Acta Biomater 2021 07 7;129:96-109. Epub 2021 May 7.
Department of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, 1111 Highland Ave. WIMRII, Madison, WI 53705, United States; University of Wisconsin Carbone Cancer Center, 600 Highland Ave, Madison, WI 53705, United States. Electronic address:
It is well established that collagen alignment in the breast tumor microenvironment provides biophysical cues to drive disease progression. Numerous mechanistic studies have demonstrated that tumor cell behavior is driven by the architecture and stiffness of the collagen matrix. However, the mechanical properties within a 3D collagen microenvironment, particularly at the scale of the cell, remain poorly defined. Read More