337 results match your criteria epigenetic clocks


The association between epigenetic clocks and physical functioning in older women: a three-year follow-up.

J Gerontol A Biol Sci Med Sci 2021 Sep 20. Epub 2021 Sep 20.

Faculty of Sport and Health Sciences, Gerontology Research Center (GEREC), University of Jyväskylä, Jyväskylä, Finland.

Background: Epigenetic clocks are composite markers developed to predict chronological age or mortality risk from DNA methylation (DNAm) data. The present study investigated the associations between four epigenetic clocks (Horvath's and Hannum's DNAmAge and DNAm GrimAge and PhenoAge) and physical functioning during a three-year follow-up.

Methods: We studied 63-76-year-old women (n = 413) from the Finnish Twin Study on Aging. Read More

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September 2021

DNA methylation-based biomarkers of aging were slowed down in a two-year diet and physical activity intervention trial: the DAMA study.

Aging Cell 2021 Sep 18:e13439. Epub 2021 Sep 18.

Institute for Cancer Research, Prevention and Clinical Network - ISPRO, Florence, Italy.

Several biomarkers of healthy aging have been proposed in recent years, including the epigenetic clocks, based on DNA methylation (DNAm) measures, which are getting increasingly accurate in predicting the individual biological age. The recently developed "next-generation clock" DNAmGrimAge outperforms "first-generation clocks" in predicting longevity and the onset of many age-related pathological conditions and diseases. Additionally, the total number of stochastic epigenetic mutations (SEMs), also known as the epigenetic mutation load (EML), has been proposed as a complementary DNAm-based biomarker of healthy aging. Read More

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September 2021

Re(Setting) Epigenetic Clocks: An Important Avenue Whereby Social Conditions Become Biologically Embedded across the Life Course.

J Health Soc Behav 2021 Sep;62(3):436-453

University of Georgia, Athens, GA, USA.

Research on biological embedding of the social environment has been expedited by increased availability of biomarkers. Recently, this arsenal of measures has been expanded to include epigenetic clocks that indicate in years the extent to which an individual is older or younger than their chronological age. These measures of biological aging, especially GrimAge, are robust predictors of both illness and time to death. Read More

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September 2021

Unstable Childhood, Adult Adversity, and Smoking Accelerate Biological Aging Among Middle-Age African Americans: Similar Findings for GrimAge and PoAm.

J Aging Health 2021 Sep 15:8982643211043668. Epub 2021 Sep 15.

University of Georgia, Athens, GA, USA.

The recent biological clocks GrimAge and PoAm are robust predictors of morbidity and mortality. Little research, however, has investigated the factors that influence their ticking speed. No study has used multivariate analyses to examine whether childhood adversity, adult hardship, lifestyle practices, or some combination of these factors best explains acceleration of these indices. Read More

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September 2021

Epigenetic clock and DNA methylation analysis of porcine models of aging and obesity.

Geroscience 2021 Sep 15. Epub 2021 Sep 15.

Department of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA, USA.

DNA-methylation profiles have been used successfully to develop highly accurate biomarkers of age, epigenetic clocks, for many species. Using a custom methylation array, we generated DNA methylation data from n = 238 porcine tissues including blood, bladder, frontal cortex, kidney, liver, and lung, from domestic pigs (Sus scrofa domesticus) and minipigs (Wisconsin Miniature Swine™). Samples used in this study originated from Large White X Landrace crossbred pigs, Large White X Minnesota minipig crossbred pigs, and Wisconsin Miniature Swine™. Read More

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September 2021

Epigenetic clocks in the pediatric population: when and why they tick?

Chin Med J (Engl) 2021 Sep 14. Epub 2021 Sep 14.

Department of Neonatology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China Center for Molecular Medicine, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China.

Abstract: Recent research efforts have provided compelling evidence of genome-wide DNA methylation alterations in pediatrics. It is currently well established that epigenetic clocks, composed of DNA methylation sites, can estimate the gestational and chronological age of cells and tissues from different ages. Also, extensive research is aimed at their correlation with early life exposure and pediatric diseases. Read More

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September 2021

DNA methylation and histone variants in aging and cancer.

Int Rev Cell Mol Biol 2021 12;364:1-110. Epub 2021 Jul 12.

Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette, France. Electronic address:

Aging-related diseases such as cancer can be traced to the accumulation of molecular disorder including increased DNA mutations and epigenetic drift. We provide a comprehensive review of recent results in mice and humans on modifications of DNA methylation and histone variants during aging and in cancer. Accumulated errors in DNA methylation maintenance lead to global decreases in DNA methylation with relaxed repression of repeated DNA and focal hypermethylation blocking the expression of tumor suppressor genes. Read More

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Epigenetic Clocks Are Not Accelerated in COVID-19 Patients.

Int J Mol Sci 2021 Aug 27;22(17). Epub 2021 Aug 27.

