162,535 results match your criteria epilepsy


Impact of antiepileptic drugs on simulated driving in patients with epilepsy.

Seizure 2021 Sep 14;92:195-199. Epub 2021 Sep 14.

Department of Psychiatry, Graduate School of Medicine, Nagoya University, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi 466-8550, Japan.

Objective: Results of observational investigations have demonstrated that the risk of a traffic accident is independent of use of AEDs. However, no reports of driving tests conducted with patients administered AEDs have been presented. This study examined this scenario in a simulated driving setting. Read More

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September 2021

Predictors and prognoses of epilepsy after anti-neuronal antibody-positive autoimmune encephalitis.

Seizure 2021 Sep 14;92:189-194. Epub 2021 Sep 14.

Department of Neurology, The Nanjing Brain Hospital Affiliated Nanjing Medical University, 210029 Nanjing, China. Electronic address:

Purpose: This study aimed to investigate the incidence and predictors of epilepsy after anti-neuronal antibody-positive autoimmune encephalitis (AIE). The clinical outcomes of patients with epilepsy after AIE were also explored.

Methods: A total of 111 AIE patients were retrospectively evaluated. Read More

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September 2021

Low-grade epilepsy-associated neuroepithelial tumours with a prominent oligodendroglioma-like component: the diagnostic challenges.

Neuropathol Appl Neurobiol 2021 Sep 22. Epub 2021 Sep 22.

APHM, CHU Timone, Service d'Anatomie Pathologique et de Neuropathologie, Marseille, France.

Aim: We searched for recurrent pathological features and molecular alterations in a retrospective series of 72 low-grade epilepsy-associated neuroepithelial tumours (LEATs) with a prominent oligodendroglioma-like component, in order to classify them according to the 2021 WHO classification of CNS tumours.

Material And Methods: Centralized pathological examination was performed as well as targeted molecular analysis of BRAF and FGFR1 by multiplexed digital PCR (mdPCR). DNA-methylation profiling was performed in cases with sufficient DNA. Read More

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September 2021

Predictive semiology of psychogenic non-epileptic seizures in an epilepsy monitoring unit.

J Neurol 2021 Sep 22. Epub 2021 Sep 22.

Department of Clinical Neurosciences, St. Vincent's Hospital Melbourne, Melbourne, VIC, Australia.

Introduction: The diagnosis of psychogenic nonepileptic seizures (PNES) is a common clinical dilemma. We sought to assess the diagnostic value of four ictal signs commonly used in differentiating PNES from epileptic seizures (ES).

Methods: We retrospectively reviewed consecutive adult video-electroencephalogram (VEM) studies conducted at a single tertiary epilepsy center between May 2009 and August 2016. Read More

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September 2021

Spectral changes following resective epilepsy surgery and neurocognitive function in children with epilepsy.

J Neurophysiol 2021 Sep 22. Epub 2021 Sep 22.

Program in Neuroscience and Mental Health, Hospital for Sick Children Research Institute, Toronto, Canada.

Decelerated resting cortical oscillations, high frequency activity and enhanced cross-frequency interactions are features of focal epilepsy. The association between electrophysiological signal properties and neurocognitive function, particularly following resective surgery is, however, unclear. In the current report, we studied intraoperative recordings from intracranial electrodes implanted in seven children with focal epilepsy and analyzed the spectral dynamics both before and after surgical resection of the hypothesized seizure focus. Read More

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September 2021

Micronutrient characteristic in recurrent seizure in medicinecontrolled epileptic children with normal nutritional status.

Acta Neurol Taiwan 2021 Jun;30(2):54-62

Departement of Child Health Faculty of Medicine, Universitas Airlangga,Indonesia.

Background: Recurrent seizure in epileptic children is correlated with future motoric disorders, behavior problems, and intellectual disabilities. Various factors are thought to modulate the risk of recurrent seizure, including micronutrient status such as calcium, 25-dehydroxycholecalciferol (25-(OH)D), and serum iron presented as hemoglobin level.

Aim: To analyze correlation between micronutrient characteristics of epileptic children and recurrence of seizure. Read More

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CAPN3: A muscle‑specific calpain with an important role in the pathogenesis of diseases (Review).

Int J Mol Med 2021 Nov 22;48(5). Epub 2021 Sep 22.

