Neuroimage 2021 Jun 8:118244. Epub 2021 Jun 8.
Department of Electrical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands; Department of Research and Development, Epilepsy Centre Kempenhaeghe, Heeze, The Netherlands; School for Mental Health and Neuroscience, Maastricht, The Netherlands; Laboratory for Clinical and Experimental Neurophysiology, Neurobiology and Neuropsychology, Ghent University Hospital, Ghent, Belgium; Department of Neurology, Maastricht University Medical Center, Maastricht, The Netherlands.
A variety of strategies are used to combine multi-echo functional magnetic resonance imaging (fMRI) data, yet recent literature lacks a systematic comparison of the available options. Here we compare six different approaches derived from multi-echo data and evaluate their influences on BOLD sensitivity for offline and in particular real-time use cases: a single-echo time series (based on Echo 2), the real-time T*-mapped time series (T*FIT) and four combined time series (T*-weighted, tSNR-weighted, TE-weighted, and a new combination scheme termed T*FIT-weighted). We compare the influences of these six multi-echo derived time series on BOLD sensitivity using a healthy participant dataset (N=28) with four task-based fMRI runs and two resting state runs. Read More