Helmholtz-Institute for Biomedical Engineering, Stem Cell Biology and Cellular Engineering, Medical Faculty of RWTH Aachen University, 52074 Aachen, Germany.

Age is a major risk factor for severe outcome of the 2019 coronavirus disease (COVID-19). In this study, we followed the hypothesis that particularly patients with accelerated epigenetic age are affected by severe outcomes of COVID-19. We investigated various DNA methylation datasets of blood samples with epigenetic aging signatures and performed targeted bisulfite amplicon sequencing. Read More

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Cellular reprogramming and epigenetic rejuvenation.

Clin Epigenetics 2021 Sep 6;13(1):170. Epub 2021 Sep 6.

MRC Human Genetics Unit, MRC Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, EH4 2XU, UK.

Ageing is an inevitable condition that afflicts all humans. Recent achievements, such as the generation of induced pluripotent stem cells, have delivered preliminary evidence that slowing down and reversing the ageing process might be possible. However, these techniques usually involve complete dedifferentiation, i. Read More

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September 2021

Epigenetic clock and methylation studies in the rhesus macaque.

Geroscience 2021 Sep 6. Epub 2021 Sep 6.

Translational Gerontology Branch, National Institute on Aging Intramural Research Program, National Institutes of Health, 16701 Elmer School Rd., MD, 20842, Dickerson, USA.

Methylation levels at specific CpG positions in the genome have been used to develop accurate estimators of chronological age in humans, mice, and other species. Although epigenetic clocks are generally species-specific, the principles underpinning them appear to be conserved at least across the mammalian class. This is exemplified by the successful development of epigenetic clocks for mice and several other mammalian species. Read More

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September 2021

DNA methylation age analysis of rapamycin in common marmosets.

Geroscience 2021 Sep 5. Epub 2021 Sep 5.

The Sam and Ann Barshop Institute for Longevity and Aging Studies, and Department of Molecular Medicine, UT Health San Antonio, and the Geriatric Research Education and Clinical Center, South Texas Veterans Healthcare System, San Antonio, TX, USA.

Human DNA methylation data have previously been used to develop highly accurate biomarkers of aging ("epigenetic clocks"). Subsequent studies demonstrate that similar epigenetic clocks can also be developed for mice and many other mammals. Here, we describe epigenetic clocks for common marmosets (Callithrix jacchus) based on novel DNA methylation data generated from highly conserved mammalian CpGs that were profiled using a custom Infinium array (HorvathMammalMethylChip40). Read More

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September 2021

Epigenetic clock and methylation studies in cats.

Geroscience 2021 Aug 31. Epub 2021 Aug 31.

Department of Human Genetics, David Geffen School of Medicine, University of California, 695 Charles E. Young Drive South, Los Angeles, CA, 90095, USA.

Human DNA methylation profiles have been used successfully to develop highly accurate biomarkers of aging ("epigenetic clocks"). Although these human epigenetic clocks are not immediately applicable to all species of the animal kingdom, the principles underpinning them appear to be conserved even in animals that are evolutionarily far removed from humans. This is exemplified by recent development of epigenetic clocks for mice and other mammalian species. Read More

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The potential positive epigenetic effects of various mind-body therapies (MBTs): a narrative review.

J Complement Integr Med 2021 Jun 22. Epub 2021 Jun 22.

Division of Behavioral Medicine, Cooper University Hospital, Cooper Medical School of Rowan University, Camden, NJ, USA.

Mind-Body Therapies (MBTs), such as mindfulness, meditation, yoga, and tai-chi, are said to improve quality of life by contributing to positive thinking and reducing overall distress. MBTs not only play a role in reducing stress and anxiety, but they are also found to epigenetically affect genes and other areas in our genomes that are implicated in inflammation, stress, and distress. This review analyzes the role of MBTs in reducing the epigenetic changes as reported in five previously conducted controlled studies found in the NCBI PubMed database. Read More

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Epigenetic Regulation of Circadian Clocks and Its Involvement in Drug Addiction.

Genes (Basel) 2021 Aug 19;12(8). Epub 2021 Aug 19.

Laboratoire de Neurosciences Cognitives et Adaptatives (LNCA), UMR 7364 CNRS, Université de Strasbourg, Neuropôle de Strasbourg, 67000 Strasbourg, France.

Based on studies describing an increased prevalence of addictive behaviours in several rare sleep disorders and shift workers, a relationship between circadian rhythms and addiction has been hinted for more than a decade. Although circadian rhythm alterations and molecular mechanisms associated with neuropsychiatric conditions are an area of active investigation, success is limited so far, and further investigations are required. Thus, even though compelling evidence connects the circadian clock to addictive behaviour and vice-versa, yet the functional mechanism behind this interaction remains largely unknown. Read More

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Accelerated Epigenetic Aging in Peripheral Blood Does not Predict Dementia Risk.

