29,934 results match your criteria equivalent disease

Associations of Maternal Characteristics and Dietary Factors with Anemia and Iron-Deficiency in Pregnancy.

J Gynecol Obstet Hum Reprod 2021 Apr 7:102137. Epub 2021 Apr 7.

Department of Nutrition and Dietetics, Faculty of Health Sciences, Ankara University, Ankara, Turkey Postal Code: 06290, Phone Number: +90 0312 381 23 50.

Objective: Anemia and iron deficiency during pregnancy influence maternal and fetal health, birth outcomes, and the risk of chronic disease in offspring. This study aimed to examine the association with sociodemographic, maternal factors, supplement use and dietary intakes, and anemia and iron deficiency in pregnancy.

Methods: A cross-sectional study was conducted on 165 pregnant women aged between 19-45 years who were interviewed, and dietary intake was assessed by 24-hours dietary recall, supplement records and food frequency questionnaire. Read More

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Changes in Compliance With Physical Activity Guidelines and Cardiovascular Disease Mortality.

J Phys Act Health 2021 Apr 9:1-6. Epub 2021 Apr 9.

Background: The effects of compliance with the US Physical Activity (PA) Guidelines and changes in compliance over time on cardiovascular disease (CVD) mortality are unknown.

Methods: Male participants in the Aerobics Center Longitudinal Study (n = 15,411; 18-100 y) reported leisure-time PA between 1970 and 2002. The frequency of and time spent in PA were converted into metabolic equivalent minutes per week. Read More

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Incidence of household catastrophic and impoverishing health expenditures among patients with Breast Cancer in Iran.

BMC Health Serv Res 2021 Apr 9;21(1):327. Epub 2021 Apr 9.

Department of Health Management and Economics, School of Public Health, Urmia University of Medical Sciences, Urmia, Iran.

Background: Breast cancer disease is the most common cancer among Iranian women and imposing a significant financial burden on the households. This study calculated out-of-pocket (OOP), catastrophic health expenditure (CHE), and impoverishing health spending attributed to breast cancer in Iran.

Methods: In this cross-sectional household study, clinical and financial information on breast cancer and also household information (expenditures and income) were obtained through face-to-face interviews and completing a questionnaire by 138 women with this disease in 2019. Read More

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Differential Inhibition of LRRK2 in Parkinson's Disease Patient Blood by a G2019S Selective LRRK2 Inhibitor.

Mov Disord 2021 Feb 11. Epub 2021 Feb 11.

ESCAPE Bio, Inc., South San Francisco, California, USA.

Background: A common genetic mutation that causes Parkinson's disease (PD) is the G2019S LRRK2 mutation. A precision medicine approach that selectively blocks only excess kinase activity of the mutant allele could yield a safe and effective treatment for G2019S LRRK2 PD.

Objective: To determine the activity of a G2019S mutant selective leucine-rich repeat kinase 2 (LRRK2) kinase inhibitor as compared to a nonselective inhibitor in blood of subjects with genetic and idiopathic PD on two LRRK2 biomarkers, pSer935 LRRK2 and pThr73 Rab10. Read More

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February 2021

Impact of Previously Unrecognized HLA Mismatches Using Ultrahigh Resolution Typing in Unrelated Donor Hematopoietic Cell Transplantation.

J Clin Oncol 2021 Apr 9:JCO2003643. Epub 2021 Apr 9.

Anthony Nolan Research Institute, Royal Free Hospital, London, UK.

Purpose: Ultrahigh resolution (UHR) HLA matching is reported to result in better outcomes following unrelated donor hematopoietic cell transplantation, improving survival and reducing post-transplant complications. However, most studies included relatively small numbers of patients. Here we report the findings from a large, multicenter validation study. Read More

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The influence of sagittal spinopelvic alignment on patient discharge disposition following minimally invasive lumbar interbody fusion.

