a case report and review of the literature.

J Med Case Rep 2021 Apr 30;15(1):221. Epub 2021 Apr 30.

Division of Hematologic Malignancies and Stem Cell Transplantation, Harold. C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.

Background: Extranodal natural killer/T-cell lymphoma is a rare, aggressive non-Hodgkin lymphoma that is treated upfront mostly with L-asparaginase containing regimens. Relapsed extranodal natural killer/T-cell lymphoma is associated with a poor prognosis, and there is no established standard of care.

Case Presentation: We report the case of a 72 year-old white male with a distant extranasal relapse of extranodal natural killer/T-cell lymphoma that has been managed successfully with a combination of radiation and immune checkpoint blockade with pembrolizumab. Read More

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