744,943 results match your criteria essential


Temperature-dependent dielectric properties of human uterine fibroids over microwave frequencies.

Biomed Phys Eng Express 2021 Sep 17. Epub 2021 Sep 17.

Electrical and Computer Engineering, Kansas State University College of Engineering, 3108 Engineering Hall Manhattan, Kansas 66506-5200, Manhattan, Kansas, 66506-5201, UNITED STATES.

Microwave ablation is under investigation as a minimally-invasive treatment for uterine fibroids. Computational models play a vital role in the development, evaluation and characterization of candidate ablation devices. The temperature-dependent dielectric properties of fibroid tissue are essential for accurate computational modeling. Read More

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September 2021

In vitro cultivation of Trypanosoma congolense bloodstream forms: State of the art and advances.

Vet Parasitol 2021 Sep 9;299:109567. Epub 2021 Sep 9.

CIRAD, UMR INTERTRYP, F-34398, Montpellier, France; INTERTRYP, Univ Montpellier, CIRAD, IRD, Montpellier, France.

Animal African Trypanosomosis (AAT or Nagana) is a severe vector-borne disease caused by protozoan parasites belonging to the Trypanosomatidae family and is usually cyclically transmitted by blood-sucking tsetse flies. AAT remains a major problem in sub-Saharan Africa. Among the main AAT causative agents, Trypanosoma congolense (T. Read More

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September 2021

The role of Escherichia coli type III secretion system 2 chaperone protein ygeG in pathogenesis of avian pathogenic Escherichia coli.

Res Vet Sci 2021 Sep 10;140:203-211. Epub 2021 Sep 10.

Anhui Province Key Laboratory of Veterinary Pathobiology and Disease Control, College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, PR China. Electronic address:

The Escherichia coli type III secretion system 2 (ETT2) is present in most E. coli strains, carries a 29.9-kb ETT2 pathogenicity island (PAI) and is involved in the virulence of avian pathogenic Escherichia coli (APEC). Read More

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September 2021

Trophoblast-derived interleukin 9 mediates immune cell conversion and contributes to maternal-fetal tolerance.

J Reprod Immunol 2021 Sep 6;148:103379. Epub 2021 Sep 6.

Obstetric Department, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China; Obstetric Department, Shanghai Key Laboratory of Female Reproductive Endocrine-Related Diseases, Shanghai, China; Institute of Biomedical Sciences, Fudan University, Shanghai, China. Electronic address:

In the maternal-fetal crosstalk, fetal derived trophoblast cells can secret several molecules to regulate immune tolerance such as cytokines and chemokines, besides human leukocyte antigens (HLA) providing. However, the mechanism of these factors in pregnancy is still unknown. Our previous study showed that IL9 could be secreted by trophoblasts and exerted a positive effect on trophoblasts themselves through autocrine signaling. Read More

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September 2021

Targeting HER2 heterogeneity in breast cancer.

Cancer Treat Rev 2021 Sep 2;100:102286. Epub 2021 Sep 2.

Genomic and Molecular Pathology Services, Pathgroup, Nashville, TN, United States.

The identification of Human epidermal growth factor receptor 2 (HER2) as a target in breast cancer and the subsequent development of HER2-targeted therapies has revolutionized the treatment of patients with HER2-positive breast cancer. However, there is an increasing awareness of how frequently tumors have low or heterogeneous expression of HER2. It is now recognized that this impacts the degree of benefit from HER2-targeted therapies. Read More

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September 2021

Conspecific alarm cues are a potential effective barrier to regulate foraging behavior of the sea urchin Mesocentrotus nudus.

Mar Environ Res 2021 Sep 10;171:105476. Epub 2021 Sep 10.