J Spine Surg 2021 Mar;7(1):8-18

Department of Neurosurgery, Henry Ford Health System, 2799 West Grand Boulevard, Detroit, MI, USA.

Background: The aim of this study was to investigate the changes to spinopelvic sagittal alignment following minimally invasive (MIS) lumbar interbody fusion, and the influence of such changes on postoperative discharge disposition.

Methods: The Michigan Spine Surgery Improvement Collaborative was queried for all patients who underwent transforaminal lumbar interbody fusion (TLIF)or lateral lumbar interbody fusion (LLIF) procedures for degenerative spine disease. Several spinopelvic sagittal alignment parameters were measured, including sagittal vertical axis (SVA), lumbar lordosis, pelvic tilt, pelvic incidence, and pelvic incidence-lumbar lordosis mismatch. Read More

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Feasibility and Safety of the Novel Vivolight Frequency Domain Optical Coherence Tomography System: A Multicenter Study.

J Invasive Cardiol 2021 Apr 8. Epub 2021 Apr 8.

Department of Cardiology, The General Hospital of the People's Liberation Army, 28 Fuxing Road, Beijing (Wukesong), China.

Objective: The study sought to assess the effectiveness and safety of the novel P60 Vivolight frequency-domain optical coherence tomography (OCT) system (Shenzhen Vivolight Medical Device & Technology).

Methods: A total of 90 patients were enrolled from 3 institutions. The pullbacks were performed with both the P60 Vivolight OCT system and the Ilumien Optis OCT system (Abbott Vascular). Read More

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Risk factors for losing hepatitis B virus surface antibody in patients with HBV surface antigen negative/surface antibody positive serostatus receiving biologic disease-modifying anti-rheumatic drugs: a nested case-control study.

Adv Rheumatol 2021 Apr 8;61(1):22. Epub 2021 Apr 8.

Department of Allergy, Immunology, and Rheumatology, Tungs' Taichung MetroHarbor Hospital, 699, Sec. 8, Taiwan Blvd., Taichung City, 43503, Taiwan.

Background: Hepatitis B virus (HBV) reactivation consequent to immunosuppressive therapy is an increasingly prevalent problem with serious clinical implications. Treatment with biologic agents conduces to the loss of protective antibody to HBV surface antigen (anti-HBs), which significantly increases the risk of HBV reactivation. Hence, we investigated the risk factors for losing anti-HBs in patients with rheumatic diseases and HBV surface antigen negative/anti-HBs positive (HBsAg-/anti-HBs+) serostatus during treatment with biologic disease-modifying anti-rheumatic drugs (DMARDs). Read More

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The General Public Knowledge, Attitude, and Practices Regarding COVID-19 During the Lockdown in Asian Developing Countries.

Int Q Community Health Educ 2021 Apr 8:272684X211004945. Epub 2021 Apr 8.

School of Education, Minnan Normal University, Zhangzhou, P.R. China.

The recent outbreak of coronavirus disease (COVID-19) is the worst global crisis. Since no successful treatment and vaccine have been reported, efforts to improve the public's knowledge, attitudes, and practices are critical to reducing the spread of COVID-19. This study aims to investigate the general public knowledge, attitude, and practices regarding COVID-19. Read More

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Comparing the diagnostic value of bronchoalveolar lavage fluid galactomannan, serum galactomannanan, and serum 1,3-β-d-glucan in non-neutropenic respiratory disease patients with invasive pulmonary aspergillosis.

Medicine (Baltimore) 2021 Apr;100(14):e25233

Center of Clinical Laboratory, Zhongshan Hospital.

Abstract: The incidence of invasive pulmonary aspergillosis (IPA) is increasing higher in non-neutropenic patients. This study aimed to assess the diagnostic performance of bronchoalveolar lavage fluid (BALF). Galactomannan (GM), serum GM, and 1,3-β-d-glucan (BDG) in non-neutropenic respiratory disease patients with IPA. Read More

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Differential neuropathology and functional outcome after equivalent traumatic brain injury in aged versus young adult mice.

