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After Theranos: Using point-of-care testing to advance measures of health biomarkers in human biology research.

Am J Hum Biol 2021 Oct 20. Epub 2021 Oct 20.

Department of Anthropology, University of Oregon, Eugene, Oregon, USA.

Objectives: The rise and fall of the health technology startup Theranos is emblematic of the promise and peril of point-of-care testing (POCT). Instruments that deliver immediate results from minimally invasive samples at the location of collection can provide powerful tools to deliver health data in clinical and public health contexts. Yet, POCT availability is driven largely by market interests, which limits the development of inexpensive tests for diverse health conditions that can be used in resource-limited settings. Read More

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October 2021

Silver Carboxylate-doped Titanium Dioxide-Polydimethylsiloxane Coating decreases Cutibacterium acnes Adherence and Biofilm Formation on Polyether Ether Ketone.

Spine J 2021 Oct 16. Epub 2021 Oct 16.

The Warren Alpert Medical School of Brown University, Providence, RI; Department of Orthopaedic Surgery, Warren Alpert Medical School of Brown University, Providence, RI; Weiss Center for Orthopaedic Trauma Research, Rhode Island Hospital, Providence, RI.

Background Context: Cutibacterium acnes (C. acnes) is a gram-positive facultative anaerobe found in the deep sebaceous follicles of the skin on the shoulder and back. C. Read More

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October 2021

Diagnostic Efficacy of Recombinase-Polymerase-Amplification Coupled with Lateral Flow Strip Reading in Patients with Cutaneous Leishmaniasis from the Amazonas Rainforest of Perú.

Vector Borne Zoonotic Dis 2021 Oct 19. Epub 2021 Oct 19.

Division of Infectious Diseases, Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas, USA.

Cutaneous leishmaniasis (CL) is highly prevalent in rural and sylvatic regions of Latin America, with an estimated 55,000 annual cases. Diagnosis in resource-limited areas still relies on microscopy of dermal scrapings, while more sensitive methods like PCR are not attainable due to costs and lack of adequate health infrastructure. Isothermal amplification of DNA can be performed without sophisticated equipment and training and may become a point of care (POC) test for health care centers with scarce resources. Read More

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October 2021

Use of some cost-effective technologies for a routine clinical pathology laboratory.

Lab Chip 2021 Oct 19. Epub 2021 Oct 19.

Interdisciplinary Laboratory of Clinical Pathology, Interlab-UMU, Regional Campus of International Excellence 'Campus Mare Nostrum', University of Murcia, 30100 Murcia, Spain.

Classically, the need for highly sophisticated instruments with important economic costs has been a major limiting factor for clinical pathology laboratories, especially in developing countries. With the aim of making clinical pathology more accessible, a wide variety of free or economical technologies have been developed worldwide in the last few years. 3D printing and Arduino approaches can provide up to 94% economical savings in hardware and instrumentation in comparison to commercial alternatives. Read More

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October 2021

Technology agnostic frequency characterization methodology for memristors.

Sci Rep 2021 Oct 18;11(1):20599. Epub 2021 Oct 18.

Centre for Electronics Frontiers, Electronics and Computer Science, University of Southampton, Southampton, SO171BJ, UK.

Over the past decade, memristors have been extensively studied for a number of applications, almost exclusively with DC characterization techniques. Studies of memristors in AC circuits are sparse, with only a few examples found in the literature, and characterization methods with an AC input are also sparingly used. However, publications concerning the usage of memristors in this working regime are currently on the rise. Read More

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October 2021

A Challenging Case of Using Manta Ray Skin Flaps in a Severe Post-Traumatic First Web Space Contracture.

Am J Case Rep 2021 Oct 19;22:e933907. Epub 2021 Oct 19.

Department of Orthopaedics and Traumatology, Medical University - Sofia, University Hospital of Orthopaedics "Prof. B. Boichev", Sofia, Bulgaria.

BACKGROUND First web space contracture affects thumb function and grasping capacity. This pathology alters normal anatomy and results in decreased ability to use the hand. Appropriate release and resurfacing are needed to restore normal hand function. Read More

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October 2021

The cost of clinical management of SARS-COV-2 (COVID-19) infection by level of disease severity in Ghana: a protocol-based cost of illness analysis.

BMC Health Serv Res 2021 Oct 18;21(1):1115. Epub 2021 Oct 18.

Ghana Health Service, Headquarters Office, Private Mail Bag, Ministries, Accra, Ghana.

