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Reading and the visual word form area (VWFA) - Management and clinical experience at one epilepsy surgery center.

Epilepsy Behav 2021 Sep 15;124:108274. Epub 2021 Sep 15.

Bielefeld University, Medical School, Department of Epileptology (Krankenhaus Mara), Bielefeld, Germany.

Objective: Presurgical evaluation has no established routine to assess reading competence and to identify essential "not to resect" reading areas. Functional models describe a visual word form area (VWFA) located in the midfusiform gyrus in the dominant ventral occipito-temporal cortex (vOTC) as essential for reading. We demonstrate the relevance and feasibility of invasive VWFA-mapping. Read More

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September 2021

Rare flavonoids and sesquiterpenoids isolated from the leaves of Goniothalamus gracilipes.

Fitoterapia 2021 Sep 15:105034. Epub 2021 Sep 15.

Institute of Marine Biochemistry of the Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam; Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam. Electronic address:

Three previously undescribed benzopyranyl sesquiterpenes gracilipins BD (1-3) and two flavonoids 5,4'-dihydroxy-6-(2-hydroxybenzyl)-3,7,3'-trimethoxyflavone (4), and 5,4'-dihydroxy-8-(2-hydroxybenzyl)-3,7-dimethoxyflavone (5) were isolated from the leaves of Goniothalamus gracilipes (Annonaceae). Their structures were determined by analyses of MS and 2D NMR data. The absolute configurations of 1 were established by analysis of X-ray diffraction data. Read More

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September 2021

In-vitro and in-vivo investigation of amygdalin, metformin, and combination of both against doxorubicin on hepatocellular carcinoma.

Life Sci 2021 Sep 15:119961. Epub 2021 Sep 15.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt; Faculty of Pharmacy, BUC, Cairo, Egypt.

Aim: Hepatocellular carcinoma (HCC) is a potentially life-threatening cancer. In the current study, anti-HCC efficacy of amygdalin, or metformin alone or in combination in comparison to doxorubicin was studied.

Main Methods: Both in-vitro and in-vivo based models. Read More

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September 2021

Life expectancy estimates based on comorbidities and frailty to inform preventive care.

J Am Geriatr Soc 2021 Sep 18. Epub 2021 Sep 18.

Department of Oncology, Division of Biostatistics and Bioinformatics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Background: Long-term prognostication is important to inform preventive care in older adults. Existing prediction indices incorporate age and comorbidities. Frailty is another important factor in prognostication. Read More

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September 2021

Sight-threatening retinopathy in 9 adolescents with early-onset type 1 diabetes.

Pediatr Diabetes 2021 Sep 18. Epub 2021 Sep 18.

Institute of Endocrinology and Diabetes, The Children's Hospital at Westmead, Westmead, NSW.

In adults, there has been a decline in the incidence of diabetic retinopathy associated with improvements in diabetes management. Data on incident severe diabetic retinopathy in adolescents are sparse. In our established diabetes complications assessment service, we recorded nine cases of sight-threatening retinopathy in youth aged 15-17. Read More

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September 2021

Selenomethionine Alleviates Intestinal Ischemia-Reperfusion Injury in Mice Through the Bax-Caspase Pathway.

Biol Trace Elem Res 2021 Sep 18. Epub 2021 Sep 18.

College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Tech Industrial Development Zone, Daqing, Heilongjiang, 163319, People's Republic of China.

Selenomethionine (SeMet) is known to alleviate ischemia-reperfusion (I/R) injury. However, its details of action have not been thoroughly elucidated in mice with intestinal I/R injury. In this study, intestinal I/R injury mice models were established, and ELISAs were performed to determine the levels of redox factors, including glutathione peroxidase (GSH-Px), catalase (CAT), superoxide dismutase (SOD), and malondialdehyde (MDA), in mice intestinal tissues. Read More

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September 2021

Cryoablation of Atypical Atrioventricular Nodal Reentry Tachycardia.

J Cardiovasc Electrophysiol 2021 Sep 17. Epub 2021 Sep 17.

Department of Cardiology, Karolinska University Hospital, Stockholm, Sweden.

