1,575 results match your criteria epilepsy personal


Automated ictal EEG source imaging: A retrospective, blinded clinical validation study.

Clin Neurophysiol 2021 Apr 27. Epub 2021 Apr 27.

Department of Clinical Neurophysiology, Danish Epilepsy Centre, Visby Allé 5, 4293 Dianalund, Denmark; Department of Clinical Neurophysiology, Aarhus University Hospital, Palle Juul-Jensens Blvd., 8200 Aarhus, Denmark. Electronic address:

Objective: EEG source imaging (ESI) is a validated tool in the multimodal workup of patients with drug resistant focal epilepsy. However, it requires special expertise and it is underutilized. To circumvent this, automated analysis pipelines have been developed and validated for the interictal discharges. Read More

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Healthcare utilization and cost outcomes for a multicenter first seizure and new onset epilepsy clinic.

Epilepsy Behav 2021 May 7;120:107972. Epub 2021 May 7.

Western University of Health Sciences College of Osteopathic Medicine of the Pacific, Northwest, 200 Mullins Dr, Lebanon, OR 97355, United States; Providence Brain and Spine Institute, 9135 SW Barnes Rd., Suite 363, Portland, OR 97225, United States.

Rationale: A First Seizure/New Onset Epilepsy (FS/NOE) protocol was implemented to ensure proper evaluation by an epileptologist and improve overall care for patients. We compared healthcare utilization and cost incurred by patients pre and post protocol implementation.

Methods: Clinical data were retrospectively collected from the EMR and cost data from the financial database. Read More

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Reply to "Psychiatric burden in psychogenic nonepileptic seizures: The tip of the iceberg?"

Epilepsy Behav 2021 May 6:107999. Epub 2021 May 6.

Department of Psychiatry, Alexandria University School of Medicine, Egypt.

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Working toward the ideal situation: A pragmatic Epi-Psy approach for the diagnosis and treatment of psychogenic nonepileptic seizures.

Epilepsy Behav 2021 May 5;120:108000. Epub 2021 May 5.

Service de Neurologie, CHRU Central Nancy, 54000 Nancy, France; Université Paris Descartes, Faculté de Médecine, 75006 Paris, France. Electronic address:

Medical international guidelines recommend regular psychiatric consultations for patients with epilepsy, in order to detect comorbidities. However, there is a lack of guidance about PNES that constitute both a differential diagnosis and a comorbidity of epilepsy. While waiting for the ideal collaboration between neurologists and psychiatrists, we develop a pragmatic approach. Read More

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Children's understanding of epilepsy: A qualitative study.

Epilepsy Behav 2021 May 5;120:107994. Epub 2021 May 5.

Usher Institute, The University of Edinburgh, UK; Muir Maxwell Epilepsy Centre, Centre for Clinical Brain Sciences, The University of Edinburgh, UK; Department of Paediatric Neurosciences, Royal Hospital for Sick Children, Edinburgh, UK; Child Life and Health, MRC Centre for Reproductive Health, The University of Edinburgh, Edinburgh, UK.

Purpose: To use a qualitative research approach to determine children's understandings of epilepsy and their epilepsy treatment.

Methods: Children aged 7-16 years with physician-confirmed active epilepsy (i.e. Read More

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Differential risks of changes in seizure frequency with transitions between hormonal and non-hormonal contraception in women with epilepsy: A prospective cohort study.

Epilepsy Behav 2021 May 5;120:108011. Epub 2021 May 5.

Harvard Neuroendocrine Unit, Beth Israel Deaconess Medical Center, Boston, MA, United States.

This prospective, observational, cohort study of 101 women with epilepsy (WWE) assesses the seizure safety of systemic hormonal contraception (HC) versus non-HC (NHC). It reports risks of changes in seizure frequency associated with transition from NHC to HC relative to HC to NHC for (1) proportions of WWE with ≥50% increase and decrease in seizure frequency, (2) changes in seizure frequency, (3) changes in seizure severity, and 4) changes in AED regimen during the study. In comparing NHC to HC versus HC to NHC, NHC to HC had greater risk of ≥50% increase in seizure frequency: RR = 1. Read More

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Pediatric and adult epileptologist perspectives and experiences of pediatric to adult epilepsy care transition: "Saying goodbye and opening a door."

Epilepsy Behav 2021 May 4;120:107981. Epub 2021 May 4.