Department of Emergency Medicine, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China.

Calpains are a family of Ca‑dependent cysteine proteases that participate in various cellular processes. Calpain 3 (CAPN3) is a classical calpain with unique N‑terminus and insertion sequence 1 and 2 domains that confer characteristics such as rapid autolysis, Ca‑independent activation and Na activation of the protease. CAPN3 is the only muscle‑specific calpain that has important roles in the promotion of calcium release from skeletal muscle fibers, calcium uptake of sarcoplasmic reticulum, muscle formation and muscle remodeling. Read More

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November 2021

Systematic Mapping Study of AI/Machine Learning in Healthcare and Future Directions.

SN Comput Sci 2021 16;2(6):461. Epub 2021 Sep 16.

AIIT, AMITY University, Noida, Uttar Pradesh, India.

This study attempts to categorise research conducted in the area of: , using a systematic mapping study methodology. In our attempt, we reviewed literature from top journals, articles, and conference papers by using the keywords . We queried Google Scholar, resulted in 1400 papers, and then categorised the results on the basis of the objective of the study, the methodology adopted, type of problem attempted and disease studied. Read More

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September 2021

IL-1β and HMGB1 are anti-neurogenic to endogenous neural stem cells in the sclerotic epileptic human hippocampus.

J Neuroinflammation 2021 Sep 21;18(1):218. Epub 2021 Sep 21.

Brain Repair and Intracranial Neurotherapeutics (BRAIN), Biomedical Research Unit, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, CF24 4HQ, UK.

Background: The dentate gyrus exhibits life-long neurogenesis of granule-cell neurons, supporting hippocampal dependent learning and memory. Both temporal lobe epilepsy patients and animal models frequently have hippocampal-dependent learning and memory difficulties and show evidence of reduced neurogenesis. Animal and human temporal lobe epilepsy studies have also shown strong innate immune system activation, which in animal models reduces hippocampal neurogenesis. Read More

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September 2021

Cerebral Visual Impairment in CDKL5 Deficiency Disorder Correlates With Developmental Achievement.

J Child Neurol 2021 Oct;36(11):974-980

Department of Child Neurology, Children's Hospital Colorado, Anschutz Medical Campus, Aurora, CO, USA.

Cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder is a rare neurodevelopmental disorder characterized by infantile-onset refractory epilepsy, profound developmental delays, and cerebral visual impairment. Although there is evidence that the presence of cerebral visual impairment in CDKL5 deficiency disorder is common, the potential impact of cerebral visual impairment severity on developmental attainment has not been explored directly. Focusing on a cohort of 46 children with CDKL5 deficiency disorder, examination features indicative of cerebral visual impairment were quantified and compared to developmental achievement. Read More

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October 2021

Altered functional connectivity in newly diagnosed benign epilepsy with unilateral or bilateral centrotemporal spikes: A multi-frequency MEG study.

Epilepsy Behav 2021 Sep 18;124:108276. Epub 2021 Sep 18.

Department of Neurology, Nanjing Brain Hospital, Nanjing Medical University, Nanjing, Jiangsu 210029, China. Electronic address:

Objective: Rolandic epilepsy (RE) is one of the most common forms of epilepsy syndromes in children. The condition is usually accompanied with either unilateral or bilateral centrotemporal epileptic discharge. Despite the term "benign", many studies have reported that children with benign epilepsy with centrotemporal spikes (BECTS) display a range of pervasive cognitive difficulties. Read More

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September 2021

More than one self-limited epilepsy of childhood in the same patient: A multicenter study.

Epilepsy Res 2021 Sep 17;177:106768. Epub 2021 Sep 17.

Hospital de Pediatría Prof. Dr. Juan P. Garrahan, Buenos Aires, Argentina. Electronic address:

Objective: We describe the evolution of the electroclinical picture of patients with different types of self-limited epilepsy of childhood (SLEC) occurring at the same or at different times with or without atypical evolutions as well as patients with SLEC associated with childhood absence epilepsy (CAE).

Material And Methods: A multicenter, retrospective, descriptive study was conducted evaluating patients with SLEC who had focal seizures of different types of SLEC including atypical evolutions as well as SLEC associated with absence epilepsy seen at eight Argentinian centers between April 2000 and April 2019. Of 7705 patients with SLEC, aged between 2 and 14 years (mean, 7. Read More

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September 2021

A Survey of Healthcare Providers About Reproductive Healthcare for Adolescent Women with Epilepsy.