Exp Neurol 2021 Apr 5:113714. Epub 2021 Apr 5.

Department of Surgery, Division of Trauma and Critical Care, Northwestern University, Chicago, IL, USA.

The CDC estimate that nearly 3 million Americans sustain a traumatic brain injury (TBI) each year. Even when medical comorbidities are accounted for, age is an independent risk factor for poor outcome after TBI. Nonetheless, few studies have examined the pathophysiology of age-linked biologic outcomes in TBI. Read More

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A Preliminary Study on the Evaluation of In-vitro Inhibition Potential of Antimicrobial Efficacy of Raw and Commercial Honey on Escherichia coli: An Emerging Periodontal Pathogen.

Mymensingh Med J 2021 Apr;30(2):547-554

Professor Dr Ira Gupta, Professor, Department of Periodontology, Rama Dental College, Hospital & Research Centre (RDC, H&RC), Kanpur (UP)- 208024, India; E-mail:

Periodontitis, a multiple pathogen disease has the latest addition to the family i.e. Escherichia coli as a potential and emerging periodontal pathogen owing to its lipopolysaccharide more potent than Porphyromonas gingivalis, which makes it an emerging threat in periodontal disease. Read More

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A Digital Patient-Provider Communication Intervention (InvolveMe): Qualitative Study on the Implementation Preparation Based on Identified Facilitators and Barriers.

J Med Internet Res 2021 Apr 8;23(4):e22399. Epub 2021 Apr 8.

Department of Digital Health Research, Division of Medicine, Oslo University Hospital, Oslo, Norway.

Background: Chronic health conditions are affecting an increasing number of individuals, who experience various symptoms that decrease their quality of life. Digital communication interventions that enable patients to report their symptoms have been shown to positively impact chronic disease management by improving access to care, patient-provider communication, clinical outcomes, and health-related quality of life. These interventions have the potential to prepare patients and health care providers (HCPs) before visits and improve patient-provider communication. Read More

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Active surveillance of patients who have sentinel node positive melanoma: An international, multi-institution evaluation of adoption and early outcomes after the Multicenter Selective Lymphadenectomy trial II (MSLT-2).

Cancer 2021 Apr 7. Epub 2021 Apr 7.

Department of Cutaneous Oncology, H. Lee Moffitt Cancer Center, Tampa, Florida.

Background: For patients with sentinel lymph node (SLN)-positive cutaneous melanoma, the Second Multicenter Selective Lymphadenectomy trial demonstrated equivalent disease-specific survival (DSS) with active surveillance using nodal ultrasound versus completion lymph node dissection (CLND). Adoption and outcomes of active surveillance in clinical practice and in adjuvant therapy recipients are unknown.

Methods: In a retrospective cohort of SLN-positive adults treated at 21 institutions in Australia, Europe, and the United States from June 2017 to November 2019, the authors evaluated the impact of active surveillance and adjuvant therapy on all-site recurrence-free survival (RFS), isolated nodal RFS, distant metastasis-free survival (DMFS), and DSS using Kaplan-Meier curves and Cox proportional hazard models. Read More

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Two-dimensional shear wave elastography and ultrasound-guided attenuation parameter for progressive non-alcoholic steatohepatitis.

PLoS One 2021 7;16(4):e0249493. Epub 2021 Apr 7.

Division of Hepatology, Department of Internal Medicine, Iwate Medical University, Iwate, Japan.

Background And Aims: We investigated the usefulness of combining two-dimensional shear wave elastography and the ultrasound-guided attenuation parameter for assessing the risk of progressive non-alcoholic steatohepatitis, defined as non-alcoholic steatohepatitis with a non-alcoholic fatty liver disease activity score of ≥4 and a fibrosis stage of ≥2.