Department of Neurology, University of Colorado School of Medicine, Aurora, CO, United States. Electronic address:

We aimed to describe perspectives of transition and transfer of adolescents and young adults with childhood-onset epilepsy from pediatric to adult care from the viewpoints of both pediatric and adult epileptologists. Telephone semi-structured interviews with pediatric (n = 15) and adult (n = 11) epileptologists at leading U.S. Read More

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A comparative study of perceived burden in parent caregivers of adolescents with epilepsy in a resource-restricted setting: Investigating the explanatory factors of perceived burden.

Epilepsy Behav 2021 May 4;120:107992. Epub 2021 May 4.

Department of Psychiatry and Behavioral Neurosciences, McMaster University/St Joseph's Healthcare Hamilton, Hamilton, ON, Canada.

Objective: Parent caregivers often play vital roles in the care of adolescents with epilepsy (AWE) in resource-restricted settings; however, little is known about the burden borne by these parents. This study investigated the burden perceived by parents of AWE and described the explanatory factors.

Methods: An equal number (n = 121) of age- and gender-matched parent caregivers of AWE (cases) and parents of adolescents with sickle cell disease (comparison group) were interviewed with the Parent Illness Intrusiveness Rating Scale to assess disruptions in their relationships and lifestyle. Read More

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Adenosine Kinase: An Epigenetic Modulator in Development and Disease.

Neurochem Int 2021 May 4:105054. Epub 2021 May 4.

Department of Neurosurgery, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ 08854; Department of Neurosurgery, New Jersey Medical School, Rutgers University, Newark, NJ 07102; Brain Health Institute, Rutgers University, Piscataway, NJ 08854. Electronic address:

Adenosine kinase (ADK) is the key regulator of adenosine and catalyzes the metabolism of adenosine to 5'-adenosine monophosphate. The enzyme exists in two isoforms: a long isoform (ADK-long, ADK-L) and a short isoform (ADK-short, ADK-S). The two isoforms are developmentally regulated and are differentially expressed in distinct subcellular compartments with ADK-L localized in the nucleus and ADK-S localized in the cytoplasm. Read More

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A pediatric case of transient periictal MRI abnormalities after repeated seizures.

Brain Dev 2021 May 3. Epub 2021 May 3.

Department of Pediatrics, Faculty of Medicine, Saga University, Saga, Japan. Electronic address:

Background: Transient periictal MRI abnormalities (TPMA) are caused by seizures, and may completely or partially reverse within a few days following seizure. Although TPMA are usually observed in patients with status epilepticus (SE), they have also been rarely reported after isolated/recurrent seizures not fulfilling the criteria for SE. Herein, we present a case of a 1-year-old girl with TPMA. Read More

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Psychological distress and burden of care among family caregivers of patients with mental illness in a neuropsychiatric outpatient clinic in Nigeria.

PLoS One 2021 6;16(5):e0250309. Epub 2021 May 6.

Society for Family Health, FCT, Abuja, Nigeria.

Background: The wellbeing of family caregivers of mentally ill persons has often been ignored, despite that family caregivers can be predisposed to psychiatric morbidities and burden in caring for their mentally ill family members. This study examined the levels of psychological distress and burden of care experienced by family caregivers who care for their mentally ill relatives in Edo State, Nigeria.

Methods: This study assessed psychological distress using the General Health Questionnaire (GHQ-12). Read More

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Quality of life at 6 years in children treated for West syndrome with hormonal therapy.

Epilepsy Behav 2021 May 1;119:107974. Epub 2021 May 1.

Department of Paediatrics, Faculty of Medicine, University of Colombo, Sri Lanka.

Introduction: West syndrome is a severe epileptic encephalopathy occurring in infancy. Majority of affected children suffer from poor epilepsy control in later life and are dependent on care-givers for daily living. There is no previous study evaluating the Quality of Life (QOL) in children suffered from WS. Read More

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Psychiatric burden in psychogenic nonepileptic seizures: The tip of the iceberg?

Epilepsy Behav 2021 Apr 30:107977. Epub 2021 Apr 30.

Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.

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Effect and tolerability of perampanel in patients with drug-resistant epilepsy.

Epilepsy Behav 2021 Apr 30;119:107965. Epub 2021 Apr 30.

The National Center for Epilepsy, Sandvika, Oslo University Hospital, Oslo, Norway; University of Oslo University, Norway; Program for Pharmacy, Department of Life Sciences and Health, Faculty of Health Sciences, Oslo Metropolitan University, Oslo, Norway.

