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Innovative marking method using novel endoscopic clip equipped with fluorescent resin to locate gastric cancer.

Asian J Endosc Surg 2021 Apr 27;14(2):254-257. Epub 2020 Jul 27.

Department of Surgery, Kochi Medical School, Nankoku, Japan.

An asymptomatic 76-year-old man presented to our department for the treatment of gastric cancer. Esophagogastroduodenoscopy revealed a superficial elevated lesion with an irregular central depression in the lower third of the stomach; this was confirmed to be adenocarcinoma by biopsy, while abdominal contrast-enhanced CT revealed no abnormal lesions. Based on the patient's clinical diagnosis of early gastric cancer, we planned laparoscopic gastrectomy with preoperative placement of four endoscopic marking clips equipped with indocyanine green-conjugated resin to determine the resection margin. Read More

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A comparison of the delivery of inhaled drugs by jet nebulizer and vibrating mesh nebulizer using dual-source dual-energy computed tomography in rabbits: a preliminary study.

Ann Transl Med 2020 Sep;8(17):1072

Department of Critical Care Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.

Background: Radionuclide imaging is the primary method of visually evaluating drug deposition in the lungs. Here, we used a new imaging technique, dual-source dual-energy computed tomography (DSDECT), to compare the ability of two nebulizers commonly used in clinical practice to deposit drugs in the lungs.

Methods: Male New Zealand White rabbits were randomly divided into a vibrating mesh nebulizer group and a small volume jet nebulizer group. Read More

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September 2020

Impact of COVID-19 on Clinical and Academic Urological Practice: A Survey from European Association of Urology Section of Uro-technology.

Eur Urol Open Sci 2020 Oct 17;21:22-28. Epub 2020 Aug 17.

SLK Kliniken Urology Department, Teaching Hospital of Heidelberg University, Heilbronn, Germany.

Background: The unexpected coronavirus disease 2019 (COVID-19) pandemic has spread worldwide rapidly, developing into a global health crisis. At the same time, it has seriously impacted the daily activities in all the fields of urology.

Objective: To better understand the impact of the COVID-19 pandemic on clinical, academic, and scientific activities as well as on the quality of life of urologists from the main centers in Europe. Read More

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October 2020

A learning experience of pandemic COVID-19 management at our medical institute.

J Family Med Prim Care 2020 Aug 25;9(8):4270-4276. Epub 2020 Aug 25.

Department of Medicine, King George's Medical University, Lucknow, Uttar Pradesh, India.

Background: Coronavirus disease-19 (COVID-19) pandemic caused by Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) is a novel disease.

Objectives: Our healthcare sector is at the epicentre of this unprecedented global pandemic challenge and we are not fully aware of it's management. Here we have discussed our learning experience in managing and tackling the COVID-19 pandemic at our institute which will set an example for other hospitals as well as instill confidence in our primary care physicians who are the frontline warriors. Read More

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Progressive Reinvention or Destination Lost? Half a Century of Cardiovascular Tissue Engineering.

Front Cardiovasc Med 2020 9;7:159. Epub 2020 Sep 9.

Christiaan Barnard Division for Cardiothoracic Surgery, University of Cape Town, Cape Town, South Africa.

The concept of tissue engineering evolved long before the phrase was forged, driven by the thromboembolic complications associated with the early total artificial heart programs of the 1960s. Yet more than half a century of dedicated research has not fulfilled the promise of successful broad clinical implementation. A historical account outlines reasons for this scientific impasse. Read More

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September 2020

Coronary micro-computed tomography angiography in mice.

Sci Rep 2020 10 8;10(1):16866. Epub 2020 Oct 8.

German Cancer Research Center (DKFZ), X-Ray Imaging and CT, Heidelberg, 69120, Germany.

Coronary computed tomography angiography is an established technique in clinical practice and a valuable tool in the diagnosis of coronary artery disease in humans. Imaging of coronaries in preclinical research, i.e. Read More

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October 2020

Polarization Differential Visible Light Communication: Theory and Experimental Evaluation.

Sensors (Basel) 2020 Oct 3;20(19). Epub 2020 Oct 3.