Background: As the global strategies to fight the SARS-COV-2 infection (COVID-19) evolved, response strategies impacted the magnitude and distribution of health-related expenditures. Although the economic consequence of the COVID-19 pandemic has been dire, and its true scale is yet to be ascertained, one key component of the response is the management of infected persons which its cost has not been adequately examined, especially in Africa.

Methods: To fill gaps in context-specific cost of treating COVID-19 patients, we adopted a health system's perspective and a bottom-up, point of care resource use data collection approach to estimate the cost of clinical management of COVID-19 infection in Ghana. Read More

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October 2021

A Potentially Dangerous Industrial Projectile Lodged in the Leg of a Steel Factory Worker.

Cureus 2021 Sep 10;13(9):e17870. Epub 2021 Sep 10.

Anaesthesiology, ESI Hospital Rohini, Delhi, IND.

Penetrating injuries due to fragments energized by an explosive event are life/limb-threatening and are associated with poor clinical and functional outcomes. Penetrating injuries are commonly inflicted in attacks with explosive devices. The extremities, especially the leg, are the most commonly affected body areas, presenting a high risk of infection, slow recovery, and the threat of amputation. Read More

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September 2021

A digitalized isothermal nucleic acid testing platform based on a pump-free open droplet array microfluidic chip.

Analyst 2021 Oct 18. Epub 2021 Oct 18.

Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an 710049, P.R. China.

Digital PCR has shown great potential for quantitative nucleic acid testing (NAT), but most existing platforms are dependent on large auxiliary equipment (, vacuum pump, amplification instrument, fluorescence microscope) to achieve target dispersion, amplification, signal capture and result analysis. Such complex, expensive and bulky NAT platforms have limited their applications in resource-limited areas, especially for point-of-care testing (POCT). In this work, we designed a digital isothermal NAT platform based on a pump-free open droplet array microfluidic chip. Read More

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October 2021

A comparative study on the influence of third point of reference on condylar guidance settings in a semi-adjustable articulator with lateral cephalographs: An in-vivo study.

Niger J Clin Pract 2021 Oct;24(10):1457-1462

Department of Preventive Dental Science, College of Dentistry, Majmaah University, Al-zulfi, Kingdom of Saudi Arabia.

Aim: The study aimed to evaluate the effect on condylar guidance values with casts mounted by facebow transfer (Guichet's point as the third point of reference), Bonwill's, and radiographic method.

Materials And Methods: The dentulous subject's casts were mounted to a semi-adjustable articulator (Artex Type AR) after facebow transfer with Guichet's point as the third point of reference and also by Bonwill's method. Protrusive records made earlier were utilized to program the right and left side condylar guidance value. Read More

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October 2021

Process analytical technology in continuous processing: Model-based real time control of pH between capture chromatography and viral inactivation for monoclonal antibody production.

J Chromatogr A 2021 Oct 8;1658:462614. Epub 2021 Oct 8.

Department of Chemical Engineering, Indian Institute of Technology, 110016, Hauz Khas, India. Electronic address:

A real time mechanistic model-based control strategy is demonstrated for in-line pH adjustment post-capture chromatography and prior to viral inactivation for continuous processing of monoclonal antibodies. At this point in the process, tight control of pH is essential, as pH fluctuations above 3.5 can result in incomplete viral inactivation, while fluctuations below 3. Read More

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October 2021

Work statistics in non-Hermitian evolutions with Hermitian endpoints.

Phys Rev E 2021 Sep;104(3-1):034107

Theoretical Quantum Physics Laboratory, RIKEN Cluster for Pioneering Research, Wako-shi, Saitama 351-0198, Japan.

Non-Hermitian systems with specific forms of Hamiltonians can exhibit novel phenomena. However, it is difficult to study their quantum thermodynamical properties. In particular, the calculation of work statistics can be challenging in non-Hermitian systems due to the change of state norm. Read More

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September 2021

[Short-term effectiveness of percutaneous pedicle screw fixation combined with intravertebral allograft by different methods for thoracolumbar fractures].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2021 Oct;35(10):1311-1317

Department of Orthopedics, the First Affiliated Hospital of Nanjing Medical University, Nanjing Jiangsu, 210000, P.R.China.

Objective: To investigate the short-term effectiveness of percutaneous pedicle fixation combined with intravertebral allograft by different methods for thoracolumbar fractures.