Key Laboratory of Mariculture & Stock Enhancement in North China's Sea, Ministry of Agriculture and Rural Affairs, Dalian Ocean University, Dalian, 116023, China. Electronic address:

A cost-effective approach to controlling foraging and feeding behaviors of sea urchins is essential for the management of kelp beds. Laboratory experiments were designed to investigate whether alarm cues from crushed conspecific urchins can effectively prevent the foraging and feeding behaviors of the sea urchin Mesocentrotus nudus under the static seawater condition. The present study found that the number of M. Read More

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September 2021

Evaluation of feeding behaviour traits to predict efficiency traits in pigs using partial least square regression.

Animal 2021 Sep 14;15(10):100351. Epub 2021 Sep 14.

Swine Research Unit, Agroscope Posieux 1725, Switzerland; Animal GenoPhenomics Group, Agroscope Posieux 1725, Switzerland. Electronic address:

The improvement of efficiency traits, such as protein efficiency (PE), digestible energy efficiency (EnE) and lipid gain (LipG), are relevant given their associations with environmental pollution, cost of production, and the quality of meat. However, these traits are difficult to measure and usually require slaughtering of pigs. Efficiency traits are complex, and several factors, such as genetic predisposition, feed composition, but also individual feeding behaviour may contribute to efficiency. Read More

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September 2021

Identification of SRSF3 target mRNAs using inducible TRIBE.

Biochem Biophys Res Commun 2021 Sep 10;578:21-27. Epub 2021 Sep 10.

Department of Orthopedic, The Second Affiliated Hospital of Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310029, China; Zhejiang University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Haining, 314400, China; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University, Hangzhou, 310029, China. Electronic address:

Serine and arginine-rich splicing factor 3 (SRSF3), the smallest member of the Ser/Arg-rich (SR) RNA-binding protein family, regulates multiple aspects of post-transcriptional gene expression program. Although SRSF3 is essential for early embryo development, reprogramming, and pluripotency maintenance, the RNA targets and specificity of RNA recognition of SRSF3 are not well understood in human pluripotent stem cells. In this study, we used inducible TRIBE (targets of RNA binding sites by editing) to identify RNA targets and binding motifs of SRSF3 in human embryonic stem cells (hESCs). Read More

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September 2021

PICO: What it is and what it is not.

Nurse Educ Pract 2021 Sep 2;56:103194. Epub 2021 Sep 2.

Foley Library, Gonzaga University, USA; University of Washington, School of Nursing, USA. Electronic address:

Aim: To assess the role and effectiveness of the mnemonic PICO (Population, Intervention, Comparator and Outcome) in evidence-based practice (EBP) pedagogy.

Background: The mnemonic "PICO" is a well-established tool in nursing EBP pedagogy. Nevertheless, application of this tool in nursing curricula is not currently supported by evidence of its effectiveness. Read More

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September 2021

"Awareness to touch": A qualitative study of nurses' perceptions of interpersonal professional contact after an experiential training.

Nurse Educ Pract 2021 Aug 30;56:103187. Epub 2021 Aug 30.

University of Rome 'Sapienza', Department of Social and Developmental Psychology, Via Dei Marsi 78, 00185 Rome, Italy.

Aim: This study aimed to explore nurses' perceptions of touch in their professional practice and how these perceptions were articulated in discourse, among participants who attended a specific training on touch and those who did not.

Background: Touch is an essential part of nursing practice. Research showed that the use of touch influences patients' general well-being, improving a sense of presence and infusing security and encouragement. Read More

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Focus groups and interviews with the public led to the development of a template for a GRADE plain language recommendation.

J Clin Epidemiol 2021 Sep 14. Epub 2021 Sep 14.

Department of Health Research Methods, Evidence and Impact, McMaster University, 1280 Main Street West, Hamilton, Canada L8S 4L8. Electronic address:

Objectives: Clear communication of health care recommendations to patients and the public is essential. Current work has focused on creating patient versions of guidelines without much attention to single recommendations. In this study, we built on previously conducted research to test a template and explore the public's perceptions of, and attitudes towards plain language guideline recommendations. Read More

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September 2021

FtsH is required for protein secretion homeostasis and full bacterial virulence in Edwardsiella piscicida.

Microb Pathog 2021 Sep 14:105194. Epub 2021 Sep 14.

