34,410 results match your criteria eradication therapy

[Helicobacter pylori eradication with a clarithromycin-based triple therapy in elderly patients: a case-control study].

Panminerva Med 2021 07 26. Epub 2021 Jul 26.

Unit of Gastroenterology, Città della Salute e della Scienza-Molinette Hospital, Turin, Italy.

Background: Helicobacter pylori (H. pylori), main agents of several gastroduodenal diseases, represents a therapeutic challenge. Since the influence of age on the success of bacterial treatment remains uncertain, in this case-control study we assessed the efficacy of a standard H. Read More

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Can Natural Products Suppress Resistant to Fight Against Gastric Diseases in Humans?

eFood 2020 Feb 19;1(1):53-60. Epub 2020 Feb 19.

Department of Microbiology and Immunology, Montana State University, Bozeman, MT, USA.

More than 50% of the world's population is infected with Helicobacter pylori. is the major causative agent of gastric ulcers and gastric cancer. eradication using antibiotics either alone or together with a proton pump inhibitor is the primary strategy to decrease the incidence of gastric cancer. Read More

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February 2020

Effect of cefoperazone sulbactam sodium combined with meropenem on the immune function in the treatment of neonatal pneumonia caused by multidrug-resistant bacteria.

Am J Transl Res 2021 15;13(6):6342-6351. Epub 2021 Jun 15.

Hospital Infection Management Office, The Hospital of Xinjiang Production and Construction Corps Urumqi 830002, Xinjiang Uygur Autonomous Region, China.

Objective: To explore the effect of cefoperazone sulbactam sodium combined with meropenem on the immune function in the treatment of neonatal multi-drug resistant pneumonia.

Methods: Altogether 130 children with pneumonia caused by multi-drug resistant bacteria admitted to our hospital from January 2016 to January 2019 were recruited as the study cohort. The children were randomly divided into a combined group (n=80, combined therapy) and a control group (n=50, cefoperazone sulbactam sodium therapy). Read More

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Methylene blue-mediated Photodynamic Therapy in human retinoblastoma cell lines.

J Photochem Photobiol B 2021 Jul 16;222:112260. Epub 2021 Jul 16.

Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, SP, Brazil.

Retinoblastoma is a malignant tumor of the retinal precursor cells and one of the rarest types of pediatric tumor, often occurring in the earliest years of life. Symptoms are conditioned by tumor size and location; one of the most recurrent symptoms is a white reflex in the pupillary area, called leukocoria or cat's eye reflex. In the present work, we studied the in vitro effectiveness of Photodynamic treatment (Pdt) in two types of human retinoblastoma, Y79 and WERI-Rb cell lines, using methylene blue (MB), a photosensitizer (PS) from the phenothiazine group. Read More

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Efficacy of Seven-Day Potassium-Competitive Acid Blocker-Based First-Line Eradication Therapy Administered with Bismuth.

Yonsei Med J 2021 Aug;62(8):708-716

Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea.

Purpose: To determine the efficacy of a potassium-competitive acid blocker (P-CAB)-based first-line eradication therapy with bismuth compared with that of proton pump inhibitor-based first-line therapy with bismuth.

Materials And Methods: Eradication-naive -infected patients were consecutively enrolled from January to November 2020. Before approval of the P-CAB-based eradication therapy, twice daily administration of a regimen containing lansoprazole 30 mg, amoxicillin 1 g, clarithromycin 500 mg, and bismuth potassium citrate 300 mg was prescribed for 7 days. Read More

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Neurotransmitters and Neuropeptides decrease PD-1 in T cells of healthy subjects and patients with hepatocellular carcinoma (HCC), and increase their proliferation and eradication of HCC cells.

Neuropeptides 2021 May 12;89:102159. Epub 2021 May 12.

Institute of Gene Therapy, Hadassah Hebrew University Hospital, Ein Karem, Jerusalem 91120, Israel.