KU Leuven, ESAT-DRAMCO, 9000 Ghent, Belgium.

Visible Light Communication (VLC) has received substantial research attention in the last decade. The vast majority of VLC focuses on the modulation of the transmitted light intensity. In this work, however, the intensity is kept constant while the polarization direction is deployed as a carrier of information. Read More

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October 2020

Impact of Using GPS L2 Receiver Antenna Corrections for the Galileo E5a Frequency on Position Estimates.

Sensors (Basel) 2020 Sep 27;20(19). Epub 2020 Sep 27.

Faculty of Civil Engineering and Geodesy, Military University of Technology, gen. S. Kaliskiego 2, 00-908 Warsaw, Poland.

Knowledge of Global Navigation Satellite System (GNSS) antenna phase center variations plays a key role in precise positioning. Proper modeling is achieved by accessing antenna phase center corrections, which are determined in the calibration process. For most receiver antenna types, the International GNSS Service provides such corrections for two GPS and GLONASS carrier signals. Read More

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September 2020

Fusion Imaging with a Mobile C-Arm for Peripheral Arterial Disease.

Ann Vasc Surg 2021 Feb 3;71:273-279. Epub 2020 Sep 3.

Center of cardiothoracic and vascular surgery, Rennes University Hospital, Rennes, France; INSERM, U1099, Rennes, France; Signal and Image Processing Laboratory (LTSI), University of Rennes 1, Rennes, France. Electronic address:

Background: Fusion imaging makes it possible to improve endovascular procedures and is mainly used in hybrid rooms for aortic procedures. The objective of this study was to evaluate the feasibility of fusion imaging for femoropopliteal endovascular procedures with a mobile flat plane sensor and dedicated software to assist endovascular navigation.

Materials And Methods: Between May and December 2017, 41 patients requiring femoropopliteal endovascular revascularization were included. Read More

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February 2021

Performance of the BL03U beamline at SSRF.

J Synchrotron Radiat 2020 Sep 28;27(Pt 5):1388-1394. Epub 2020 Jul 28.

Center for Excellence in Superconducting Electronics, State Key Laboratory of Functional Materials for Informatics, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, People's Republic of China.

The vacuum ultraviolet beamline BL03U with a photon energy range from 7 eV upwards has been constructed at the 3.5 GeV Shanghai Synchrotron Radiation Facility. Equipped with an APPLE-Knot undulator, this beamline is dedicated to angle-resolved photoemission spectroscopy. Read More

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September 2020

Evaluation of handheld and portable Raman spectrometers with different laser excitation wavelengths for the detection and characterization of organic minerals.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Dec 11;243:118818. Epub 2020 Aug 11.

Institute of Geochemistry, Mineralogy and Mineral Resources, Faculty of Science, Charles University, Albertov 6, 128 43 Prague 2, Czech Republic.

Organic minerals occur rather rarely in some types of peat bogs, sedimentary geological environments, and hydrothermal veins. Commonly, calcium oxalates are produced by several plants, terpenoids are often associated with conifers. Because of the organic precursor, these minerals, from the smallest group of the mineralogical system, are sometimes considered as biomarkers. Read More

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December 2020

The development of a dedicated polymer support for the solid-phase oligosaccharide synthesis.

Chem Commun (Camb) 2020 Sep 12;56(72):10568-10571. Epub 2020 Aug 12.

Department of Chemistry and Biochemistry, University of Missouri - St. Louis, One University Boulevard, St. Louis, Missouri 63121, USA.

Reported herein is the development of a novel polystyrene-based resin that we named PanzaGel. The resin was equipped with diethylene glycol-derived cross-linker with the dedicated application to polymer supported glycan synthesis in mind. After investigating its swelling properties and obtaining encouraging data for its chemical and thermal stability we accessed the amenability of PanzaGel to the HPLC-based platform for the automated synthesis. Read More

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September 2020

Advancing health equity through CTSA programs: Opportunities for interaction between health equity, dissemination and implementation, and translational science.

