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Long Multi-Stage Training for a Motor-Impaired User in a BCI Competition.

Front Hum Neurosci 2021 25;15:647908. Epub 2021 Mar 25.

Université Côte d'Azur, Inria, France.

In a Mental Imagery Brain-Computer Interface the user has to perform a specific mental task that generates electroencephalography (EEG) components, which can be translated in commands to control a BCI system. The development of a high-performance MI-BCI requires a long training, lasting several weeks or months, in order to improve the ability of the user to manage his/her mental tasks. This works aims to present the design of a MI-BCI combining mental imaginary and cognitive tasks for a severely motor impaired user, involved in the BCI race of the Cybathlon event, a competition of people with severe motor disability. Read More

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Oxidative stress and endoplasmic reticulum stress contribute to subsp. M5L exopolysaccharide-induced apoptosis in HT-29 cells.

Food Sci Nutr 2021 Mar 29;9(3):1676-1687. Epub 2021 Jan 29.

College of Food Science and Technology Northwest University Xi'an China.

Colorectal cancer is the third most malignant cancer occurring around the world. Effective prevention and treatment have been increasingly the focus of global attention. Long-term diet of fermented dairy inhibits proliferation of colon cancer cell, which is considered that not only live lactic acid bacteria but also the secreted exopolysaccharides exert the function. Read More

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Alternative oxidase encoded by sequence-optimized and chemically-modified RNA transfected into mammalian cells is catalytically active.

Gene Ther 2021 Mar 4. Epub 2021 Mar 4.

Faculty of Medicine and Health Technology, FI-33014 Tampere University, Tampere, Finland.

Plants and other organisms, but not insects or vertebrates, express the auxiliary respiratory enzyme alternative oxidase (AOX) that bypasses mitochondrial respiratory complexes III and/or IV when impaired. Persistent expression of AOX from Ciona intestinalis in mammalian models has previously been shown to be effective in alleviating some metabolic stresses produced by respiratory chain inhibition while exacerbating others. This implies that chronic AOX expression may modify or disrupt metabolic signaling processes necessary to orchestrate adaptive remodeling, suggesting that its potential therapeutic use may be confined to acute pathologies, where a single course of treatment would suffice. Read More

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Downregulation of XBP1 protects kidney against ischemia-reperfusion injury via suppressing HRD1-mediated NRF2 ubiquitylation.

Cell Death Discov 2021 Mar 2;7(1):44. Epub 2021 Mar 2.

Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Key Laboratory of Organ Transplantation of Ministry of Education, National Health Commission and Chinese Academy of Medical Sciences, 430030, Wuhan, Hubei, China.

Ischemia-reperfusion (IR) injury to the renal epithelia is associated with endoplasmic reticulum stress (ERS) and mitochondria dysfunction, which lead to oxidative stress-induced acute kidney injury (AKI). X-box binding protein 1 (XBP1), an ERS response protein, could play a prominent role in IR-induced AKI. In this study, we revealed that XBP1 and its downstream target HRD1 participated in the crosstalk between ERS and mitochondrial dysfunction via regulation of NRF2/HO-1-mediated reactive oxidative stress (ROS) signaling. Read More

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Proteolytic Targeting Chimeras with Specificity for Plasma Membrane and Intracellular Estrogen Receptors.

Mol Pharm 2021 03 18;18(3):1455-1469. Epub 2021 Feb 18.

Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, Iowa 52242, United States.

Decisions regarding the assignment of hormonal therapy for breast cancer are based solely upon the presence of nuclear estrogen receptors (ERs) in biopsied tumor tissue. This is despite the fact that the G-protein-coupled estrogen receptor (GPER) is linked to advanced breast cancer and is required for breast cancer stem cell survival, an observation that suggests that effective endocrine therapy should also target this receptor. Here, two ER/GPER-targeting proteolytic chimeras (UI-EP001 and UI-EP002) are described that effectively degrade ERα, ERβ, and GPER. Read More

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Bariatric surgery can acutely modulate ER-stress and inflammation on subcutaneous adipose tissue in non-diabetic patients with obesity.

Diabetol Metab Syndr 2021 Feb 16;13(1):19. Epub 2021 Feb 16.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Ribeirao Preto Medical School, University of Sao Paulo (USP), Avenida Bandeirantes, 3900-Vila Monte Alegre, Ribeirao Preto, SP, 14049-900, Brazil.

Background: Bariatric surgery, especially Roux-en-Y gastric bypass (RYGB), is the most effective and durable treatment option for severe obesity. The mechanisms involving adipose tissue may be important to explain the effects of surgery.