Methods: This prospective study included 202 patients with non-alcoholic fatty liver disease who underwent two-dimensional shear wave elastography, ultrasound-guided attenuation parameter, vibration-controlled transient elastography, the controlled attenuation parameter, and liver biopsy on the same day. Patients were grouped according to liver stiffness measurement using two-dimensional shear wave elastography and the attenuation coefficient, assessed using the ultrasound-guided attenuation parameter: A, low liver stiffness measurement/low attenuation coefficient; B, low liver stiffness measurement/high attenuation coefficient; C, high liver stiffness measurement/low attenuation coefficient; and D, high liver stiffness measurement/high attenuation coefficient. Read More

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D-pouch: a modified ileal J-pouch for patients with ulcerative colitis and familial adenomatous polyposis.

Tech Coloproctol 2021 Apr 7. Epub 2021 Apr 7.

Department of Colorectal and Anal Surgery of Zhongnan Hospital of Wuhan University, Clinical Center of Intestinal and Colorectal Diseases of Hubei Province, Hubei Key Laboratory of Intestinal and Colorectal Diseases (Zhongnan Hospital of Wuhan University), Colorectal and Anal Disease Research Center of Medical School (Zhongnan Hospital of Wuhan University), Quality Control Center of Colorectal and Anal Surgery of Health Commission of Hubei Province, No. 169, DongHu Road, Wuhan, China.

Background: Ileal J-pouch anal anastomosis (J-IPAA) is the standard approach for patients requiring restorative proctocolectomy due to familial adenomatous polyposis (FAP) or ulcerative colitis (UC). To obviate the risk of a J-tip leak, we modified the J-pouch with a D-pouch anal anastomosis (D-IPAA) designed to eliminate the ileal stump. The aim of our study was to evaluate the feasibility, safety and medium-term functional outcomes of D-IPAA. Read More

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Long-Term Variability of Blood Pressure, Cardiovascular Outcomes, and Mortality: The Look AHEAD Study.

Am J Hypertens 2021 Apr 2. Epub 2021 Apr 2.

Department of Medicine, Division of Endocrinology, Diabetes & Metabolism, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.

Background: We evaluated the associations of visit-to-visit blood pressure (BP) variability with incident cardiovascular disease (CVD) and deaths in adults with type 2 diabetes.

Methods: We analyzed 4,152 participants in Look AHEAD (Action for Health in Diabetes) free of CVD events and deaths during the first 36 months of follow-up. Variability of systolic BP (SBP) and diastolic BP (DBP) across 4 annual visits was assessed using the intraindividual SD, variation independent of the mean, and coefficient of variation. Read More

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[Treatment of acute tandem occlusion of arteries of anterior cerebral circulation without emergency stenting].

Angiol Sosud Khir 2021 ;27(1):53-64

Department of Roentgenovascular Methods of Diagnosis and Treatment, Municipal Clinical Hospital named after S.P. Botkin of the Moscow Healthcare Department, Moscow, Russia; Chair of Therapy and Adolescent Medicine, Russian Medical Academy of Continuous Professional Education of the RF Ministry of Public Health, Moscow, Russia.

The article deals with problems of endovascular treatment of acute tandem and isolated occlusions of arteries of the anterior cerebral circulation, as well as the problem of reocclusions and new occlusions of these target arteries in the early postoperative period after thrombectomy.

Purpose: To determine the effect of reocclusions and new, previously not identified occlusions of the carotid artery and middle cerebral artery after cerebral thrombectomy on the outcomes of ischaemic stroke, as well as to substantiate feasibility of endovascular policy without simultaneous carotid stenting in thrombectomy in case of tandem occlusions of arteries of the anterior cerebral circulation.

Patients And Methods: We studied the results of endovascular treatment of 52 patients with acute ischaemic stroke, including 26 patients with combined occlusions of the internal carotid and middle cerebral arteries (group 1) and 26 patients with isolated occlusion of the M1 segment of the middle cerebral artery or its equivalent (group 2). Read More

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Despite Equivalent Outcomes, Men Receive Neoadjuvant Chemotherapy Less Often Than Women for Lymph Node-Positive Breast Cancer.