J Clin Transl Sci 2020 Jan 28;4(3):168-175. Epub 2020 Jan 28.

Department of Sociomedical Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA.

Dissemination and implementation (D&I) science is dedicated to studying how to effectively translate and apply research in real-world contexts. There has been increasing interest in health equity within the D&I field to ensure the equitable implementation of evidence-based programs/practices across a range of diverse populations and settings. At the same time, health equity researchers recognize the potential of D&I science to promote the more widespread dissemination, implementation, and sustainment of evidence-based interventions to address health inequities. Read More

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January 2020

Finite-Horizon H State Estimation for Stochastic Coupled Networks With Random Inner Couplings Using Round-Robin Protocol.

IEEE Trans Cybern 2021 Mar 17;51(3):1204-1215. Epub 2021 Feb 17.

This article is concerned with the problem of finite-horizon H state estimation for time-varying coupled stochastic networks through the round-robin scheduling protocol. The inner coupling strengths of the considered coupled networks are governed by a random sequence with known expectations and variances. For the sake of mitigating the occurrence probability of the network-induced phenomena, the communication network is equipped with the round-robin protocol that schedules the signal transmissions of the sensors' measurement outputs. Read More

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Preparation of a radiology department in an Italian hospital dedicated to COVID-19 patients.

Radiol Med 2020 Sep 11;125(9):894-901. Epub 2020 Jul 11.

Radiology Department, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Via Francesco Sforza, 35, 20122, Milan, Italy.

Preparedness for the ongoing coronavirus disease 2019 (COVID-19) and its spread in Italy called for setting up of adequately equipped and dedicated health facilities to manage sick patients while protecting healthcare workers, uninfected patients, and the community. In our country, in a short time span, the demand for critical care beds exceeded supply. A new sequestered hospital completely dedicated to intensive care (IC) for isolated COVID-19 patients needed to be designed, constructed, and deployed. Read More

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September 2020

Fluoroscopy guided electrode-array insertion for cochlear implantation with straight electrode-arrays: a valuable tool in most cases.

Eur Arch Otorhinolaryngol 2021 Apr 25;278(4):965-975. Epub 2020 Jun 25.

Department of Otolaryngology-Head Neck Surgery, University Hospital Center, CHU Gabriel Montpied, 58 rue Montalembert, 63000, Clermont-Ferrand, France.

Purpose: To highlight the advantages of real time fluoroscopy guided electrode-array (EA) insertion (FGI) during cochlear implants surgery.

Methods: All surgical procedures were performed in a dedicated operating room equipped with a robotic C-arm cone beam device, allowing for intraoperative real time 2D FGI and postoperative 3D imaging. Only straight EAs were used. Read More

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Facilitating Advancement of Clinical-Track Pharmacy Faculty Members.

Am J Pharm Educ 2020 05;84(5):7910

University at Buffalo, School of Pharmacy and Pharmaceutical Sciences, Buffalo, New York.

Clinical faculty members in most pharmacy practice departments are expected to engage in practice, teaching, research and scholarship, and service. Although new clinical faculty members are typically well equipped to engage in the clinical practice aspect of their position, they generally lack experience in the other academic pillars and, depending on the institution, may not have dedicated time to engage in each area of effort, particularly research and scholarship. Consequently, achieving balance and realizing success in the tripartite mission of academia can be challenging. Read More

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Multi-Camera Vehicle Tracking Using Edge Computing and Low-Power Communication.

Sensors (Basel) 2020 Jun 11;20(11). Epub 2020 Jun 11.

Neurosoft Sp. z o.o., ul. Życzliwa 8, 53-030 Wrocław, Poland.

Typical approaches to visual vehicle tracking across large area require several cameras and complex algorithms to detect, identify and track the vehicle route. Due to memory requirements, computational complexity and hardware constrains, the video images are transmitted to a dedicated workstation equipped with powerful graphic processing units. However, this requires large volumes of data to be transmitted and may raise privacy issues. Read More

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Novel endoscopic marking clip equipped with resin-conjugated fluorescent indocyanine green during laparoscopic surgery for gastrointestinal cancer.

