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The vicious circle between physical, psychological, and physiological characteristics of shift work in nurses: a multidimensional approach.

Sleep Breath 2021 Apr 17. Epub 2021 Apr 17.

Department of Physical Education and Sport Science, University of Thessaly, Karies, 42100, Trikala, Thessaly, Greece.

Purpose: To compare physical, psychological, and physiological adaptations between rotating and morning shift health workers using objective and subjective approaches.

Methods: Forty nurses [n = 20 morning shift (MS) group; n = 20 rotating shift (RS) group] were evaluated for anthropometry, body composition, and handgrip strength. Quality of life, depression, fatigue, daytime sleepiness, and sleep quality were assessed with SF-36, Zung Self-Rating Depression Scale (SDS), Fatigue Severity Scale (FSS), Epworth Sleepiness Scale (ESS), and Pittsburgh Sleep Quality Index (PSQI), respectively. Read More

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Effectiveness of intranasal steroids on rhinitis symptoms, sleep quality, and quality of life in patients with perennial allergic rhinitis.

Eur Arch Otorhinolaryngol 2021 Apr 17. Epub 2021 Apr 17.

Department of Otorhinolaryngology, Faculty of Medicine, Minia University, Minia, Egypt.

Purpose: Evaluate the impact of perennial allergic rhinitis (PAR) on the health-related quality of life (HRQL) and measure performance issues that are of major concerns for PAR patients, as well as determining the effect of intra-nasal steroids (INS) on PAR and associated congestion, sleep complaints, and daytime sleepiness.

Methods: This study was a cross-sectional study. A total of 78 PAR patients underwent otorhinolaryngological examination and skin test. Read More

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Impact of endothelial shear stress on absorption process of resorbable magnesium scaffold: A BIOSOLVE-II substudy.

Cardiovasc Revasc Med 2021 Apr 9. Epub 2021 Apr 9.

Section of Interventional Cardiology, MedStar Washington Hospital Center, Washington DC, USA. Electronic address:

Background/purpose: Local hemodynamic forces such as endothelial shear stress (ESS) may have an influence on appropriate neointimal healing, vessel remodeling, and struts absorption process following second-generation drug-eluting resorbable magnesium scaffold (RMS, Magmaris, Biotronik AG, Buelach, Switzerland) placement. The aim of this study was to investigate the impact of ESS assessed by optical coherence tomography (OCT)-based computational fluid dynamic (CFD) simulations on absorption process and coronary lumen dimension after Magmaris implantation.

Methods And Results: A total of 22 patients who were enrolled in the BIOSOLVE-II trial and underwent serial OCT assessment immediately after Magmaris implantation and at 6- and 12-month follow-up were included. Read More

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The effect of platelet-rich fibrin (PRF) on wound healing, adhesion, and hemostasis after endoscopic sinus surgery in patients with nasal polyposis.

Am J Otolaryngol 2021 Mar 29;42(5):103010. Epub 2021 Mar 29.

Prof. Dr. Cemil Tascioglu City Hospital, Otorhinolaryngology Department, Turkey.

Purpose: Chronic rhinosinusitis (CRS) is one of the most common chronic diseases seen worldwide. Endoscopic sinus surgery (ESS) has become a widely accepted procedure for medically refractory chronic rhinosinusitis and nasal polyps. Prevention of revision surgery often depends on good wound healing and less adhesion formation. Read More

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Semi-coherent cation-rich Mn-Cu oxides heterostructures as cathode for novel aqueous potassium dual-ion energy storage devices.

J Colloid Interface Sci 2021 Apr 5;597:75-83. Epub 2021 Apr 5.