Curr Alzheimer Res 2021 Aug 22. Epub 2021 Aug 22.

School of Public Health and Preventive Medicine, Monash University, Melbourne, 3004, Victoria. Australia.

Background: There is strong evidence that epigenetic age acceleration is associated with increased risk of later-life diseases and all-cause mortality. However, there is currently limited evidence that suggests accelerated epigenetic age is associated with dementia risk.

Objective: This study aims to clarify whether epigenetic biomarkers of accelerated aging can pre- dict dementia risk, which is an important consideration as aging is the greatest risk factor for the disease. Read More

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Epigenetic age is associated with baseline and 3-year change in frailty in the Canadian Longitudinal Study on Aging.

Clin Epigenetics 2021 Aug 23;13(1):163. Epub 2021 Aug 23.

Health Sciences North Research Institute, 41 Ramsey Lake Road, Sudbury, ON, P3E 5J1, Canada.

Background: The trajectory of frailty in older adults is important to public health; therefore, markers that may help predict this and other important outcomes could be beneficial. Epigenetic clocks have been developed and are associated with various health-related outcomes and sociodemographic factors, but associations with frailty are poorly described. Further, it is uncertain whether newer generations of epigenetic clocks, trained on variables other than chronological age, would be more strongly associated with frailty than earlier developed clocks. Read More

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Epigenetic age prediction.

Aging Cell 2021 Sep 20;20(9):e13452. Epub 2021 Aug 20.

MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.

Advanced age is the main common risk factor for cancer, cardiovascular disease and neurodegeneration. Yet, more is known about the molecular basis of any of these groups of diseases than the changes that accompany ageing itself. Progress in molecular ageing research was slow because the tools predicting whether someone aged slowly or fast (biological age) were unreliable. Read More

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September 2021

Impact of excessive alcohol abuse on age prediction using the VISAGE enhanced tool for epigenetic age estimation in blood.

Int J Legal Med 2021 Aug 18. Epub 2021 Aug 18.

Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7A, 30-348, Krakow, Poland.

DNA methylation-based clocks provide the most accurate age estimates with practical implications for clinical and forensic genetics. However, the effects of external factors that may influence the estimates are poorly studied. Here, we evaluated the effect of alcohol consumption on epigenetic age prediction in a cohort of extreme alcohol abusers. Read More

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The protein inputs of an ultra-predictive aging clock represent viable anti-aging drug targets.

Ageing Res Rev 2021 09 6;70:101404. Epub 2021 Jul 6.

Alkahest, Inc., San Carlos, California, United States.

Machine learning models capable of predicting age given a set of inputs are referred to as aging clocks. We recently developed an aging clock that utilizes 491 plasma protein inputs, has an exceptional accuracy, and is capable of measuring biological age. Here, we demonstrate that this clock is extremely predictive (r = 0. Read More

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September 2021

Castration delays epigenetic aging and feminizes DNA methylation at androgen-regulated loci.

Elife 2021 07 6;10. Epub 2021 Jul 6.

Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, United States.

In mammals, females generally live longer than males. Nevertheless, the mechanisms underpinning sex-dependent longevity are currently unclear. Epigenetic clocks are powerful biological biomarkers capable of precisely estimating chronological age and identifying novel factors influencing the aging rate using only DNA methylation data. Read More

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The Socioeconomic Gradient in Epigenetic Ageing Clocks: Evidence from the Multi-Ethnic Study of Atherosclerosis and the Health and Retirement Study.

Epigenetics 2021 Jul 6:1-23. Epub 2021 Jul 6.

Department of Epidemiology, School of Public Health, University of Michigan, USA.

Epigenetic clocks have been widely used to predict disease risk in multiple tissues or cells. Their success as a measure of biological ageing has prompted research on the connection between epigenetic pathways of ageing and the socioeconomic gradient in health and mortality. However, studies examining social correlates of epigenetic ageing have yielded inconsistent results. Read More

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Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging.

Genome Biol 2021 06 29;22(1):194. Epub 2021 Jun 29.

Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.

Background: Biological aging estimators derived from DNA methylation data are heritable and correlate with morbidity and mortality. Consequently, identification of genetic and environmental contributors to the variation in these measures in populations has become a major goal in the field.

Results: Leveraging DNA methylation and SNP data from more than 40,000 individuals, we identify 137 genome-wide significant loci, of which 113 are novel, from genome-wide association study (GWAS) meta-analyses of four epigenetic clocks and epigenetic surrogate markers for granulocyte proportions and plasminogen activator inhibitor 1 levels, respectively. Read More

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Novel epigenetic clock for fetal brain development predicts prenatal age for cellular stem cell models and derived neurons.

Mol Brain 2021 06 26;14(1):98. Epub 2021 Jun 26.