Aim: Data on ablation for atypical recurrent atrioventricular nodal reentry tachycardia (AVNRT) and long-term follow-up are generally sparse. Furthermore, the rate of recurrence and safety of cryoablation for atypical AVNRT has not been established. We compared patients cryoablated for atypical AVNRT and typical AVNRT during long-term follow-up. Read More

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September 2021

Single-Sweep Pulmonary Vein Isolation using the new third-generation laser balloon - Evolution in ablation style using endoscopic ablation system.

J Cardiovasc Electrophysiol 2021 Sep 17. Epub 2021 Sep 17.

Cardioangiologisches Centrum Bethanien, Frankfurt, Germany.

Background: The endoscopic ablation system (EAS) is an established ablation device for pulmonary vein isolation (PVI) in patients with atrial fibrillation (AF). The novel X3 EAS is now equipped with a contiguous circumferential ablation mode (RAPID mode).

Aim: To determine the feasibility of single-shot fashioned ablation using X3. Read More

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September 2021

Prevalence of peripheral intravenous catheters and policy adherence: A point prevalence in a tertiary care university hospital.

J Clin Nurs 2021 Sep 17. Epub 2021 Sep 17.

Department of Nursing, Canterbury District Health Board, Christchurch, New Zealand.

Aims And Objectives: To determine prevalence and policy adherence for peripheral intravenous catheters (PIVC) in adult inpatients at a tertiary care university hospital (with about 83,000 inpatient admissions annually).

Background: Up to 80% of hospitalised patients receive intravenous therapy, most commonly via PIVCs. However, these devices are not risk-free. Read More

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September 2021

Physiologically-based pharmacokinetic model predictions of inter-ethnic differences in imatinib pharmacokinetics and dosing regimens.

Br J Clin Pharmacol 2021 Sep 17. Epub 2021 Sep 17.

Sydney Pharmacy School, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.

Aims: This study implements a physiologically-based pharmacokinetic (PBPK) modelling approach to investigate inter-ethnic differences in imatinib pharmacokinetics and dosing regimens.

Methods: A PBPK model of imatinib was built in the Simcyp Simulator (version 17) integrating in vitro drug metabolism and clinical pharmacokinetic data. The model accounts for ethnic differences in body size and abundance of drug-metabolising enzymes and proteins involved in imatinib disposition. Read More

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September 2021

The Toxicology Investigators Consortium 2020 Annual Report.

J Med Toxicol 2021 Sep 17. Epub 2021 Sep 17.

University of Colorado School of Medicine, 13001 E 17th Pl, Aurora, CO, 80045, USA.

The Toxicology Investigators Consortium (ToxIC) Registry was established by the American College of Medical Toxicology in 2010. The registry collects data from participating sites with the agreement that all bedside and telehealth medical toxicology consultation will be entered. This eleventh annual report summarizes the Registry's 2020 data and activity with its additional 6668 cases. Read More

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September 2021

[Insights into pregnancy and breastfeeding in inflammatory rheumatic diseases through observational data].

Z Rheumatol 2021 Sep 17. Epub 2021 Sep 17.

Programmbereich Epidemiologie und Versorgungsforschung, Deutsches Rheuma-Forschungszentrum Berlin, Charitéplatz 1, 10117, Berlin, Deutschland.

Information on pregnancy and breastfeeding in women with chronic inflammatory rheumatic diseases is relevant for a successful pregnancy and also for maternal and child health. In general, pregnant and breastfeeding women are excluded from randomized clinical trials and therefore evidence for clinical care and counselling has to be generated from observational studies. In the past decades, various data collections have been established for this purpose in addition to the existing spontaneous reporting systems initiated by drug authorities, with the aim of monitoring the teratogenic risk of a drug. Read More

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September 2021

Tumor microenvironment is associated with clinical and genetic properties of diffuse gliomas and predicts overall survival.

Cancer Immunol Immunother 2021 Sep 17. Epub 2021 Sep 17.

Department of Neurosurgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China.