T cells of aged people, and of patients with either cancer or severe infections (including COVID-19), are often exhausted, senescent and dysfunctional, leading to increased susceptibilities, complications and mortality. Neurotransmitters and Neuropeptides bind their receptors in T cells, and induce multiple beneficial T cell functions. Yet, T cells of different people vary in the expression levels of Neurotransmitter and Neuropeptide receptors, and in the magnitude of the corresponding effects. Read More

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Septic Arthritis of the Acromioclavicular Joint: A Single-Center, 11-Year Retrospective Review.

Orthopedics 2021 Jul-Aug;44(4):e493-e497. Epub 2021 Jul 1.

Septic arthritis of the smaller acromioclavicular joint is uncommon, with only a few reports and case series available in the literature. The aim of this outcomes analysis was to determine the prevalence of shoulder girdle septic arthritis within the authors' institution, with a particular focus on describing the authors' experience with acromioclavicular joint septic arthritis. A retrospective outcomes analysis was conducted of patients admitted to a single tertiary referral center from 2008 to 2018 with acromioclavicular joint septic arthritis. Read More

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An ESPGHAN Position Paper on the Use of Breath Testing in Paediatric Gastroenterology.

J Pediatr Gastroenterol Nutr 2021 Jul 20. Epub 2021 Jul 20.

Department of Paediatrics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany Department of Paediatric Gastroenterology, Great Ormond Street Hospital, London, UK Department of Paediatrics, University Medical Centre Maribor, Maribor, Slovenia Department of Paediatric Gastroenterology, Hepatology and Nutrition, Hospital Sant Joan de Déu, Barcelona, Spain Unité de Gastroentérologie, Hépatologie, Nutrition, Diabétologie et Maladies Héréditaires du Métabolisme, Hôpital des Enfants, CHU de Toulouse, Toulouse, France; IRSD, Université de Toulouse, INSERM, INRA, ENVT, UPS, Toulouse, France Department of Translational Medical Science, Section of Paediatrics, University of Naples "Federico", Naples, Italy Department of Paediatrics, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania Department of Paediatric Gastroenterology, Hepatology & Nutrition, La Fe University Hospital, Valencia, Spain Department of Paediatric Medicine, Division of Paediatric and Adolescent Medicine, Oslo University Hospital, Norway Centre for Paediatric Gastroenterology, Sheffield Children's Hospital, Sheffield, UK Department of Paediatric Gastroenterology, Al Jalila Children's Specialty Hospital, Dubai, UAE Department of Paediatric Gastroenterology and Nutrition, Emma Children's Hospital, Amsterdam University Medical Centres, Amsterdam, The Netherlands.

Objectives: Given a lack of a systematic approach to the use of breath testing in paediatric patients, the aim of this position paper is to provide expert guidance regarding the indications for its use and practical considerations to optimise its utility and safety.

Methods: Nine clinical questions regarding methodology, interpretation, and specific indications of breath testing and treatment of carbohydrate malabsorption were addressed by members of the Gastroenterology Committee (GIC) of the European Society for Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN).A systematic literature search was performed from 1983 to 2020 using PubMed, the MEDLINE and Cochrane Database of Systematic Reviews. Read More

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Inhibition of Measles Viral Fusion Is Enhanced by Targeting Multiple Domains of the Fusion Protein.

ACS Nano 2021 Jul 22. Epub 2021 Jul 22.

Center for Host-Pathogen Interaction, Columbia University Vagelos College of Physicians and Surgeons, New York, New York 10032, United States.

Measles virus (MeV) infection remains a significant public health threat despite ongoing global efforts to increase vaccine coverage. As eradication of MeV stalls, and vulnerable populations expand, effective antivirals against MeV are in high demand. Here, we describe the development of an antiviral peptide that targets the MeV fusion (F) protein. Read More

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Therapeutic efficiency of adipose-derived mesenchymal stem cells in healing of experimentally induced gastric ulcers in rats.