J Pediatr Adolesc Gynecol 2021 Sep 18. Epub 2021 Sep 18.

Division of General Academic Pediatrics, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania. Electronic address:

Study Objective: Evaluate knowledge, attitudes, and practices about sexual and reproductive health (SRH) for adolescent and young adult (AYA) women with epilepsy among general pediatricians, adolescent medicine specialists, and pediatric gynecologists.

Design: Survey comprising previously validated and novel items that underwent content validity testing, distributed through specialty listservs. Categorical variables analyzed with Chi-Square or Fisher's exact tests, and continuous variables with Kruskal-Wallis tests. Read More

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September 2021

Fully automated delineation of the optic radiation for surgical planning using clinically feasible sequences.

Hum Brain Mapp 2021 Sep 21. Epub 2021 Sep 21.

The Australian e-Health Research Centre, CSIRO, Brisbane, Queensland, Australia.

Quadrantanopia caused by inadvertent severing of Meyer's Loop of the optic radiation is a well-recognised complication of temporal lobectomy for conditions such as epilepsy. Dissection studies indicate that the anterior extent of Meyer's Loop varies considerably between individuals. Quantifying this for individual patients is thus an important step to improve the safety profile of temporal lobectomies. Read More

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September 2021

Encephalitis patient-derived monoclonal GABAA receptor antibodies cause epileptic seizures.

J Exp Med 2021 Nov 21;218(11). Epub 2021 Sep 21.

German Center for Neurodegenerative Diseases (DZNE) Berlin, Berlin, Germany.

Autoantibodies targeting the GABAA receptor (GABAAR) hallmark an autoimmune encephalitis presenting with frequent seizures and psychomotor abnormalities. Their pathogenic role is still not well-defined, given the common overlap with further autoantibodies and the lack of patient-derived mAbs. Five GABAAR mAbs from cerebrospinal fluid cells bound to various epitopes involving the α1 and γ2 receptor subunits, with variable binding strength and partial competition. Read More

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November 2021

Towards Interpretable Machine Learning in EEG Analysis.

Stud Health Technol Inform 2021 Sep;283:32-38

Institute of Medical Informatics, Medical Faculty, RWTH Aachen University, Aachen, Germany.

In this paper a machine learning model for automatic detection of abnormalities in electroencephalography (EEG) is dissected into parts, so that the influence of each part on the classification accuracy score can be examined. The most successful setup of several shallow artificial neural networks aggregated via voting results in accuracy of 81%. Stepwise simplification of the model shows the expected decrease in accuracy, but a naive model with thresholding of a single extracted feature (relative wavelet energy) is still able to achieve 75%, which remains strongly above the random guess baseline of 54%. Read More

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September 2021

Intraoperative MR Imaging in epilepsy surgery: systematic review of the literature and meta-analysis.

J Neurosurg Sci 2021 Sep 21. Epub 2021 Sep 21.

Department of Neurosurgery, Medical University of Vienna, Vienna, Austria -

Introduction: Intraoperative magnetic resonance imaging (iopMRI) is increasingly incorporated into neurosurgery to improve outcomes. However, its usefulness in epilepsy surgery remains debated. To elucidate its current role we conducted a systematic review of the data published to date. Read More

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September 2021

Treatment with the combination of clavulanic acid and valproic acid led to recovery of neuronal and behavioral deficits in an epilepsy rat model.

Fundam Clin Pharmacol 2021 Sep 20. Epub 2021 Sep 20.

Department of Psychology, Chung Shan Medical University Hospital, Chung Shan Medical University, Taichung, Taiwan, ROC.

Epilepsy, which is caused by abnormal neuronal firing in the brain, is a common neurological disease and affects motor and cognitive functions. Excessive levels of glutamate and insufficient levels of inhibitory GABA are involved in its pathophysiology. Valproic acid (Val), a GABAergic agonist, is one of the first-line antiepileptic drugs, but it shows many adverse side effects at the clinical dose. Read More

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September 2021

Multimodal electrophysiological analyses reveal that reduced synaptic excitatory neurotransmission underlies seizures in a model of NMDAR antibody-mediated encephalitis.

