2,934 results match your criteria epileptic attacks

How often do neurological disorders lead to dizziness in childhood?

Turk Arch Pediatr 2021 6;56(3):249-253. Epub 2021 Jan 6.

Depatment of Pediatric Neurology, Ordu University Faculty of Medicine, Ordu, Turkey.

Objective: The aim of the study was to determine the features and differential diagnosis of childhood dizziness and find out the prevalence of neurological diseases in children who were referred to the pediatric neurology outpatient clinic. A secondary aim was to evaluate the outcome of dizziness after 12 months.

Material And Methods: The records of children with a complaint of dizziness that were referred to the pediatric neurology outpatient clinic were retrospectively reviewed, and detailed medical and family history, clinical characteristics, laboratory investigations including vitamin B12 levels, and neuroimaging tests were analyzed. Read More

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January 2021

Porphyria attacks in prepubertal children and adolescents.

Mol Genet Metab 2021 May 7. Epub 2021 May 7.

Department of Pediatrics, Division of Pediatric Endocrinology, IPS Universitaria Universidad de Antioquia, Medellin, Colombia.

Context: The clinical and laboratory features of dominant acute hepatic porphyrias (AHPs) in prepubertal children and adolescents have not been well established.

Objective: To evaluate clinical and laboratory features of AHPs in prepubertal children and adolescents compared to adults.

Data Sources: OVID (Embase Classic+Embase and MEDLINE), Scopus, and Google Scholar. Read More

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Headache in patients with mesial temporal lobe epilepsy with hippocampal sclerosis.

Epilepsy Behav 2021 May 29;121(Pt A):108081. Epub 2021 May 29.

Ankara Dışkapı Yıldırım Beyazıt Training and Research Hospital, Department of Neurology, University of Health Sciences, Turkey. Electronic address:

Objective: It is remarkable that epilepsy and migraine are similar diseases with many parallel clinical features, as well as sharing common pathophysiological mechanisms. However, the pathogenetic role of hippocampal sclerosis (HS) in epilepsy and headache coexistence has not been clarified. In this study, we aimed to investigate the frequency of headache/migraine and the relationship between headache and HS lateralizations in patients with mesial temporal lobe epilepsy (MTLE), accompanied by HS. Read More

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Diagnostic accuracy of clinical signs and symptoms for psychogenic nonepileptic attacks versus epileptic seizures: A systematic review and meta-analysis.

Epilepsy Behav 2021 May 21;121(Pt A):108030. Epub 2021 May 21.

Department of Clinical Neurosciences, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada; Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada; Department of Community Health Sciences and O'Brien Institute for Public Health, University of Calgary, Calgary, Alberta, Canada. Electronic address:

Background: Psychogenic nonepileptic attacks (PNEA) are events of altered behavior that resemble epileptic seizures (ES) but are not caused by abnormal electrical cortical activity. Understanding which clinical signs and symptoms are associated with PNEA may allow better triaging for video-electroencephalogram monitoring (VEM) and for a more accurate prediction when such testing is unavailable.

Methods: We performed a systematic review searching Medline, Embase, and Cochrane Central from inception to March 29, 2019. Read More

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Alternating Hemiplegia of Childhood: A Series of Genetically Confirmed Four Cases from Southern India with Review of Published Literature.

J Pediatr Genet 2021 Jun 13;10(2):111-115. Epub 2020 Aug 13.

Department of Pediatric Neurology, Indira Gandhi Institute of Child Health, Bengaluru, Karnataka, India.

Alternating hemiplegia of childhood (AHC) is a rare autosomal dominant neurodevelopmental disorder with mutation on gene. Delay in diagnosis and inappropriate diagnosis are common. In this article, we described four genetically confirmed AHC patients to provide an improved understanding of the disorder. Read More

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Post-Traumatic Seizures: A Deep-Dive Into Pathogenesis.

Cureus 2021 Apr 10;13(4):e14395. Epub 2021 Apr 10.

Neurology, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.

Post-traumatic seizures (PTS) have become an emerging challenge for neurologists worldwide with the rise of brain injuries. Trauma can lead to various outcomes, ranging from naive spasms to debilitating post-traumatic epilepsy (PTE). In this article, we will explore the pathogenesis of convulsions following a concussion. Read More

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Epilepsy and episodic ataxia type 2: family study and review of the literature.