Anat Cell Biol 2021 Jul 21. Epub 2021 Jul 21.

Histology and Cell Biology Department, Faculty of Medicine, Assiut University, Assiut, Egypt.

Gastric (peptic) ulcer is a major gastrointestinal disorder with high morbidity and mortality. While several drugs have been used to treat gastric ulcers, such as proton pump inhibitor-based triple therapy for eradication, but hey result in adverse side effects. Therefore, development of new alternative therapies is desirable. Read More

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Associations of Seasonal Variations and Meteorological Parameters with Incidences of Upper and Lower Gastrointestinal Bleeding.

J Gastroenterol Hepatol 2021 Jul 21. Epub 2021 Jul 21.

School of Public Health, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China.

Background: Previous studies have demonstrated the seasonal variations of non-variceal upper gastrointestinal bleeding (UGIB), but there is scanty data on lower gastrointestinal bleeding (LGIB) and the association with other meteorological parameters.

Methods: We included all patients hospitalized for UGIB and LGIB between 2009 and 2018 in Hong Kong. The monthly age- and sex-standardized GIB incidences were fitted to meteorological data including average temperature (AT), maximum temperature (MaxT), minimum temperature (MinT), temperature range (TR), average precipitation, average atmospheric pressure (AtomP) and average relative humidity after adjusting for prescriptions of aspirin, proton pump inhibitors and Helicobacter pylori eradication therapy using the autoregressive integrated moving average (ARIMA) model. Read More

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Working towards full eradication of lipid-driven cardiovascular risk?

Neth Heart J 2021 Jul 19. Epub 2021 Jul 19.

Department of Vascular Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

Lipid-driven cardiovascular disease (CVD) risk is caused by atherogenic apolipoprotein B (apoB) particles containing low-density lipoprotein cholesterol (LDL-C), triglycerides and lipoprotein(a) [Lp(a)] and resembles a large and modifiable proportion of the total CVD risk. While a surplus of novel lipid-lowering therapies has been developed in recent years, management of lipid-driven CVD risk in the Netherlands remains suboptimal. To lower LDL‑C levels, statins, ezetimibe and proprotein convertase subtilisin/kexin type 9 inhibiting antibodies are the current standard of therapy. Read More

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Abnormal function of telomere protein TRF2 induces cell mutation and the effects of environmental tumor‑promoting factors (Review).

Oncol Rep 2021 Aug 19;46(2). Epub 2021 Jul 19.

Ministry of Education and Training, Chengdu Second People's Hospital, Chengdu, Sichuan 610000, P.R. China.

Recent studies have found that somatic gene mutations and environmental tumor‑promoting factors are both indispensable for tumor formation. Telomeric repeat‑binding factor (TRF)2 is the core component of the telomere shelterin complex, which plays an important role in chromosome stability and the maintenance of normal cell physiological states. In recent years, TRF2 and its role in tumor formation have gradually become a research hot topic, which has promoted in‑depth discussions into tumorigenesis and treatment strategies, and has achieved promising results. Read More

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[A multicenter randomized controlled study of bismuth-containing quadruple therapy followed by Jing-Hua-Wei-Kang in the treatment of patients newly diagnosed with infection and dyspepsia].

Zhonghua Yi Xue Za Zhi 2021 Jul;101(26):2060-2065

Department of Gastroenterology, the First Affiliated Hospital of Zhejiang Chinese Medical University, Key Laboratory for Pathophysiological Research on Digestive System Diseases of Zhejiang Province, Hangzhou 310060, China.

To investigate the () eradication rate and improvement of dyspepsia in patients who were newly diagnosed with infection and dyspepsia and treated by bismuth-containing quadruple therapy followed by Jing-Hua-Wei-Kang(JHWK). Patients who were newly diagnosed with dyspepsia and infection and treated in 16 medical centers in China between December 1, 2017 and September 30, 2019 were randomly divided into two groups. The experimental group received bismuth-containing quadruple therapy (esomeprazole+amoxicillin+furazolidone+colloidal bismuth pectin capsule, 14 days), followed by JHWK (30 days), and the course of treatment was 44 days in total. Read More

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Mitochondria-targeted vitamin E succinate delivery for reversal of multidrug resistance.