Guangxi Key Laboratory of Electrochemical and Magneto-chemical Functional Materials, Department of Chemistry and Biological Engineering, Guilin University of Technology, Guilin 541004, China; Guangdong Institute of Semiconductor Industrial Technology, Guangdong Academy of Science, Guangzhou 510650, China; Siyuan Laboratory, Guangdong Provincial Engineering Technology Research Center of Vacuum Coating Technologies and New Materials, Department of Physics, Jinan University, Guangzhou 510632, China. Electronic address:

In this work, combining both advantages of aqueous energy storage systems (ESS) and conventional dual-ion ESS, a novel aqueous dual-ion ESS is developed based on K and OH electrochemistry by employing semi-coherent KMnO-CuO (sc-Mn-Cu) cathode. Profting from the elaborate design, the electrolyte and cathode simultaneously act as source of cations. In the novel aqueous dual-ion ESS configuration, the dependence of the performance on the electrolyte salt concentration is reduced and the sc-Mn-Cu cathode can host OH with lower working potentials by conversion mechanism. Read More

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The central role of host reproduction in determining the evolution of virulence in spatially structured populations.

J Theor Biol 2021 Apr 13:110717. Epub 2021 Apr 13.

Centre for Ecology and Conservation, College of Life and Environmental Sciences, University of Exeter, Penryn Campus, Penryn, TR10 9FE, UK; Department of Integrative Biology, University of California, Berkeley, CA, 94720, USA.

A substantial body of work has shown that local transmission selects for less acute, 'prudent' parasites that have lower virulence and transmission rates. This is because parasite strains with higher transmission rates 'self-shade' due to a combination of genetic correlations (self: clustered related parasite strains compete for susceptible individuals) and ecological correlations (shade: infected individuals clustering and blocking transmission). However, the interaction of ecological and genetic correlations alongside higher order ecological effects such as patch extinctions means that spatial evolutionary effects can be nuanced; theory has predicted that a relatively small proportion of local infection can select for highest virulence, such that there is a humped relationship between the degree of local infection and the harm that parasites are selected to cause. Read More

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Reward-related Decision-making Deficits in Internet Gaming Disorder: A Systematic Review and Meta-analysis.

Addiction 2021 Apr 16. Epub 2021 Apr 16.

Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.

Aims: To estimate the aggregated effect sizes of reward-related decision-making deficits in internet gaming disorder (IGD) and to explore potential moderators on the variability of effect sizes across studies.

Design: Review of peer-reviewed studies comparing reward-related decision-making performance between IGD and control participants identified via PubMed, Web of Science, and ProQuest databases. Random-effects modeling was conducted using Hedge's g as the effect size (ES). Read More

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Surgical, clinical, and functional outcomes of transoral robotic surgery used in sleep surgery for obstructive sleep apnea syndrome: A systematic review and meta-analysis.

Head Neck 2021 Apr 16. Epub 2021 Apr 16.

Research Committee, Robotic Surgery Group of Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.

We investigated safety and efficacy of transoral robotic surgery (TORS) for base of tongue (BOT) reduction in obstructive sleep apnea syndrome (OSAS) patients. PubMed, Cochrane Library, and Scopus were searched. A meta-analysis was performed. Read More

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Removal and repositioning of urinary tract implants by use of an endovascular snare system in dogs and cats (2013-2019).

J Am Vet Med Assoc 2021 May;258(9):983-990

Objective: To report the fluoroscopic removal or repositioning of urinary tract implants in dogs and cats by use of an endovascular snare system (ESS) and to report procedural usefulness and complications in dogs and cats.

Animals: 3 cats and 14 dogs.

Procedures: A medical records review was performed to identify dogs and cats that underwent removal or repositioning of urinary tract foreign bodies or implants by use of an ESS with fluoroscopic guidance at a veterinary teaching hospital from 2013 to 2019. Read More

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Non-invasive characterization of complex coronary lesions.

Sci Rep 2021 Apr 14;11(1):8145. Epub 2021 Apr 14.

Department of Biomedical Engineering, Duke University, Durham, NC, 27705, USA.

