8,912 results match your criteria epidermis dermis

Rhabdomyomatous mesenchymal hamartoma presenting as telangiectasia in a 57-year-old man.

J Cutan Pathol 2021 May 8. Epub 2021 May 8.

Razi laboratory, Rasht, Iran.

Rhabdomyomatous mesenchymal hamartoma (RMH) is a rare congenital malformation of the dermis and subcutaneous tissue. Usually, RMH occurs in the midline of the face and neck region. We described a case of RMH presenting as telangiectasia in a 57-year-old man with a history of pityriasis lichenoides chronicus. Read More

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Monopolar gene electrotransfer enhances plasmid DNA delivery to skin.

Bioelectrochemistry 2021 Apr 17;140:107814. Epub 2021 Apr 17.

Department of Medical Engineering, University of South Florida, Tampa, FL, United States.

A novel monopolar electroporation system and methodologies were developed for in vivo electroporation intended for potential clinical applications such as gene therapy. We hypothesized that an asymmetric anode/cathode electrode applicator geometry could produce favorable electric fields for electroporation, without the typical drawback associated with traditional needle and parallel plate geometries. Three monopolar electrode applicator prototypes were built and tested for gene delivery of reporter genes to the skin in a guinea pig model. Read More

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Polymorphous Light Eruption- An Indian Scenario.

Indian Dermatol Online J 2021 Mar-Apr;12(2):211-219. Epub 2021 Mar 2.

Department of Dermatology, Venereology and Leprosy, Pondicherry Institute of Medical Sciences, Pondicherry, India.

Polymorphous light eruption (PMLE) is the most common, idiopathic, acquired photodermatosis, characterized by abnormal, recurrent, and delayed reaction to sunlight. Polymorphous light eruption is common worldwide but the morphology, distribution, and pigmentary changes are unique in Indian skin which is discussed in this review. The prevalence of PMLE is around 10-20% in the general population. Read More

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Interference of with in the treatment of infected burns in Wistar rats.

Iran J Basic Med Sci 2021 Feb;24(2):143-149

Department of Microbiology, Damghan Branch, Islamic Azad University, Damghan, Iran.

Objectives: Burns are the most common type of trauma with a high mortality rate worldwide. The use of modern and natural medicines, especially probiotic products, has been recently considered for cutaneous wound healing. The present study was designed to investigate the effect of on wound healing caused by . Read More

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February 2021

Effect of Application Amounts on In Vitro Dermal Absorption Test Using Caffeine and Testosterone.

Pharmaceutics 2021 Apr 30;13(5). Epub 2021 Apr 30.

College of Pharmacy, Dankook University, 119 Dandae-ro, Cheonan 31116, Korea.

Dermal absorption of chemicals is a key factor in risk assessment. This study investigated the effects of different amounts of application on dermal absorption and suggested an appropriate application dose for proper dermal absorption. Caffeine and testosterone were chosen as test compounds. Read More

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Application of Cellular Resolution Full-Field Optical Coherence Tomography in vivo for the Diagnosis of Skin Tumours and Inflammatory Skin Diseases: A Pilot Study.

Dermatology 2021 May 4:1-11. Epub 2021 May 4.

Department of Dermatology, MacKay Memorial Hospital, Taipei, Taiwan.

Background: Optical coherence tomography (OCT) has been shown to provide non-invasive diagnosis of common skin neoplasms, especially basal cell carcinoma. OCT produces a cross-sectional view of the tissue, similar to a traditionally sectioned histopathological view, but the resolution of conventional OCT is low and thus limits clinical application.

Objectives: This study aimed to investigate the application ability of a full-field (FF)OCT system which was newly developed to scan the skin at the cellular level. Read More

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Topical creams of piperine loaded lipid nanocarriers for management of atopic dermatitis: development, characterization, and investigation using BALB/c mice model.

J Liposome Res 2021 May 4:1-9. Epub 2021 May 4.

Department of Pharmaceutics, Laureate Institute of Pharmacy, Jwalamukhi, India.

