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Assessment of MRI and US Screening for Tethered Cord Syndrome in Patients Diagnosed With Esophageal Atresia/Tracheoesophageal Fistula.

J Surg Res 2022 Jun 29;279:193-199. Epub 2022 Jun 29.

Division of Pediatric Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin.

Introduction: Infants with esophageal atresia and/or tracheoesophageal fistula (EA/TEF) undergo screening for tethered cord syndrome (TCS) via ultrasound and magnetic resonance imaging. Existing literature lacks data to guide optimal timing of screening and magnetic resonance imaging (MRI) is often delayed until 3-6 mo of age, when it is frequently forgotten. Detethering surgery has a high rate of success in patients with TCS and is often performed prophylactically due to potential irreversible deficits. Read More

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Association Between Socioeconomic and Insurance Status and Delayed Diagnosis of Gastrointestinal Cancers.

J Surg Res 2022 Jun 29;279:170-186. Epub 2022 Jun 29.

Department of Surgery, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, New York; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York; Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey. Electronic address:

Introduction: Association between socioeconomic status (SES) and stage at diagnosis in gastrointestinal (GI) cancers is poorly described. Relationship between low SES and stage at diagnosis as well as the mediating role of insurance status (IS) was examined.

Methods: The Surveillance, Epidemiology, and End Results database was queried for esophageal, gastric, liver, biliary, pancreatic, colon, and rectal cancers diagnosed in 2012-2016. Read More

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The benefit of concurrent chemotherapy with radiotherapy for esophageal cancer is limited in Asian patients aged 80 years or older: a SEER database analysis.

Esophagus 2022 Jul 2. Epub 2022 Jul 2.

Department of Radiation Oncology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-chou, Aoba-ku, Sendai, 980-8574, Japan.

Purpose: To evaluate the benefit of concurrent chemotherapy with radiotherapy (RT) for esophageal cancer in Asian patients aged ≥ 80 years using the Surveillance, Epidemiology, and End Results (SEER) database.

Materials And Methods: Among more than 7000 patients with squamous cell carcinoma or adenocarcinoma who were treated by RT without surgery for esophageal cancer in the SEER database, 2047 patients aged ≥ 80 years were analyzed. Patients who received chemoradiotherapy (CRT group) and patients who received RT alone (RT alone group) were matched with a propensity score. Read More

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Impact of body composition on survival of PD-1/PD-L1-treated metastatic gastro-esophageal junction/gastric cancer.

Gastric Cancer 2022 Jul 2. Epub 2022 Jul 2.

Drug Development Unit, Sarah Cannon Research Institute UK, London, UK.

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Definitive chemoradiotherapy has comparable survival outcomes to esophagectomy in patients with clinical T1N0M0 esophageal squamous cell carcinoma: real-world data.

Int J Clin Oncol 2022 Jul 2. Epub 2022 Jul 2.

Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.

Background: Recently, the JCOG0502 has shown a comparable efficacy of chemoradiotherapy and esophagectomy in patients with clinical T1N0M0 esophageal squamous cell carcinoma. However, few studies have compared the clinical outcomes of these treatments in esophageal squamous cell carcinoma patients (including elderly patients) based on real-world data.

Methods: This retrospective study determined real-world outcomes in patients who underwent chemoradiotherapy or esophagectomy, including those with clinical T1N0M0 esophageal squamous cell carcinoma, between 2009 and 2017 at the National Cancer Center Hospital East. Read More

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Eosinophilic Esophagitis: Immune Mechanisms and Therapeutic Targets.

Clin Exp Allergy 2022 Jul 1. Epub 2022 Jul 1.

Mary H Weiser Food Allergy Center, University of Michigan, Ann Arbor, MI, USA.