J Neurol 2021 May 13. Epub 2021 May 13.

Clinical Neurology Unit, Department of Neurosciences, Santa Maria della Misericordia University Hospital, ASUFC, Udine, Italy.

Episodic ataxia type 2 (EA2) is a hereditary disorder characterized by paroxysmal attacks of ataxia, vertigo and nausea, due to mutations in the CACNA1A gene, which encodes for α1 subunit of the P/Q-type voltage-gated Ca channel (CaV2.1). Other manifestations may be associated to CACNA1A mutations, such as migraine and epilepsy. Read More

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Bilateral epileptic networks in congenital and acquired corpus callosum defects: EEG-fMRI study.

Epilepsy Behav 2021 Jul 6;120:107986. Epub 2021 May 6.

Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address:

Objectives: Electroencephalography-correlated functional magnetic resonance imaging (EEG-fMRI) allows imaging of brain-wide epileptic networks, and demonstrates that focal interictal epileptic activity is sometimes accompanied by bilateral functional activations. The corpus callosum (CC) facilitates bilateral spread of epileptic activity and at times targeted surgically for drug-resistant epilepsy (DRE). We hypothesized that focal epileptic networks are more unilateral in patients lacking intact CC. Read More

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Confirming the contribution and genetic spectrum of de novo mutation in infantile spasms: Evidence from a Chinese cohort.

Mol Genet Genomic Med 2021 May 5:e1689. Epub 2021 May 5.

Department of Medical Genetics, Capital Institute of Pediatrics, Beijing, China.

Objective: We determined the yield, genetic spectrum, and actual origin of de novo mutations (DNMs) for infantile spasms (ISs) in a Chinese cohort. The efficacy of levetiracetam (LEV) for STXBP1-related ISs was explored also.

Methods: Targeted sequencing of 153 epilepsy-related candidate genes was applied to 289 Chinese patients with undiagnosed ISs. Read More

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Epilepsy lifetime prevalence in Iran: a large population- based national survey.

Sci Rep 2021 May 3;11(1):9437. Epub 2021 May 3.

Shefa Neuroscience Research Center, Khatam-Ol-Anbia Hospital, Tehran, Iran.

Epilepsy has garnered increased public health focus because patients who suffer from epilepsy experience pronounced and persistent health and socioeconomic disparities despite treatment and care advances. The epidemiology of epilepsy is diverse in different countries and regions. This nationwide population-based cross-sectional study was conducted to determine the life time prevalence and health related factors of epilepsy for the first time in Iran through a two-phase door-to-door survey method. Read More

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Rage and aggressive behaviour in frontal lobe epilepsy: description of a case and review of the mechanisms of aggressive behaviour in epilepsy and dementia.

Epileptic Disord 2021 Apr;23(2):419-425

Epilepsy Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy, Division of Clinical Neurophysiology and Epilepsy Center, IRCCS Ospedale Policlinico San Martino, Genova, Italy.

The study of dementia and epilepsy may provide particular insight into behavioural alterations. We describe a rare case of ictal aggressive behaviour in a patient with focal epilepsy associated with a non-dominant dorso-lateral prefrontal lesion. During focal seizures, our patient showed intense agitation and anger, for a long time misinterpreted as psychogenic attacks, which disappeared after epilepsy surgery. Read More

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Phenotypic Spectrum of Seizure Disorders in MBD5-Associated Neurodevelopmental Disorder.

Neurol Genet 2021 Apr 18;7(2):e579. Epub 2021 Mar 18.