Methods: We aimed to identify the genetic signatures of adipose tissue in patients undergoing RYGB. Read More

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February 2021

Dexmedetomidine and Netrin-1 Combination Therapy Inhibits Endoplasmic Reticulum Stress by Regulating the ERK5/MEF2A Pathway to Attenuate Cerebral Ischemia Injury.

Front Neurosci 2021 28;15:641345. Epub 2021 Jan 28.

Department of Anesthesiology, West China Hospital of Sichuan University, Chengdu, China.

The complexity of hard-to-treat diseases such as ischemic stroke strongly undermines the therapeutic potential of available treatment options. Therefore, current developments have gently shifted from a focus on monotherapy to combined or multiple therapies. Both dexmedetomidine and Netrin-1 have anti-neuronal apoptosis effects, but the mechanism is still unclear. Read More

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January 2021

Multi-Stakeholder Retrospective Acceptability of a Peer Support Intervention for Exercise Referral.

Int J Environ Res Public Health 2021 Feb 10;18(4). Epub 2021 Feb 10.

Health Research Institute, Edge Hill University, Ormskirk L39 4QP, UK.

Perceived social support opportunities are central to successful exercise referral scheme (ERS) client experiences. However, there remains a lack of guidance on how ERSs can embed social support opportunities within their provision. This study presents retrospective acceptability findings from a 12-week social-identity-informed peer support intervention to enhance perceived social support among clients of an English ERS. Read More

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February 2021

The novel GLP-1/GIP dual agonist DA3-CH is more effective than liraglutide in reducing endoplasmic reticulum stress in diabetic rats with cerebral ischemia-reperfusion injury.

Nutr Metab Cardiovasc Dis 2021 01 12;31(1):333-343. Epub 2020 Sep 12.

Second Hospital, Neurology Department, Shanxi Medical University, Taiyuan 030001, Shanxi province, PR China; Research and Experimental Center, Henan University of Chinese Medicine, Zhengzhou 450046, Henan province, PR China.

Background And Aims: Diabetes is one of the most important risk factors and comorbidities of ischemic stroke. Endoplasmic reticulum stress (ERS) is considered to be the major injury mechanism of ischemic stroke with diabetes. Studies have found that incretin can inhibit ERS in ischemia-reperfusion injury of the liver and heart. Read More

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January 2021

EEG signals respond differently to idea generation, idea evolution and evaluation in a loosely controlled creativity experiment.

Sci Rep 2021 Jan 22;11(1):2119. Epub 2021 Jan 22.

Concordia Institute for Information Systems Engineering, Gina Cody School of Engineering and Computer Science, Concordia University, Montreal, QC, Canada.

Many neurocognitive studies endeavor to understand neural mechanisms of basic creative activities in strictly controlled experiments. However, little evidence is available regarding the neural mechanisms of interactions between basic activities underlying creativity in such experiments. Moreover, strictly controlled experiments might limit flexibility/freedom needed for creative exploration. Read More

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January 2021

Complex home assessment of long-term non-invasive ventilation efficacy using transcutaneous monitoring of PCO and polygraphy - A feasibility study.

Adv Med Sci 2021 Jan 15;66(1):105-112. Epub 2021 Jan 15.

Department of Internal Medicine, Pulmonary Diseases and Allergy, Medical University of Warsaw, Warsaw, Poland.

Purpose: Home non-invasive ventilation (HNIV) during sleep is a standard treatment for chronic hypercapnic respiratory failure (CHRF). The aim of this study was to evaluate the feasibility of the complex overnight assessment of HNIV in adults performed at home and the efficacy of HNIV after one year of treatment.

Methods: Stable patients with CHRF on HNIV for more than 12 months had unattended polygraphy (PG) with transcutaneous monitoring of PCO (tcPCO) at home during one night. Read More

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January 2021

A novel DNA chromatography method to discriminate Mycobacterium abscessus subspecies and macrolide susceptibility.

EBioMedicine 2021 Feb 11;64:103187. Epub 2021 Jan 11.

Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases, Toyko, Japan. Electronic address:

Background: The clinical impact of infection with Mycobacterium (M.) abscessus complex (MABC), a group of emerging non-tuberculosis mycobacteria (NTM), is increasing. M. Read More

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February 2021

Unprecedented enhancement of wear resistance for epoxy-resin graphene composites.

Nanoscale 2021 Feb;13(5):2855-2867

Key Laboratory for Precision and Non-Traditional Machining Technology of Ministry of Education, Dalian University of Technology, Dalian 116024, China.

