12,413 results match your criteria eosin stained


TUMORS AND TUMOR-LIKE LESIONS OF THE SALIVARY GLANDS: MORPHOLOGICAL CHARACTERISTICS OF THE SURGICAL MATERIAL.

Wiad Lek 2021 ;74(4):929-933

TARAS SHEVCHENKO NATIONAL UNIVERSITY OF KYIV, KYIV, UKRAINE.

Objective: The aim is to give a morphological characteristic of tumors and tumor-like lesions of the salivary glands in the course of a comprehensive analysis of the surgical material.

Patients And Methods: Materials and methods: The study used surgical material from 67 patients with various pathologies of the salivary glands. The patients were treated at Kyiv City Clinical Hospital No. Read More

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January 2021

Effects of sporadic transthyretin amyloidosis frequently on the gallbladder and the correlation between amyloid deposition in the gallbladder and heart: A forensic autopsy-based histopathological evaluation.

Pathol Int 2021 Jun 21. Epub 2021 Jun 21.

Department of Legal Medicine, Faculty of Medicine, University of Toyama, Toyama, Japan.

The aim of the study is to evaluate the clinicopathological features of cholecystic ATTR deposition in patients with cardiac involvement, investigate the correlation of amyloid deposition severity in the gallbladder and the heart, and compare its prevalence in the gallbladder and other organs. Fifty patients with sporadic ATTR amyloidosis were identified. Of these, we evaluated 15 patients who underwent gallbladder sampling accurately. Read More

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Degenerative nuclear atypia in pleomorphic adenoma of salivary glands: Histological and immunohistochemical observations.

Pathol Res Pract 2021 May 13;224:153482. Epub 2021 May 13.

School of Dentistry, Institute of Life Course and Medical Sciences | Faculty of Health & Life Sciences, University of Liverpool, Liverpool, United Kingdom; Department of Pathology, Liverpool Clinical Laboratories, Liverpool, United Kingdom. Electronic address:

The occurrence and topographical distribution of nuclear changes regarded as degenerative were examined in 84 salivary pleomorphic adenomas (PAs). Haematoxylin and eosin-stained sections from them were light-microscopically studied for unusual variations in size, shape and chromatin pattern of tumour-cell nuclei. Selected cases were further examined by immunohistochemical techniques valuable in characterising cell phenotypes in PA, and cell cycle antigens. Read More

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Co-administration of obeticholic acid and simvastatin protects against high-fat diet-induced non-alcoholic steatohepatitis in mice.

Exp Ther Med 2021 Aug 3;22(2):830. Epub 2021 Jun 3.

The Key Laboratory of Hepatic Fibrosis Mechanisms of Chronic Liver Diseases in Hebei Province, Department of Traditional and Western Medical Hepatology, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei 050051, P.R. China.

Non-alcoholic steatohepatitis (NASH) has no approved therapy. The farnesoid X nuclear receptor (FXR) agonist obeticholic acid (OCA) has shown promise as a drug for NASH, but can adversely affect plasma lipid profiles. Therefore, the present study aimed to investigate the effects and underlying mechanisms of OCA in combination with simvastatin (SIM) in a high-fat diet (HFD)-induced model of NASH. Read More

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Histomorphological and Morphometric Evaluation of Microvessel Density in Nodal Non-Hodgkin Lymphoma Using CD34 and CD105.

J Lab Physicians 2021 Mar 22;13(1):22-28. Epub 2021 May 22.

Department of Pathology, Pt. B. D. Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India.

 Expression of angiogenic markers determined by microvessel density (MVD) could be used as a reliable predictor of prognosis and as a potential target for antiangiogenic therapy in different categories of non-Hodgkin lymphoma (NHL).  The aim of this study was to evaluate MVD using immunohistochemical methods and computer-assisted quantitative image analysis in nodal NHL patients and compare CD34 and CD105 expression in lymph nodes of NHL patients.  The present study was conducted on 60 lymph node biopsies received in the Department of Pathology at our tertiary care center for histopathological examination. Read More

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Histology of some major immune system organs in Lake Van fish Alburnus tarichi (Güldenstädt, 1814) (Cyprinidae).

Anat Histol Embryol 2021 Jun 17. Epub 2021 Jun 17.

Department of Biology, Institute of Natural and Applied Sciences, University of Van Yuzuncu Yil, Tuşba, Van, Turkey.