Research Institute of the McGill University Health Centre (K.M.), Montreal, PQ; Division of Child Neurology (K.M.), Department of Pediatrics, Montreal Children's Hospital, McGill University, Montreal, PQ; Department of Neurology & Neurosurgery (K.M.), Montreal Children's Hospital, McGill University, Montreal, PQ; Child Neurology and Psychiatry (C.M.), Salesi Pediatric Hospital, United Hospitals of Ancona, Ancona, Italy; Division of Genetic Medicine (G.L.C., J.N., H.C.M.), Department of Pediatrics, University of Washington, Seattle, WA; Department of Neurology (A.M.), Great Ormond Street Hospital for Children, London, UK; Developmental Neurosciences Programme (A.M.), UCL Great Ormond Street Institute of Child Health, London, UK; Neurology Network Melbourne (J.P.), Melbourne, Victoria, Australia; Murdoch Children's Research Institute (C.S., I.E.S.), Parkville, Victoria, Australia; Department of Paediatrics and Child Health (T.S.), School of Medicine and Health Sciences, University of Otago, Wellington, New Zealand; Division of Neurology (S.M.), Department of Pediatrics, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada; Neurology Unit and Neurogenetic Laboratories (C.B., A.R., R.G.), Meyer Children's Hospital, Florence, Italy; Department of Clinical Genetics (R.H.S.), Great Ormond Street Hospital, London, UK; Epilepsy Research Centre (I.E.S.), Department of Medicine, The University of Melbourne, Austin Health, Heidelberg, Victoria, Australia; Department of Paediatrics (I.E.S.), Royal Children's Hospital, The University of Melbourne, Parkville, Victoria, Australia; and The Florey Institute of Neuroscience and Mental Health (I.E.S.), Heidelberg, Victoria, Australia.

Objective: To describe the phenotypic spectrum in patients with MBD5-associated neurodevelopmental disorder (MAND) and seizures; features of MAND include intellectual disability, epilepsy, psychiatric features of aggression and hyperactivity, and dysmorphic features including short stature and microcephaly, sleep disturbance, and ataxia.

Methods: We performed phenotyping on patients with deletions, duplications, or point mutations and a history of seizures.

Results: Twenty-three patients with MAND and seizures were included. Read More

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Alternating Hemiplegia of Childhood: Genotype-Phenotype Correlations in a Cohort of 39 Italian Patients.

Front Neurol 2021 8;12:658451. Epub 2021 Apr 8.

Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa, Italy.

Alternating hemiplegia of childhood is a rare neurological disease characterized by paroxysmal movement disorders and chronic neurological disturbances, with onset before 18 months of age. Mutations in the gene have been identified in up to 80% of patients. Thirty-nine patients [20 females, 19 males, mean age 25. Read More

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SMART syndrome: a late-onset and not always reversible complication of radiotherapy.

BMJ Case Rep 2021 Apr 15;14(4). Epub 2021 Apr 15.

Neurology Department, Hospital Pedro Hispano, Matosinhos, Portugal.

Stroke-like migraine attacks after radiation (SMART) syndrome is a rare and late complication of cerebral radiotherapy of unknown pathophysiology. It is characterised by hemicranial headache associated with persistent unilateral focal neurological signs and, occasionally, epileptic seizures. An increase in the frequency of SMART syndrome can be attributed to an increase in the survival rate of patients undergoing radiation therapy This study details the case of a 60-year-old woman with a history of small-cell lung carcinoma, who, in her late forties, was treated with prophylactic cranial irradiation. Read More

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Gender differences in geriatric syndromes as mental illness and nervous system diseases in hospitalized Thai older patients.

Psychogeriatrics 2021 Apr 13. Epub 2021 Apr 13.

Lecturer of Department of Food and Beverage Management, Jin-Wen University of Science and Technology, New Taipei City, Taiwan.

Background: Older persons are affected by mental and neurological disorders differently, and gender plays a significant role influencing geriatric disorder differentiation. Accordingly this study characterized gender differences in geriatric syndromes among hospitalized elderly Thai patients.

Methods: Probabilities of disease occurrence reflecting gender differences were calculated using historical data obtained from the Ministry of Public Health website, Thailand. Read More

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R1352Q Variant in a Patient with Sporadic Hemiplegic Migraine, Ataxia, Seizures and Cerebral Oedema: A Case Report.

Case Rep Neurol 2021 Jan-Apr;13(1):123-130. Epub 2021 Feb 16.

Headache and Facial Pain Group, UCL Queen Square Institute of Neurology and National Hospital for Neurology and Neurosurgery, London, United Kingdom.