Conventional invasive diagnostic imaging techniques do not adequately resolve complex Type B and C coronary lesions, which present unique challenges, require personalized treatment and result in worsened patient outcomes. These lesions are often excluded from large-scale non-invasive clinical trials and there does not exist a validated approach to characterize hemodynamic quantities and guide percutaneous intervention for such lesions. This work identifies key biomarkers that differentiate complex Type B and C lesions from simple Type A lesions by introducing and validating a coronary angiography-based computational fluid dynamic (CFD-CA) framework for intracoronary assessment in complex lesions at ultrahigh resolution. Read More

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Reply to Best and Ashby: The concept of evolutionarily stable strategies (ESS) helps link ecology and evolution.

Proc Natl Acad Sci U S A 2021 May;118(18)

Centre for Ecological and Evolutionary Synthesis, Department of Biosciences, University of Oslo, NO-0316 Oslo, Norway;

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Bayesian semiparametric meta-analytic-predictive prior for historical control borrowing in clinical trials.

Stat Med 2021 Apr 13. Epub 2021 Apr 13.

Takeda Pharmaceuticals, Cambridge, Massachusetts, USA.

When designing a clinical trial, borrowing historical control information can provide a more efficient approach by reducing the necessary control arm sample size while still yielding increased power. Several Bayesian methods for incorporating historical information via a prior distribution have been proposed, for example, (modified) power prior, (robust) meta-analytic predictive prior. When utilizing historical control borrowing, the prior parameter(s) must be specified to determine the magnitude of borrowing before the current data are observed. Read More

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Supplemental light exposure improves sleep architecture in people with type 2 diabetes.

Acta Diabetol 2021 Apr 14. Epub 2021 Apr 14.

Centre for Vision and Eye Research, Queensland University of Technology (QUT), Brisbane, QLD, 4059, Australia.

Aims: People with type 2 diabetes (T2D) suffer from sleep disorders, with the mechanism not clearly understood. In T2D, the light transducing retinal photoreceptors that regulate sleep behaviours are dysfunctional; hence, we determine here whether supplemental light exposure ameliorates sleep quality and daytime sleepiness in T2D.

Methods: Supplemental light (10,000 Lux, polychromatic) was self-administered for 30 min every morning for 14 days by ten participants with T2D with no diabetic retinopathy (DR). Read More

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Shift work disorder and related influential factors among shift workers in China.

Sleep Med 2021 Mar 13;81:451-456. Epub 2021 Mar 13.

Center for Public Health Initiatives, University of Pennsylvania, Philadelphia, PA, USA.

Background: Shift work may cause insomnia and sleepiness in individuals. The present study aimed to exam shift work disorder (SWD), and to investigate their associations with individual characteristics.

Methods: A total of 1833 shift workers were assessed using the Pittsburg Sleep Quality Index, Epworth Sleepiness Scale (ESS), Composite Scale of Morningness (CSM), Circadian Type Inventory (CTI), Center for Epidemiologic Studies-Depression Scale (CES-D), Beck Anxiety Inventory (BAI) and other self-compiled socio-demographic questionnaires. Read More

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Preliminary Validation of the Sleep and Concussion Questionnaire as an Outcome Measure for Sleep Following Brain Injury.

Brain Inj 2021 Apr 11:1-8. Epub 2021 Apr 11.

Oakville Centre for Cognitive Therapy, Oakville, Canada.

Background: Sleep and wakefulness disturbances are common with traumatic brain injury (TBI); however, there are no condition-specific measures to evaluate sleep following TBI.

Objective: To assess the convergent validity of the Sleep and Concussion Questionnaire (SCQ), a condition-specific (TBI) measure is compared to polysomnography and existing self-report sleep questionnaires.

Participants Included: Thirty-two adults diagnosed with mild TBI, 3-24 months post-injury, average age, 38. Read More

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Results of a prospective cardiovascular disease prevention program.

Prev Med Rep 2021 Jun 12;22:101344. Epub 2021 Mar 12.

