Immunobiology 2020 Nov 4;226(3):152027. Epub 2020 Nov 4.
Philipps University Marburg, Department of Medicine, D-355 Marburg, Lahn, Germany(2); Gastroenterology Research Laboratory, University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USA(2); Research Laboratories, Chemie Grünenthal GmbH, D-52062 Aachen, Germany(2). Electronic address:
While the angiotensin converting enzyme 2 (ACE2) protein is defined as the primary severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor, the viral serine molecule might be mobilized by the host's transmembrane protease serine subtype 2 (TMPRSS2) enzyme from the viral spike (S) protein and hijack the host's N-acetyl-D-galactosamine (GalNAc) metabolism. The resulting hybrid, serologically A-like/Tn (T nouvelle) structure potentially acts as a host-pathogen functional molecular bridge. In humans, this intermediate structure will hypothetically be replaced by ABO(H) blood group-specific, mucin-type structures, in the case of infection hybrid epitopes, implicating the phenotypically glycosidic accommodation of plasma proteins. Read More