542 results match your criteria epizootic hemorrhagic

Spatio-temporal modelling of Culicoides Latreille (Diptera: Ceratopogonidae) populations on Reunion Island (Indian Ocean).

Parasit Vectors 2021 May 27;14(1):288. Epub 2021 May 27.

ASTRE, University of Montpellier, CIRAD, INRAE, Montpellier, France.

Background: Reunion Island regularly faces outbreaks of bluetongue and epizootic hemorrhagic diseases, two insect-borne orbiviral diseases of ruminants. Hematophagous midges of the genus Culicoides (Diptera: Ceratopogonidae) are the vectors of bluetongue (BTV) and epizootic hemorrhagic disease (EHDV) viruses. In a previous study, statistical models based on environmental and meteorological data were developed for the five Culicoides species present in the island to provide a better understanding of their ecology and predict their presence and abundance. Read More

View Article and Full-Text PDF

Long-term shedding from fully convalesced individuals indicates that Pacific herring are a reservoir for viral hemorrhagic septicemia virus.

Dis Aquat Organ 2021 May 27;144:245-252. Epub 2021 May 27.

US Geological Survey, Western Fisheries Research Center, Marrowstone Marine Field Station, Nordland, WA 98328, USA.

Processes that allow viral hemorrhagic septicemia (VHS) virus to persist in the marine environment remain enigmatic, owing largely to the presence of covert and cryptic infections in marine fishes during typical sub-epizootic periods. As such, marine host reservoirs for VHS virus have not been fully demonstrated, nor have the mechanism(s) by which infected hosts contribute to virus perpetuation and transmission. Here, we demonstrate that after surviving VHS, convalesced Pacific herring continue to shed virus at a low rate for extended periods. Read More

View Article and Full-Text PDF

A Duplex Fluorescent Microsphere Immunoassay for Detection of Bluetongue and Epizootic Hemorrhagic Disease Virus Antibodies in Cattle Sera.

Viruses 2021 04 15;13(4). Epub 2021 Apr 15.

Center for Grain and Animal Health, Agricultural Research Service, Arthropod-Borne Animal Diseases Research Unit, United States Department of Agriculture, Manhattan, KS 66502, USA.

Bluetongue virus (BTV) causes internationally reportable hemorrhagic disease in cattle, sheep, and white-tailed deer. The closely related, and often co-circulating, epizootic hemorrhagic disease virus causes a clinically similar devastating disease in white-tailed deer, with increasing levels of disease in cattle in the past 10 years. Transmitted by biting midges, together, they constitute constant disease threats to the livelihood of livestock owners. Read More

View Article and Full-Text PDF

Altered microRNA Transcriptome in Cultured Human Liver Cells upon Infection with Ebola Virus.

Int J Mol Sci 2021 Apr 6;22(7). Epub 2021 Apr 6.

CHU de Québec Research Center, Department of Microbiology, Infectious Diseases and Immunology, Faculty of Medicine, Université Laval, Quebec, QC G1V 4G2, Canada.

Ebola virus (EBOV) is a virulent pathogen, notorious for inducing life-threatening hemorrhagic fever, that has been responsible for several outbreaks in Africa and remains a public health threat. Yet, its pathogenesis is still not completely understood. Although there have been numerous studies on host transcriptional response to EBOV, with an emphasis on the clinical features, the impact of EBOV infection on post-transcriptional regulatory elements, such as microRNAs (miRNAs), remains largely unexplored. Read More

View Article and Full-Text PDF

Adenovirus Hemorrhagic Disease in Moose (Alces americanus gigas) in Alaska, USA.

J Wildl Dis 2021 04;57(2):418-422

Alaska Department of Fish and Game, 3200 College Road, Fairbanks, Alaska 99701, USA.

In 1993, an epizootic of adenovirus hemorrhagic disease (AHD) caused the death of at least 1,000 mule deer (Odocoileus hemionus) in California, US. Since then, numerous cervid species throughout the US have had deaths confirmed to be caused by AHD. In 2015, the death of two captive moose (Alces americanus gigas) calves marked the first recognized AHD-caused deaths in Alaska, a state in which moose are important economically as well as for food security and cultural identity. Read More

View Article and Full-Text PDF

Vector Competence of Florida (Diptera: Ceratopogonidae) for Epizootic Hemorrhagic Disease Virus Serotype-2.