Ann Surg Oncol 2021 Apr 6. Epub 2021 Apr 6.

Division of Surgical Oncology, Department of Surgery, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA.

Background: Neoadjuvant chemotherapy (NAC) downstages breast cancer and provides prognostic information. Males with breast cancer are known to receive less treatment overall and have poorer outcomes relative to females. We hypothesized that males would be less likely to receive NAC. Read More

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Mandated Kindergarten Eye Examinations in a US Suburban Clinic: Is It Worth the Cost?

Clin Ophthalmol 2021 29;15:1331-1337. Epub 2021 Mar 29.

Wheaton Eye Clinic, Ltd., Wheaton, IL, USA.

Purpose: The state of Illinois has required an examination by an optometrist or ophthalmologist prior to mandatory kindergarten since 2008. This requirement has allowed us to gather information regarding disease prevalence in a local suburban population.

Methods: A retrospective chart review was undertaken of kindergarten eye examinations performed at the Wheaton Eye Clinic between September 2008 and February 2017. Read More

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Validation of the Thermo Scientific™ SARS-CoV-2 RT-PCR Detection Workflow for the Detection of SARS-CoV-2 from Stainless Steel Environmental Surface Swabs AOAC Performance Tested MethodSM 012103.

J AOAC Int 2021 Apr 5. Epub 2021 Apr 5.

Thermo Fisher Scientific, Wade Road, Basingstoke, Hampshire, RG24 8PW, UK.

Background: The Thermo Scientific™ SARS-CoV-2 RT-PCR Detection Workflow, packaged with Applied Biosystems™ TaqMan™ 2019-nCoV Assay Kit v1 targets three different SARS-CoV-2 genomic regions in a single RT-PCR reaction.

Objective: To validate the Thermo Scientific™ SARS-CoV-2 RT-PCR Workflow, for the detection of SARS-CoV-2 virus on stainless steel surfaces as part of the AOAC Performance Tested Method  SM Emergency Response Validation program.

Methods: The Applied Biosystems™ TaqMan™ 2019-nCoV Assay Kit v1, as part of the Thermo Scientific SARS-CoV-2 RT-PCR Workflow was evaluated for specificity using in silico analysis of 15,764 SARS-CoV-2 sequences and 65 exclusivity organisms. Read More

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Cardiovascular morbidity and mortality associations with biomass- and fossil-fuel-combustion fine-particulate-matter exposures in Dhaka, Bangladesh.

Int J Epidemiol 2021 Apr 6. Epub 2021 Apr 6.

Department of Environmental Medicine, New York University School of Medicine, New York, NY, USA.

Background: Fine-particulate-matter (i.e. with an aerodynamic diameter of ≤2. Read More

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Review of the Breathability and Filtration Efficiency of Common Household Materials for Face Masks.

ACS Nano 2021 Apr 6. Epub 2021 Apr 6.

Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, Georgia 30307, United States.

The World Health Organization and the United States Centers for Disease Control have recommended universal face masking by the general public to slow the spread of COVID-19. A number of recent studies have evaluated the filtration efficiency and pressure differential (an indicator of breathability) of various, widely available materials that the general public can use to make face masks at home. In this review, we summarize those studies to provide guidance for both the public to select the best materials for face masks and for future researchers to rigorously evaluate and report on mask material testing. Read More

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Pharmacokinetics of Asfotase Alfa in Adult Patients With Pediatric-Onset Hypophosphatasia.

J Clin Pharmacol 2021 Apr 6. Epub 2021 Apr 6.

Orthopedic Department, University of Würzburg, Würzburg, Bavaria, Germany.