Epoxy resins (ERs) have extraordinary mechanical, electrical and chemical properties, and are widely used in the aerospace, electronics and marine industries. Nonetheless, solidified ERs have intrinsic brittleness and low wear resistance. Until now, the promotion of the wear resistance of ER is limited to 30 times, through blending from one to four reinforcing materials. Read More

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February 2021

Evaluating the real-life effect of MP-AzeFlu on asthma outcomes in patients with allergic rhinitis and asthma in UK primary care.

World Allergy Organ J 2020 Dec 19;13(12):100490. Epub 2020 Dec 19.

Observational and Pragmatic Research Institute, Singapore.

Background: MP-AzeFlu (Dymista®; spray of azelastine/fluticasone propionate) is the most effective allergic rhinitis (AR) treatment available. Its effect on asthma outcomes in patients with AR and asthma is unknown.

Methods: This pre-post historical cohort study, using the Optimum Patient Care Research Database, included patients aged ≥12 years, from UK general practice with active asthma (defined as a recorded diagnosis, with ≥1 prescription for reliever or controller inhaler) in the year before or at the initiation date. Read More

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December 2020

Readily usable strategies to control mastitis for production augmentation in dairy cattle: A review.

Vet World 2020 Nov 9;13(11):2364-2370. Epub 2020 Nov 9.

Department of Animal Nutrition, ICAR-National Dairy Research Institute, ERS, Kalyani Nadia, West Bengal, India.

Mastitis in dairy cattle is the most common management disorder that causes higher economic losses by lowering production and quality of milk leads to substantial economical loss. The aim of this article was to review worldwide important advances in strategies to control mastitis for production augmentation in dairy cattle. Many scientists worked to identify effective strategies to control mastitis caused by , and others. Read More

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November 2020

Stabilization of PFAS-contaminated soil with activated biochar.

Sci Total Environ 2021 Apr 8;763:144034. Epub 2020 Dec 8.

Department of Environmental Chemistry, Norwegian Geotechnical Institute (NGI), Oslo, Norway; Faculty of Environmental Science and Natural Resource Management (MINA), University of Life Sciences (NMBU), Ås, Norway.

Biochars are considered potential sustainable sorbents to reduce the leaching of per- and polyfluoroalkyl substances (PFAS) from contaminated soils. However, biochar characteristics must probably be optimized to achieve useful sorption capacity. In the present work, eight waste timber biochars were produced, including biochars activated to different degrees, at different temperatures, and using both steam and CO. Read More

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Therapeutic Perspectives on the Modulation of G-Protein Coupled Estrogen Receptor, GPER, Function.

Front Endocrinol (Lausanne) 2020 23;11:591217. Epub 2020 Nov 23.

Department of Surgery, University of Iowa, Carver College of Medicine, Iowa City, IA, United States.

Estrogens exert their physiological and pathophysiological effects cellular receptors, named ERα, ERβ, and G-protein coupled estrogen receptor (GPER). Estrogen-regulated physiology is tightly controlled by factors that regulate estrogen bioavailability and receptor sensitivity, while disruption of these control mechanisms can result in loss of reproductive function, cancer, cardiovascular and neurodegenerative disease, obesity, insulin resistance, endometriosis, and systemic lupus erythematosus. Restoration of estrogen physiology by modulating estrogen bioavailability or receptor activity is an effective approach for treating these pathological conditions. Read More

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November 2020

Understanding adherence of hypertensive patients in Mexico to an exercise-referral scheme for increasing physical activity.

Health Promot Int 2020 Dec 3. Epub 2020 Dec 3.

Health Systems Research Center, National Institute of Public Health, Cuernavaca, Morelos, Mexico.

Among the strategies developed thus far for promoting physical activity (PA), exercise-referral schemes (ERs) have gained in popularity as an effective means of preventing secondary health conditions such as hypertension. However, information on the factors affecting adherence to these programs is limited. Using a mixed-methods approach, we undertook the present study to determine the factors associated with adherence to a specific ER aimed at increasing PA among the hypertensive patients in a Social Security institution in Mexico. Read More

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December 2020

Extracellular vesicles from hydroxycamptothecin primed umbilical cord stem cells enhance anti-adhesion potential for treatment of tendon injury.

Stem Cell Res Ther 2020 11 25;11(1):500. Epub 2020 Nov 25.

Department of Orthopaedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, No. 600 Yishan Road, Shanghai, China.

