Pediatr Res 2003 Dec 20;54(6):814-8. Epub 2003 Aug 20.
Department of Pediatrics, Beatrix Children's Hospital, University Hospital Groningen, 9700 RB Groningen, The Netherlands.
The objective of this study was to obtain insight into bone formation and resorption in children with newly diagnosed untreated acute lymphoblastic leukemia (ALL). In 23 consecutive children with ALL, a bone biopsy was taken from the crista iliaca posterior under ketamine anesthesia, together with the diagnostic marrow aspiration, before any treatment was given. Histomorphometric assessment was done of bone volume, bone area, trabecular thickness, osteoid volume, osteoid area, osteoid width, number of osteoblasts, erosion area, and number of osteoclasts. Read More