Biochim Biophys Acta 2015 May 9;1854(5):349-55. Epub 2015 Jan 9.
Latvian Biomedical Research and Study Centre, Ratsupites 1, LV-1067 Riga, Latvia; University of Latvia, Kronvalda bulv. 4, LV-1586, Riga, Latvia.
Borrelia burgdorferi is the causative agent of Lyme disease, which can be acquired after the bite of an infected Ixodes tick. As a strategy to resist the innate immunity and to successfully spread and proliferate, B. burgdorferi expresses a set of outer membrane proteins that are capable of binding complement regulator factor H (CFH), factor H-like protein 1 (CFHL-1) and factor H-related proteins (CFHR) to avoid complement-mediated killing. Read More