Methods: The clinical data of 94 patients with single segment thoracolumbar fracture who underwent percutaneous pedicle fixation combined with intravertebral allograft by different methods between October 2018 and October 2019 were retrospectively analyzed. According to the different methods of intravertebral allograft, they were divided into group A (bone grafting by Jack dilator, 40 cases) and group B (bone grafting by funnel, 54 cases). Read More

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October 2021

[An arthroscopic "inlay" Bristow procedure with suture button fixation: Surgical technique and radiology evaluation].

Beijing Da Xue Xue Bao Yi Xue Ban 2021 Oct;53(5):896-901

Department of Sports Medicine, Peking University Third Hospital, Institute of Sports Medicine of Peking University, Beijing Key Laboratory of Sports Injuries, Beijing 100191, China.

Objective: To introduce an arthroscopic "inlay" Bristow procedure based on the Mortise-Tenon joint structure concept using suture button fixation, and to evaluate its clinical and radiology results postoperatively with a minimal 3-year follow-up.

Methods: A total of 56 patients who received arthroscopic "inlay" Bristow procedure with suture button fixation between June 2015 to June 2016 were eventually enrolled in this study. Radiological assessment on the 3D CT scan was performed preoperatively, immediately after operation, and postoperatively at the end of 3 months, 6 months and the final follow-up. Read More

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October 2021

Genetic analysis with pyrosequencing using loop pipetting and a light dependent resistor.

Anal Methods 2021 Oct 14. Epub 2021 Oct 14.

Department of Biological Sciences, Faculty of Basic & Applied Sciences, International Islamic University, Sector H-10, Islamabad, Pakistan.

DNA sequencing is among the most important techniques in biology to decipher the key genetic players of health and disease. The existing laboratory instruments for DNA sequencing are well established and reliable. However, these instruments are still out of reach of most laboratories in the world due to very high equipment and running costs and require trained personnel to keep them running. Read More

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October 2021

A Setup for Measuring the Centering Error of a Dual-Element Pyroelectric Infrared Sensor Module.

Sensors (Basel) 2021 Oct 8;21(19). Epub 2021 Oct 8.

School of Mechanical Engineering, Hanoi University of Science and Technology, Hanoi 100000, Vietnam.

This paper presents an experimental setup to measure the horizontal centering error of a pre-built pyroelectric infrared (PIR) sensor module, in which a dual-element PIR sensor is aligned at the focal point of a single-zone Fresnel Lens. In the setup, the sensor module was placed facing a modulated infrared radiating source and turned over a range of horizontal angles. The position of the optical axis of the sensor module was determined based on the analysis of the output response of the sensor at turned angles. Read More

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October 2021

On the Use of Ridge Gap Waveguide Technology for the Design of Transverse Stub Resonant Antenna Arrays.

Sensors (Basel) 2021 Oct 2;21(19). Epub 2021 Oct 2.

Signal Theory and Communications Department, Universidad Carlos III de Madrid, 28911 Leganes, Spain.

This paper presents some considerations on the design of a novel antenna consisting of the combination of a transverse stubs (TS) array excited by Ridge Gap Waveguides (RGWs), as well as a discussion of the experimental results obtained from a prototype that was manufactured and measured. A combination of Continuous Transverse Stubs (CTSs) is used as the starting point. Subsequently, the CTSs are modified to include some metallic blockers that split each CTS into a combination (array) of shorter TSs. Read More

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October 2021

Development of a New Negative Obstacle Sensor for Augmented Electric Wheelchair.

Sensors (Basel) 2021 Sep 23;21(19). Epub 2021 Sep 23.

Laboratoire Aimé Cotton, Université Paris-Saclay, CNRS, CEDEX, 91405 Orsay, France.

Due to pathologies or age-related problems, in some disabled people, motor impairment is associated with cognitive and/or visual impairments. This combination of limitations unfortunately leads to an inability to move around independently. Indeed, their situation does not allow them to use a conventional electric wheelchair, for safety reasons, and for the moment there is no other technological solution providing safe movement capacity. Read More

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September 2021

Effect of Service Environmental Parameters on Electrochemical Corrosion Behavior of L80 Casing Steel.

Materials (Basel) 2021 Sep 25;14(19). Epub 2021 Sep 25.

Institute for Advanced Materials and Technology, University of Science and Technology Beijing, Beijing 100083, China.