State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China; Shanghai Engineering Research Center of Maricultured Animal Vaccines, Shanghai, 200237, China. Electronic address:

Edwardsiella piscicida, as an important pathogen of fish, has caused huge losses in aquaculture. The virulence in E. piscicida has been increasingly concerned, but few studies have focused on the relationship between virulence and protein secretion homeostasis. Read More

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September 2021

Surface plasmon resonance approach to study drug interactions with SARS-CoV-2 RNA-dependent RNA polymerase highlights treatment potential of suramin.

J Virol Methods 2021 Sep 14:114283. Epub 2021 Sep 14.

Department of Biology, Biotechnical Faculty, University of Ljubljana, Ljubljana 1000, Slovenia. Electronic address:

The SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) is essential for virus replication, therefore it is a promising drug target. Here we present a surface plasmon resonance approach to study the interaction of RdRp with drugs in real time. We monitored the effect of favipiravir, ribavirin, sofosbuvir triphosphate PSI-7409 and suramin on RdRp binding to RNA immobilized on the chip. Read More

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September 2021

Potential of microalgae as a sustainable feed ingredient for aquaculture.

J Biotechnol 2021 Sep 14. Epub 2021 Sep 14.

Department of Chemistry, Bioscience, and Environmental Engineering, Faculty of Science and Technology, University of Stavanger, 4021 Stavanger, Norway. Electronic address:

An increase in fish consumption, combined with a decrease in wild fish harvest, is driving the aquaculture industry at rapid pace. Today, farmed seafood accounts for about half of all global seafood demand for human consumption. As the aquaculture industry continues to grow, so does the market for aquafeed. Read More

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September 2021

The Cardiac Effects of COVID-19 Review of articles.

Curr Probl Cardiol 2021 Sep 14:100981. Epub 2021 Sep 14.

Cardiovascular Research Center of Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Cardiovascular wellbeing has been dramatically affected by SARS-CoV-2, the reason for the COVID-19 pandemic. There is a greater risk of morbidity and death in individuals with preexisting heart diseases. Clinical syndromes of the acute coronary syndrome, acute myocardial injury, myocarditis, arrhythmias, heart failure, and venous thromboembolism can, directly and indirectly, affect the heart. Read More

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September 2021

Integrated strategies for enzyme assisted extraction of bioactive molecules: A review.

Int J Biol Macromol 2021 Sep 14. Epub 2021 Sep 14.

Department of Chemical Engineering, Institute of Chemical Technology, Matunga (E) Mumbai 400019, India. Electronic address:

Conventional methods of extracting bioactive molecules are gradually losing pace due to their numerous disadvantages, such as product degradation, lower efficiency, and toxicity. Thus, in light of the rising demand for these bioactive, enzymes have garnered much attention for their efficiency in extraction. However, enzyme-assisted extraction is also plagued with a high capital cost that cannot justify the extraction yields obtained. Read More

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September 2021

RNA-Seq based global transcriptome analysis of rice unravels the key players associated with brown planthopper resistance.

Int J Biol Macromol 2021 Sep 14. Epub 2021 Sep 14.

RS&RRS, Rudrur, Professor Jayashankar Telangana State Agricultural University, Nizamabad, Telangana, India.

Rice production is adversely affected by biotic and abiotic stresses. Among the biotic stresses, brown planthopper (BPH) majorly affects the rice yield. Comprehending the genome and candidate players is essential for the resistance to BPH. Read More

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September 2021

The semaphorin 4A-neuropilin 1 axis alleviates kidney ischemia reperfusion injury by promoting the stability and function of regulatory T cells.

Kidney Int 2021 Sep 14. Epub 2021 Sep 14.