Cardiovascular Health Program Registry, Henry M. Jackson Foundation for the Advancement of Military Medicine, 6720A Rockledge Drive, Bethesda, MD 20817, United States.

The Cardiovascular Health Program (CHP) Registry is a 12-month, prospective study of therapeutic lifestyle change (TLC). Adult participants received comprehensive assessment of health behaviors and cardiovascular disease (CVD) risk factors. Personalized TLC action plans addressed modifiable health behaviors for diet, exercise, stress management, and sleep. Read More

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Survey of Anesthesiologists on Topical Vasoconstrictors and Intravenous Tranexamic Acid for Endoscopic Sinus Surgery.

Ann Otol Rhinol Laryngol 2021 Apr 12:34894211005940. Epub 2021 Apr 12.

Department of Otolaryngology-Head and Neck Surgery, University of Texas Health Science Center San Antonio, San Antonio, TX, USA.

Objectives: Topical vasoconstrictors and intravenous tranexamic acid (IV TXA) are safe and efficacious to decrease bleeding and improve the surgical field during endoscopic sinus surgery (ESS). The purpose of this study was to investigate practice patterns, awareness of clinical evidence, and comfort levels among anesthesia providers regarding these hemostatic agents for ESS.

Methods: A total of 767 attending anesthesiologists, residents, and certified registered nurse anesthetists (CRNAs) at 5 United States academic centers were invited to participate in a survey regarding their experience with IV TXA and 3 topical vasoconstrictor medications (oxymetazoline, epinephrine, and cocaine) during ESS. Read More

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Sleep quality and daytime sleepiness in epilepsy: Systematic review and meta-analysis of 25 studies including 8,196 individuals.

Sleep Med Rev 2021 Mar 13;57:101466. Epub 2021 Mar 13.

Department of Neurology, Medical University Innsbruck, Austria. Electronic address:

We sought to gain a better understanding of the relationship between epilepsy and sleep quality and daytime sleepiness by performing a literature search of PubMed for case-control studies that compared patients with epilepsy to controls and reported the Pittsburgh sleep quality index (PSQI) and/or the Epworth sleepiness scale (ESS). Study-specific mean differences in the PSQI and ESS between cases and controls were extracted from the publications and pooled using random-effects meta-analysis. Twenty-five studies (2964 cases, 5232 controls) were included. Read More

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Endometrial Stem/Progenitor cell (ES/PC) Marker Expression Profile in Adenosarcoma and Endometrial Stromal Sarcoma.

Cancer Treat Res Commun 2021 Mar 31;27:100363. Epub 2021 Mar 31.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada; Department of Pathology, Toronto General Hospital, Toronto, ON, Canada.

Background: The uterus is one of the most dynamic organs in the human body, and this dynamic homeostasis is supported by endometrial stem/progenitor cells (ES/PCs), which are heterogeneous in their phenotype and degree of differentiation. ES/PCs are generally localized in the endometrial stroma, the site of origin for adenosarcoma and endometrial stromal sarcoma (ESS). Subsets of ESSs and adenosarcomas harbor SUZ12 or DICER1 gene alterations, two genes with roles in embryonic stem cell biology. Read More

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Sleep symptomatology is associated with greater subjective cognitive concerns: Findings from the community-based Healthy Brain Project.

Sleep 2021 Apr 10. Epub 2021 Apr 10.

The Turner Institute for Brain and Mental Health, Monash University, Clayton, Victoria, Australia.

Study Objectives: To examine if sleep symptomatology was associated with subjective cognitive concerns or objective cognitive performance in a dementia-free community-based sample.