Tumor microenvironment (TME) is a complex and dynamic evolving environment which facilitates tumor proliferation and progression. We aimed at investigating the characteristics of tumor microenvironment and its prognostic value in gliomas. Transcriptome data of 702 glioma samples from The Cancer Genome Atlas were included as training dataset, while 325 samples from Chinese Glioma Genome Atlas database and 268 samples from GSE16011 database were used to validate. Read More

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September 2021

Circular Ribonucleic Acid Expression Alteration in the Spinal Cord Tissue after Spinal Cord Injury in Rats.

Neuroimmunomodulation 2021 Sep 14:1-20. Epub 2021 Sep 14.

Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu, China.

Background And Purpose: Increased researches focus into pathophysiological mechanisms of spinal cord injury (SCI), particularly toward the relationship between relevant biomarkers and the degree of SCI and prognosis. Circular ribonucleic acids (circRNAs) possess microRNA (miRNA) binding sites that can play the role of miRNA sponges and thus participate in the expression of parental gene modification. This study focused on rat SCI models and explore the relationship between circRNAs and SCI at a genomic level. Read More

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September 2021

Consequences of a match made in hell: the harm caused by menthol smoking to the African American population over 1980-2018.

Tob Control 2021 Sep 16. Epub 2021 Sep 16.

Health Management and Policy, University of Michigan, Ann Arbor, Michigan, USA

Background: For many years, national surveys have shown a consistently disproportionately high prevalence of menthol smokers among African Americans compared with the general population. However, to our knowledge, no prior study has quantified the harm that menthol smoking has caused on that population. In this work, we estimate the public health harm that menthol cigarettes have caused to the African American community over the last four decades. Read More

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September 2021

Identifying persistent somatic symptoms in electronic health records: exploring multiple theory-driven methods of identification.

BMJ Open 2021 Sep 17;11(9):e049907. Epub 2021 Sep 17.

Health, Medical and Neuropsychology, Leiden University Faculty of Social and Behavioural Sciences, Leiden, The Netherlands.

Objective: Persistent somatic symptoms (PSSs) are defined as symptoms not fully explained by well-established pathophysiological mechanisms and are prevalent in up to 10% of patients in primary care. The present study aimed to explore methods to identify patients with a recognisable risk of having PSS in routine primary care data.

Design: A cross-sectional study to explore four identification methods that each cover part of the broad spectrum of PSS was performed. Read More

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September 2021

Validity of a rapid diagnostic programme for head and neck cancer.

Acta Otorrinolaringol Esp (Engl Ed) 2021 Sep-Oct;72(5):271-279

Servicio de Oncología Médica, Parc Taulí Hospital Universitari, Sabadell, Barcelona, Spain.

Introduction And Objectives: Given the epidemiological knowledge of squamous cell carcinomas of the head and neck (SCHN), the prognosis in survival according to the staging at diagnosis and the absence of screening programmes that have proven cost-effective, we undertook a rapid diagnosis programme. The objective of this study was to analyse whether a rapid diagnostic programme (RDP) to be used by General Practitioners (GP) would achieve a change in the proportion of diagnoses in early versus late stages in these tumours.

Methods: A prospective observational study of patients diagnosed with a tumour of ENT location in our centre, was carried out for 24 consecutive months. Read More

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Underlying factors related to HIV/AIDS prevention: investigating the willingness to take pre-exposure prophylaxis among men-who-have-sex-with-men in Germany.

AIDS Res Ther 2021 Sep 17;18(1):61. Epub 2021 Sep 17.

University of Leipzig, Leipzig, Germany.

Background: This study investigates the willingness of men-who-have-sex-with-men (MSM) to use HIV pre-exposure prophylaxis (PrEP). Research in the HIV/AIDS field typically relies on clinical and epidemiological studies, thereby often excluding social dimensions of the illness as well as factors explaining its prevention. The current study analyzes HIV-prevention through an interdisciplinary theoretical approach. Read More

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September 2021

Up-regulation of GSTT1 in serous ovarian cancer associated with resistance to TAXOL / carboplatin.

J Ovarian Res 2021 Sep 17;14(1):122. Epub 2021 Sep 17.