Eosinophilic esophagitis (EoE) is an emerging chronic inflammatory disease of the esophagus and is clinically characterized by upper gastrointestinal (GI) symptoms including dysphagia and esophageal food impaction. Histopathologic manifestations, which include intraepithelial eosinophilic inflammation and alterations of the esophageal squamous epithelium, such as basal zone hyperplasia (BZH) and dilated intercellular spaces (DIS), are thought to contribute to esophageal dysfunction and disease symptoms. Corroborative clinical and discovery science-based studies have established that EoE is characterized by an underlying allergic inflammatory response, in part, related to the IL-13/CCL26/eosinophil axis driving dysregulation of several key epithelial barrier and proliferative regulatory genes including kallikrein (KLK) serine proteases, calpain 14 (CAPN14) and anoctamin 1 (ANO1). Read More

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FOXD2-AS1 acts an oncogene in esophageal squamous cell carcinoma through sponging miR-204-3p.

Clin Transl Oncol 2022 Jul 1. Epub 2022 Jul 1.

Department of Thoracic Surgery, Affiliated Tumor Hospital of Xinjiang Medical University, Suzhou Street 789, Ürümqi, 830011, China.

Purpose: A growing number of evidences has revealed that long non-coding RNAs (lncRNAs) have vital effect in the pathogenesis of esophageal squamous cell carcinoma (ESCC). In our work, we found that lncRNA FOXD2 adjacent opposite strand RNA 1 (FOXD2-AS1) was significantly increased in clinical ESCC samples and cell lines.

Methods: The biological effect of FOXD2-AS1 on EC109 and KYSE150 cells showed that the low expression of FOXD2-AS1 inhibited the proliferation through CCK8 and colony formation assays, invasion by transwell chamber test, migration abilities by wound healing assay, and enhance apoptosis rates by flow cytometry assay. Read More

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A comparison of the effects of anti-reflux procedures during esophagogastrostomy after proximal gastrectomy on the postoperative quality of life.

Surg Today 2022 Jul 1. Epub 2022 Jul 1.

Department of Laboratory Medicine, The Jikei University School of Medicine, Tokyo, Japan.

Purpose: To investigate the postoperative quality of life (QOL) in patients with proximal gastric cancer (PGC) or esophago-gastric junction cancer, a nationwide multi-institutional study (PGSAS NEXT trial) was conducted.

Methods: Patients who had undergone radical resection more than 6 months previously were enrolled from 70 Japanese institutions between July 2018 and June 2020. The Postgastrectomy Syndrome Assessment Scale (PGSAS)-45 questionnaire was distributed to eligible patients, and responses were collected by mail. Read More

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An artificial intelligence algorithm is highly accurate for detecting endoscopic features of eosinophilic esophagitis.

Sci Rep 2022 Jul 1;12(1):11115. Epub 2022 Jul 1.

(Internal) Medicine III - Gastroenterology, University Hospital of Augsburg, Stenglinstrasse 2, 86156, Augsburg, Germany.

The endoscopic features associated with eosinophilic esophagitis (EoE) may be missed during routine endoscopy. We aimed to develop and evaluate an Artificial Intelligence (AI) algorithm for detecting and quantifying the endoscopic features of EoE in white light images, supplemented by the EoE Endoscopic Reference Score (EREFS). An AI algorithm (AI-EoE) was constructed and trained to differentiate between EoE and normal esophagus using endoscopic white light images extracted from the database of the University Hospital Augsburg. Read More

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Propensity-score matched analysis to evaluate efficacy of endoscopic submucosal dissection for superficial esophageal cancer in gastrectomized patients.

Sci Rep 2022 Jul 1;12(1):11142. Epub 2022 Jul 1.

Department of Gastroenterology and Hepatology, Mie University Hospital, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan.

Endoscopic submucosal dissection (ESD) is a minimally invasive treatment option for superficial esophageal cancer (SEC) with high rates of complete resection. However, limited research exists on the efficacy of ESD for SEC in gastrectomized patients. This study aimed to evaluate the efficacy of ESD for SEC in gastrectomized patients. Read More

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The role of polyglycolic acid sheets in the management of post-endoscopic submucosal dissection gastrointestinal bleeding and esophageal stricture: A PRISMA compliant systematic review and meta-analysis.

Medicine (Baltimore) 2022 Jul 1;101(26):e29770. Epub 2022 Jul 1.