The aim of the research work was to investigate the efficacy of cream loaded with lipid nanocarriers (ethosomes) of piperine for the management of atopic dermatitis (AD) in comparison to conventional cream. Ethosomes of piperine were formulated with varying concentration of phosphatidylcholine and ethanol; and evaluated for entrapment efficiency (EE), sedimentation behaviour, vesicle size, zeta potential, drug release, and shape. Creams loaded with optimized ethosomal dispersion of piperine were formulated and evaluated for physicochemical parameters, permeation and drug retention in skin layers. Read More

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Case Report: Wound Closure Acceleration in a Patient With Toxic Epidermal Necrolysis Using a Lyophilised Amniotic Membrane.

Front Bioeng Biotechnol 2021 16;9:649317. Epub 2021 Apr 16.

Department of Burns and Plastic Surgery, Faculty of Medicine, University Hospital Brno, Masaryk University, Brno, Czechia.

Toxic epidermal necrolysis (TEN) is a rare life-threatening disease that mainly affects the skin and mucous membranes, resulting from a toxic delayed-type hypersensitivity (DTH) reaction (type IV reaction) to the presence of foreign antigens such as drugs. The clinical symptoms are caused by pathophysiological processes leading to massive apoptosis of keratinocytes in the dermo-epidermal junction. This results in the formation of a bulla and subsequent separation of the entire epidermis with the exposure of the dermis. Read More

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CD137: A Member of the TNFR Family - in Psoriasis Skin Lesions in Comparison with Normal Skin Specimens.

Iran J Pathol 2021 20;16(2):103-108. Epub 2020 Dec 20.

Department of Pathology, Faculty of Medical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.

Background & Objective: CD137 is a member of the TNF-Receptor family. TNF-alpha antagonists have therapeutic effect in active psoriasis. In this study, the relative frequency of CD137 expression was investigated in the inflammatory cells of psoriasis lesions for the first time. Read More

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December 2020

Preparation of Topical Itraconazole with Enhanced Skin/Nail Permeability and In Vivo Antifungal Efficacy against Superficial Mycosis.

Pharmaceutics 2021 Apr 27;13(5). Epub 2021 Apr 27.

Department of Biomedicine, Health & Life Convergence Sciences, BK21 Four, Biomedical and Healthcare Research Institute, Mokpo National University, Jeonnam 58554, Korea.

In this study, a stable and highly skin-permeable topical delivery system for itraconazole (ITZ) was designed to provide effective treatment against superficial mycosis. Herein, ITZ was incorporated into a solution composed of ethanol, benzyl alcohol, hydrochloric acid, Transcutol P, and cyclomethicone as a delivery vehicle, solubilizer, protonating agent, permeation enhancer, and spreading agent, respectively. At 72 h, the optimal topical ITZ formulation (ITZ-TF#11) exhibited 135% enhanced skin permeability, which led to increases in drug deposition in the stratum corneum, epidermis, and dermis of 479%, 739%, and 2024%, respectively, compared with the deposition of 1% ITZ in ethanol (control). Read More

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Responses to Mineral Supplementation and Salmon Lice () Infestation in Skin Layers of Atlantic Salmon ( L.).

Genes (Basel) 2021 Apr 19;12(4). Epub 2021 Apr 19.

Nofima AS, Muninbakken 9, 9019 Tromsø, Norway.

The crustacean ectoparasite salmon louse (), which severely affects Atlantic salmon health and welfare is one of the main problems of commercial aquaculture. In the present study, fish were fed a diet supplemented with extra minerals through the inclusion of a commercial additive (Biofeed Forte Salmon), substituting wheat in the control diet, before experimental infestation with salmon lice. Lice counts reduced with time but with no apparent effect of the diets. Read More

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Microneedles: A New Generation Vaccine Delivery System.

Micromachines (Basel) 2021 Apr 14;12(4). Epub 2021 Apr 14.

College of Medicine, QU Health, Qatar University, Doha P.O. Box 2731, Qatar.

