13 results match your criteria erα mice

  • Page 1 of 1

[Effect of endoplasmic reticulum stress induced by all-trans retinoic acid on apoptosis of FLT3-ITD mutated leukemia cells by activating autophagy in FLT3-ITD mutated protein].

Zhonghua Xue Ye Xue Za Zhi 2020 Oct;41(10):836-842

Pediatric Department, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.

Endoplasmic reticulum stress(ERS)was used as the research emphasis to further investigate the mechanisms of apoptosis of FLT3-ITD-mutated leukemia cells and decreased expression of FLT3-ITD mutated protein induced by all-trans retinoic acid(ATRA). FLT3-ITD-mutated leukemia cell lines(MV4-11 and MOLM13)were treated with ATRA. Flow cytometry was conducted to assess cell apoptosis. Read More

View Article and Full-Text PDF
October 2020

Costs and long-term outcomes following pulmonary vein isolation for atrial fibrillation in elderly patients using second-generation cryoballoon vs. open-irrigated radiofrequency in China.

J Interv Card Electrophysiol 2020 Dec 31;59(3):557-564. Epub 2019 Dec 31.

Department of Cardiology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, #261 Huansha Road, Hangzhou, 310000, Zhejiang Province, China.

Purpose: Limited comparative data are available regarding catheter ablation (CA) of atrial fibrillation (AF) using second-generation cryoballoon (CB-2) vs. radiofrequency (RF) ablation in elderly patients (> 75 years old). The present study aimed to compare the costs and clinical outcomes in elderly patients using these two strategies. Read More

View Article and Full-Text PDF
December 2020

Predictors of Short and Long Term Recurrences of Paroxysmal AF after Radiofrequency Ablation. Is Blanking Period Really Benign?

J Atr Fibrillation 2018 Dec 31;11(4):2012. Epub 2018 Dec 31.

Cardiology department, Ain shams university, Cairo, Egypt.

Background: Following pulmonary vein isolation for paroxysmal atrial fibrillation (PAF), early recurrences of atrial arrhythmias (ERAA) are frequent, classified benign as a part of a blanking period. But recently it seems that there is increased incidence of late recurrences in patients with ERAA but mechanism is still unknown.

Purpose: To assess the incidence and risk factors for early and late AF recurrences post AF ablation and the impact of these ERAA on long-term success. Read More

View Article and Full-Text PDF
December 2018

Usefulness of Failed Electrical Cardioversion for Early Recurrence After Catheter Ablation for Atrial Fibrillation as a Predictor of Future Recurrence.

Am J Cardiol 2019 03 4;123(5):794-800. Epub 2018 Dec 4.

Department of Cardiology, Sakurabashi Watanabe Hospital, Osaka, Japan. Electronic address:

Early recurrence of atrial arrhythmia (ERAA) during a blanking period after catheter ablation (CA) for atrial fibrillation (AF) does not always result in subsequent AF recurrence. We investigated whether failed electrical cardioversion (ECV) during the blanking period was associated with recurrence. A total of 1,240 consecutive patients who underwent first-time CA for AF at our institution between March 2012 and March 2016 were investigated. Read More

View Article and Full-Text PDF

Clinical significance of the timing of early recurrence of atrial arrhythmia after pulmonary vein isolation: a two-institution clinical study.

Heart Vessels 2019 May 2;34(5):842-850. Epub 2018 Nov 2.

Department of Cardiology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, 466-8550, Japan.

Early recurrence of atrial arrhythmia (ERAA) after ablation frequently occurs, but there is limited evidence about ERAA-timing. This study aimed to investigate the association between ERAA-timing and late recurrence. We retrospectively investigated 332 patients who underwent PVI for paroxysmal atrial fibrillation at Nagoya University Hospital and Komaki City Hospital. Read More

View Article and Full-Text PDF

Early Recurrences During the Blanking Period after Atrial Fibrillation Ablation.

J Atr Fibrillation 2018 Feb 28;10(5):1726. Epub 2018 Feb 28.

Division of Cardiology, Electrophysiology Section, Hospital of the University of Pennsylvania, Philadelphia, PA.

Early recurrences of atrial arrhythmias (ERAA) after ablation are common and predict late recurrences and ablation failure.However,becausea proportion of patients with ERAA will have no subsequent arrhythmias after the blanking period, consensus guidelines recommend against immediate repeat ablation for ERAA episodes occurring during the first 3 months post-ablation. In this review, we summarize the predictors, significance, and treatment of ERAA after AF ablation. Read More

View Article and Full-Text PDF
February 2018

Mechanisms and clinical significance of early recurrences of atrial arrhythmias after catheter ablation for atrial fibrillation.

World J Cardiol 2016 Nov;8(11):638-646

Jackson J Liang, Sanjay Dixit, Pasquale Santangeli, Division of Cardiology, Electrophysiology Section, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, United States.