Mutations in the gene show a wide range of neurological phenotypes including hemiplegic migraine, ataxia, mental retardation and epilepsy. In some cases, hemiplegic migraine attacks can be triggered by minor head trauma and culminate in encephalopathy and cerebral oedema. A 37-year-old male without a family history of complex migraine experienced hemiplegic migraine attacks from childhood. Read More

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February 2021

Multiple stenting using anchoring technique with balloon guiding catheter for common carotid artery dissection after aortic arch replacement: A case report.

Int J Surg Case Rep 2021 Apr 11;81:105748. Epub 2021 Mar 11.

Department of Neurosurgery, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.

Introduction And Importance: Common carotid artery (CCA) dissection is a minor complication during aortic arch replacement (AAR). Although endovascular treatment can be considered for symptomatic CCA dissection despite internal therapy, no report has mentioned about carotid stenting for CCA dissection after vascular graft replacement.

Case Presentation: The patient was a 68-year-old man presented with recurrent transient right hemiparesis. Read More

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Measuring synchrony in bio-medical timeseries.

Chaos 2021 Jan;31(1):013138

Sleep-Wake-Epilepsy Center and Center for Experimental Neurology, Department of Neurology, Inselspital Bern, University Hospital, University of Bern, 3010 Bern, Switzerland.

Paroxysms are sudden, unpredictable, short-lived events that abound in physiological processes and pathological disorders, from cellular functions (e.g., hormone secretion and neuronal firing) to life-threatening attacks (e. Read More

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January 2021

From Genotype to Phenotype: Expanding the Clinical Spectrum of Variants in the Era of Next Generation Sequencing.

Front Neurol 2021 2;12:639994. Epub 2021 Mar 2.

Center for Rare Movement Disorders Innsbruck, Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.

Ion channel dysfunction is a key pathological substrate of episodic neurological disorders. A classical gene associated to paroxysmal movement disorders is , which codes for the pore-forming subunit of the neuronal calcium channel P/Q. Non-polyglutamine variants underlie familial hemiplegic ataxia type 1 (FHM1) and episodic ataxia type 2 (EA2). Read More

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COVID-19-associated meningoencephalitis: A care report and literature review.

Exp Ther Med 2021 Apr 14;21(4):362. Epub 2021 Feb 14.

Department of Healthcare, China-Japan Friendship Hospital, Ministry of Health, Beijing 100029, P.R. China.

Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may target the central nervous system and several neurological symptoms have been reported in patients with coronavirus disease 2019 (COVID-19). In the present study, a case of a SARS-CoV-2 complicated with meningoencephalitis was reported. Cerebrospinal fluid (CSF) analyses indicated hyperproteinorrachia but the specimen was negative for SARS-CoV-2 RNA. Read More

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Peri-Ictal and Para-Ictal Psychiatric Phenomena: A Relatively Common Yet Unrecognized Disorder.

Curr Top Behav Neurosci 2021 Mar 17. Epub 2021 Mar 17.

Instituto de Ensino e Pesquisa, Santa Casa BH, Belo Horizonte, Brazil.

Patients with epilepsy can experience different neuropsychiatric symptoms related (peri-ictal) or not (interictal) with seizures. Peri-ictal symptoms can precede (pre-ictal) or follow (post-ictal) the seizure, or even be the expression of the seizure activity (ictal). Neuropsychiatric symptoms, such as irritability and apathy, are among the most frequent pre-ictal manifestations. Read More

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Perampanel in brain tumor and SMART-syndrome related epilepsy - A single institutional experience.

J Neurol Sci 2021 04 5;423:117386. Epub 2021 Mar 5.

Department of Neurology, Medical University of Innsbruck, Austria.

Epilepsy is common in patients with brain tumors and frequently presents as the first clinical manifestation of an underlying tumor. Despite a number of available antiepileptic drugs (AED), brain tumor related epilepsy (BTRE) may still be difficult to control. Recently, the AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid)-type glutamate receptor antagonist perampanel (PER) is increasingly acknowledged as an attractive novel add-on AED for seizure control in BTRE. Read More

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Familial paroxysmal kinesigenic dyskinesia with a novel missense variant (Arg2866Trp) in NBEA.

J Hum Genet 2021 Mar 10. Epub 2021 Mar 10.