Objective: Perampanel is one of the most recently approved antiseizure medications. The aim of the present study was to assess clinical efficacy and tolerability, in combination with pharmacokinetic variability, of perampanel treatment in patients at a tertiary referral center for epilepsy.

Methods: We performed a retrospective observational study of patients given perampanel as adjunctive treatment in the period January 2013 - February 2019 at the National Center for Epilepsy at Oslo University Hospital, Norway. Read More

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CSF and Serum Biomarkers of Cerebral Damage in Autoimmune Epilepsy.

Front Neurol 2021 16;12:647428. Epub 2021 Apr 16.

Department of Epileptology, University Hospital Bonn, Bonn, Germany.

Our goal was to investigate whether biomarkers of cerebral damage are found in autoimmune-mediated epilepsy (AIE) and whether these can differentiate AIE from other seizure disorders. We retrospectively searched our cerebrospinal fluid (CSF) database for patients with definite AIE, hippocampal sclerosis due to other causes (HS), genetic generalized epilepsy (GGE), and psychogenic, non-epileptic seizures (PNES). We measured serum and CSF tau, neurofilament 1 (NFL), glial fibrillary acid protein (GFAP), and ubiquitin-carboxy-terminal hydrolase L1 with a single-molecule array. Read More

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Brain-responsive neurostimulation in adult-onset rasmussen's encephalitis.

Epilepsy Behav Rep 2021 29;15:100445. Epub 2021 Mar 29.

Mayo Clinic Florida, Jacksonville, FL, United States.

Epilepsy associated with Rasmussen's encephalitis (RE) is highly resistant to standard therapy and continues to present a therapeutic challenge. While epilepsy surgery remains the most effective management for patients with drug-resistant focal epilepsy and RE, hemispherotomy may debilitating consequences on adult patients. Here we present the outcome of a 32-year-old woman with adult-onset Rasmussen's, who was treated with brain-responsive neurostimulation (RNS) after failure of several immunotherapeutic and anti-seizure medications. Read More

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Surgical revision after Vagus Nerve Stimulation. A case series.

Epilepsy Behav Rep 2021 26;15:100437. Epub 2021 Mar 26.

Department of Neurosurgery, Charité - University Medicine Berlin, Germany.

With increasing use of vagus nerve stimulation (VNS) as an adjunct treatment for drug-resistant epilepsy, revision surgery of VNS grows in importance. Indications for revision surgery are diverse and extend of surgery varies. We report a retrospective review on indications and complications of VNS revision surgery at our center. Read More

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Prevalence and Therapy Rates for Stuttering, Cluttering, and Developmental Disorders of Speech and Language: Evaluation of German Health Insurance Data.

Front Hum Neurosci 2021 12;15:645292. Epub 2021 Apr 12.

Epilepsy Center Frankfurt Rhine-Main, Department of Neurology and Neurosurgery, Goethe University Frankfurt, Frankfurt, Germany.

Purpose: To evaluate the prevalence and treatment patterns of speech and language disorders in Germany.

Methods: A retrospective analysis of data collected from 32% of the German population, insured by the statutory German health insurance (AOK, Local Health Care Funds). We used The International Statistical Classification of Diseases and Related Health Problems, 10th revision, German Modification (ICD-10 GM) codes for stuttering (F98. Read More

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Non-lesional mesial temporal lobe epilepsy requires bilateral invasive evaluation.

Epilepsy Behav Rep 2021 27;15:100441. Epub 2021 Mar 27.

Department of Neurology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-8508, USA.

Purpose: Mesial temporal lobe epilepsy (MTLE) usually responds well to surgical treatment, although in non-lesional cases up to 50% of patients experience seizure relapse. The possibility of bilateral independent seizure onset should be considered as a reason for epilepsy surgery failure.

Methods: In a cohort of 177 patients who underwent invasive presurgical evaluation with stereo-tactically placed electrodes in two level four epilepsy centers, 29 had non-lesional MTLE. Read More

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Characterizing the phenotype of drug-resistant childhood epilepsy associated with leukemia: A case series.

Epilepsy Behav Rep 2021 31;15:100432. Epub 2021 Jan 31.

Cleveland Clinic, Epilepsy Center, Neurological Institute - Desk S50, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, United States.