The teleostean immune system is variable between and within taxa in terms of morphology. Accordingly, in the current study, the histology of some immune organs (thymus, kidney and spleen) of Lake Van fish (Alburnus tarichi) was investigated. For this purpose, the tissues from eight mature fish were fixed and embedded in paraffin wax, and then the sections were stained with haematoxylin and eosin, Mallory's triple, periodic acid-Schiff and Alcian blue (pH of 2. Read More

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Early development of the cortical layers in the human brain.

J Anat 2021 Jun 17. Epub 2021 Jun 17.

Human Health Science, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

The cortical plate (CP) first appears at seven postconceptional weeks (pcw), when it splits the preexisting preplate into two layers, the marginal zone and the presubplate (pSP). Although three-dimensional (3D) analysis using fetal magnetic resonance imaging and two-dimensional tissue observations have been reported, there have been no studies analyzing the early development of the layer structure corresponding to the pSP stage in 3D. Here, we reconstructed 3-D models of the brain with a focus on the cortical layers in pSP stage. Read More

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Hepatotoxic effects of melamine exposure from the weaning period in rats: a flow cytometric, electron microscopic, and histopathologic study.

Toxicol Res (Camb) 2021 May 26;10(3):418-424. Epub 2021 Apr 26.

Dicle University, Faculty of Medicine, Department of Histology and Embryology, Sur, Diyarbakir 21200, Turkey.

This study aims to investigate the effects of melamine exposure from the weaning period (21st postnatal days in rats) on liver tissue. Female Wistar albino rats ( = 18) were divided into three groups. About 0. Read More

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Ink stained gastric lesions: a rare cause of gastrointestinal bleeding.

Rev Esp Enferm Dig 2021 Jun 18. Epub 2021 Jun 18.

Gastroenterology, The First Affiliated Hospital of Soochow University, suzhou.

A 61-year-old man was hospitalized in our department due to Intermittent melena for 4 days. Laboratory test showed reduced hemoglobin level (10,7g/L). Abdominal computed tomography (CT) showed gastric wall thickening in the body. Read More

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Comparison of clinical and histologic findings in daylight photodynamic therapy for skin field cancerization: a randomized controlled four-arm study on physical methods-assisted delivery of methyl aminolevulinate.

Photodiagnosis Photodyn Ther 2021 Jun 13:102404. Epub 2021 Jun 13.

Department of Clinical Medicine - Dermatology, Universidade Federal Fluminense, Brazil.

Background: Daylight photodynamic therapy (DL-PDT) has similar efficacy to conventional photodynamic therapy in treating actinic keratosis (AKs). Good clinical outcomes have been reported when associated with physical methods, but a comparison of different methods and histologic studies is lacking.

Objectives: To evaluate clinical and histologic modifications induced by standard DL-PDT and compare with DL-PDT associated with physical methods in treating skin field cancerization of the face. Read More

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Human Neutrophil Elastase Mediates MUC5AC Hypersecretion via the Tumour Necrosis Factor-α Converting Enzyme-Epidermal Growth Factor Receptor Signalling Pathway in vivo.

ORL J Otorhinolaryngol Relat Spec 2021 Jun 15:1-9. Epub 2021 Jun 15.

Department of Otolaryngology, The First Affiliated Hospital of Nanchang University, Nanchang, China.

Objectives: The objective of this study is to examine the role of the tumour necrosis factor-α converting enzyme-epidermal growth factor receptor (TACE-EGFR) pathway in human neutrophil elastase (HNE)-induced MUC5AC mucin expression in mice.

Method: Four groups of mice, treated with HNE alone (HNE group), HNE plus TACE inhibitor (HNE + TAPI-2 group), HNE plus EGFR inhibitor (HNE + AG1478 group), and untreated (control group), were used in the experiment. Histopathological changes were monitored by haematoxylin-eosin (HE) and periodic acid-Schiff (PAS) staining. Read More

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Redefining chronic endometritis: the importance of endometrial stromal changes.

Fertil Steril 2021 Jun 10. Epub 2021 Jun 10.

Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Chicago, Illinois. Electronic address:

Objective: To develop diagnostic criteria for chronic endometritis and compare the prevalence of chronic endometritis between women with recurrent pregnancy loss (RPL) and controls.

Design: Cohort study.

Setting: Single academic fertility center. Read More

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Dentinal Lesions in Dogs with Dental Calculus.