Department of Urology, The 3(rd) Medical Center of Chinese PLA General Hospital, Beijing, China; Department of Urology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. Electronic address:

Previous studies have suggested the role of CD4Foxp3 regulatory T cells (Tregs) in protection against kidney ischemia reperfusion injury via their immunosuppressive properties. Unfortunately, the associated mechanisms of Tregs in kidney ischemia reperfusion injury have not been fully elucidated. Semaphorin 4A (Sema4A) is essential for maintaining the immunosuppressive capacity of Tregs in tumors. Read More

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September 2021

Blocking effect of ferritin on the ryanodine receptor-isoform 2.

Arch Biochem Biophys 2021 Sep 14:109031. Epub 2021 Sep 14.

Institute of Medical Physics, Biophysics, Informatics and Telemedicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia. Electronic address:

Iron, an essential element for most living organism, participates in a wide variety of physiological processes. Disturbance in iron homeostasis has been associated with numerous pathologies, particularly in the heart and brain, which are the most susceptible organs. Under iron-overload conditions, the generation of reactive oxygen species leads to impairment in Ca signaling, fundamentally implicated in cardiac and neuronal physiology. Read More

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September 2021

Inhibition of huntingtin aggregation by its N-terminal 17-residue peptide and its analogs.

Arch Biochem Biophys 2021 Sep 14:109033. Epub 2021 Sep 14.

Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, 781 039, India. Electronic address:

The N-terminal 17-residue stretch of huntingtin (htt) folds into an amphipathic α-helix. The htt-harboring polyQ peptides form oligomers that are mediated via the assembly of the htt α-helices. The oligomerization results in higher local concentration of the polyglutamine (polyQ) region, thereby facilitating amyloid formation. Read More

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September 2021

Economic Status and Mortality in Patients with Alzheimer's Disease in Japan: The Longevity Improvement and Fair Evidence Study.

J Am Med Dir Assoc 2021 Sep 14. Epub 2021 Sep 14.

Kyushu University Graduate School of Medical Sciences, Department of Health Care Administration and Management, Kyushu, Japan.

Objectives: As more countries are implementing measures to address Alzheimer's disease (AD), it is essential to update the available knowledge on the relationship between economic status and mortality in patients with AD. This study examined the influence of economic status on mortality in Japanese individuals with AD using a medical claims dataset.

Design: This was a retrospective cohort study. Read More

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September 2021

SPT5 stabilizes RNA polymerase II, orchestrates transcription cycles, and maintains the enhancer landscape.

Mol Cell 2021 Sep 10. Epub 2021 Sep 10.

Fudan University Shanghai Cancer Center, Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology), Institutes of Biomedical Sciences, Fudan University, Shanghai, China; Shanghai Key Laboratory of Radiation Oncology, Shanghai, China. Electronic address:

Transcription progression is governed by multitasking regulators including SPT5, an evolutionarily conserved factor implicated in virtually all transcriptional steps from enhancer activation to termination. Here we utilize a rapid degradation system and reveal crucial functions of SPT5 in maintaining cellular and chromatin RNA polymerase II (Pol II) levels. Rapid SPT5 depletion causes a pronounced reduction of paused Pol II at promoters and enhancers, distinct from negative elongation factor (NELF) degradation resulting in short-distance paused Pol II redistribution. Read More

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September 2021

Development of multisensory integration following prolonged early-onset visual deprivation.

Curr Biol 2021 Sep 10. Epub 2021 Sep 10.

Applied Cognitive Psychology, Faculty for Computer Science, Engineering, and Psychology, Ulm University, Ulm 89081, Germany.

Adult humans make effortless use of multisensory signals and typically integrate them in an optimal fashion. This remarkable ability takes many years for normally sighted children to develop. Would individuals born blind or with extremely low vision still be able to develop multisensory integration later in life when surgically treated for sight restoration? Late acquisition of such capability would be a vivid example of the brain's ability to retain high levels of plasticity. Read More

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September 2021

The radial artery: Open harvesting technique.

Multimed Man Cardiothorac Surg 2021 Sep 10;2021. Epub 2021 Sep 10.

D'arcy Sutherland Cardiothoracic Surgical Unit, The Royal Adelaide Hospital, Adelaide, Australia.