Children with leukemia are at risk for epilepsy due to primary disease or neurotoxic therapies. We describe the phenotypes of drug-resistant epilepsy in 10 children with history of leukemia. Of 10 cases, 6 had features of Lennox-Gastaut syndrome, and 4 had focal epilepsy. Read More

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January 2021

Autoimmune Encephalitis in Late-Onset Seizures: When to Suspect and How to Treat.

Front Neurol 2021 7;12:633999. Epub 2021 Apr 7.

Department of Neurology, Epilepsy Center, University Medicine Greifswald, Greifswald, Germany.

This study was conducted to elucidate prevalence, clinical features, outcomes, and best treatment in patients with late-onset seizures due to autoimmune encephalitis (AE). This is a single-institution prospective cohort study (2012-2019) conducted at the Epilepsy Center at the University of Greifswald, Germany. A total of 225 patients aged ≥50 years with epileptic seizures were enrolled and underwent an MRI/CT scan, profiling of neural antibodies (AB) in serum and cerebrospinal fluid (CSF), and neuropsychological testing. Read More

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Nasopharyngeal electrodes in temporal lobe epilepsy: A reappraisal of their diagnostic utility.

Clin Neurophysiol 2021 Apr 8. Epub 2021 Apr 8.

Department of Neurology, Epilepsy Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address:

Objective: To compare electroencephalography (EEG) recordings with nasopharyngeal electrodes (NPEs) plus anterior temporal electrodes (ATEs) (NPE recordings) and those with only ATEs (non-NPE recordings) for the detection of interictal epileptiform discharges (IEDs) in patients with suspected temporal lobe epilepsy (TLE).

Methods: We retrospectively analyzed the initial EEGs of 229 patients that were recorded simultaneously with ATEs and NPEs in addition to the electrodes of the 10-20 system of electrode placement. Two data sets of NPE and non-NPE recordings were reviewed independently by three interpreters with differing degrees of experience. Read More

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A six-year longitudinal study of neurocognitive problems in children with epilepsy.

Brain Dev 2021 Apr 20. Epub 2021 Apr 20.

Institute of Neurology and Neuropsychology, 83/11, Vaja-Pshavela Ave., 0186 Tbilisi, Georgia; Iv. Javakhishvili Tbilisi State University, 1, Chavchavadze Ave., 0179 Tbilisi, Georgia.

Introduction: This study describes the specific neuropsychological abnormalities among children with epilepsy (CH-E) living in Georgia.

Methods: A cohort of CH-E and children without epilepsy (CH-NoE), aged 6-13 years, admitted to the epilepsy center of the Institute of Neurology and Neuropsychology from 1st January 2010 to 31st December 2015, was selected and investigated with a structured protocol. Neurological/epileptological assessments were made and neuropsychological testing was done on all study subjects. Read More

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Tuberous Sclerosis Complex.

Authors:
Monica P Islam

Semin Pediatr Neurol 2021 Apr 11;37:100875. Epub 2021 Feb 11.

Nationwide Children's Hospital, The Ohio State University College of Medicine, 700 Children's Drive, Columbus, OH. Electronic address:

Affecting approximately 1 per 6000-10,000 individuals, tuberous sclerosis complex (TSC) is a neurocutaneous disorder that is not only uncommon but at risk to go underrecognized. Similar to other phakomatoses, TSC is a disorder of cellular proliferation and migration producing hamartomas-benign tumors or malignant cancers affecting the skin and brain-and also involving the heart, kidneys, lungs and eyes in ways that can vary across the lifetime. It also occurs and varies across generations. Read More

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Relationship and sexual satisfaction are associated with better disease self-management in persons with epilepsy.

Epilepsy Behav 2021 Apr 20;119:107937. Epub 2021 Apr 20.

School of Nursing, Indiana University, United States.

Prior research has demonstrated that PWEs view intimate interpersonal relationships as personally important and as a substantive challenge in their lives. This is significant as high-quality intimate relationships have been linked with greater well-being and better healthcare self-management in other disease contexts. For persons with epilepsy (PWEs), self-management is critical for seizure control, lower mortality, and better quality of life. Read More

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Unexpected pain with electrocortical stimulation in a teenager with temporal encephalocele.

Epilepsy Behav Rep 2021 31;16:100444. Epub 2021 Mar 31.

Department of Neurology, University of Wisconsin-Madison School of Medicine and Public Health, 1685 Highland Ave, Madison, WI 53705, United States.