J Comp Pathol 2021 May 16;185:8-17. Epub 2021 Apr 16.

Laboratório de Patologia Veterinária do Departamento de Clínica e Cirurgia Veterinárias, Escola de Veterinária da Universidade Federal de Minas Gerais, , Belo Horizonte, Minas Gerais, Brazil. Electronic address:

Histopathological changes in tooth structures in dogs with calculus have not been described. The aim of this study was to evaluate the frequency of various histopathological changes in the dentine of teeth that had been surgically extracted from dogs with calculus. Data including breed, sex, age, reason for tooth extraction and dental history were obtained for each animal. Read More

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Evaluation of Villus Synovium From Unaffected Metacarpophalangeal Joints of Adult and Juvenile Horses.

J Equine Vet Sci 2021 Jul 29;102:103637. Epub 2021 Apr 29.

Deparment for horses, Faculty of Veterinary Medicine, Leipzig University, Leipzig, Germany.

Horses are a widely accepted model for osteoarthritis (OA) research. Synovial tissue sampling is commonly used in studies to evaluate and grade the progress of OA or to assess treatment effects. Synovial explants play an important role in ex-vivo studies, increasingly replacing the use of living animals. Read More

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Prognostic impact of histological review of high-grade endometrial carcinomas in a large Danish cohort.

Virchows Arch 2021 Jun 11. Epub 2021 Jun 11.

Department of Pathology, Copenhagen University Hospital, Herlev and Gentofte Hospital, Copenhagen University, Borgmester Ib Juuls Vej 73, 2730, Herlev, Denmark.

The aim of this study was to investigate the outcome of histological subtype review of high-grade endometrial carcinoma (EC) and its prognostic impact in a large well-documented Danish nationwide cohort. From the Danish Gynecological Cancer Database (DGCD) 2005-2012 cohort, we included 425 patients with an original diagnosis of high-grade EC, independent of histologic subtype. Of these, at least one hematoxylin and eosin (H&E)-stained slide from 396 cases (93. Read More

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Icariin contributes to healing skull defects in rabbit model.

J Tradit Chin Med 2021 Jun;41(3):471-478

Department of Oral and maxillofacial surgery, Hebei Key Laboratory of Stomatology, Hebei Clinical Research Center for Oral Diseases, School and Hospital of Stomatology, Hebei Medical University, Shijiazhuang, 050017, China.

Objective: To investigate the efficacy of icariin for healing skull defects in rabbit models.

Methods: Thirty-six 3-month-old female New Zealand white rabbits, weighing 1.8-2. Read More

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A comprehensive dataset of histopathology images, grades and patient demographics for human Osteoarthritis Cartilage.

Data Brief 2021 Aug 14;37:107129. Epub 2021 May 14.

Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.

Osteoarthritis (OA) is a leading cause of disability in older adults and takes substantial toll at personal, economic and societal levels. There is inadequate comprehension of OA disease progression specifically during the early phases of OA. This knowledge is critical to understanding the heterogeneity in OA progression as well as enable development of targeted therapeutics at the start of the disease rather than end-stage. Read More

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Prolyl-4-Hydroxylase α Subunit 2 as a Novel Potential Biomarker for Predicting the Prognosis of Epithelial Ovarian Carcinoma.

Cancer Manag Res 2021 3;13:4455-4462. Epub 2021 Jun 3.

Department of Obstetrics and Gynaecology, Hebei Medical University, Fourth Hospital, Shijiazhuang, People's Republic of China.

Objective: Epithelial ovarian cancer (EOC) is one of the leading causes of death worldwide. The aim of this study was to explore the prognostic significance of prolyl-4-hydroxylase α subunit 2 (P4HA2) in patients with EOC.

Patients And Methods: A total of 217 clinical samples (EOC tissues, 167 cases; normal ovarian, 50 cases) were collected and pathologically confirmed using hematoxylin and eosin (H&E) staining. Read More

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FEATURES OF GRANULATION TISSUE MORPHOLOGY AROUND THE NET ALLOTRANSPLANT WHEN APPLYING POSTOPERATIVE RADIATION THERAPY.

Georgian Med News 2021 Apr(313):139-146

Higher State Educational Institution of Ukraine Bukovinian State Medical University, Chernivtsi, Ukraine.