Department of Gastroenterology, Affiliated Hospital of Southwest Medical University, Luzhou, China.

Background: As a relatively minimally invasive technique, endoscopic submucosal dissection (ESD) is widely used for the treatment of gastrointestinal lesions. However, it is associated with complications, such as postoperative bleeding, stricture, and perforation. A covering method using polyglycolic acid (PGA) sheets for ESD-induced ulcers has been reported to be effective in reducing the risk of post-ESD bleeding and esophageal stricture. Read More

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Objective Outcomes of an Extended Anti-reflux Mucosectomy in the Treatment of PPI-Dependent Gastroesophageal Reflux Disease (with Video).

J Gastrointest Surg 2022 Jul 1. Epub 2022 Jul 1.

Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.

Background: Anti-reflux mucosectomy (ARMS) is a choice for proton pump inhibitor (PPI)-dependent patients with gastroesophageal reflux disease (GERD). We present an extended anti-reflux mucosectomy, named ligation-assisted anti-reflux mucosectomy (L-ARMS). The aim of this study was to assess the feasibility of the procedure and short-term outcomes on PPI use and symptom resolution. Read More

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The negative feedback loop FAM129A/CXCL14 aggravates the progression of esophageal cancer.

Eur Rev Med Pharmacol Sci 2022 Jun;26(12):4220-4227

Department of Thoracic Surgery, Shangqiu First People's Hospital, Shangqiu, China.

Objective: To explore the molecular mechanisms of FAM129A in regulating the progression of esophageal cancer and its prognosis.

Patients And Methods: FAM129A levels in esophageal cancer tissues and paracancerous ones were detected by quantitative real-time polymerase chain reaction (qRT-PCR). Its influences on clinical features and prognosis in esophageal cancer patients were analyzed. Read More

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[Minimally invasive esophagectomy for benign esophageal diseases: results of a two-center study].

Khirurgiia (Mosk) 2022 (7):5-11

Petrovsky National Research Centre of Surgery, Moscow, Russia.

Objective: To analyze the results of thoracoscopic esophagectomy for benign esophageal diseases.

Material And Methods: The study included 78 patients who underwent thoracoscopic esophagectomy between 2011 and 2019. Peptic and burn strictures of the esophagus were diagnosed in 53 patients, achalasia - in 24 patients. Read More

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January 2022

Gastric perforation: An unusual complication after esophageal intubation.

Ulus Travma Acil Cerrahi Derg 2022 Jul;28(7):1035-1037

Department of Radiology, Sancaktepe Şehit Prof. Dr. İlhan Varank Training and Research Hospital, İstanbul-Türkiye.

Gastric perforation secondary to accidental esophageal intubation is a very rare mortal complication with only a few cases reported in the literature. In the management of this fatal complication, the early diagnosis and rapid surgical intervention are critical. In this case report, we present our experience with an unusual case, who required intubation in the intensive care unit due to acute hypoxemia and subsequently developed gastric perforation. Read More

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Laparoscopic fundoplication after oesophageal atresia repair.

Afr J Paediatr Surg 2022 Jul-Sep;19(3):149-152

Department of Pediatric Surgery and Urology, Institute for Maternal and Child Health - IRCCS "Burlo Garofolo," Trieste, Italy.

Background: Esophageal atresia (EA) is a rare congenital malformation. A high incidence of GER unresponsive to medical management is noted with EA. Literature suggests that complications from GER can persist in adulthood. Read More

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Clinical Improvement With Pyridostigmine in a Patient With Acetylcholine Receptor Antibody-Associated Autoimmune Gastrointestinal Dysmotility.

ACG Case Rep J 2022 Jun 27;9(6):e00796. Epub 2022 Jun 27.

Division of Gastroenterology and Hepatology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI.

Autoimmune gastrointestinal dysmotility (AGID) is a rare form of limited autoimmune dysautonomia caused by autoantibodies against the enteric nervous system. Our patient was a 53-year-old man with 1 year of bloating, intolerance of oral intake, and recurrent ileus. Esophageal manometry showed aperistalsis and hypotensive lower sphincter, consistent with scleroderma esophagus. Read More

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Massive Mural Thrombus Masquerading as Myxoma.