Temporal lobe encephalocele has emerged as a potentially unrecognized cause of drug-resistant temporal lobe epilepsy (TLE) that can be effectively treated with epilepsy surgery. Here we present a case in which a 17-year-old male with drug-resistant epilepsy and left temporal encephalocele underwent workup for epilepsy surgery, and experienced unexpected pain with electrocortical stimulation. Stimulation of stereo-EEG electrodes in the left temporal pole resulted in severe, unilateral left-sided facial pain due to inadvertent stimulation of the trigeminal nerve. Read More

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Presurgical accuracy of dipole clustering in MRI-negative pediatric patients with epilepsy: Validation against intracranial EEG and resection.

Clin Neurophysiol 2021 Mar 26. Epub 2021 Mar 26.

Laboratory of Children's Brain Dynamics, Division of Newborn Medicine, Department of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; Jane and John Justin Neurosciences Center, Cook Children's Health Care System, Fort Worth, TX, USA; School of Medicine, Texas Christian University and University of North Texas Health Science Center, Fort Worth, TX, USA; Department of Bioengineering, University of Texas at Arlington, Arlington, TX, USA. Electronic address:

Objective: To assess the utility of interictal magnetic and electric source imaging (MSI and ESI) using dipole clustering in magnetic resonance imaging (MRI)-negative patients with drug resistant epilepsy (DRE).

Methods: We localized spikes in low-density (LD-EEG) and high-density (HD-EEG) electroencephalography as well as magnetoencephalography (MEG) recordings using dipoles from 11 pediatric patients. We computed each dipole's level of clustering and used it to discriminate between clustered and scattered dipoles. Read More

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Valproate but not levetiracetam slows the EEG alpha peak frequency - A pharmaco-EEG study.

Clin Neurophysiol 2021 Mar 31. Epub 2021 Mar 31.

Department of Neurology and Epilepsy Center Frankfurt Rhine-Main, Goethe University Frankfurt, Frankfurt am Main, Germany; LOEWE Center for Personalized Translational Epilepsy Research (CePTER), Goethe University Frankfurt, Frankfurt am Main, Germany.

Objective: Studies of the effect of valproate (VPA) on the background EEG have shown varying results. Therefore, we compared the effect of VPA and levetiracetam (LEV) on the EEG alpha peak frequency (APF).

Methods: We retrospectively examined the APF in resting-state EEG of patients undergoing inpatient video-EEG monitoring (VEM) during withdrawal of VPA or LEV. Read More

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Morphometric analysis of spike-wave complexes (SWCs) causing myoclonic seizures in children with idiopathic myoclonic epilepsies - A positive SWC component correlates with myoclonic intensity.

Brain Dev 2021 Apr 16. Epub 2021 Apr 16.

Department of Pediatrics, Tokyo Women's Medical University, 8-1 Kawada-Cho, Shinjuku-cu, Tokyo 162-8666, Japan.

Aim: To elucidate the morphological characteristics of spike-wave complexes (SWCs) causing myoclonic seizures (MS) in childhood-onset idiopathic myoclonic epilepsies.

Subjects And Methods: The subjects were 8 patients, including 4 with epilepsy with myoclonic-atonic seizures (EMAS), 3 with myoclonic epilepsy in infancy (MEI) and 1 with idiopathic unclassifiable myoclonic epilepsy. Morphometric parameters of the SWCs were compared between those with MS [SWC-MS (+)] and those without MS [SWC-MS (-)], and a correlation coefficient analysis was performed between the SWC parameters and the duration of myoclonic electromyogram (EMG) potentials. Read More

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Stereoelectroencephalography-guided radiofrequency thermocoagulation for hypothalamic hamartoma: Electroclinical patterns and the relationship with surgical prognosis.

Epilepsy Behav 2021 May 16;118:107957. Epub 2021 Apr 16.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; Department of Stereotactic and Functional Neurosurgery, Beijing Neurosurgical Institute, Beijing, China. Electronic address:

Background: Radiofrequency thermocoagulation (RFTC) guided by stereo-electroencephalography (SEEG) has been proved to be a safe method to reduce seizure frequency in patients with drug-resistant epilepsy. However, there are few reports addressing the value and safety of this procedure in hypothalamic hamartoma (HH).

Objective: To present the results of our experience using SEEG-guided RFTC in HH patients with drug-resistant epilepsy, and identify outcome predictors. Read More

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