Viruses 2021 03 5;13(3). Epub 2021 Mar 5.

Florida Medical Entomology Laboratory, Institute of Food and Agricultural Sciences, University of Florida, Vero Beach, FL 32962, USA.

Epizootic hemorrhagic disease virus (EHDV; family , genus ) is an arthropod-borne virus of ungulates, primarily white-tailed deer in North America. , the only confirmed North American vector of EHDV, is rarely collected from Florida despite annual virus outbreaks. is an abundant species in Florida and is also a confirmed vector of the closely related Bluetongue virus. Read More

View Article and Full-Text PDF

Spatial Analysis of the 2017 Outbreak of Hemorrhagic Disease and Physiographic Region in the Eastern United States.

Viruses 2021 03 25;13(4). Epub 2021 Mar 25.

Southeastern Cooperative Wildlife Disease Study, College of Veterinary Medicine, University of Georgia, 589 D.W. Brooks Dive, Athens, GA 30602, USA.

Hemorrhagic disease (HD) is considered one of the most significant infectious diseases of white-tailed deer in North America. Investigations into environmental conditions associated with outbreaks suggest drought conditions are strongly correlated with outbreaks in some regions of the United States. However, during 2017, an HD outbreak occurred in the Eastern United States which appeared to be associated with a specific physiographic region, the Appalachian Plateau, and not drought conditions. Read More

View Article and Full-Text PDF

The Effect of Maternal Antibodies on Clinical Response to Infection with Epizootic Hemorrhagic Disease Virus in White-Tailed Deer (Odocoileus virginianus) Fawns.

J Wildl Dis 2021 01;57(1):189-193

Southeastern Cooperative Wildlife Disease Study, Department of Population Health, College of Veterinary Medicine, University of Georgia, 589 D. W. Brooks Drive, Athens, Georgia 30602, USA.

We investigated whether naturally acquired maternal antibodies to epizootic hemorrhagic disease virus serotype 2 (EHDV-2) would protect white-tailed deer (Odocoileus virginianus) fawns against infection and clinical disease following an EHDV-2 challenge. We compared viremia and clinical response in 27-47-d-old, experimentally infected fawns with and without maternally derived antibodies to EHDV-2. Mild to moderate clinical signs were observed in four seronegative (maternal antibody-negative) fawns, which were viremic from 3 to 14 d postinoculation. Read More

View Article and Full-Text PDF
January 2021


J Wildl Dis 2021 01;57(1):82-93

Department of Fisheries and Wildlife, Michigan State University, 480 Wilson Road, Room 13, East Lansing, Michigan 48824, USA.

Epizootic hemorrhagic disease (EHD) is the most significant source of viral disease-related mortality in white-tailed deer (Odocoileus virginianus) in the US. Deer mortality from EHD has increased in the state of Michigan, US, since 2006, with the largest outbreak occurring in 2012. The 2012 outbreak provided an opportunity to evaluate how this disease affected EHD-related mortality in deer populations at a spatial scale typical of that expected for the greatest disease risk. Read More

View Article and Full-Text PDF
January 2021


J Zoo Wildl Med 2021 Jan;51(4):745-751

Spatial Epidemiology and Ecology Research Laboratory, Department of Geography, University of Florida, Gainesville, FL 32611, USA,

Epizootic hemorrhagic disease virus (EHDV) and bluetongue virus (BTV) are vector-borne viruses of ruminants nearly worldwide. They can affect white-tailed deer (WTD; ), the ranching industry, and nonindigenous hoof stock species managed for conservation. One potential risk factor for ranched WTD is commingling with nonindigenous species on high-fenced properties. Read More

View Article and Full-Text PDF
January 2021

Resource Selection by Wild and Ranched White-Tailed Deer () during the Epizootic Hemorrhagic Disease Virus (EHDV) Transmission Season in Florida.

Animals (Basel) 2021 Jan 16;11(1). Epub 2021 Jan 16.

Spatial Epidemiology & Ecology Research Laboratory, Department of Geography, University of Florida, Gainvesille, FL 32611, USA.

Epizootic hemorrhagic disease virus (EHDV) causes serious disease in wild and privately ranched white-tailed deer () in the United States. In Florida, there is high EHDV prevalence, yet no treatments. There are few management strategies for the disease due to limited knowledge of virus-vector-host interactions. Read More

View Article and Full-Text PDF
January 2021

Randomly primed, strand-switching, MinION-based sequencing for the detection and characterization of cultured RNA viruses.