Commun Biol 2021 Sep 20;4(1):1106. Epub 2021 Sep 20.

Institute of Health and Neurodevelopment, College of Health and Life Sciences, Aston University, Birmingham, UK.

Seizures are a prominent feature in N-Methyl-D-Aspartate receptor antibody (NMDAR antibody) encephalitis, a distinct neuro-immunological disorder in which specific human autoantibodies bind and crosslink the surface of NMDAR proteins thereby causing internalization and a state of NMDAR hypofunction. To further understand ictogenesis in this disorder, and to test a potential treatment compound, we developed an NMDAR antibody mediated rat seizure model that displays spontaneous epileptiform activity in vivo and in vitro. Using a combination of electrophysiological and dynamic causal modelling techniques we show that, contrary to expectation, reduction of synaptic excitatory, but not inhibitory, neurotransmission underlies the ictal events through alterations in the dynamical behaviour of microcircuits in brain tissue. Read More

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September 2021

Slo2/K Channels in Protect Against Spontaneous and Induced Seizure-like Behavior Associated with an Increased Persistent Na Current.

J Neurosci 2021 Sep 17. Epub 2021 Sep 17.

Department of Biomedical Sciences, Colorado State University, 1617 Campus Delivery, Fort Collins, CO 80523

Na-sensitivity is a unique feature of Na-activated K (K) channels, making them naturally suited to counter a sudden influx in Na ions. As such, it has long been suggested that K channels may serve a protective function against excessive excitation associated with neuronal injury and disease. This hypothesis, however, has remained largely untested. Read More

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September 2021

Somatostatin-positive Interneurons Contribute to Seizures in Epileptic Encephalopathy.

J Neurosci 2021 Sep 17. Epub 2021 Sep 17.

Department of Anesthesiology, University of Virginia Health System, Charlottesville, VA USA.

epileptic encephalopathy is a devastating epilepsy syndrome caused by mutant which encodes the voltage-gated sodium channel Na1.6. To date, it is unclear if and how inhibitory interneurons, which express Na1. Read More

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September 2021

HFOApp: A MATLAB graphical user interface for high frequency oscillation marking.

eNeuro 2021 Sep 17. Epub 2021 Sep 17.

Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, United States of America.

Epilepsy affects 3.4 million people in the United States, and despite availability of numerous antiepileptic drugs, 36% of patients have uncontrollable seizures, which severely impacts quality of life. High frequency oscillations (HFOs) are a potential biomarker of epileptogenic tissue that could be useful in surgical planning. Read More

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September 2021

Risk of seizure clusters and status epilepticus following rapid and ultra-rapid medication discontinuation during intracranial EEG monitoring.

Epilepsy Res 2021 Sep 13;177:106756. Epub 2021 Sep 13.

Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, Nebraska, 68198-8435, USA. Electronic address:

Objective: Anti-seizure medications (ASMs) are discontinued in the course of intracranial EEG (iEEG) monitoring for presurgical evaluation. The ASM withdrawal facilitates an emergence of seizures but may also precipitate seizure clusters (SC) and status epilepticus (SE). The aim of this study was to compare the rates of SC and SE during the ultra-rapid withdrawal (URW) and rapid withdrawal (RW) of ASMs during iEEG. Read More

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September 2021

CSF high-mobility group box 1 is associated with drug-resistance and symptomatic etiology in adult patients with epilepsy.

Epilepsy Res 2021 Sep 15;177:106767. Epub 2021 Sep 15.

Department of Neurology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan, 450003, China. Electronic address:

Purpose: Extracellular high-mobility group box 1 (HMGB1) is considered a proinflammatory mediator and is involved in various neurological disorders. This study aims to determine the expression profiles of HMGB1 in cerebrospinal fluid (CSF) and paired serum, and to explore whether there is a relationship between CSF HMGB1 concentrations with seizure parameters in adult patients with epilepsy.

Methods: CSF and paired serum HMGB1 concentrations were measured in patients with drug-refractory epilepsy (DRE, n = 27), newly diagnosed epilepsy (NDE, n = 56), and other non-inflammatory neurological disorders (ONNDs, n = 22). Read More

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September 2021

The Efficacy, Safety and Outcomes of Brain-responsive Neurostimulation (RNS® System) therapy in older adults.