The aim of the research was to study experimentally the morphologic peculiarities of the granular tissue around the elements of the reticular allotransplant of the muscular aponeurotic layer of the anterior abdominal wall when using postoperative distant gamma therapy. The experiment has been done on 168 laboratory rats which were implanted with a prolenic mesh allograft into the tissues of muscular aponeurotic layer of the anterior abdominal wall. From the 13th to 19th day after the implantation of the reticular allograft, animals from the main group (96 rats) received irradiation of the site of the last one. Read More

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Pathology, bacteriology and molecular studies on caseous lymphadenitis in Camelus dromedarius in the Emirate of Abu Dhabi, UAE, 2015-2020.

PLoS One 2021 8;16(6):e0252893. Epub 2021 Jun 8.

Veterinary Laboratories, Animal Wealth Sector, Abu Dhabi Agriculture and Food Safety Authority (ADAFSA), Abu Dhabi, United Arab Emirates (UAE).

Caseous lymphadenitis (CLA) or pseudotuberculosis is a chronic zoonotic bacterial disease caused by Corynebacterium pseudotuberculosis, which affects livestock and humans. This study aimed to describe the pathology, bacteriology and confirm the identity of the pathogen by 16S rRNA gene sequencing in Camelus dromedarius. A total of 12 camels with suspected CLA in three regions of Abu Dhabi Emirate (Abu Dhabi, Al Ain and Al Dhafra), United Arab Emirate (UAE) were subjected to clinical and postmortem examinations from January 2015 to December 2020. Read More

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Histological and immunohistochemical features suggesting aetiological differences in lymph node and (muco)cutaneous feline tuberculosis lesions.

J Small Anim Pract 2021 Jun 7. Epub 2021 Jun 7.

*Royal (Dick) School of Veterinary Studies and The Roslin Institute, The University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, UK.

Objectives: To identify and describe histological and immunohistochemical criteria that may differentiate between skin and lymph node lesions associated with Mycobacterium (M.) bovis and M. microti in a diagnostic pathology setting. Read More

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Age-Related Retinal Changes in Wild-Type C57BL/6J Mice Between 2 and 32 Months.

Invest Ophthalmol Vis Sci 2021 Jun;62(7)

Department of Ophthalmology, Emory University, Atlanta, Georgia, United States.

Purpose: The purpose of this study was to extend our understanding of how aging affects normal retina function and morphology in wild-type C57BL/6J mice, by analyzing electrophysiological recordings and in vivo and post mortem anatomy.

Methods: Electroretinograms (ERGs), spectral domain optical coherence tomography (SD-OCT), and confocal scanning laser ophthalmoscope (cSLO) in vivo images were obtained from mice between the ages of 2 and 32 months in four groups: group 1 (<0.5 years), group 2 (1. Read More

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Three-Dimensionally Printed Skin Substitute Using Human Dermal Fibroblasts and Human Epidermal Keratinocytes.

Ann Plast Surg 2021 Jun;86(6S Suppl 5):S628-S631

Department of Biomedical Engineering.

Introduction: Wound healing affects millions of people annually. After injury, keratinocytes from the wound edge proliferate, migrate, and differentiate to recapitulate the 3-dimensional (3D) structure needed to provide a barrier function. If the wound is too large, skin grafting may be required. Read More

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Effect of fulvic acid on gastric mucosa damage caused by chronic water avoidance stress.

Biotech Histochem 2021 Jun 8:1-8. Epub 2021 Jun 8.

Hamidiye Medical School, Department of Histology and Embryology, University of Health Science, Istanbul, Turkey.

We investigated the antioxidant and anti-ulcerogenic effects of fulvic acid (FA) on oxidative damage caused by water avoidance stress (WAS) in rat gastrointestinal mucosa. Three experimental groups were established: control (C), chronic stress (CS), and chronic stress + FA (CS + FA). After WAS, a single dose of FA was administered for 10 days to the CS + FA group. Read More

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Histological, behavioural and flow cytometric datasets relating to acute ischaemic stroke in young, aged and ApoE mice in the presence and absence of immunomodulation with fingolimod.

Data Brief 2021 Jun 15;36:107146. Epub 2021 May 15.

Department of Pharmacology and Therapeutics, Western Gateway Building, University College Cork, Cork, Ireland.