The corrosion behavior of L80 casing steel was studied in a simulating annulus environment using the electrochemical measurement method, immersion test, and tensile test under a high-temperature and high-pressure HS/CO environment. The partial pressure of CO (PCO2), the partial pressure of HS (PH2S), water content, and preloading stress remarkably affected the corrosion behavior of L80 steel. The influence of PCO2 on stress corrosion cracking (SCC) susceptibility has an inflection point of approximately 1. Read More

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September 2021

Pesticide Use, Perceived Health Risks and Management in Ethiopia and in Hungary: A Comparative Analysis.

Int J Environ Res Public Health 2021 Oct 3;18(19). Epub 2021 Oct 3.

Department of Public Health and Epidemiology, Faculty of Medicine, University of Debrecen, 4000 Debrecen, Hungary.

Pesticides play a very important role for ensuring food security and economic growth but their use can cause harmful effects to human health and to the environment. The study aimed to investigate the level of knowledge, health risk perceptions, and experiences on the practice of pesticide use and management among extension officers in Ethiopia and plant doctors in Hungary. A questionnaire survey among 326 officers was conducted in the two study areas and data were analyzed by ordinal logistic regression. Read More

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October 2021

High-accuracy quantitative principle of a new compact digital PCR equipment: Lab On An Array.

Genomics Inform 2021 Sep 30;19(3):e34. Epub 2021 Sep 30.

Department of Bioconvergence Engineering, Dankook University, Yongin 16890, Korea.

Digital PCR (dPCR) is the third-generation PCR that enables real-time absolute quantification without reference materials. Recently, global diagnosis companies have developed new dPCR equipment. In line with the development, the Lab On An Array (LOAA) dPCR analyzer (Optolane) was launched last year. Read More

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September 2021

A proof of concept study for the differentiation of SARS-CoV-2, hCoV-NL63, and IAV-H1N1 in vitro cultures using ion mobility spectrometry.

Sci Rep 2021 10 11;11(1):20143. Epub 2021 Oct 11.

Department of Internal Medicine II, University Hospital Rechts Der Isar, School of Medicine, Technical University of Munich, Munich, Germany.

Rapid, high-throughput diagnostic tests are essential to decelerate the spread of the novel coronavirus disease 2019 (COVID-19) pandemic. While RT-PCR tests performed in centralized laboratories remain the gold standard, rapid point-of-care antigen tests might provide faster results. However, they are associated with markedly reduced sensitivity. Read More

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October 2021

A wearable eddy current based pulmonary function sensor for continuous non-contact point-of-care monitoring during the COVID-19 pandemic.

Sci Rep 2021 10 11;11(1):20144. Epub 2021 Oct 11.

Department of Medical Engineering, California Institute of Technology, 1200 E California Blvd, MC 136-93, Pasadena, CA, 91125, USA.

Pulmonary function testing (PFT) allows for quantitative analysis of lung function. However, as a result of the coronavirus disease 2019 (COVID-19) pandemic, a majority of international medical societies have postponed PFTs in an effort to mitigate disease transmission, complicating the continuity of care in high-risk patients diagnosed with COVID-19 or preexisting lung pathologies. Here, we describe the development of a non-contact wearable pulmonary sensor for pulmonary waveform analysis, pulmonary volume quantification, and crude thoracic imaging using the eddy current (EC) phenomenon. Read More

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October 2021

ExoPRIME: Solid-phase immunoisolation and OMICS analysis of surface-marker-specific exosomal subpopulations.

Talanta 2022 Jan 11;236:122870. Epub 2021 Sep 11.

School of Biological Sciences, Louisiana Tech University, Ruston, LA, USA. Electronic address:

Exosomes encapsulate genomic and proteomic biomarkers for non-invasive diagnosis and disease monitoring. However, exosome surface-markers heterogeneity is a major drawback of current isolation methods. Here, we report a direct, one-step exosome sampling technology, ExoPRIME, for selective capture of CD63 exosome subpopulations using an immune-affinity protocol. Read More

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January 2022

[Retrospective study of 50 cases of tibial pilon fractures in adults at the Department of Orthopedics of the University Hospital Center Habib Bourguiba, Sfax, Tunisia].

Pan Afr Med J 2021 2;39:223. Epub 2021 Aug 2.

Service d'Orthopédie et de Traumatologie, Centre Hospitalier Universitaire Habib Bourguiba, Sfax, Tunisie.