J Control Release 2021 Jul 16;337:117-131. Epub 2021 Jul 16.

Ministry of Education (MOE) Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China. Electronic address:

Inducing mitochondrial malfunction is an appealing strategy to overcome tumor multidrug resistance (MDR). Reported here a versatile mitochondrial-damaging molecule, vitamin E succinate (VES), is creatively utilized to assist MDR reversal of doxorubicin hydrochloride (DOX·HCl) via a nanovesicle platform self-assembled from amphiphilic polyphosphazenes containing pH-sensitive 1H-benzo-[d]imidazol-2-yl) methanamine (BIMA) groups. Driven by multiple non-covalent interactions, VES is fully introduced into the hydrophobic membrane of DOX·HCl-loaded nanovesicles with loading content of 23. Read More

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Biochemical and functional characterization of mutant KRAS epitopes validates this oncoprotein for immunological targeting.

Nat Commun 2021 07 16;12(1):4365. Epub 2021 Jul 16.

Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Activating RAS missense mutations are among the most prevalent genomic alterations observed in human cancers and drive oncogenesis in the three most lethal tumor types. Emerging evidence suggests mutant KRAS (mKRAS) may be targeted immunologically, but mKRAS epitopes remain poorly defined. Here we employ a multi-omics approach to characterize HLA class I-restricted mKRAS epitopes. Read More

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Novel "High-dose Quad" Salvage Therapy Approach for Infection: A Case Report.

J Pharm Pract 2021 Jul 16:8971900211033143. Epub 2021 Jul 16.

Department of Pharmacy, UC Health, 22095University of Colorado Hospital, Aurora, CO, USA.

This case report outlines the successful eradication of chronic () infection using a novel, "high-dose quad" salvage therapy approach. Gastroenterologists may consider using this approach for patients who have previously failed first- and second-line treatment regimens, as recommended by the American College of Gastroenterology (ACG). infection is associated with multiple chronic gastrointestinal diseases, and patients who test positive for should undergo treatment until eradication is achieved. Read More

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Efficacy of Clarithromycin Depends on the Bacterial Density in Clarithromycin-Heteroresistant Infections: An Detected Susceptibility and Quantitative Morphometry-Based Retrospective Study.

Pathol Oncol Res 2021 29;27:1609863. Epub 2021 Jun 29.

2nd Department of Pathology, Semmelweis University, Budapest, Hungary.

The global rise in clarithromycin (Cla) resistance is considered to be the main contributor of () eradication failures. In nearly half of the Cla-resistant infections, Cla-susceptible bacteria are simultaneously present with the Cla-resistant ones (Cla-heteroresistance). The proportion of resistant bacteria in the bacterial population (R-fraction) and its predictive role for the use of Cla-based therapies in Cla-heteroresistant infections has not yet been investigated. Read More

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Chimeric antigen receptor- and natural killer cell receptor-engineered innate killer cells in cancer immunotherapy.

Cell Mol Immunol 2021 Jul 15. Epub 2021 Jul 15.

NK CellTech Co., Ltd., Shanghai International Medical Park, Shanghai, China.

Chimeric antigen receptor (CAR)-engineered T-cell (CAR-T) therapy has demonstrated impressive therapeutic efficacy against hematological malignancies, but multiple challenges have hindered its application, particularly for the eradication of solid tumors. Innate killer cells (IKCs), particularly NK cells, NKT cells, and γδ T cells, employ specific antigen-independent innate tumor recognition and cytotoxic mechanisms that simultaneously display high antitumor efficacy and prevent tumor escape caused by antigen loss or modulation. IKCs are associated with a low risk of developing GVHD, thus offering new opportunities for allogeneic "off-the-shelf" cellular therapeutic products. Read More

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Double-edged effects of interferons on the regulation of cancer-immunity cycle.