Hypophosphatasia is a rare metabolic disease resulting from variant(s) in the gene encoding tissue-nonspecific isozyme of alkaline phosphatase. In this 13-week, Phase 2a, multicenter, randomized, open-label, dose-response study (ClinicalTrials.gov: NCT02797821), the pharmacokinetics of asfotase alfa, an enzyme replacement therapy approved for the treatment of hypophosphatasia, was assessed in adult patients with pediatric-onset hypophosphatasia. Read More

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Mosquito Identification From Bulk Samples Using DNA Metabarcoding: a Protocol to Support Mosquito-Borne Disease Surveillance in Canada.

J Med Entomol 2021 Apr 2. Epub 2021 Apr 2.

Public Health Risk Sciences Division, National Microbiology Laboratory, Public Health Agency of Canada, Saint-Hyacinthe, Québec, Canada.

Approximately 80 species of mosquitoes (Diptera: Culicidae) have been documented in Canada. Exotic species such as Aedes albopictus (Skuse) (Diptera: Culicidae) are becoming established. Recently occurring endemic mosquito-borne diseases (MBD) in Canada including West-Nile virus (WNV) and Eastern Equine Encephalitis (EEE) are having significant public health impacts. Read More

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Impact of gestational and postmenstrual age on excretion of fetal zone steroids in preterm infants determined by GC-MS.

J Clin Endocrinol Metab 2021 Apr 4. Epub 2021 Apr 4.

Neonatal Neuroprotection Laboratory, Department of Neonatology and Pediatric Intensive Care, University Medicine Greifswald, Sauerbruchstraße, Greifswald, Germany.

Context: Fetal zone steroids (FZS) are excreted in high concentrations in preterm infants. Experimental data suggest protective effects of FZS in models of neonatal disease.

Objective: We aimed to characterize the postnatal FZS metabolome of well preterm and term infants. Read More

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The Effect of Telehealth Services on Provider Productivity.

Med Care 2021 05;59(5):456-460

Department of Veterans Affairs Office of Productivity, Efficiency, and Staffing, West Haven, CT.

Background: Telehealth services historically have played a small role in the provision of health care in the United States. However during the coronavirus disease 2019 (COVID-19) pandemic, public and private insurers rapidly expanded access to telehealth in order to reduce exposure and avoid transmission. It is unknown whether telehealth will become a more regular substitute for in-person care beyond the pandemic. Read More

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Advanced Therapies for the Management of Dopamine Dysregulation Syndrome in Parkinson's Disease.

Mov Disord Clin Pract 2021 Apr 11;8(3):400-405. Epub 2021 Mar 11.

Division of Neurology University of Toronto Toronto Ontario Canada.

Background: Dopamine Dysregulation Syndrome (DDS) is an adverse non-motor complication of dopamine replacement therapy in Parkinson's disease. The current literature on this syndrome is limited, and it remains underdiagnosed and challenging to manage.

Objective: To assess the role of advanced therapies in the management of DDS. Read More

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Respiratory impedance measured using impulse oscillometry in a healthy urban population.

ERJ Open Res 2021 Jan 29;7(1). Epub 2021 Mar 29.

Dept of Population Health, NYU Grossman School of Medicine, New York, NY, USA.

This study derives normative prediction equations for respiratory impedance in a healthy asymptomatic urban population using an impulse oscillation system (IOS). In addition, this study uses body mass index (BMI) in the equations to describe the effect of obesity on respiratory impedance. Data from an urban population comprising 472 healthy asymptomatic subjects that resided or worked in lower Manhattan, New York City were retrospectively analysed. Read More

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January 2021

Developments in statistical inference when assessing spatiotemporal disease clustering with the tau statistic.

Spat Stat 2021 Apr;42:100438

London School of Hygiene & Tropical Medicine, UK.

The uses geolocation and, usually, symptom onset time to assess global spatiotemporal clustering from epidemiological data. We test different methods that could bias the clustering range estimate based on the statistic or affect its apparent precision, by comparison with a baseline analysis of an open access measles dataset. From re-analysing this data we find evidence against no clustering and no inhibition, (global envelope test). Read More

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