Division of Genomics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, 812-8582, Japan.

Paroxysmal kinesigenic dyskinesia (PKD) is a movement disorder characterized by episodic involuntary movement attacks triggered by sudden movements, acceleration, or intention to move. We ascertained two Japanese familial cases with PKD. The proband is a 22-year-old woman who had noted sudden brief (<30 s) of involuntary movements provoked by kinesigenic trigger such as starting to run, getting on a train, picking up a telephone receiver and so on at the age of 14. Read More

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Evidence of objective sleep impairment in nonepileptic attack disorder: A naturalistic prospective controlled study using actigraphy and daily sleep diaries over six nights.

Epilepsy Behav 2021 04 5;117:107867. Epub 2021 Mar 5.

Department of Psychology, Queen's University Belfast, David Keir Building, Belfast, Northern Ireland, UK. Electronic address:

Poor sleep is reported by many with nonepileptic attack disorder (NEAD) with correlations evident between self-reported sleep quality and mood and functional impairment. However, it is contended that self-reported sleep impairment in NEAD is a subjective phenomenon, which represents a general tendency to over-report symptoms or misinterpret bodily states in those with NEAD. The present study was therefore designed to investigate the extent of subjective and objective sleep impairments in those with NEAD. Read More

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Does iron therapy have a place in the management of all breath-holding spells?

Pediatr Int 2021 Mar 7. Epub 2021 Mar 7.

Aksaray University, Faculty of Medicine, Pediatrics, Aksaray, Turkey.

Breath-holding spells are non-epileptic paroxysmal events of infancy with a reported prevalence of 3-5% in the general population. They occur between the ages of six months and four years (1). These spells are usually triggered by physical or emotional stimuli and have a benign prognosis in the long term. Read More

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Narcolepsy type 1 features across the life span: age impact on clinical and polysomnographic phenotype.

J Clin Sleep Med 2021 Mar 5. Epub 2021 Mar 5.

IRCCS, Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.

Study Objectives: Narcolepsy type 1 (NT1) is a chronic neurological disorder typically arising during adolescence and young adulthood. Recent studies demonstrated that NT1 presents with age-specific features, especially in children. With this study we aimed to describe and to compare the clinical pictures of NT1 in different age groups. Read More

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Investigating rare and ultrarare epilepsy syndromes with models.

Fac Rev 2021 29;10:10. Epub 2021 Jan 29.

Department of Human Genetics, Radboud University Medical Centre, Nijmegen, Netherlands.

One in three epilepsy cases is drug resistant, and seizures often begin in infancy, when they are life-threatening and when therapeutic options are highly limited. An important tool for prioritizing and validating genes associated with epileptic conditions, which is suitable for large-scale screening, is disease modeling in . Approximately two-thirds of disease genes are conserved in , and gene-specific fly models exhibit behavioral changes that are related to symptoms of epilepsy. Read More

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January 2021

Structural brain network characteristics in patients with episodic and chronic migraine.

J Headache Pain 2021 Mar 3;22(1). Epub 2021 Mar 3.

Section of Movement Disorders and Neurostimulation, Biomedical Statistics and Multimodal Signal Processing unit, Department of Neurology, Focus Program Translational Neuroscience (FTN), University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.

Background: Migraine is a primary headache disorder that can be classified into an episodic (EM) and a chronic form (CM). Network analysis within the graph-theoretical framework based on connectivity patterns provides an approach to observe large-scale structural integrity. We test the hypothesis that migraineurs are characterized by a segregated network. Read More

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Neurological complications of cardiomyopathies.

Handb Clin Neurol 2021 ;177:91-109

Neurology Service, Hospital Santa Maria, Centro Hospitalar Lisboa Norte and Faculty of Medicine, University of Lisbon, Lisbon, Portugal. Electronic address:

There is a multifaceted relationship between the cardiomyopathies and a wide spectrum of neurological disorders. Severe acute neurological events, such as a status epilepticus and aneurysmal subarachnoid hemorrhage, may result in an acute cardiomyopathy the likes of Takotsubo cardiomyopathy. Conversely, the cardiomyopathies may result in a wide array of neurological disorders. Read More

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January 2021