Department of Clinical Laboratory, Fudan University Shanghai Cancer Center, No.270, Dong'An Road, Xuhui District, Shanghai, 200032, China.

Serous ovarian cancer (SOC) is the most common women cancer and the leading cause of cancer-related mortality among the gynaecological malignancies. Although effective chemotherapeutics combined with surgery are developed for the treatment, the five-year survival rate is unsatisfactory due to chemoresistance. To overcome this shortcoming of chemotherapy, we established taxol and carboplatin resistant SOC cell lines for the understandings of the molecular and cellular mechanisms of chemoresistance. Read More

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September 2021

LncRNA LBX2-AS1 promotes colorectal cancer progression and 5-fluorouracil resistance.

Cancer Cell Int 2021 Sep 17;21(1):501. Epub 2021 Sep 17.

Department of Reproductive Heredity Center, Changhai Hospital, Second Military Medical University, Shanghai, 200433, China.

Background: Recent reports suggest that the long non-coding RNA LBX2 antisense RNA 1 (LBX2-AS1) acts as an important regulator in cancer progression, but its significance in colorectal cancer (CRC) remains undetermined.

Methods: LBX2-AS1 expression levels in CRC were determined from the GEPIA database and CRC tissues to investigate clinical relevance. meRIP-PCR assays investigated the molecular mechanisms underlying the function of m6A in LBX2-AS1. Read More

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September 2021

COVID-19 mRNA vaccine and antibody response in lactating women: a prospective cohort study.

BMC Pregnancy Childbirth 2021 Sep 17;21(1):632. Epub 2021 Sep 17.

Centro Hospitalar Universitário de Lisboa Central (CHULC), Lisboa, Portugal.

Background: Immunological protection via breastfeeding is well known. The immunological profile of human milk changes during lactation. No clinical trials have been conducted in lactating women with the newest mRNA vaccines against SARS- CoV-2. Read More

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September 2021

Development and validation of a 1 K sika deer (Cervus nippon) SNP Chip.

BMC Genom Data 2021 Sep 17;22(1):35. Epub 2021 Sep 17.

Key Laboratory of Molecular Biology of Special Economic Animals, Institute of Special Products, Chinese Academy of Agricultural Sciences, Changchun, 130112, China.

Background: China is the birthplace of the deer family and the country with the most abundant deer resources. However, at present, China's deer industry faces the problem that pure sika deer and hybrid deer cannot be easily distinguished. Therefore, the development of a SNP identification chip is urgently required. Read More

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September 2021

An IDO1-related immune gene signature predicts overall survival in acute myeloid leukemia.

Blood Adv 2021 Sep 17. Epub 2021 Sep 17.

Institute of Hematology, Bologna, Italy.

The contribution of the bone marrow (BM) immune microenvironment (TME) to acute myeloid leukemia (AML) development is well-known, but its prognostic significance is still elusive. Indoleamine 2,3-dioxygenase 1 (IDO1), which is negatively regulated by the BIN1 proto-oncogene, is an interferon (IFN)-γ-inducible mediator of immune tolerance. With the aim to develop a prognostic IDO1-based immune gene signature, biological and clinical data of 732 patients with newly diagnosed, non-promyelocytic AML were retrieved from public datasets and analyzed using established computational pipelines. Read More

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September 2021

Perioperative renal protection.

Curr Opin Crit Care 2021 Sep 15. Epub 2021 Sep 15.

Department of Anesthesiology, Intensive Care and Pain Medicine, University of Muenster, Muenster, Germany.

Purpose Of Review: Acute kidney injury (AKI) is a common but underestimated syndrome in the perioperative setting. AKI can be induced by different causes and is associated with increased morbidity and mortality. Unfortunately, no specific treatment options are available at the moment. Read More

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September 2021

The assessment of good character in nursing and midwifery pre-registration students: A modified Delphi approach.

Authors:
Sharon Arkell

Nurse Educ Today 2021 Sep 11;107:105145. Epub 2021 Sep 11.