Background: Peritendinous fibrosis represents a fibrotic healing process that usually occurs after tendon injury or surgery. This worldwide challenge hampers the functional rehabilitation and the mobility of extremities. However, effective treatment is still lacking at present. Read More

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November 2020

Estrogen receptors α, β and GPER in the CNS and trigeminal system - molecular and functional aspects.

J Headache Pain 2020 Nov 10;21(1):131. Epub 2020 Nov 10.

Department of Clinical Experimental Research, Glostrup Research Institute, Rigshospitalet, Glostrup, Denmark.

Background: Migraine occurs 2-3 times more often in females than in males and is in many females associated with the onset of menstruation. The steroid hormone, 17β-estradiol (estrogen, E2), exerts its effects by binding and activating several estrogen receptors (ERs). Calcitonin gene-related peptide (CGRP) has a strong position in migraine pathophysiology, and interaction with CGRP has resulted in several successful drugs for acute and prophylactic treatment of migraine, effective in all age groups and in both sexes. Read More

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November 2020

Discovering Electron-Transfer-Driven Changes in Chemical Bonding in Lead Chalcogenides (PbX, where X = Te, Se, S, O).

Adv Mater 2020 Dec 2;32(49):e2005533. Epub 2020 Nov 2.

Institute of Physics IA, RWTH Aachen University, Aachen, 52074, Germany.

Understanding the nature of chemical bonding in solids is crucial to comprehend the physical and chemical properties of a given compound. To explore changes in chemical bonding in lead chalcogenides (PbX, where X = Te, Se, S, O), a combination of property-, bond-breaking-, and quantum-mechanical bonding descriptors are applied. The outcome of the explorations reveals an electron-transfer-driven transition from metavalent bonding in PbX (X = Te, Se, S) to iono-covalent bonding in β-PbO. Read More

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December 2020

Dexmedetomidine Attenuates Cellular Injury and Apoptosis in H9c2 Cardiomyocytes by Regulating p-38MAPK and Endoplasmic Reticulum Stress.

Drug Des Devel Ther 2020 12;14:4231-4243. Epub 2020 Oct 12.

Department of Anesthesiology, The Second Affiliated Hospital of Jiaxing University, Jiaxing City, Zhejiang Province 314000, People's Republic of China.

Background: Myocardial ischaemia-reperfusion injury (IRI) has been confirmed to induce endoplasmic reticulum stress (ERS) when myocardial cell function continues to deteriorate to a certain degree. The clinical applications of effective tested strategies are sometimes inconsistent with the applications evaluated in experiments, although reasonable mechanisms and diverse signalling pathways have been broadly explored. Dexmedetomidine (DEX) has been shown to attenuate IRI of the heart in animal studies. Read More

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October 2020

Chlorin A-mediated photodynamic therapy induced apoptosis in human cholangiocarcinoma cells via impaired autophagy flux.

Am J Transl Res 2020 15;12(9):5080-5094. Epub 2020 Sep 15.

Shanghai Key Laboratory of Pancreatic Diseases and Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine Shanghai, China.

Background: Photodynamic therapy (PDT) is a promising strategy for multiple cancers. Chlorin e6 and its derivative 13-[2'-(2-pyridyl)ethylamine] Chlorin e6 (Chlorin A) are effective photosensitizers, although their cytotoxic mechanisms have not yet been fully characterized.

Methods: Cell viability and apoptosis were evaluated by CCK8 assay, TUNEL assay, and Annexin V/PI staining. Read More

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September 2020

Real-life effectiveness of mepolizumab in patients with severe refractory eosinophilic asthma and multiple comorbidities.

World Allergy Organ J 2020 Sep 18;13(9):100462. Epub 2020 Sep 18.

Respiratory Medicine Unit, A.O.U. "Policlinico-Vittorio Emanuele", Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.

Background: Data on mepolizumab in patients with severe eosinophilic asthma (EA) and comorbidities are needed to assess whether randomized controlled trial results are applicable in the real world.

Objective: To evaluate real-life effectiveness and the presence/absence of predictors of treatment response in patients with one or more comorbidities (nasal polyps, allergic rhinitis, gastro-esophageal reflux disease, nonallergic rhinitis with eosinophilia syndrome, obesity, bronchiectasis) who received mepolizumab (MEPO) for the treatment of severe EA.

Methods: We performed a single-center retrospective study in patients with severe asthma and presence of comorbidities treated with mepolizumab at the respiratory outpatient clinic, Policlinico-Vittorio Emanuele, Catania, Italy. Read More

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September 2020

SARS-CoV-2 and the possible connection to ERs, ACE2, and RAGE: Focus on susceptibility factors.