Methods: A total of 1421 middle-aged participants (mean±standard deviation = 57±7; 77% female) from the Healthy Brain Project completed the Pittsburgh Sleep Quality Index (PSQI), Insomnia Severity Index (ISI), and Epworth Sleepiness Scale (ESS) to measure sleep quality, insomnia symptom severity, and daytime sleepiness, respectively. Participants were classified as having no sleep symptomatology (normal scores on each sleep measure), moderate sleep symptomatology (abnormal scores on one sleep measure), or high sleep symptomatology (abnormal scores on at least two sleep measures), using established cut-off values. Read More

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[A 180-day mortality predictive score based on frailty syndrome in elderly patients with sepsis: a Logistic regression analysis model].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 Mar;33(3):257-262

Department of Medical Intensive Care Unit, General Hospital of Southern Theatre Command; Guangzhou Key Laboratory of Geriatric Infection and Organ Function Support, Branch of National Clinical Research Center for Geriatric Diseases (Chinese PLA General Hospital), Guangzhou 510010, Guangdong, China.

Objective: To establish a 180-day mortality predictive score based on frailty syndrome in elderly sepsis patients [elderly sepsis score (ESS)].

Methods: A prospective study for sepsis patients aged 60 years and above who were admitted to a medical intensive care unit of the General Hospital of Southern Theatre Command from January 1st, 2018 to December 31st, 2018 was conducted. Univariate analysis was performed on 19 independent variables including gender, age, body mass index (BMI), tumor, charlson comorbidity index (CCI), activity of daily living (ADL), instrumental activity of daily living (IADL), mini-mental state examination (MMSE), geriatric depression scale (GDS), clinical frail scale (CFS), sequential organ failure assessment (SOFA), Glasgow coma scale (GCS), acute physiology and chronic health evaluation (APACHE II, APACHE IV), modified NUTRIC score (MNS), multiple drug resistance (MDR), mechanical ventilation (MV), continuous renal replacement therapy (CRRT) and palliative care. Read More

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Postoperative Infection Rate and Associated Factors Following Endoscopic Sinus Surgery.

Ann Otol Rhinol Laryngol 2021 Apr 9:34894211007240. Epub 2021 Apr 9.

Division of Rhinology and Endoscopic Skull Base Surgery, Department of Otolaryngology-Head and Neck Surgery, University of Washington, Seattle WA, USA.

Objectives: There is a paucity of data on postoperative infections after endoscopic sinus surgery and associated risk factors. Our objective was to evaluate a cohort of patients undergoing endoscopic sinus surgery (ESS) for chronic rhinosinusitis to determine which perioperative factors may be associated with infection in the 30-day postoperative period.

Methods: A retrospective cohort study of adults who underwent ESS at a tertiary academic medical center from 2015 to 2018 was performed. Read More

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A simulational study of the indirect-geometry neutron spectrometer BIFROST at the European Spallation Source, from neutron source position to detector position.

J Appl Crystallogr 2021 Feb 1;54(Pt 1):263-279. Epub 2021 Feb 1.

European Spallation Source ESS ERIC, PO Box 176, SE-221 00 Lund, Sweden.

The European Spallation Source (ESS) is intended to become the most powerful spallation neutron source in the world and the flagship of neutron science in upcoming decades. The exceptionally high neutron flux will provide unique opportunities for scientific experiments but also set high requirements for the detectors. One of the most challenging aspects is the rate capability and in particular the peak instantaneous rate capability, the number of neutrons hitting the detector per channel or cm at the peak of the neutron pulse. Read More

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February 2021

The efficacy of surgery for upper airway resistance syndrome: A systematic review, meta-analysis and case series.

Am J Otolaryngol 2021 Mar 29;42(5):103011. Epub 2021 Mar 29.

Department of Head and Neck Surgery, Kaiser Permanente Medical Center at Oakland, Oakland, CA, United States of America. Electronic address:

Purpose: Upper airway resistance syndrome (UARS) is a sleep related breathing disorder that was first described in 1993. This goal of this study is to determine the efficacy of surgical intervention for UARS.

Materials And Methods: Systematic review of the literature and a case series of UARS patients at a large integrated healthcare system. Read More

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Maxillomandibular advancement versus multilevel surgery for treatment of obstructive sleep apnea: A systematic review and meta-analysis.