The radial artery is an important conduit in coronary artery surgical revascularization due to its robust long-term clinical outcomes. The use of the radial artery has become popularized in recent times. Therefore it is essential for junior surgeons to master harvest techniques that are safe, reliable, and easy to replicate. Read More

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September 2021

Identification of ksg1 mutation showing long-lived phenotype in fission yeast.

Genes Cells 2021 Sep 17. Epub 2021 Sep 17.

Laboratory of Molecular Microbiology, Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University, Chikusa-Ku, Nagoya, 464-8601, Japan.

Fission yeast is a good model organism for the study of lifespan. To elucidate the mechanism, we screened for long-lived mutants. We found a nonsense mutation in the ksg1 gene, which encodes an ortholog of mammalian PDK1 (phosphoinositide-dependent protein kinase). Read More

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September 2021

Bat signal (of selection) summons evolutionary hope in face of epidemic disease: an example of the power and promise of genetic monitoring.

Mol Ecol 2021 Sep 17. Epub 2021 Sep 17.

Department of Biology, Graduate Degree Program in Ecology, Colorado State University, Fort Collins, Colorado, USA.

A long-standing question in evolutionary biology is the extent to which adaptation to novel stressors can buffer populations from extinction. This question is arguably one of the most important questions for evolutionary biologists to answer in this age of rapid global change. Knowledge of how best to manage genetic variation in organisms faced with dramatic changes in their abiotic or biotic environment, such as those associated with anthropogenic climate change or emerging infectious disease, is critical for mitigating these threats. Read More

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September 2021

The CRL4DTL E3 ligase induces degradation of the DNA replication initiation factor TICRR/TRESLIN specifically during S phase.

Nucleic Acids Res 2021 Sep 17. Epub 2021 Sep 17.

Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.

A DNA replication program, which ensures that the genome is accurately and wholly replicated, is established during G1, before the onset of S phase. In G1, replication origins are licensed, and upon S phase entry, a subset of these will form active replisomes. Tight regulation of the number of active replisomes is crucial to prevent replication stress-induced DNA damage. Read More

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September 2021

COPII Sec23 proteins form isoform-specific endoplasmic reticulum exit sites with differential effects on polarized growth.

Plant Cell 2021 Sep 17. Epub 2021 Sep 17.

Department of Biological Sciences, Dartmouth College, Hanover, NH.

COPII, a coat protein complex that forms vesicles on the endoplasmic reticulum (ER), mediates trafficking to the Golgi. While metazoans have few genes encoding each COPII component, plants have expanded these gene families, leading to the hypothesis that plant COPII has functionally diversified. In the moss Physcomitrium (Physcomitrella) patens, the Sec23/24 gene families are each composed of seven genes. Read More

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September 2021

PlantGSAD: a comprehensive gene set annotation database for plant species.

Nucleic Acids Res 2021 Sep 17. Epub 2021 Sep 17.

State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing 100193, China.

With the accumulation of massive data sets from high-throughput experiments and the rapid emergence of new types of omics data, gene sets have become more diverse and essential for the refinement of gene annotation at multidimensional levels. Accordingly, we collected and defined 236 007 gene sets across different categories for 44 plant species in the Plant Gene Set Annotation Database (PlantGSAD). These gene sets were divided into nine main categories covering many functional subcategories, such as trait ontology, co-expression modules, chromatin states, and liquid-liquid phase separation. Read More

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September 2021

Serum Amyloid A Is Present in Human Saccular Intracranial Aneurysm Walls and Associates With Aneurysm Rupture.

J Neuropathol Exp Neurol 2021 Sep 17. Epub 2021 Sep 17.

Neurosurgery Research Group, Biomedicum, Helsinki, Finland.

Saccular intracranial aneurysm (sIA) rupture leads to a disabling subarachnoid hemorrhage. Chronic inflammation and lipid accumulation in the sIA wall contribute to wall degenerative remodeling that precedes its rupture. A better understanding of the pathobiological process is essential for improved future treatment of patients carrying sIAs. Read More

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September 2021