Cureus 2022 May 29;14(5):e25440. Epub 2022 May 29.

Interventional Cardiology, HCA Florida Bayonet Point Hospital, Hudson, USA.

A 75-year-old Caucasian female with a past medical history including insulin-dependent diabetes mellitus, hypertension, and dyslipidemia, presented to the emergency room for having palpitations for three weeks. Echocardiography revealed a very large left atrial mass mimicking myxoma. Mass was excised and examined by pathology, revealing a mural thrombus. Read More

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Pseudocirrhosis Due to Desmoplastic Response to Chemotherapy in Breast Cancer Liver Metastases.

Cureus 2022 May 25;14(5):e25321. Epub 2022 May 25.

Department of Gastroenterology and Medicine, Fukuoka University Faculty of Medicine, Fukuoka, JPN.

Pseudocirrhosis can result in cirrhosis-like symptoms of portal hypertension and is observed mostly in patients with breast cancer; however, its cause is unclear. Herein, we report a case of pseudocirrhosis in a 76-year-old woman with metastatic breast cancer. The patient developed irregular contours of the liver, resembling cirrhosis, and esophageal varices during chemotherapy for breast cancer with liver metastases. Read More

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Treatment With Endoscopic Ultrasound (EUS)-Guided Transesophageal Coil Embolization Without Sclerotherapy: A Novel Therapy for Giant Distal Esophageal Hemangioma.

Cureus 2022 May 24;14(5):e25303. Epub 2022 May 24.

Department of Medicine, Sultan Qaboos University Hospital, Muscat, OMN.

Giant esophageal hemangiomas are rare. The extent is usually in the mediastinum but may spread down to the upper abdomen. Such vascular pathology is hard to treat and typically to be resected along with the organs it is attached to. Read More

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Cost-Effectiveness Analysis of Pembrolizumab Plus Chemotherapy vs. Chemotherapy Alone as First-Line Treatment in Patients With Esophageal Squamous Cell Carcinoma and PD-L1 CPS of 10 or More.

Front Public Health 2022 14;10:893387. Epub 2022 Jun 14.

Department of Pharmacy, Fujian Medical University Union Hospital, Fuzhou, China.

Background: This study aimed to analyze the economics of pembrolizumab plus chemotherapy as first-line treatment in patients with esophageal squamous cell carcinoma (ESCC) and programmed cell death-Ligand 1 (PD-L1) combined positive score (CPS) of 10 or more in China.

Methods: Based on the advanced ESCC of the KEYNOTE-590 clinical trial data, a Markov model was performed to simulate the clinical course and evaluate the patient's total lifetime, total costs, quality-adjusted life-years (QALYs), and incremental cost-effectiveness ratio (ICER) for pembrolizumab plus chemotherapy (cisplatin and 5-fluorouracil) vs. chemotherapy alone in first-line treatment of ESCC and PD-L1 CPS of 10 or more. Read More

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Health Care Resource Utilization for Esophageal Cancer Using Proton versus Photon Radiation Therapy.

Int J Part Ther 2022 23;9(1):18-27. Epub 2022 Jun 23.

Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Purpose: In patients treated with chemoradiation for esophageal cancer (EC), randomized trial data demonstrate that proton beam therapy (PBT) reduces toxicities and postoperative complications (POCs) compared with intensity-modulated radiation therapy (IMRT). However, whether radiation therapy modality affects postoperative health care resource utilization remains unknown.

Materials And Methods: We examined 287 patients with EC who received chemoradiation (prescribed 50. Read More

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Case Report: Successful Repair of Primary Aortoesophageal Fistula With an Endovascular Stent Graft and an Esophageal Stent.

Front Surg 2022 14;9:868663. Epub 2022 Jun 14.

Department of Emergency, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.