Langenbecks Arch Surg 2020 Jun 30;405(4):503-508. Epub 2020 May 30.

Department of Surgery, Kochi Medical School, Nankoku, Kochi, Japan.

Purpose: Intraoperative identification of the cancer location is often difficult to conduct during laparoscopic surgery, especially in early-stage cancers. This study aimed to investigate the feasibility and accuracy of a novel endoscopic clip resin-conjugated fluorescent indocyanine green during laparoscopic surgery for gastrointestinal cancer.

Methods: Preoperative placement of endoscopic marking clips equipped with resin-conjugated fluorescent indocyanine green was performed to determine the resection margin in eight patients with gastrointestinal cancer. Read More

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GEANT4 Monte Carlo simulations for virtual clinical trials in breast X-ray imaging: Proof of concept.

Phys Med 2020 Jun 26;74:133-142. Epub 2020 May 26.

Università di Napoli Federico II, Dipartimento di Fisica "Ettore Pancini", and INFN Sezione di Napoli, Napoli, Italy.

Virtual clinical trials (VCT) are in-silico reproductions of medical examinations, which adopt digital models of patients and simulated devices. They are intended to produce clinically equivalent outcome data avoiding long execution times, ethical issues related to radiation induced risks and huge costs related to real clinical trials with a patient population. In this work, we present a platform for VCT in 2D and 3D X-ray breast imaging. Read More

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A Microfluidic Device for Imaging Samples from Microbial Suspension Cultures.

MethodsX 2020 24;7:100891. Epub 2020 Apr 24.

Department of Biomedical Engineering, University of Wisconsin-Madison, United States.

Traditional methods to assess microbial cells during suspension culture require laborious and frequent manual sampling. Approaches to automate sampling and assessment utilize dedicated, sophisticated equipment and suffer from a lack of temporal resolution and sampling efficiency. In this study we describe a simple microfluidic device that allows microbial cells to be sampled from suspension culture and rapidly slowed and concentrated for single-cell imaging on a standard laboratory microscope. Read More

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Potential for nocturnal satellite detection of suspended matter concentrations in coastal waters using a panchromatic band: a feasibility study based on VIIRS (NASA/NOAA) spectral and radiometric specifications.

Opt Express 2020 May;28(10):15314-15330

Satellite remote sensing of coastal waters is important for understanding the functioning of these complex ecosystems. High satellite revisit frequency is required to permit a relevant monitoring of the strong dynamical processes involved in such areas, for example rivers discharge or tidal currents. One key parameter that is derived from satellite data is the suspended particulate matter (SPM) concentration. Read More

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Soft x-ray laser beamline for surface processing and damage studies.

Appl Opt 2020 Apr;59(12):3692-3698

We have developed a soft x-ray laser (SXRL) beamline equipped with an intensity monitor dedicated to ablation study such as surface processing and damage formation. The SXRL beam having a wavelength of 13.9 nm, pulse width of 7 ps, and pulse energy of around 200 nJ is generated from Ag plasma mediums using an oscillator-amplifier configuration. Read More

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Guidance for building a dedicated health facility to contain the spread of the 2019 novel coronavirus outbreak.

Indian J Med Res 2020 Feb & Mar;151(2 & 3):177-183

Former Director, Communicable Diseases, World Health Organization, South-East Asia Regional Office, New Delhi, India.

Preparedness for the ongoing coronavirus disease 2019 (COVID-19) and its spread in India calls for setting up of adequately equipped and dedicated health facilities to manage sick patients while protecting healthcare workers and the environment. In the wake of other emerging dangerous pathogens in recent times, such as Ebola, Nipah and Zika, it is important that such facilities are kept ready during the inter-epidemic period for training of health professionals and for managing cases of multi-drug resistant and difficult-to-treat pathogens. While endemic potential of such critically ill patients is not yet known, the health system should have surge capacity for such critical care units and preferably each tertiary government hospital should have at least one such facility. Read More

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[Emergency Medical Services: COVID-19 crisis].

Rev Med Suisse 2020 Apr;16(N° 691-2):810-814

Service des urgences, CHUV, 1011 Lausanne.