Tibial pilon fractures are polymorphic fractures posing therapeutic and prognostic challenges. The purpose of this study is to examine the epidemiological profile of these fractures and to assess our findings from an anatomical and functional point of view. We collected data fom 50 medical records of patients treated for tibial pilon fractures and monitored over the period 2004-2013 at the Orthopedic-Trauma Department of the Habib Bourguiba University Hospital in Sfax. Read More

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October 2021

Rapid development and optimization of paper microfluidic designs using software automation.

Anal Chim Acta 2021 Nov 28;1184:338985. Epub 2021 Aug 28.

Department of Bioengineering, University of California, Riverside, CA, 92521, USA. Electronic address:

Paper microfluidic or lateral flow devices have found many applications, especially in medical diagnostics. Their low cost and ease of use makes them particularly valuable in resource-limited and point-of-care applications. However, the process of developing new paper microfluidic devices is slowed by the need to find optimal values for their various design parameters, which determine the overall size and fluid volume requirements of the device. Read More

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November 2021

Is there an optimal place to hold the endotracheal tube during direct laryngoscopy for patients undergoing surgery under general anesthesia? Protocol for a randomized controlled trial.

Trials 2021 Oct 9;22(1):684. Epub 2021 Oct 9.

AIIMS Bhubaneswar: All India Institute of Medical Sciences, Bbsr, Bhubaneswar, Odisha, India.

Background: Endotracheal intubation by direct laryngoscopy is a widely performed lifesaving technique. Although there are guidelines for optimal size and depth of insertion of an endotracheal tube (ETT) for successful intubation, there is no consensus on the point at which it should be held along its length. This will arguably affect the time, ease, and success of the technique due to a difference in visualization and torque applied to the ETT after glottic visualization. Read More

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October 2021

Undernutrition risk and nutritional screening implementation in hospitals: Barriers and time trends (2019-2020).

Clin Nutr ESPEN 2021 10 2;45:192-199. Epub 2021 Sep 2.

Faculty of Nutrition and Food Sciences, University of Porto, Rua do Campo Alegre, 823, 4150-180, Porto, Portugal; Directorate-General of Health, Alameda Afonso Henriques, 45 1049-005, Lisboa, Portugal.

Background & Aims: Undernutrition screening is the starting point for high-quality nutrition care. In Portugal, the systematic nutritional risk assessment became mandatory for every inpatient in hospitals of the National Health System in 2019. The aims of this study were to describe the country's nutritional risk prevalence of hospitalized patients, and the experience of implementing a systematic undernutrition screening method, including time trends, barriers, and facilitators. Read More

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October 2021

Influence of posterior pedicle screw fixation at L4-L5 level on biomechanics of the lumbar spine with and without fusion: a finite element method.

Biomed Eng Online 2021 Oct 7;20(1):98. Epub 2021 Oct 7.

Department of Mechanical Engineering, TOBB University of Economics and Technology, Çankaya, Ankara, Turkey.

Background: Posterior pedicle screw (PS) fixation, a common treatment method for widespread low-back pain problems, has many uncertain aspects including stress concentration levels, effects on adjacent segments, and relationships with physiological motions. A better understanding of how posterior PS fixation affects the biomechanics of the lumbar spine is needed. For this purpose, a finite element (FE) model of a lumbar spine with posterior PS fixation at the L4-L5 segment level was developed by partially removing facet joints (FJs) to imitate an actual surgical procedure. Read More

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October 2021

Visual Detection of Adenosine Triphosphate by Taylor Rising: A Simple Point-of-Care Testing Method Based on Rolling Circle Amplification.

Chembiochem 2021 Oct 7. Epub 2021 Oct 7.

Collaborative Innovation Center of Tumor Marker Detection Technology, Equipment and Diagnosis-Therapy Integration in Universities of Shandong, Shandong Provincial Key Laboratory of Detection Technology for Tumor Markers, College of Chemistry and Chemical Engineering, Linyi University, Linyi, 276005, P. R. China.

Rapid and sensitive point-of-care testing (POCT) is an extremely critical mission in practical applications, especially for rigorous military medicine, home health care, and in the third world. Here, we report a visual POCT method for adenosine triphosphate (ATP) detection based on Taylor rising in the corner of quadratic geometries between two rod surfaces. We discuss the principle of Taylor rising, demonstrating that it is significantly influenced by contact angle, surface tension, and density of the sample, which are controlled by ATP-dependent rolling circle amplification (RCA). Read More

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October 2021