Oncoimmunology 2021 30;10(1):1929005. Epub 2021 Jun 30.

Department of Stomatology, Shenzhen Second People's Hospital, the First Affiliated Hospital of Shenzhen University, Shenzhen, China.

Interferons (IFNs) are a large family of pleiotropic cytokines that regulate both innate and adaptive immunity and show anti-cancer effects in various cancer types. Moreover, it was revealed that IFN signaling plays critical roles in the success of cancer therapy strategies, thereby enhancing their therapeutic effects. However, IFNs have minimal or even adverse effects on cancer eradication, and mediate cancer immune escape in some instances. Read More

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The status and progress of first-line treatment against infection: a review.

Therap Adv Gastroenterol 2021 28;14:1756284821989177. Epub 2021 Jun 28.

Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital; Key Laboratories of Molecular Oncology of Heilongjiang Province, No.150 Haping Road, Nangang District, Harbin, China.

(HP) is a major causative agent of chronic gastritis and peptic ulcer. HP is also engaged in the development of gastric cancer and gastric mucosa-associated lymphoid tissue lymphoma. It is an important pathogenic factor in various other systemic diseases, such as vitamin B12 deficiency, iron deficiency, and idiopathic thrombocytopenia. Read More

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Transition from esophagectomy to endoscopic therapy for early esophageal cancer.

Dis Esophagus 2021 Jul 15. Epub 2021 Jul 15.

Esophago-Gastric Surgery, Guy's and St.Thomas' Esophago-Gastric Centre, London UK.

Background: To assess the outcomes of patients with early esophageal cancer and high-grade dysplasia comparing esophagectomy, the historical treatment of choice, to endoscopic eradication therapy (EET).

Methods: Retrospective cohort study of consecutive patients with early esophageal cancer/high-grade dysplasia, treated between 2000 and 2018 at a tertiary center. Primary outcomes were all-cause and disease-specific mortality assessed by multivariable Cox regression and a propensity score matching sub analysis, providing hazard ratios (HR) with 95% confidence intervals (CI) adjusted for age, tumor grade (G1/2 vs. Read More

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Electrochemically activated solution as bladder irrigation-An individual curative trial in patients with neurogenic lower urinary tract dysfunction and recurrent urinary infections.

Neurourol Urodyn 2021 Jul 14. Epub 2021 Jul 14.

Department of Neuro-Urology, Clinic of Urology, University Hospital Bonn, Bonn, Germany.

Aims: Driven by increasing awareness of antibiotic stewardship, especially in the vulnerable group of patients with neurogenic lower urinary tract dysfunction (NLUTD), whose frequent need for invasive interventions leads to a high incidence of recurrent urinary tract infections (rUTIs), the goal was to find an alternative to antibiotic treatment. Our intention was for the treatment to be locally administered and well-tolerated as well as to avoid the risk of antimicrobial resistance.

Methods: A retrospective analysis of 12 catheterized NLUTD patients was performed within the setting of an individual curative trial. Read More

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Efficacy of the new therapeutic approach in curing malignant neoplasms on the model of human glioblastoma.

Cancer Biol Med 2021 Jul 14. Epub 2021 Jul 14.

Institute of Cytology and Genetics SB RAS, Novosibirsk 630090, Russia.

Objective: Glioma is a highly invasive tumor, frequently disposed in essential areas of the brain, which makes its surgical excision extremely difficult; meanwhile adjuvant therapy remains quite ineffective.

Methods: In the current report, a new therapeutic approach in curing malignant neoplasms has been performed on the U87 human glioblastoma model. This approach, termed "Karanahan", is aimed at the eradication of cancer stem cells (CSCs), which were recently shown to be capable of internalizing fragments of extracellular double-stranded DNA. Read More

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The cost-effectiveness of sequential versus standard triple therapy for eradication in Saudi Arabia.