The COVID-19 epidemic required rapid and frequent adaptations from the prehospital emergency medical services (EMS). The exposure of EMS providers is significant, particularly during procedures at risk of aerosolization such as advanced airways management or cardiopulmonary resuscitation. EMS personal need to be equipped with appropriate personal protective equipment and trained in its use. Read More

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Development of a Computational Tool for Automated Interpretation of Intact -Glycopeptide Tandem Mass Spectra from Single Proteins.

Anal Chem 2020 05 21;92(9):6777-6784. Epub 2020 Apr 21.

Precise and automated analysis of site-specific -glycosylation on single proteins is crucial for comprehensive characterization of some important glycoproteins, such as tumor biomarkers and recombinant drug proteins. Mass spectrometry has been proven to be a powerful technique for protein sequencing and -glycosylation analysis. However, challenges remain in developing computational tools for intact -glycopeptide analysis, which has greatly hindered the development of mass-spectrometry-based -glycosylation analysis. Read More

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Neutrophil chemoattractant receptors in health and disease: double-edged swords.

Cell Mol Immunol 2020 05 1;17(5):433-450. Epub 2020 Apr 1.

Laboratory of Molecular Immunology, Rega Institute, KU Leuven, Herestraat 49 bus 1042, B-3000, Leuven, Belgium.

Neutrophils are frontline cells of the innate immune system. These effector leukocytes are equipped with intriguing antimicrobial machinery and consequently display high cytotoxic potential. Accurate neutrophil recruitment is essential to combat microbes and to restore homeostasis, for inflammation modulation and resolution, wound healing and tissue repair. Read More

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Ultrasound Molecular Imaging With BR55, a Predictive Tool of Antiangiogenic Treatment Efficacy in a Chemo-Induced Mammary Tumor Model.

Invest Radiol 2020 10;55(10):657-665

From the Bracco Suisse SA, Bracco Global Research & Development, Plan-Les-Ouates, Geneva, Switzerland.

Objectives: The aim of this study was to evaluate the added value of ultrasound molecular imaging of the vascular growth factor receptor 2 (VEGFR2) expression, using the clinical grade contrast agent BR55, for the early evaluation of antiangiogenic treatment efficacy in a chemo-induced rat mammary tumor model.

Materials And Methods: In this preclinical study, chemo-induced rat mammary tumors were obtained after a single injection of N-nitroso-N-methylurea intraperitoneally in 46 prepubescent (age 38 ± 2 days) female rats. All experiments were performed under the authorization of the Direction Générale de la Santé, Geneva, Switzerland. Read More

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October 2020

Comparison of three different phantoms used for Winston-Lutz test with Artiscan software.

Rep Pract Oncol Radiother 2020 May-Jun;25(3):351-354. Epub 2020 Mar 4.

Dosimetry Department of Medical Equipment, The Maria Skłodowska-Curie Greater Poland Cancer Centre, Poznań, Poland.

Background: One of the most important test in every quality assurances process of medical linear accelerators is the Winston-Lutz test, allowing an evaluation of the treatment isocentre in the light of uncertainty of the position of the collimator, the gantry and the couch.

Aim: The purpose of this work was analysis of the results of the Winston-Lutz test performed with three different phantoms for two different accelerators.

Materials And Methods: Measurements were performed on two Varian machines: TrueBeam equipped with aS1200 EPID and TrueBeam equipped with aS1000 EPID. Read More

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Lesion Detectability and Radiation Dose in Spiral Breast CT With Photon-Counting Detector Technology: A Phantom Study.

Invest Radiol 2020 08;55(8):515-523

From the Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

Objectives: The aim of the article was to evaluate the lesion detectability, image quality, and radiation dose of a dedicated clinical spiral breast computed tomography (CT) system equipped with a photon-counting detector, and to propose optimal scan parameter settings to achieve low patient dose levels and optimal image quality.

Methods: A breast phantom containing inserts mimicking microcalcifications (diameters 196, 290, and 400 μm) and masses (diameters 1.8, 3. Read More

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