Transdermal vaccination route using biodegradable microneedles is a rapidly progressing field of research and applications. The fear of painful needles is one of the primary reasons most people avoid getting vaccinated. Therefore, developing an alternative pain-free method of vaccination using microneedles has been a significant research area. Read More

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hTERT-Driven Immortalization of RDEB Fibroblast and Keratinocyte Cell Lines Followed by Cre-Mediated Transgene Elimination.

Int J Mol Sci 2021 Apr 7;22(8). Epub 2021 Apr 7.

Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Pirogov Russian National Research Medical University, Ostrovityanova 1, 117997 Moscow, Russia.

The recessive form of dystrophic epidermolysis bullosa (RDEB) is a crippling disease caused by impairments in the junctions of the dermis and the basement membrane of the epidermis. Using ectopic expression of hTERT/hTERT + BMI-1 in primary cells, we developed expansible cultures of RDEB fibroblasts and keratinocytes. We showed that they display the properties of their founders, including morphology, contraction ability and expression of the respective specific markers including reduced secretion of type VII collagen (C7). Read More

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Upper limb sensory evaluations and ultrasonographic skin measurements in breast cancer-related lymphedema receiving complex decongestive physiotherapy.

Support Care Cancer 2021 Apr 29. Epub 2021 Apr 29.

Faculty of Physical Therapy and Rehabilitation, Hacettepe University, 06100, Samanpazari, Ankara, Turkey.

Purpose: The aims of this study were to investigate if/how the presence of lymphedema affects the sensation of the upper limb and to assess whether complex decongestive physiotherapy (CDP) has a favorable impact on sensory testing.

Methods: A total of 27 patients with unilateral stage 2 breast cancer-related lymphedema (BCRL) were included in the study. Bilateral circumferential measurements were taken with a tape measure at different levels. Read More

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A Case of Generalized Lichen Sclerosus et Atrophicus.

Ann Dermatol 2020 Aug 30;32(4):327-330. Epub 2020 Jun 30.

Department of Dermatology, College of Medicine, Hallym University, Anyang, Korea.

A 62-year-old female, with previous history of asthma and hypertension, presented with generalized hyperpigmented skin lesion, found a year ago. Physical examination revealed brown colored lichenified and sclerotic patches on the lower abdomen and flexural areas of extremities. Punch biopsy was performed and histopathological examination revealed hyperkeratosis, follicular plugging and thinning in epidermis. Read More

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Exploratory Study of Epidermis, Basement Membrane Zone, Upper Dermis Alterations and Wnt Pathway Activation in Melasma Compared to Adjacent and Retroauricular Skin.

Ann Dermatol 2020 Apr 11;32(2):101-108. Epub 2020 Mar 11.

Department of Dermatology and Radioterapy, Botucatu School of Medicine, São Paulo State University, Botucatu, Brazil.

Background: Melasma is a chronic acquired focal hypermelanosis which pathogenesis has not been fully elucidated. Classical pathophysiologic studies have analysed the affected and perilesional areas, but little is known about the status of sun-protected skin, which is subjected to the same endogenous and genetic factors.

Objective: To assess the histological characteristics of melasma compared to adjacent and retroauricular skin. Read More

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High-frequency ultrasound as a scientific tool for skin imaging analysis.

Exp Dermatol 2021 Apr 27. Epub 2021 Apr 27.

Graduate Program in Internal Medicine, School of Medical Sciences - University of Campinas (UNICAMP), Campinas, Brazil.

Ultrasonic imaging is one of the most important diagnostic tools in clinical medicine due to its cost, availability and good correlation with pathological results. High-frequency ultrasound (HFUS) is a technique used in skin science that has been little explored, especially in comparison with other sites and imaging techniques. HFUS shows real-time images of the skin layers, appendages and skin lesions in vivo and can significantly contribute to advances in skin science. Read More

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Clinical, biometric and ultrasound assessment of the effects of the autologous fibroblast cells transplantation on nasolabial fold wrinkles.

J Cosmet Dermatol 2021 Apr 27. Epub 2021 Apr 27.

Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Background: Feeling beautiful and staying young have always been important to the people. Therefore, an extensive body of research has focused on the efforts made to remove the skin problems, especially wrinkles. Fibroblast cells of the skin are the various autologous cells currently used in repairing several wounds, scars, and skin aging. Read More

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Aplasia Cutis Congenita: A Case Report.

West Afr J Med 2021 Apr;38(4):391-394

Department of Paediatrics and Child Health, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria.

Aplasia cutis congenita (ACC) is a rare developmental disorder that is not fully understood. It often occurs in isolation but can also be syndromic. Usually, there is an absence of the epidermis and dermis. Read More

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Cutaneous involvement of multiple myeloma.

Malays J Pathol 2021 Apr;43(1):75-79

Universiti Putra Malaysia, Faculty of Medicine and Health Sciences, Departments of Pathology, Selangor, Malaysia.

Cutaneous multiple myeloma (MM) is a rare disease. It can be primary or secondary in origin. The secondary type is further classified into specific and nonspecific types. Read More

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Dermatokinetic assessment of luliconazole-loaded nanostructured lipid carriers (NLCs) for topical delivery: QbD-driven design, optimization, and in vitro and ex vivo evaluations.

Drug Deliv Transl Res 2021 Apr 24. Epub 2021 Apr 24.

Industrial Research Laboratory, Department of Pharmacy, Birla Institute of Technology and Science, Pilani Campus, 333031, Pilani, India.

The present study is concerned with the QbD-based design and development of luliconazole-loaded nanostructured lipid carriers (NLCs) hydrogel for enhanced skin retention and permeation. The NLCs formulation was optimized employing a 3-factor, 3-level Box-Behnken design. The effect of formulation variable lipid content, surfactant concentration, and sonication time was studied on particle size and % EE. Read More

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Differential Expression of Insulin-Like Growth Factor 1 and Wnt Family Member 4 Correlates With Functional Heterogeneity of Human Dermal Fibroblasts.

Front Cell Dev Biol 2021 6;9:628039. Epub 2021 Apr 6.

Centre for Stem Cells and Regenerative Medicine, King's College London, Guy's Hospital, London, United Kingdom.

Although human dermis contains distinct fibroblast subpopulations, the functional heterogeneity of fibroblast lines from different donors is under-appreciated. We identified one commercially sourced fibroblast line (c64a) that failed to express α-smooth muscle actin (α-SMA), a marker linked to fibroblast contractility, even when treated with transforming growth factor-β1 (TGF-β1). Gene expression profiling identified insulin-like growth factor 1 (IGF1) as being expressed more highly, and Asporin (ASPN) and Wnt family member 4 (WNT4) expressed at lower levels, in c64a fibroblasts compared to three fibroblast lines that had been generated in-house, independent of TGF-β1 treatment. Read More

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Localized Delivery of Drugs through Medical Textiles for Treatment of Burns: A Perspective Approach.

Adv Pharm Bull 2021 Feb 15;11(2):248-260. Epub 2020 Jul 15.

Department of Pharmacy, Pranveer Singh Institute of Technology, Kalpi Road, Bhauti, Kanpur-208020, India.

The topical delivery offers numerous benefits, such as the ability to deliver drugs specifically on site selectively, prevents fluctuations in the levels of the drug, improved compliance, and improved self-medication capacity. Skin is the main route of the administration of the drug delivery system (DDS) and burns mainly cause skin damage. A burn is a kind of damage caused to skin and tissues by fire, ice, electrical energy, pollutants, friction, and radiation. Read More

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February 2021

Characterisation of an ischemia reperfusion model for the formation of a stage I pressure ulcer in mouse skin.

J Tissue Viability 2021 Mar 26. Epub 2021 Mar 26.

Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Clinical Sciences Building, 11, Mandalay Road, 308232, Singapore; Skin Research Institute Singapore, Level 17, Clinical Sciences Building, 11, Mandalay Road, 308232, Singapore. Electronic address:

Pairs of magnets were applied to the loose skin on the backs of mice in order to cause ischemia for periods of 1.5, 2, 2.5 and 3 h followed by reperfusion. Read More

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An orthogonal methods assessment of topical drug concentrations in skin and the impact for risk assessment in the viable epidermis.

Regul Toxicol Pharmacol 2021 Apr 16;123:104934. Epub 2021 Apr 16.

Pfizer Drug Safety Research and Development, Eastern Point Road, Groton, CT, 06340, USA.

Systemic toxicity assessments for oral or parenteral drugs often utilize the concentration of drug in plasma to enable safety margin calculations for human risk assessment. For topical drugs, there is no standard method for measuring drug concentrations in the stratum basale of the viable epidermis. This is particularly important since the superficial part of the epidermis, the stratum corneum (SC), is nonviable and where most of a topically applied drug remains, never penetrating deeper into the skin. Read More

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Dermatoscopy and Reflective Confocal Microscopy for Facial Seborrheic Keratosis, Verruca Plana, and Nevus Pigmentosus.

J Coll Physicians Surg Pak 2021 Apr;30(4):450-454

Department of Dermatology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.

Objective: To describe the features of facial seborrheic keratosis, verruca plana, and nevus pigmentosus by dermatoscopy and reflective confocal microscope (RCM).

Study Design: Cross-sectional observational study.

Place And Duration Of Study: Dermatology Department of The Affiliated Hospital of Xuzhou Medical University from January 2017 to January 2019. Read More

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Combinatorial lipid-nanosystem for dermal delivery of 5-fluorouracil and resveratrol against skin cancer: Delineation of improved dermatokinetics and epidermal drug deposition enhancement analysis.

Eur J Pharm Biopharm 2021 Jun 14;163:223-239. Epub 2021 Apr 14.

Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India. Electronic address:

In the present study, combinatorial nanostructured lipid carrier gel of 5-fluorouracil and resveratrol was formulated, optimized and characterized to enhance permeation in between epidermis and dermis layers of the skin to obtain a synergistic effect against skin cancer. After extensive trials, a newly modified emulsiosonication method was developed and additionally, for the first time, stability studies were done in the beginning to optimize formulation technique, which exhibited two major benefits simultaneously; first, it provided best-optimized technique for preparation of combinatorial lipid-nanosystem, and secondly, it also demonstrated a detailed report card of durability of formulations. In vitro release study showed a significantly improved, slow and prolonged release of drugs from the optimized lipid-nanosystem (***p < 0. Read More

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Persistent expression of interleukin-17 and downstream effector cytokines in recalcitrant psoriatic lesions after ustekinumab treatment.

J Dermatol 2021 Apr 15. Epub 2021 Apr 15.

Department of Dermatology, Seoul National University College of Medicine and Seoul National University Bundang Hospital, Seongnam, Korea.

The interleukin (IL)-23/T-helper (Th)17 axis is considered central to the pathogenesis of psoriasis, with IL-36γ considered a marker for histological differential diagnosis. However, expression data regarding key cytokines in the pathogenesis of psoriasis, as well as data on the effects of IL-23 inhibition on downstream cytokines in human psoriatic skin, are limited. We investigated the expression profile of key cytokines and the effect of ustekinumab (UST) on cytokine expression in human psoriatic tissue. Read More

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Tumor Lysis Syndrome: Introduction of a Cutaneous Variant and a New Classification System.

Cureus 2021 Mar 11;13(3):e13816. Epub 2021 Mar 11.

Center for Personalized Cancer Therapy, University of California San Diego Moores Cancer Center, La Jolla, USA.

Tumor lysis syndrome, an oncological emergency, is characterized by laboratory parameters such as hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia, as well as renal injury with an elevated creatinine. Tumor lysis syndrome is seen in patients with aggressive malignancies and high tumor burden. More frequently, it occurs in individuals with hematologic malignancies such as high-grade lymphomas (such as Burkitt lymphoma) and leukemia (such as acute lymphocytic leukemia). Read More

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