In this work, the sphingosine-1-phosphate receptor modulator fingolimod was assessed as a preclinical candidate for the treatment of acute ischaemic stroke according to the Stroke Therapy Academic Industry Roundtable (STAIR) preclinical recommendations. Young (15-17 weeks), aged (72-73 weeks), and ApoE mice (20-21 weeks) fed a high fat diet (all C57BL/6 mice) underwent permanent electrocoagulation of the left middle cerebral artery. Mice received either saline or fingolimod (0. Read More

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The value of tumor-infiltrating lymphocytes and CD8 expression as a predictor of response to anthracycline-based neoadjuvant chemotherapy in invasive breast carcinoma of no special type.

Breast Dis 2021 May 28. Epub 2021 May 28.

Department of Pathology Anatomy, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia.

Background: The immune system is known to play an important role in tumor cell eradication. Although cancer cells were able to escape from the immune system, many studies showed mononuclear inflammatory cell infiltrates known as tumor-infiltrating lymphocytes (TILs) on breast cancer histopathology specimens showed better prognosis, including in disease-free survival (DFS) and chemotherapy responses.

Objective: This study aimed to reveal the predictive value of tumor-infiltrating lymphocytes (TILs) levels and CD8 expression in invasive breast carcinoma of no special type patients' samples on response to anthracycline-based neoadjuvant chemotherapy. Read More

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Mature t/nk-cell lymphomas of the oral and maxillofacial region: a multi-institutional collaborative study.

J Oral Pathol Med 2021 Jun 5. Epub 2021 Jun 5.

Department of Oral Diagnosis and Pathology, School of Dentistry, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

Background: The diagnosis of oral and maxillofacial mature T/NK-cell neoplasms is challenging because of their rarity, morphological heterogeneity and complex immunophenotype, with scarce available data describing their clinical and microscopic aspects. Therefore, in this study we investigated a series of mature T/NK-cell neoplasms affecting this anatomical region and provided an updated literature review.

Methods: Cases diagnosed as mature T/NK cell lymphomas affecting the oral and maxillofacial region were retrospectively retrieved from six pathology files and their diagnoses were confirmed using haematoxylin and eosin-stained slides, immunohistochemical reactions and in situ hybridization for Epstein-Barr virus (EBV) detection. Read More

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An Open Source, Automated Tumor Infiltrating Lymphocyte Algorithm for Prognosis in Triple-Negative Breast Cancer.

Clin Cancer Res 2021 Jun 4. Epub 2021 Jun 4.

Department of Pathology, Yale School of Medicine.

Purpose: Although tumor infiltrating lymphocytes (TIL) assessment has been acknowledged to have both prognostic and predictive importance in triple negative breast cancer (TNBC), it is subject to inter and intra-observer variability that has prevented widespread adoption. Here we constructed a machine-learning based breast cancer TIL scoring approach and validated its prognostic potential in multiple TNBC cohorts.

Experimental Design: Using the QuPath open source software, we built a neural-network classifier for tumor cells, lymphocytes, fibroblasts and "other" cells on hematoxylin-eosin (H&E) stained sections. Read More

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First evidence of infection in Aceh cattle: Pathomorphology and antigenic distribution in the lungs.

Vet World 2021 Apr 27;14(4):1007-1013. Epub 2021 Apr 27.

Department of Veterinary Clinic Reproduction and Pathology, Faculty of Veterinary Medicine, IPB University, Bogor, Indonesia.

Background And Aim: is an emerging zoonotic and foodborne pathogen worldwide. Hypervirulent (hvKp) was reported as the causative agent of bovine mastitis. This is the first study in Indonesia that has been conducted to determine the capsular serotype of , pulmonary gross pathology and histopathology, and distribution of hvKp in the lungs of Aceh cattle. Read More

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Characterization of liver GSD IX γ2 pathophysiology in a novel Phkg2 mouse model.

Mol Genet Metab 2021 Jul 25;133(3):269-276. Epub 2021 May 25.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA; Division of Medical Genetics, Department of Pediatrics, Duke University Medical Center, Durham, NC, USA. Electronic address:

Introduction: Liver Glycogen Storage Disease IX is a rare metabolic disorder of glycogen metabolism caused by deficiency of the phosphorylase kinase enzyme (PhK). Variants in the PHKG2 gene, encoding the liver-specific catalytic γ2 subunit of PhK, are associated with a liver GSD IX subtype known as PHKG2 GSD IX or GSD IX γ2. There is emerging evidence that patients with GSD IX γ2 can develop severe and progressive liver disease, yet research regarding the disease has been minimal to date. Read More

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