Saudi J Gastroenterol 2021 Jul 8. Epub 2021 Jul 8.

Department of Medicine, Section of Gastroenterology, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.

Background: The utilization rate of different treatment regimens for Helicobacter pylori infection is believed to be high; however, the cost-effectiveness of these regimens has not been examined before. Therefore, the aim of this study was to examine the cost-effectiveness of the two commonly prescribed treatments for H. pylori infection. Read More

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Research Trends on Clinical Helicobacter pylori Eradication: A Bibliometric Analysis from 1983 to 2020.

Helicobacter 2021 Jul 13:e12835. Epub 2021 Jul 13.

Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Jiangxi Province, China.

Background: Numerous studies related to Helicobacter pylori (H. pylori) eradication have been published since the discovery of H. pylori. Read More

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Discovery and Development of Antiviral Therapies for Chronic Hepatitis C Virus Infection.

Adv Exp Med Biol 2021 ;1322:139-157

IrsiCaixa AIDS Research Institute, Hospital Universitari Germans Trias I Pujol, Universitat Autònoma de Barcelona, Badalona, Spain.

At the beginning of this decade, an estimated 71 million people were living with chronic hepatitis C virus (HCV) infection worldwide. After the acute stage of HCV infection, 18-34% of individuals exhibit spontaneous clearance. However, the remaining 66-82% of infected individuals progress to chronic HCV infection and are at subsequent risk of progression to hepatic fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). Read More

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An Update on Antiretroviral Therapy.

Adv Exp Med Biol 2021 ;1322:31-61

Centro de Biología Molecular "Severo Ochoa", Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid, Madrid, Spain.

Human immunodeficiency virus (HIV) infection and acquired immune deficiency syndrome (AIDS) still claim many lives across the world. However, research efforts during the last 40 years have led to the approval of over 30 antiretroviral drugs and the introduction of combination therapies that have turned HIV infection into a chronic but manageable disease. In this chapter, we provide an update on current available drugs and treatments, as well as future prospects towards reducing pill burden and developing long-acting drugs and novel antiretroviral therapies. Read More

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The Novel Oral BET-CBP/p300 Dual Inhibitor NEO2734 Is Highly Effective in Eradicating Acute Myeloid Leukemia Blasts and Stem/Progenitor Cells.

Hemasphere 2021 Aug 8;5(8):e610. Epub 2021 Jul 8.

Department of Hematology, Amsterdam UMC Location VUmc, Cancer Center Amsterdam, the Netherlands.

Acute myeloid leukemia (AML) is a disease characterized by transcriptional dysregulation that results in a block in differentiation and aberrant self-renewal. Inhibitors directed to epigenetic modifiers, aiming at transcriptional reprogramming of AML cells, are currently in clinical trials for AML patients. Several of these inhibitors target bromodomain and extraterminal domain (BET) proteins, cyclic AMP response binding protein-binding protein (CBP), and the E1A-interacting protein of 300 kDa (p300), affecting histone acetylation. Read More

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Disruptor of telomeric silencing 1-like promotes ovarian cancer tumor growth by stimulating pro-tumorigenic metabolic pathways and blocking apoptosis.

Oncogenesis 2021 Jul 12;10(7):48. Epub 2021 Jul 12.

Department of Biochemistry and Molecular Genetics, The University of Alabama at Birmingham, Birmingham, AL, 35233, USA.

Ovarian cancer is the leading cause of gynecological malignancy-related deaths. Current therapies for ovarian cancer do not provide meaningful and sustainable clinical benefits, highlighting the need for new therapies. We show that the histone H3K79 methyltransferase disruptor of telomeric silencing 1-like (DOT1L) is overexpressed in ovarian cancer and that a higher level of DOT1L expression correlates with shorter progression-free and overall survival (OS). Read More

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