Early recurrence of atrial arrhythmias (ERAA) after ablation is common and strongly predicts late recurrences and ablation failure. However, since arrhythmia may eventually resolve in up to half of patients with ERAA, guidelines do not recommend immediate reintervention for ERAA episodes occurring during a 3-mo post-ablation blanking period. Certain clinical demographic, electrophysiologic, procedural, and ERAA-related characteristics may predict a higher likelihood of long-term ablation failure. Read More

View Article and Full-Text PDF
November 2016

Ospemifene for the treatment of postmenopausal vulvar and vaginal atrophy: recommendations for clinical use.

Expert Opin Pharmacother 2015 3;16(17):2703-14. Epub 2015 Dec 3.

b Department of Obstetrics, Gynecology, and Reproductive Sciences , University of California San Francisco East Bay Physicians Medical Group affiliated with Sutter East Bay Medical Foundation , Berkeley , CA 94704 , USA.

Introduction: Vulvar vaginal atrophy (VVA), a component of genitourinary syndrome of menopause, is a chronic, progressive medical condition that results from estrogen deficiency at menopause. Ospemifene is a nonhormonal, estrogen receptor agonist/antagonist (ERAA) FDA-approved for the treatment of moderate to severe dyspareunia, a symptom of VVA, due to menopause.

Areas Covered: PubMed was searched from inception to March 2015 with keywords ospemifene and vulvar vaginal atrophy; no other similar clinical reviews were found. Read More

View Article and Full-Text PDF

Early recurrence of atrial arrhythmias following pulmonary vein antral isolation: Timing and frequency of early recurrences predicts long-term ablation success.

Heart Rhythm 2015 Dec 14;12(12):2461-8. Epub 2015 Jul 14.

Cardiovascular Division, Electrophysiology Section, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

Background: Early recurrence of atrial arrhythmia (ERAA) is common after atrial fibrillation (AF) ablation and is associated with long-term recurrence. However, the association between timing or frequency of ERAA and long-term ablation success remains unclear.

Objective: We aimed to examine whether timing or frequency of ERAA after pulmonary vein antral isolation (PVAI) affects long-term ablation success. Read More

View Article and Full-Text PDF
December 2015

Clinical management of paradoxical psoriasiform reactions during TNF- α therapy.

Authors:
R Navarro E Daudén

Actas Dermosifiliogr 2014 Oct 9;105(8):752-61. Epub 2013 Aug 9.

Departamento de Dermatología, Hospital Universitario La Princesa, Madrid, España.

There have been reports of paradoxical induction or worsening of psoriasis during treatment with tumor necrosis factor (TNF) α agents (infliximab, etanercept, adalimumab, and certolizumab). It has been hypothesized that an imbalance between TNF-α and interferon α might have a role in the etiology and pathogenesis of these reactions. Paradoxical psoriasiform reactions can be divided clinically into de novo psoriasis and exacerbation of preexisting psoriasis. Read More

View Article and Full-Text PDF
October 2014

Safety and effectiveness of ustekinumab and antitumour necrosis factor therapy in patients with psoriasis and chronic viral hepatitis B or C: a retrospective, multicentre study in a clinical setting.

Br J Dermatol 2013 Mar;168(3):609-16

Department of Dermatology, Hospital Universitario de la Princesa, Madrid, Spain.

Background: Both the safety and efficacy of biologic therapy may be affected in the presence of highly prevalent chronic viral hepatitis.

Objective: To evaluate the safety and effectiveness of ustekinumab and antitumour necrosis factor therapy in patients with psoriasis and concomitant chronic viral hepatitis.

Methods: This was a retrospective, multicentre study. Read More

View Article and Full-Text PDF

Superior type of atypical AV nodal reentrant tachycardia: incidence, characteristics, and effect of slow pathway ablation.

Pacing Clin Electrophysiol 2008 Aug;31(8):998-1009

Division of Cardiology, Cardiovascular Center, Tsuchiura Kyodo Hospital, Tsuchiura, Japan.

Background: Atypical atrioventricular (AV) nodal reentrant tachycardias (AVNRT) usually exhibit the earliest retrograde atrial activation (ERAA) at the right inferoseptum (Rt-IS) or proximal coronary sinus (PCS). The purpose of this study was to characterize atypical AVNRT with the ERAA at the right superoseptum (Rt-SS).

Methods: Seventy-three atypical AVNRTs induced in 63 cases were classified into the superior type with the ERAA at the Rt-SS and inferior type with the ERAA at the Rt-IS or PCS. Read More

View Article and Full-Text PDF

Sorting, recognition and activation of the misfolded protein degradation pathways through macroautophagy and the proteasome.

Autophagy 2008 Feb 19;4(2):141-50. Epub 2007 Oct 19.

Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15231, USA.

Based on a functional categorization, proteins may be grouped into three types and sorted to either the proteasome or the macroautophagy pathway for degradation. The two pathways are mechanistically connected but their capacity seems different. Macroautophagy can degrade all forms of misfolded proteins whereas proteasomal degradation is likely limited to soluble ones. Read More

View Article and Full-Text PDF
February 2008
  • Page 1 of 1