Aortoesophageal fistula (AEF), secondary to thoracic pseudoaneurysm as a result of upper gastrointestinal bleeding, is a rare condition and will be undoubtedly lethal without prompt surgical intervention. The estimated annual incidence of primary AEFs and secondary AEFs is about 0.0015% and 0. Read More

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Nomogram for Predicting Occult Locally Advanced Esophageal Squamous Cell Carcinoma Before Surgery.

Front Surg 2022 14;9:917070. Epub 2022 Jun 14.

Department of Thoracic Surgery, Fujian Medical University Union Hospital, Fuzhou, China.

Introduction: The limitations of preoperative examination result in locally advanced esophageal squamous cell carcinoma (ESCC) often going undetected preoperatively. This study aimed to develop a clinical tool for identifying patients at high risk for occult locally advanced ESCC; the tool can be supplemented with preoperative examination to improve the reliability of preoperative staging.

Materials And Methods: Data of 598 patients who underwent radical resection of ESCC from 2010 to 2017 were analyzed. Read More

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Esophageal epithelial immunoglobulin G is an important marker for the diagnosis and management of pediatric eosinophilic esophagitis.

JGH Open 2022 Jun 14;6(6):402-407. Epub 2022 May 14.

Center for Digestive Health and Nutrition Arnold Palmer Hospital for Children Orlando Florida USA.

Background And Aim: Our primary aim was to describe the prevalence of immunoglobulin G (IgG) and its subclass IgG4 in immunohistochemistry staining in esophageal biopsy specimens of children with eosinophilic esophagitis (EoE) compared with that of specimens from children with gastroesophageal reflux disease (GERD).

Methods: Esophageal biopsy specimens from children with EoE or GERD were stained prospectively for IgG and IgG4 antibodies. Subjects with EoE were divided into cohorts with either active EoE or EoE in remission. Read More

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Left-sided atrial tachycardia ablation in an atrial-esophageal fistula survivor.

HeartRhythm Case Rep 2022 Jun 18;8(6):428-432. Epub 2022 Mar 18.

Department of Cardiology, Maastricht University Medical Center, Maastricht, the Netherlands.

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The effect of enhanced recovery after minimally invasive esophagectomy: a randomized controlled trial.

Surg Endosc 2022 Jun 30. Epub 2022 Jun 30.

Department of Anesthesiology, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, China.

Background: The purpose of this randomized controlled trial was to determine if enhanced recovery after surgery (ERAS) would improve outcomes for three-stage minimally invasive esophagectomy (MIE).

Methods: Patients with esophageal cancer undergoing MIE between March 2016 and August 2018 were consecutively enrolled, and were randomly divided into 2 groups: ERAS+group that received a guideline-based ERAS protocol, and ERAS- group that received standard care. The primary endpoint was morbidity after MIE. Read More

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Evaluation of Expression Of ADAM 10 as a Predictor of Lymph Node Metastasis in Oral Squamous Cell Carcinoma-An Immunohistochemical Study.

Head Neck Pathol 2022 Jun 30. Epub 2022 Jun 30.

Dental Surgeon, Department of Pedodontics, Government Dental College and Hospital, Aurangabad, Maharashtra, India.

Background: Lymph node metastasis (LNM) is a well-known prognostic factor in Oral Squamous Cell Carcinoma(OSCC). A biological marker that predicts the Lymph Node Metastasis (LNM) in OSCC cases is the need of the hour. A Disintegrin And Metalloproteinases (ADAMs), a family of proteins that exhibit a metalloproteinase domain play a pivotal role in the pathogenesis of tumor growth and metastasis. Read More

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Nocturnal acid breakthrough and esophageal acidification during treatment with dexlansoprazole as compared to omeprazole in patients with gastroesophageal reflux disease.

Indian J Gastroenterol 2022 Jun 30. Epub 2022 Jun 30.

Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, 226 014, India.

Background: Nocturnal acid breakthrough (NAB) may differ based on duration of proton pump inhibitor (PPI) action and Helicobacter pylori (H. pylori) infection; NAB may influence esophageal acidification (EA) and mucosal damage. Dexlansoprazole, a long-acting PPI, was not compared with omeprazole for NAB, gastric acid suppression, and EA in relation to H. Read More

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