Epilepsia Open 2021 Sep 20. Epub 2021 Sep 20.

Epilepsy Center, Neurological Institute, Cleveland Clinic, Cleveland, OH, 44195, USA.

Responsive neurostimulation is approved in patients above 18 years of age with drug resistant focal epilepsy. We aimed to investigate whether RNS outcomes and safety varied based on age. We included patients who had been implanted with RNS for >6 months (N=55), dividing them into older (N=11) and younger adults (N=44) depending on implantation age (≥50 and <50 years, respectively). Read More

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September 2021

Drug-Resistant Epilepsy: drug target hypothesis and beyond the receptors.

Epilepsia Open 2021 Sep 20. Epub 2021 Sep 20.

Pharmacobiology Department, Center for Research and Advanced Studies, México City, México.

Epilepsy is a chronic neurological disorder that affects over 70 million people worldwide. Despite a recent introduction of antiseizure drugs for the treatment of epileptic seizures, one-third of these patients suffer from drug-resistant epilepsy (DRE). The therapeutic target hypothesis is a cited theory to explain DRE. Read More

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September 2021

Transporter hypothesis in pharmacoresistant epilepsies Is it at the central or peripheral level?

Epilepsia Open 2021 Sep 20. Epub 2021 Sep 20.

Institute for Research in Physiopathology and Clinical Biochemistry (INFIBIOC), Clinical Biochemistry Department, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina.

The multidrug resistance (MDR) phenotype is typically observed in patients with refractory epilepsy (RE) whose seizures are not controlled despite receiving several combinations of more than two antiseizure medications (ASMs) directed against different ion channels or neurotransmitter receptors. Since the use of bromide in 1860, more than 20 ASMs have been developed; however, historically ~30% of cases of RE with MDR phenotype remains unchanged. Irrespective of metabolic biotransformation, the biodistribution of ASMs and their metabolites depends on the functional expression of some ATP-binding cassette transporters (ABC-t) in different organs, such as the blood-brain barrier (BBB), bowel, liver, and kidney, among others. Read More

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September 2021

Preventive Effects of Sinigrin Against the Memory Deterioration in the Pentylenetetrazole-Kindled Male Wistar Rats: Possible Modulation of NLRP3 Pathway.

Neuromolecular Med 2021 Sep 20. Epub 2021 Sep 20.

Department of Animal Sciences and Biotechnology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran.

Mainly found in brussels sprouts, broccoli, and black mustard seeds, sinigrin (2-propenyl glucosinolate) has enjoyed some attention currently for its effects on health and disease prevention. The present research design is aimed at investigating the effects of sinigrin on inflammation, oxidative stress (OS) and memory. Randomly, six groups of male Wistar rats were categorized into the control and experimental groups. Read More

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September 2021

Effective connectivity differs between focal cortical dysplasia types I and II.

Epilepsia 2021 Sep 20. Epub 2021 Sep 20.

Charles Shor Epilepsy Center, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA.

Objective: To determine whether brain connectivity differs between focal cortical dysplasia (FCD) types I and II.

Methods: We compared cortico-cortical evoked potentials (CCEPs) as measures of effective brain connectivity in 25 FCD patients with drug-resistant focal epilepsy who underwent intracranial evaluation with stereo-electroencephalography (SEEG). We analyzed the amplitude and latency of CCEP responses following ictal-onset single-pulse electrical stimulation (iSPES). Read More

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September 2021

Long-term seizure outcomes in patients with hypothalamic hamartoma treated by stereotactic radiofrequency thermocoagulation.

Epilepsia 2021 Sep 20. Epub 2021 Sep 20.

Department of Neurosurgery, Niigata Seiro Hospital, Niigata, Japan.

Objective: To investigate long-term seizure outcomes in patients with hypothalamic hamartoma (HH) following stereotactic radiofrequency thermocoagulation (SRT).

Methods: A total of 131 patients with HH who underwent SRT and were followed for at least three years after the last SRT were enrolled. Seizure outcomes were evaluated for gelastic seizures (GS) and other types of seizures (nGS) separately using the International League Against Epilepsy classification. Read More

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September 2021