J Vet Diagn Invest 2021 Mar 24;33(2):202-215. Epub 2020 Dec 24.

Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens, GA.

RNA viruses rapidly mutate, which can result in increased virulence, increased escape from vaccine protection, and false-negative detection results. Targeted detection methods have a limited ability to detect unknown viruses and often provide insufficient data to detect coinfections or identify antigenic variants. Random, deep sequencing is a method that can more fully detect and characterize RNA viruses and is often coupled with molecular techniques or culture methods for viral enrichment. Read More

View Article and Full-Text PDF

Novel Serotype of Epizootic Hemorrhagic Disease Virus, China.

Emerg Infect Dis 2020 12;26(12):3081-3083

In 2018, a strain of epizootic hemorrhagic disease virus (EHDV), named YNDH/V079/2018, was isolated from a sentinel calf in Mangshi County, Yunnan Province, China. Nucleotide sequencing and neutralization tests indicated that the virus belongs to a novel serotype of EHDV that had not been reported previously. Read More

View Article and Full-Text PDF
December 2020

Constitutive low expression of antiviral effectors sensitizes melanoma cells to a novel oncolytic virus.

Int J Cancer 2021 May 14;148(9):2321-2334. Epub 2020 Dec 14.

Shmunis School of Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.

STAT1 is a critical effector and a target gene of interferon (IFN) signaling, and thus a central mediator of antiviral responses. As both a mediator and a target of IFN signals, STAT1 expression reports on, and determines IFN activity. Gene expression analyses of melanoma patient samples revealed varied levels of STAT1 expression, which highly correlated with expression of >700 genes. Read More

View Article and Full-Text PDF

Serologic Evidence of Arthropod-Borne Virus Infections in Wild and Captive Ruminants in Ontario, Canada.

Am J Trop Med Hyg 2020 11;103(5):2100-2107

Southeastern Cooperative Wildlife Disease Study, University of Georgia, Athens, Georgia.

Arthropod-borne viruses (arboviruses) are globally widespread, and their transmission cycles typically involve numerous vertebrate species. Serologic testing of animal hosts can provide a routine surveillance approach to monitoring animal disease systems, can provide a surveillance alternative to arthropod testing and human case reports, and may augment knowledge of epizootiology. Wild and captive ruminants represent good candidate sentinels to track geographic distribution and prevalence of select arboviruses. Read More

View Article and Full-Text PDF
November 2020

Serosurveillance and Molecular Investigation of Wild Deer in Australia Reveals Seroprevalence of Infection.

Viruses 2020 07 13;12(7). Epub 2020 Jul 13.

Department of Physiology, Molecular Virology Laboratory, Anatomy and Microbiology, School of Life Sciences, La Trobe University, Melbourne 3086, Australia.

Since deer were introduced into Australia in the mid-1800s, their wild populations have increased in size and distribution, posing a potential risk to the livestock industry, through their role in pathogen transmission cycles. In comparison to livestock, there are limited data on viral infections in all wildlife, including deer. The aim of this study was to assess blood samples from wild Australian deer for serological evidence of exposure to relevant viral livestock diseases. Read More

View Article and Full-Text PDF

Genome Sequence of a CHeRI Orbivirus 3 Strain Isolated from a Dead White-Tailed Deer (Odocoileus virginianus) in Florida, USA.

Microbiol Resour Announc 2020 Jun 25;9(26). Epub 2020 Jun 25.

Department of Infectious Diseases and Immunology, College of Veterinary Medicine, University of Florida, Gainesville, Florida, USA

We report the genome sequence of an orbivirus isolated from a dead farmed white-tailed deer in Florida. The deer was coinfected with epizootic hemorrhagic disease virus type 2. Phylogenetic and genetic analyses supported the virus as the fourth strain of the CHeRI orbivirus 3 species. Read More

View Article and Full-Text PDF

Epizootic Hemorrhagic Disease Virus and Bluetongue Virus Seroprevalence in Wild White-Tailed Deer (Odocoileus virginianus) in Florida, USA.

J Wildl Dis 2020 10;56(4):928-932

Spatial Epidemiology and Ecology Research Laboratory, Department of Geography, University of Florida, 3141 Turlington Hall, Gainesville, Florida 32611, USA.