FASEB J 2020 11 23;34(11):14103-14119. Epub 2020 Sep 23.

Department of Biological Sciences, Universidade Federal de São Paulo, Diadema, Brazil.

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has provoked major stresses on the health-care systems of several countries, and caused the death of more than a quarter of a million people globally, mainly in the elderly population with preexisting pathologies. Previous studies with coronavirus (SARS-CoV) point to gender differences in infection and disease progression with increased susceptibility in male patients, indicating that estrogens may be associated with physiological protection against the coronavirus. Therefore, the objectives of this work are threefold. Read More

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November 2020

Diazoxide Protects against Myocardial Ischemia/Reperfusion Injury by Moderating ERS via Regulation of the miR-10a/IRE1 Pathway.

Oxid Med Cell Longev 2020 8;2020:4957238. Epub 2020 Sep 8.

Guizhou Key Laboratory of Anesthesia and Organ Protection, Affiliated Hospital of Zunyi Medical University, 563000 Zunyi, China.

Nowadays, reperfusion is still the most effective treatment for ischemic heart disease. However, cardiac reperfusion therapy would lead to reperfusion injury, which may have resulted from endoplasmic reticulum stress (ERS) during reperfusion. Diazoxide (DZ) is a highly selective mitochondrial adenosine triphosphate-sensitive potassium channel opener. Read More

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September 2020

Systematic Review of Contraceptive Use Among Sex Workers in North America.

J Obstet Gynecol Neonatal Nurs 2020 11 12;49(6):537-548. Epub 2020 Sep 12.

Objective: To systematically review the literature regarding contraceptive use by sex workers in North America and to understand factors that limit reproductive agency and affect contraceptive use and decision making.

Data Sources: We searched PubMed, CINAHL, and Embase databases using the search terms "sex work(ers)," "transactional sex," "exchange sex," "prostitution," "contraception," "contraceptive agents," "birth control," "female," and "women."

Study Selection: Articles were eligible for inclusion in this review if they (a) reported quantitative or qualitative studies based in North America, (b) were written in English, (c) included sex workers (self-identified sex workers or engaged in sex work behavior) as the primary or secondary population of the study, (d) included a population assigned female sex at birth, (e) reported contraceptive outcomes for sex workers, and (f) were published in peer-reviewed journals. Read More

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November 2020

Antitumorigenic Effect of Hsp90 Inhibitor SNX-2112 on Tongue Squamous Cell Carcinoma is Enhanced by Low-Intensity Ultrasound.

Onco Targets Ther 2020 12;13:7907-7919. Epub 2020 Aug 12.

Department of Stomatology, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, 518020, People's Republic of China.

Purpose: The novel Hsp90 inhibitor SNX-2112 showed broad antitumor activity. However, it was still necessary to optimize the therapeutic dosage of SNX-2112 applied on tumors to obtain effective therapy with minimal dose to reduce toxicity. We investigated the role of low-intensity US in promoting antitumorigenic effect of low doses of SNX-2112 on tongue squamous cell carcinoma. Read More

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Study of saline optical coherence tomography-guided percutaneous coronary intervention (SOCT-PCI Study).

Indian Heart J 2020 Jul - Aug;72(4):239-243. Epub 2020 Apr 13.

Army College of Medical Sciences, New Delhi, India.

Aim: The aim of this study was to evaluate the feasibility of heparinised saline as flushing media for frequency-domain optical coherence tomography (FD-OCT) image acquisition during percutaneous coronary intervention (PCI) optimisation.

Methods And Results: Twenty-seven patients undergoing FD-OCT-guided PCI were enrolled. Heparinised saline was injected into the coronary during FD-OCT image acquisition. Read More

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Study of phenol biodegradation in different agitation systems and fixed bed column: experimental, mathematical modeling, and numerical simulation.

Environ Sci Pollut Res Int 2020 Dec 12;27(36):45250-45269. Epub 2020 Aug 12.

Post-Graduate Program in Science and Environmental Technology, Federal University of Fronteira Sul, ERS 135-Km 72, No 200, PO Box 764, Erechim, RS, 99700-970, Brazil.

Phenol degradation was studied in two different agitation systems in a batc h reactor (mechanical agitation and orbital agitation) and the support of the most efficient system was used for fixed bed bioreactor studies. The support used was coconut shell charcoal. The results showed that the mechanical agitation bioreactor was more effective in phenol removal, due to the amount of biomass adhered to the support (8. Read More

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December 2020