University of Wolverhampton, Wulfruna St, Wolverhampton WV1 1LY. Electronic address:

Aims: To examine the perspectives of decision-makers when assessing the good character of nursing and midwifery pre-registration students in relation to their continued fitness to practise.

Design: A qualitative iterative survey design in the interpretive paradigm.

Methods: An expert panel of fitness to practise decision-makers was established to examine their perspectives when assessing the good character of nursing and midwifery pre-registration students. Read More

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September 2021

PICO: What it is and what it is not.

Nurse Educ Pract 2021 Sep 2;56:103194. Epub 2021 Sep 2.

Foley Library, Gonzaga University, USA; University of Washington, School of Nursing, USA. Electronic address:

Aim: To assess the role and effectiveness of the mnemonic PICO (Population, Intervention, Comparator and Outcome) in evidence-based practice (EBP) pedagogy.

Background: The mnemonic "PICO" is a well-established tool in nursing EBP pedagogy. Nevertheless, application of this tool in nursing curricula is not currently supported by evidence of its effectiveness. Read More

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September 2021

Efficacy of a family-based cardiovascular risk reduction intervention in individuals with a family history of premature coronary heart disease in India (PROLIFIC): an open-label, single-centre, cluster randomised controlled trial.

Lancet Glob Health 2021 Oct;9(10):e1442-e1450

Public Health Foundation of India, New Delhi, India; Centre for Chronic Disease Control, New Delhi, India; Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.

Background: Coronary heart disease, a leading cause of death globally, is amenable to lifestyle interventions. The family environment can affect the ability or willingness of individuals to make lifestyle changes. We aimed to investigate the efficacy of a targeted family-based intervention for reduction of total cardiovascular risk in individuals with a family history of premature coronary heart disease. Read More

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October 2021

Antigen dominance hierarchies shape TCF1 progenitor CD8 T cell phenotypes in tumors.

Cell 2021 Sep;184(19):4996-5014.e26

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

CD8 T cell responses against different tumor neoantigens occur simultaneously, yet little is known about the interplay between responses and its impact on T cell function and tumor control. In mouse lung adenocarcinoma, we found that immunodominance is established in tumors, wherein CD8 T cell expansion is predominantly driven by the antigen that most stably binds MHC. T cells responding to subdominant antigens were enriched for a TCF1 progenitor phenotype correlated with response to immune checkpoint blockade (ICB) therapy. Read More

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September 2021

Clathrin packets move in slow axonal transport and deliver functional payloads to synapses.

Neuron 2021 Sep;109(18):2884-2901.e7

Department of Pathology, University of California, San Diego, La Jolla, CA, USA; Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA. Electronic address:

In non-neuronal cells, clathrin has established roles in endocytosis, with clathrin cages enclosing plasma membrane infoldings, followed by rapid disassembly and reuse of monomers. However, in neurons, clathrin is conveyed in slow axonal transport over days to weeks, and the underlying transport/targeting mechanisms, mobile cargo structures, and even its precise presynaptic localization and physiologic role are unclear. Combining live imaging, photobleaching/conversion, mass spectrometry, electron microscopy, and super-resolution imaging, we found that unlike in dendrites, where clathrin cages rapidly assemble and disassemble, in axons, clathrin and related proteins organize into stable "transport packets" that are unrelated to endocytosis and move intermittently on microtubules, generating an overall slow anterograde flow. Read More

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September 2021

Barriers and facilitators to the access to specialized female genital cutting healthcare services: Experiences of Somali and Sudanese women in Norway.

PLoS One 2021 17;16(9):e0257588. Epub 2021 Sep 17.

Section for Trauma, Catastrophes and Forced Migration-Adults and Elderly, Norwegian Centre for Violence and Traumatic Stress Studies, Oslo, Norway.

Background: Girls and women subjected to female genital cutting (FGC) risk experiencing obstetrical, gynecological, sexual, and psychological health problems. Therefore, Norway has established low-threshold specialized healthcare services where girls and women with FGC-related health problems can directly seek medical attention. Nevertheless, we lack data about access to these services, especially for non-maternity-related purposes. Read More

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September 2021