A wild population of white-tailed deer (Odocoileus virginianus) was surveyed for evidence of past or current epizootic hemorrhagic disease virus (EHDV) and current bluetongue virus (BTV) infections. We collected 121 blood samples from hunter-harvested or live-captured deer from two state-managed properties in northwest Florida, US; live captures were in support of a movement ecology study. Blood samples were tested for antibodies against titers to three EHDV serotypes (EHDV-1, EHDV-2, and EHDV-6), and multiplex quantitative reverse transcription PCR was used to identify the presence of EHDV or BTV viral RNA. Read More

View Article and Full-Text PDF
October 2020

An Embryonated Egg Transmission Model for Epizootic Hemorrhagic Disease Virus.

Vector Borne Zoonotic Dis 2020 09 18;20(9):728-730. Epub 2020 May 18.

Southeastern Cooperative Wildlife Disease Study, College of Veterinary Medicine, University of Georgia, Athens, Georgia, USA.

Epizootic hemorrhagic disease virus (EHDV) is a vector-borne orbivirus of ruminants; in North America there are three serotypes (EHDV-1, -2, and -6) and these primarily affect white-tailed deer (). EHDV is vectored by biting midges, spp. Embryonated chicken eggs (ECE) have recently been used as an experimental host to investigate the vector competence of Australian spp. Read More

View Article and Full-Text PDF
September 2020

West Nile Virus Epidemic in Germany Triggered by Epizootic Emergence, 2019.

Viruses 2020 04 15;12(4). Epub 2020 Apr 15.

Bernhard Nocht Institute for Tropical Medicine, WHO Collaborating Centre for Arbovirus and Hemorrhagic Fever Reference and Research, 20359 Hamburg, Germany.

One year after the first autochthonous transmission of West Nile virus (WNV) to birds and horses in Germany, an epizootic emergence of WNV was again observed in 2019. The number of infected birds and horses was considerably higher compared to 2018 (12 birds, two horses), resulting in the observation of the first WNV epidemy in Germany: 76 cases in birds, 36 in horses and five confirmed mosquito-borne, autochthonous human cases. We demonstrated that Germany experienced several WNV introduction events and that strains of a distinct group (Eastern German WNV clade), which was introduced to Germany as a single introduction event, dominated mosquito, birds, horse and human-related virus variants in 2018 and 2019. Read More

View Article and Full-Text PDF

Endemic and Emerging Arboviruses in Domestic Ruminants in East Asia.

Front Vet Sci 2020 7;7:168. Epub 2020 Apr 7.

Viral Disease and Epidemiology Research Division, National Institute of Animal Health, NARO, Tsukuba, Japan.

Epizootic congenital abnormalities caused by Akabane, Aino, and Chuzan viruses have damaged the reproduction of domestic ruminants in East Asia for many years. In the past, large outbreaks of febrile illness related to bovine ephemeral fever and Ibaraki viruses severely affected the cattle industry in that region. In recent years, vaccines against these viruses have reduced the occurrence of diseases, although the viruses are still circulating and have occasionally caused sporadic and small-scaled epidemics. Read More

View Article and Full-Text PDF

Evaluation of a commercial ELISA for detection of epizootic haemorrhagic disease antibodies in domestic and wild ruminant sera.

Transbound Emerg Dis 2020 Nov 14;67(6):2475-2481. Epub 2020 May 14.

Laboratoire de Santé Animale d'Alfort, ANSES, ENVA, INRA, UMR 1161 VIROLOGIE, Université Paris Est, Maisons-Alfort, France.

Bluetongue (BT) and epizootic haemorrhagic disease (EHD) are vector-borne viral diseases affecting domestic and wild ruminants. Both are notifiable under OIE rules. BT and EHD viruses (BTV and EHDV) are closely related Orbiviruses with structural, antigenic and molecular similarities. Read More

View Article and Full-Text PDF
November 2020

Living la Vida T-LoCoH: site fidelity of Florida ranched and wild white-tailed deer () during the epizootic hemorrhagic disease virus (EHDV) transmission period.

Mov Ecol 2020 16;8:14. Epub 2020 Mar 16.

1Spatial Epidemiology & Ecology Research Laboratory, Department of Geography, University of Florida, Gainesville, FL USA.