Sleep Med Rev 2021 Mar 17;57:101471. Epub 2021 Mar 17.

Department of Oral and Maxillofacial Surgery, Amsterdam UMC Location AMC and Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam, Amsterdam, the Netherlands.

Multilevel surgery (MLS) and maxillomandibular advancement surgery (MMA) are two established options in surgical management of obstructive sleep apnea (OSA), which target different levels of airway obstruction. The objective of this review was to comparatively evaluate the clinical efficacy and safety of MMA and MLS in the treatment of OSA. MEDLINE and Embase databases were searched for studies on MMA and/or MLS in OSA patients. Read More

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Increased prevalence of obstructive sleep apnea in women diagnosed with endometrial or breast cancer.

PLoS One 2021 7;16(4):e0249099. Epub 2021 Apr 7.

Ludwig Engel Centre for Respiratory Research, The Westmead Institute for Medical Research, Sydney, Australia.

Background: Epidemiological studies demonstrate associations between obstructive sleep apnea (OSA) and cancer incidence and mortality. The aim of this study was to measure OSA in women with breast (BC) or endometrial cancer (EC) and associations with clinico-pathological tumor variables.

Methods And Findings: In a cross sectional study, women with BC (12 months) or EC (3 months) post-diagnosis were recruited from cancer clinics. Read More

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Scoping review: Health needs of the family caregivers of elderly stroke survivors.

Health Soc Care Community 2021 Apr 6. Epub 2021 Apr 6.

Department of Sociology, Faculty of Social and Political Science, Universitas Gadjah Mada, Yogyakarta, Indonesia.

This scoping review mapped out the relevant literature, identified gaps and made suggestions on the subject of the health needs of family caregivers (FC) of elderly stroke survivors (ESS). The authors utilised the PRISMA-ScR checklist to guide the scoping review. The databases PubMed, Elsevier and BioMed Central were searched for academic articles published in the English Language between the years 2010 and 2020 that met a pre-set criteria of content on the health needs of FC of ESS. Read More

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A seasonal hybrid model for the evolution of flowering onset.

J Theor Biol 2021 Apr 3:110668. Epub 2021 Apr 3.

Department of Mathematics and Statistics and Department of Biology, University of Ottawa, Ottawa, ON, K1N 6N5. Electronic address:

In strongly seasonal environments, many plants tend to divide the favorable season into an earlier part, where they allocate resources to vegetative growth, and a later part, where they allocate resources to reproduction. The onset of flowering typically indicates the shift from one to the other. We derive and analyze a model for the evolution of flowering onset on the phenotypic level. Read More

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A comparative study of two grading systems for epistaxis in hereditary haemorrhagic telangiectasia.

Rhinology 2021 Apr;59(2):212-218

Department of Otorhinolaryngology and Head and Neck Surgery, Oslo University Hospital, Medical Faculty, University of Oslo, Oslo, Norway.

Background: Different institutions use different grading systems for hereditary haemorrhagic telangiectasia (HHT)-associated epistaxis. It is important to have a universal, standardized grading system to compare and evaluate the effectiveness of different treatment options. We introduced the "Intensity, Frequency and need for Blood Transfusion" (IFT) grading system for HHT-associated epistaxis in 2008. Read More

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Quantification of Training Load Relative to Match Load of Youth National Team Soccer Players.

Sports Health 2021 Apr 5:19417381211004902. Epub 2021 Apr 5.

Department of Health Sciences and Sport Medicine, University of Physical Education, Budapest, Hungary.

Background: Previous studies have examined the training load relative to match load in club settings. The aims of this study were to (1) quantify the external training load relative to match load in days before a subsequent international game and (2) examine the cumulative training load in relation to match load of U-17 national team field soccer players.

Hypothesis: Volume and intensity load parameters will vary between trainings; the farthermost trainings have the highest load gradually decreasing toward the match. Read More

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