College of Medicine and Health, University of Exeter, RILD Building Level 3, Barrack Rd, Exeter, UK.

Induced pluripotent stem cells (iPSCs) and their differentiated neurons (iPSC-neurons) are a widely used cellular model in the research of the central nervous system. However, it is unknown how well they capture age-associated processes, particularly given that pluripotent cells are only present during the earliest stages of mammalian development. Epigenetic clocks utilize coordinated age-associated changes in DNA methylation to make predictions that correlate strongly with chronological age. Read More

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Epigenetic clocks reveal a rejuvenation event during embryogenesis followed by aging.

Sci Adv 2021 Jun 25;7(26). Epub 2021 Jun 25.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

The notion that the germ line does not age goes back to the 19th-century ideas of August Weismann. However, being metabolically active, the germ line accumulates damage and other changes over time, i.e. Read More

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Longitudinal changes in epigenetic age acceleration in aviremic HIV-infected recipients of long-term antiretroviral treatment.

J Infect Dis 2021 Jun 24. Epub 2021 Jun 24.

HIV/AIDS and Infectious Diseases Research Group, Hospital La Paz Institute for Health Research (IdiPAZ), Madrid 28046, Spain.

Background: HIV infection induces epigenetic age acceleration (EAA), but it remains unclear whether epigenetic aging continues to accelerate during successful ART and prolonged virological suppression.

Methods: We longitudinally analyzed 63 long-term aviremic HIV-infected adults. Using blood DNA methylation patterns, we calculated EAA measures based on three epigenetic clocks (Horvath´s clock, PhenoAge and GrimAge). Read More

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Nonlethal age estimation of three threatened fish species using DNA methylation: Australian lungfish, Murray cod and Mary River cod.

Mol Ecol Resour 2021 Oct 23;21(7):2324-2332. Epub 2021 Jun 23.

School of Biological Sciences, The University of Western Australia, Crawley, WA, Australia.

Age-based demography is fundamental to management of wild fish populations. Age estimates for individuals can determine rates of change in key life-history parameters such as length, maturity, mortality and fecundity. These age-based characteristics are critical for population viability analysis in endangered species and for developing sustainable harvest strategies. Read More

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October 2021

The association of epigenetic clocks in brain tissue with brain pathologies and common aging phenotypes.

Neurobiol Dis 2021 Sep 19;157:105428. Epub 2021 Jun 19.

Rush Alzheimer's Disease Center, Chicago, IL, United States of America; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, United States of America.

Epigenetic clocks are calculated by combining DNA methylation states across select CpG sites to estimate biologic age, and have been noted as the most successful markers of biologic aging to date. Yet, limited research has considered epigenetic clocks calculated in brain tissue. We used DNA methylation states in dorsolateral prefrontal cortex specimens from 721 older participants of the Religious Orders Study and Rush Memory and Aging Project, to calculate DNA methylation age using four established epigenetic clocks: Hannum, Horvath, PhenoAge, GrimAge, and a new Cortical clock. Read More

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September 2021

Breast-Specific Molecular Clocks Comprised of Expression and Promoter Methylation Identify Individuals Susceptible to Cancer Initiation.

Cancer Prev Res (Phila) 2021 Aug 17;14(8):779-794. Epub 2021 Jun 17.

Department of Population Sciences, Beckman Research Institute at City of Hope, Duarte, California.

A robust breast cancer prevention strategy requires risk assessment biomarkers for early detection. We show that expression of , a transcription factor critical for normal mammary development, is downregulated in mammary luminal epithelia with age. DNA methylation of the promoter is negatively correlated with expression in an age-dependent manner. Read More

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Does the epigenetic clock GrimAge predict mortality independent of genetic influences: an 18 year follow-up study in older female twin pairs.

Clin Epigenetics 2021 Jun 13;13(1):128. Epub 2021 Jun 13.

Faculty of Sport and Health Sciences, Gerontology Research Center (GEREC), University of Jyväskylä, P.O. Box 35 (VIV), 40014, Jyväskylä, Finland.

Background: Epigenetic clocks are based on DNA methylation (DNAm). It has been suggested that these clocks are useable markers of biological aging and premature mortality. Because genetic factors explain variations in both epigenetic aging and mortality, this association could also be explained by shared genetic factors. Read More

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Epigenetic clock and methylation studies in elephants.

Aging Cell 2021 07 12;20(7):e13414. Epub 2021 Jun 12.

Department of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, CA, USA.

Age-associated DNA-methylation profiles have been used successfully to develop highly accurate biomarkers of age ("epigenetic clocks") in humans, mice, dogs, and other species. Here we present epigenetic clocks for African and Asian elephants. These clocks were developed using novel DNA methylation profiles of 140 elephant blood samples of known age, at loci that are highly conserved between mammalian species, using a custom Infinium array (HorvathMammalMethylChip40). Read More

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