Background: Epizootic hemorrhagic disease virus (EHDV) is a pathogen vectored by midges that causes significant economic loss in the cervid farming industry and affects wild deer as well. Despite this, its ecology is poorly understood. Studying movement and space use by ruminant hosts during the transmission season may elucidate EHDV ecology by identifying behaviors that can increase exposure risk. Read More

View Article and Full-Text PDF

The role of drought as a determinant of hemorrhagic disease in the eastern United States.

Glob Chang Biol 2020 07 27;26(7):3799-3808. Epub 2020 Apr 27.

Southeastern Cooperative Wildlife Disease Study, Department of Population Health, College of Veterinary Medicine, The University of Georgia, Athens, GA, USA.

Bluetongue virus and epizootic hemorrhagic disease (HD) virus are globally distributed, vector-borne viruses that infect and cause disease in domestic and wild ruminant species. The forces driving increases in resulting HD may be linked to weather conditions and increasing severity has been noted in northerly latitudes. We evaluated the role of drought severity in both space and time on changes in HD reports across the eastern United States for a recent 15 year period. Read More

View Article and Full-Text PDF


J Zoo Wildl Med 2020 Mar;51(1):232-235

Animal Health Institute, Department of Pathology and Population Medicine, Midwestern University, Glendale, AZ.

This study presents the gross and histopathological findings of adenoviral hemorrhagic disease (AHD) in two yearling and one adult mule deer (). These cases represent the first known outbreak of deer adenovirus ( adenovirus 1) in Arizona. Over the span of a month, three female captive mule deer were submitted to Midwestern University's Animal Health Institute for postmortem examination. Read More

View Article and Full-Text PDF

Development and optimization of a DNA-based reverse genetics systems for epizootic hemorrhagic disease virus.

Arch Virol 2020 May 6;165(5):1079-1087. Epub 2020 Mar 6.

The Key Laboratory of Veterinary Public Health, Ministry of Agriculture, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150069, China.

Epizootic hemorrhagic disease virus (EHDV) is a member of the genus Orbivirus, family Reoviridae, and has a genome consisting of 10 linear double-stranded (ds) RNA segments. The current reverse genetics system (RGS) for engineering the EHDV genome relies on the use of in vitro-synthesized capped viral RNA transcripts. To obtain more-efficient and simpler RGSs for EHDV, we developed an entirely DNA (plasmid or PCR amplicon)-based RGS for viral rescue. Read More

View Article and Full-Text PDF

Survival of white-tailed deer fawns in central Iowa.

PLoS One 2020 3;15(3):e0229242. Epub 2020 Mar 3.

Department of Natural Resource Ecology and Management, Iowa State University, Ames, Iowa, United States of America.

Understanding demographic parameters such as survival is important for scientifically sound wildlife management. Survival can vary by region, sex, age-class, habitat, and other factors. White-tailed deer fawn survival is highly variable across the species' range. Read More

View Article and Full-Text PDF

Genetic Diversity of Culicoides stellifer (Diptera: Ceratopogonidae) in the Southeastern United States Compared With Sequences From Ontario, Canada.

J Med Entomol 2020 07;57(4):1324-1327

Department of Entomology, Texas A&M University, College Station, TX.

Much of the bluetongue (BT) and epizootic hemorrhagic disease (EHD) research in North America focuses on white-tail deer and Culicoides sonorensis (Wirth & Jones) (Diptera: Ceratopogonidae), though several other biting midge species have been suggested as vectors. Culicoides stellifer (Coquillett) has been associated with hosts susceptible to hemorrhagic disease (HD), and more recently, specimens from Florida have tested positive for EHD and BT viral RNA. If C. Read More

View Article and Full-Text PDF

Prospective Study of Epizootic Hemorrhagic Disease Virus and Bluetongue Virus Transmission in Captive Ruminants.

J Med Entomol 2020 07;57(4):1277-1285

Department of Entomology, Louisiana State University Agricultural Center, Agricultural Experiment Station, Life Sciences, Baton Rouge, LA.

Bluetongue virus (BTV) and epizootic hemorrhagic disease virus (EHDV) cause hemorrhagic disease (HD) in wild ruminants and bluetongue disease (BT) and epizootic hemorrhagic disease (EHD) in livestock. These viruses are transmitted by biting midges in the genus Culicoides (family Ceratopogonidae). Mortality from this disease can reach 90% in certain breeds of sheep and in white-tailed deer (Odocoileus virginianus). Read More

View Article and Full-Text PDF